Article
Multidisciplinary Sciences
Laura Marr, Dipsikha Biswas, Leonard A. Daly, Christopher Browning, Sarah C. M. Vial, Daniel P. Maskell, Catherine Hudson, Jay A. Bertrand, John Pollard, Neil A. Ranson, Heena Khatter, Claire E. Eyers, Kei Sakamoto, Elton Zeqiraj
Summary: The study describes the structural basis of glycogen synthase (GS) regulation, specifically its inactivation mechanism through phosphorylation. The findings provide insights into glycogen synthesis regulation and facilitate research on glycogen-related diseases.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Hairong Huang, Jiajun Chen, Xiaobo Hu, Yi Chen, Jianhua Xie, Tianxiang Ao, Hui Wang, Jiayan Xie, Qiang Yu
Summary: This study aims to investigate the interaction effect between dietary fiber components and bound polyphenol components in tea residues (TRDF) on the anti-hyperglycemic activity. The results showed that bound polyphenol components are essential for the anti-hyperglycemic activity of TRDF, and they also modulate gut microbiota and increase the content of short chain fatty acids.
Article
Engineering, Environmental
Yun Liao, Chuan Yan, Ke Zeng, Chenglin Liao, Meng Wang
Summary: The use of polysaccharide binders in asymmetrical RGH electrode configuration enhances the electrosorption performance for uranium removal, leading to faster kinetics and higher adsorption capacity compared to symmetrical PVDF-bound RGH configuration. This innovative design shows practical significance and economic benefits for electrosorption applications.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Agricultural Engineering
Rehebati Nuerxiati, Paiheerding Mutailifu, Chunfang Lu, Aytursun Abuduwaili, Amina Aierken, Zi Yang, Yanhua Gao, Gafurjon T. Mavlonov, Haji Akber Aisa, Abulimiti Yili
Summary: This study compared the effects of different solvents on the viscosity of Plantago ovata Forssk (POF) seeds to select the extraction solvent, and determined the optimum extraction conditions for maximum yields of polysaccharides. Two novel protein-bound heteropolysaccharides were isolated, showing potential as natural antioxidants in the medical and food industries.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Editorial Material
Medicine, General & Internal
Walter J. O'Donnell
Summary: The patient-safety movement has transformed clinical medicine into a team sport, but administrators have been overlooked. Consequently, the impact of administrative decisions and changes on patients remains unclear, unexamined, and unimprovable.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Sylvia Colliec-Jouault, Fabiana Esposito, Helene Ledru, Corinne Sinquin, Laetitia Marchand, Arnaud Fillaudeau, Sylvain Routier, Frederic Buron, Chrystel Lopin-Bon, Stephane Cuenot, Emiliano Bedini, Agata Zykwinska
Summary: Sulfated glycosaminoglycans (GAGs) play important roles in cell-cell and cell-matrix interactions. This study explores the use of microwave-assisted sulfation to obtain highly sulfated GAG mimetics. NMR structural analysis shows that microwave-assisted sulfation is as efficient as the conventional method, with a 12-fold shorter reaction time.
Article
Medicine, General & Internal
Ting-Yao Wang, Chao-Yu Chen, Tzu-Hao Huang, Yao-Hsu Yang, Ko-Jung Chen, Wen-Chi Chou, Chang-Hsien Lu
Summary: This study evaluated the efficacy of protein-bound polysaccharide K (PSK) in gastric cancer patients. Through a population-based historical cohort study using the National Health Insurance Research Database of Taiwan, it was found that adjuvant chemotherapy combined with PSK significantly prolonged overall survival in patients after gastrectomy.
Article
Public, Environmental & Occupational Health
Haoxiang Lin, Min Li, Li Xiao, Chun Chang, Gordon G. Liu
Summary: This study evaluated the effectiveness of a personalized text message-based smoking cessation intervention. The results showed that compared to a non-personalized intervention, the personalized text message intervention was more likely to decrease the frequency and amount of smoking in smokers who failed to quit. The study also explored the possible psychological mechanisms underlying these effects.
JOURNAL OF GLOBAL HEALTH
(2023)
Editorial Material
Medicine, General & Internal
Danielle R. Davis, Suchitra Krishnan-Sarin, Carolyn M. Mazure
Summary: This Viewpoint discusses the potential differential impacts of tobacco products on sex and gender subpopulations and suggests that the FDA should formulate regulations in ways that are clinically meaningful.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Biochemistry & Molecular Biology
Baifei Hu, Huabing Yang, Guangming Chen, Xiongjie Sun, Xiaojuan Zou, Jun Ma, Xiaowei Yao, Qiong Liang, Hongtao Liu
Summary: This study demonstrated the potential of Bletilla striata oligosaccharides (BOs) as a functional food for the treatment of non-alcoholic fatty liver disease (NAFLD). By regulating hepatic metabolism and reducing lipid accumulation and fibrosis, BOs showed improvement in NAFLD.
Article
Chemistry, Applied
Severin Eder, Patrick Zueblin, Michael Diener, Mohammad Peydayesh, Samy Boulos, Raffaele Mezzenga, Laura Nystrom
Summary: The study investigates the impact of polysaccharide conformation on ultrafiltration performance, revealing significant deviations between nominal MWCO and apparent M-w due to conformational variations. Results indicate that polysaccharides with different conformations show varied recovery rates during ultrafiltration processes based on experimental data.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Applied
Tiantian Sun, Shiyan Mai, Hongzhao Mao, Huiting Li, Yunyao Duan, Shuai Meng, Jiaolin Bao, Ning Ding, Chengli Zong
Summary: Around 100 serotypes of Streptococcus pneumonia (Spn) have been discovered, with 90% of severe diseases in children caused by 13 serotypes. The burden of pneumococcal disease has been significantly reduced with the success of pneumococcal bacterial polysaccharide conjugate vaccines (PCVs). The non-vaccine serotype 31 has increased in prevalence. The revised structure of the serotype 31 polysaccharide (s-31-ps) has been reported, and a conjugate vaccine has been prepared using organic solvent instead of water.
CARBOHYDRATE POLYMERS
(2022)
Review
Food Science & Technology
He Liu, Jiaxin Xu, Xinyue Xu, Zhiheng Yuan, Hong Song, Lina Yang, Danshi Zhu
Summary: This review provides a foundation for future research and development of bean polysaccharides. It summarizes the sources, structure, and functions of bioactive bean polysaccharides, focusing on their role in immunology, antioxidant, and anti-diabetic activities. The article offers useful guidance for optimizing polysaccharide structure and developing bean polysaccharides as novel functional materials.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Wei-Lun Qiu, Hung-Chih Lo, Mei-Kuang Lu, Tung-Yi Lin
Summary: In this study, Ganoderma lucidum mycelia were harvested at different cultural stages to obtain GPS and GSPS. The results showed that GPS and GSPS isolated from mycelia cultured for 49 days exhibited the best anticancer effect and inhibited lung cancer growth.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nutrition & Dietetics
Shanshan Wang, Hao Wu, Xiaoshuang Zhang, Shihong Luo, Shuang Zhou, Haiyan Fan, Chunmao Lv
Summary: In this study, chestnut polysaccharide (CP) was extracted and purified, and its antioxidant activity was improved. The purified CP showed increased branching structure, rod, and spherical structure, and reduced lamellar structure. Selenized chestnut polysaccharide (CP-Se) was prepared using nano-selenium method, and its scavenging abilities for radicals were significantly higher than those of CP. These findings provide insight into the effects of purification and selenization on the antioxidant activity of chestnut polysaccharide.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemical Research Methods
Stefano Capaldi, Beniamino Faggion, Maria E. Carrizo, Laura Destefanis, Maria C. Gonzalez, Massimiliano Perduca, Michele Bovi, Monica Galliano, Hugo L. Monaco
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Federico M. Issoglio, Nicolas Campolo, An Zeida, Tilman Grune, Rafael Radi, Dario A. Estrin, Silvina Bartesaghi
Article
Biochemistry & Molecular Biology
Maria C. Gonzalez, Jorge M. Romero, Mar Ia C. Ingaramo, Christian J. Munoz Sosa, Juan A. Curtino, Maria E. Carrizo
Article
Biochemistry & Molecular Biology
Virginia Lorenz, Yanina Ditamo, Romina B. Cejas, Maria E. Carrizo, Eric P. Bennett, Henrik Clausen, Gustavo A. Nores, Fernando J. Irazoqui
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Multidisciplinary Sciences
Martin Hugo, Alejandra Martinez, Madia Trujillo, Damian Estrada, Mauricio Mastrogiovanni, Edlaine Linares, Ohara Augusto, Federico Issoglio, Ari Zeida, Dario A. Estrin, Harry F. G. Heijnen, Lucia Piacenza, Rafael Radi
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Biochemistry & Molecular Biology
Jorge Miguel Romero, Maria Elena Carrizo, Juan Agustin Curtino
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2018)
Article
Biochemical Research Methods
Massimiliano Perduca, Michele Bovi, Mattia Bertinelli, Edoardo Bertini, Laura Destefanis, Maria E. Carrizo, Stefano Capaldi, Hugo L. Monaco
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
(2014)
Article
Physiology
Angela Fago, Chandrasekhar Natarajan, Martin Pettinati, Federico G. Hoffmann, Tobias Wang, Roy E. Weber, Salvador Drusin, Federico Issoglio, Marcelo A. Marti, Dario Estrin, Jay F. Storz
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Nicolas Campolo, Federico M. Issoglio, Dario A. Estrin, Silvina Bartesaghi, Rafael Radi
Article
Chemistry, Physical
F. N. Pedron, F. Issoglio, D. A. Estrin, D. A. Scherlis
JOURNAL OF CHEMICAL PHYSICS
(2020)
Article
Biochemistry & Molecular Biology
Christian J. Munoz Sosa, Federico M. Issoglio, Maria E. Carrizo
Summary: TRIM7 is an important E3 ubiquitin ligase that plays a role in cancer, viral pathogenesis, and atherosclerosis, making it a potential therapeutic target. It has a structure containing TRIM and B30.2 domains, with the X-ray crystal structure of the B30.2 domain revealing a putative binding interface for GN1. This information could be useful in developing potential therapeutic agents that target this interaction.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Samuel L. Freeman, Vera Skafar, Hanna Kwon, Alistair J. Fielding, Peter C. E. Moody, Alejandra Martinez, Federico M. Issoglio, Lucas Inchausti, Pablo Smircich, Ari Zeida, Lucia Piacenza, Rafael Radi, Emma L. Raven
Summary: This study solved the structure and examined the reactivity of the Trypanosoma cruzi ascorbate peroxidase-cytochrome c peroxidase enzyme (TcAPx-CcP), a hybrid heme peroxidase in the protozoan parasite Trypanosoma cruzi. The results showed that TcAPx-CcP has overall structural similarity to other peroxidases, with differences in substrate-binding regions. Additionally, TcAPx-CcP preserves the electron transfer pathway from cytochrome c to heme, preferentially oxidizing cytochrome c but still capable of oxidizing ascorbate.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Brenna J. C. Walsh, Sofia Soares Costa, Katherine A. Edmonds, Jonathan C. Trinidad, Federico M. Issoglio, Jose A. Brito, David P. Giedroc
Summary: Hydrogen sulfide (H2S) is a cytoprotective agent used by bacteria in response to stress, and this study found that exogenous sulfide alters protein abundance and metabolic reactions in the gut microorganism Enterococcus faecalis, potentially affecting fatty acid pathways.
Article
Biochemistry & Molecular Biology
Nicolas Campolo, Mauricio Mastrogiovanni, Michele Mariotti, Federico M. Issoglio, Dario Estrin, Per Hagglund, Tilman Grune, Michael J. Davies, Silvina Bartesaghi, Rafael Radi
Summary: Glutamine synthetase (GS) is an important enzyme that plays a crucial role in nitrogen metabolism. This study investigated the oxidative inactivation of human GS by peroxynitrite (ONOO-) in vitro. The results showed that ONOO- exposure led to a dose-dependent loss of GS activity and various oxidative modifications of the enzyme. Multiple tyrosine nitration sites and dityrosine cross-links were identified, but nitration of specific tyrosine residues alone was not responsible for enzyme inactivation. In addition, ONOO- induced GS aggregation and activity loss, with thiol oxidation being a key modification to elicit aggregation.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)