Article
Pharmacology & Pharmacy
Jose A. Pino, Gabriel Nunez-Vivanco, Gabriela Hidalgo, Miguel Reyes Parada, Habibeh Khoshbouei, Gonzalo E. Torres
Summary: This study reveals that G protein beta gamma subunits can bind to the dopamine transporter (DAT) and activate DAT-mediated dopamine efflux, similar to the mechanism of action of psychostimulants like amphetamine (AMPH). Through a combination of computational biology, mutagenesis, biochemical, and functional assays, the amino acid residues within the 582-596 sequence of the DAT carboxy terminus involved in the DAT-G beta gamma interaction and G beta gamma-induced dopamine efflux were identified. Residues like R588 and F587 within the carboxy terminus of DAT play critical roles in the physical interaction between DAT and G beta gamma, influencing dopamine efflux.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Rosaria Formisano, Katarzyna D. Rosikon, Abhyudai Singh, Harbinder S. Dhillon
Summary: The study examined the mechanisms of dopamine release and clearance, finding that DAT-1 acts as a negative feedback modulator in regulating neurotransmitter vesicle fusion. Through experimental results and a mechanistic model, the dynamics of synaptic vesicle fusion were dissected, and the feedback effects of DAT-1 were compared with dopamine auto-receptors. The findings have broader significance as similar dynamics may be utilized by other synaptic modulators across species.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Daria S. Kalinina, Vsevolod A. Lyakhovetskii, Oleg V. Gorskii, Polina Yu. Shkorbatova, Natalia V. Pavlova, Elena Yu. Bazhenova, Yurii I. Sysoev, Raul R. Gainetdinov, Pavel E. Musienko
Summary: Dopamine is a critical neurotransmitter involved in controlling muscle tone and body posture. In this study, we investigated the effects of dopamine deficiency on motor capacities and muscle responses to postural disturbance. The results showed that dopamine deficiency led to bradykinesia, rigidity, and postural instability, and affected the initiation pattern of corrective responses. These findings provide insights into the role of dopamine in postural reactions and can be used to study dopamine-related diseases.
Article
Biochemistry & Molecular Biology
Rachel A. Davies, Vy T. Nguyen, Jose M. Eltit, Richard A. Glennon
Summary: a-Pyrrolidinohexiophenone (a-PHP) is a synthetic cathinone central stimulant that is structurally similar to a-PVP. It is a potent dopamine transporter (DAT) reuptake inhibitor. In this study, a series of 4-substituted a-PHP analogues were examined, and most showed selective DAT reuptake inhibition with a narrow range of potency. The 4-CF3 analogue was an outlier with reduced potency and selectivity. QSAR study was not possible due to limited empirical results.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Adithya Gopinath, Tabish Riaz, Emily Miller, Leah Phan, Aidan Smith, Ohee Syed, Stephen Franks, Luis R. Martinez, Habibeh Khoshbouei
Summary: Methamphetamine, a commonly abused psychostimulant, targets the dopamine transporter (DAT) and inhibits dopamine uptake while increasing dopamine release in the brain. It also affects peripheral immune cells expressing DAT, leading to impaired wound healing and increased susceptibility to infection. The study showed that methamphetamine treatment down-regulated DAT expression in innate and adaptive immune cells, without affecting their total numbers. Additionally, serum cytokine distributions were altered in methamphetamine-treated mice. These findings suggest that methamphetamine modulates peripheral immune responses by regulating DAT expression.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Article
Neurosciences
Vindhya Nawaratne, Sean P. McLaughlin, Felix P. Mayer, Zayna Gichi, Alyssa Mastriano, Lucia Carvelli
Summary: The dopamine 2 receptors (D2R) play an important role in mediating the effects of amphetamine, which primarily rely on the ability of amphetamine to increase extracellular dopamine. This study found that prolonged exposure to amphetamine can decrease or increase endogenous hD2R at the cellular membrane in HEK293 cells. Moreover, the effects of amphetamine on D2R expression may occur independently of dopamine and DAT.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Maria Ptukha, Zoia Fesenko, Anastasia Belskaya, Arina Gromova, Arseniy Pelevin, Natalia Kurzina, Raul R. Gainetdinov, Anna Volnova
Summary: This study evaluated the effect of atomoxetine on the behavior and brain activity of dopamine transporter knockout (DAT-KO) rats, which exhibit ADHD-like behavior. Atomoxetine improved PPI and reduced repetitive behaviors in DAT-KO rats and also influenced the behavior of wild-type rats. Furthermore, it led to significant changes in power spectra and coherence of both DAT-KO and wild type rats.
Article
Biochemistry & Molecular Biology
Tao Ke, Ganesh Ambigapathy, Thanh Ton, Archana Dhasarathy, Lucia Carvelli
Summary: This study found that chronic embryonic exposure to amphetamine leads to changes in the expression of the DAT-1 gene in adult C. elegans, which is associated with an enhanced behavioral response to amphetamine in adult animals. Pharmacological and genetic interventions can prevent the long-lasting behavioral effects induced by amphetamine during embryogenesis. These findings are important for understanding how drugs of abuse can predispose to addiction, as the dopaminergic system and epigenetic mechanisms are highly conserved between C. elegans and mammals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Adithya Gopinath, Phillip M. Mackie, Leah T. Phan, Rosa Mirabel, Aidan R. Smith, Emily Miller, Stephen Franks, Ohee Syed, Tabish Riaz, Brian K. Law, Nikhil Urs, Habibeh Khoshbouei
Summary: The dopamine transporter (DAT) is not only expressed in the central nervous system and involved in neurological and neuropsychiatric diseases, but also in peripheral immune cells where it regulates immune responses. Blocking DAT activity enhances immune stimulation in macrophages, leading to increased inflammatory response and altered T and B cell populations.
Article
Neurosciences
Charles Sutton, Erin Q. Williams, Hoomam Homsi, Pieter Beerepoot, Reza Nazari, Dong Han, Amy J. Ramsey, Deborah C. Mash, David E. Olson, Bruce Blough, Ali Salahpour
Summary: Mutations in the dopamine transporter gene (SLC6A3) have been linked to Dopamine Transporter Deficiency Syndrome (DTDS), a disease characterized by minimal functional dopamine transporter protein and severe motor symptoms. Two pharmacological chaperones, bupropion and ibogaine, have shown efficacy in rescuing disease-causing variants. In this study, structure-activity relationships (SARs) were explored for these two compounds, identifying the important chemical features required for their chaperone activity. The findings contribute to the development of improved dopamine transporter pharmacological chaperones.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Karolina E. Kolaczynska, Paula Ducret, Daniel Trachsel, Marius C. Hoener, Matthias E. Liechti, Dino Luethi
Summary: This article examines the pharmacological properties of MDA analogs and related amphetamine-based compounds, including monoamine uptake inhibition and release, as well as transporter and receptor binding and activation properties. The study finds that some MDA analogs have similar pharmacological profiles to MDMA, while others have more pronounced dopaminergic activity. Further research on the pharmacokinetics and pharmacodynamics of these drugs is needed to better evaluate their risks and therapeutic potential.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jihye Yoo, In Kook Chun
Summary: F-18-FP-CIT PET/CT is a useful diagnostic tool that can differentiate between idiopathic Parkinson disease and atypical Parkinson syndrome by visualizing the striatum, where the nigrostriatal dopaminergic neurons' nerve endings are located. We present a case of an 83-year-old man with an unusual accumulation of F-18-FP-CIT in the infarct and peri-infarct brain area, who was referred for suspected cerebral infarction management due to sudden dysarthria and delirium.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Miguel A. Labrador-Espinosa, Michel J. Grothe, Daniel Macias-Garcia, Silvia Jesus, Astrid Adarmes-Gomez, Laura Munoz-Delgado, Paula Fernandez-Rodriguez, Juan Francisco Martin-Rodriguez, Ismael Huertas, David Garcia-Solis, Pablo Mir
Summary: The study found that reductions in DAT levels in the sensorimotor striatal subregion were most pronounced in PD patients who developed LID, providing a potentially sensitive tool for early detection and improved prognosis of this common complication in PD.
CLINICAL NUCLEAR MEDICINE
(2021)
Review
Cell Biology
Joanne Ng, Serena Barral, Simon N. Waddington, Manju A. Kurian
Summary: Infantile parkinsonism-dystonia due to dopamine transporter deficiency syndrome (DTDS) is an ultrarare childhood movement disorder caused by biallelic loss-of-function mutations in the SLC6A3 gene. Advances in genomic analysis have revealed an evolving spectrum of SLC6A3-related neurological and neuropsychiatric disorders. In this review, we provide an overview of the expanding clinical phenotype of DTDS and the precision therapies in development, including pharmacochaperones and gene therapy.
Article
Neurosciences
Sarah Threlfell, Amir Saeid Mohammadi, Brent J. Ryan, Natalie Connor-Robson, Nicola J. Platt, Rishi Anand, Florence Serres, Trevor Sharp, Nora Bengoa-Vergniory, Richard Wade-Martins, Andrew Ewing, Stephanie J. Cragg, Katherine R. Brimblecombe
Summary: This study investigated the impact of human alpha-synuclein on DAT function in a transgenic mouse model of early PD. The results show that alpha-synuclein can promote striatal DAT function, which is regulated by extracellular cholesterol.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Prashant Donthamsetti, Eduardo F. Gallo, David C. Buck, Edward L. Stahl, Ying Zhu, J. Robert Lane, Laura M. Bohn, Kim A. Neve, Christoph Kellendonk, Jonathan A. Javitch
MOLECULAR PSYCHIATRY
(2020)
Review
Neurosciences
Joseph J. Lebowitz, Habibeh Khoshbouei
NEUROBIOLOGY OF DISEASE
(2020)
Article
Multidisciplinary Sciences
Najeah Okashah, Shane C. Wright, Kouki Kawakami, Signe Mathiasen, Joris Zhou, Sumin Lu, Jonathan A. Javitch, Asuka Inoue, Michel Bouvier, Nevin A. Lambert
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Biochemistry & Molecular Biology
Caline S. Karam, Brenna L. Williams, Sandra K. Jones, Jonathan A. Javitch
Summary: The study reveals that amphetamine affects sleep and activity in fruit flies, with differing effects observed in flies without functional DAT. Amphetamine can reduce activity and restore sleep in these flies by modulating sleep structure. Fruit flies are shown to be a robust model for studying the mechanisms regulating DAT function and the action of psychostimulants.
NEUROCHEMICAL RESEARCH
(2022)
Review
Neurosciences
Mengfei Bu, Matthew J. Farrer, Habibeh Khoshbouei
Summary: The dopamine transporter (DAT) plays a crucial role in regulating dopamine neurotransmission and is implicated in neurodegenerative diseases like Parkinson's. Surface expression of DAT is dynamically regulated through endocytic trafficking, impacting dopamine signaling. Research shows that dysregulation of DAT trafficking is linked to neurodegenerative diseases.
NPJ PARKINSONS DISEASE
(2021)
Article
Neurosciences
Douglas R. Miller, Dylan T. Guenther, Andrew P. Maurer, Carissa A. Hansen, Andrew Zalesky, Habibeh Khoshbouei
Summary: The dopaminergic neurons in the substantia nigra pars compacta (SNC) and ventral tegmental area (VTA) exhibit regional differences in network connectivity, with a higher incidence of hub-like neurons in the VTA compared to the SNC. Neuronal loss in the SNC increases network clustering, whereas the VTA compensates by decreasing network clustering due to a larger number of hub-neurons. Network properties in these dopaminergic brain regions can be regulated via a dopamine transporter mechanism, demonstrating novel regulatory mechanisms of functional network topology.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Zixiu Xiang, Xiaohui Lv, Xin Lin, Daniel E. O'Brien, Molly K. Altman, Craig W. Lindsley, Jonathan A. Javitch, Colleen M. Niswender, P. Jeffrey Conn
Summary: Studies have shown that mGluR2 and mGluR4 exist as functional heterodimers, regulating excitatory transmission in a synapse-specific manner within the rodent medial prefrontal cortex. Activation of mGlu(2)/mGlu(4) heterodimers inhibits glutamatergic signaling.
Article
Oncology
Ping Shi, Lan B. Hoang-Minh, Jia Tian, Alice Cheng, Reemsha Basrai, Neil Kalaria, Joseph J. Lebowitz, Habibeh Khoshbouei, Loic P. Deleyrolle, Matthew R. Sarkisian
Summary: HDAC6 plays a critical role in promoting the proliferation of glioma cells through primary cilia, and inhibiting HDAC6 activity leads to reduced tumor cell proliferative capacity and increased cell differentiation, dependent on the presence of cilia in the cells.
Review
Biochemistry & Molecular Biology
Eleanor H. Simpson, Eduardo F. Gallo, Peter D. Balsam, Jonathan A. Javitch, Christoph Kellendonk
Summary: Research suggests that the etiology of schizophrenia involves overstimulation of dopamine receptors, particularly the D2 receptors. Animal models have shown that alterations in D2 receptor levels can affect the manifestation of schizophrenia symptoms, especially in terms of striatal circuit function and motivated behavior.
MOLECULAR PSYCHIATRY
(2022)
Review
Clinical Neurology
Carissa A. Hansen, Douglas R. Miller, Stephanie Annarumma, Carley T. Rusch, Adolfo Ramirez-Zamora, Habibeh Khoshbouei
Summary: This manuscript provides a comprehensive review of treatment protocols, absorption, distribution, and drug/food interactions related to L-DOPA-induced dyskinesia, and discusses current strategies and future directions.
JOURNAL OF NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eduardo F. Gallo, Julia Greenwald, Jenna Yeisley, Eric Teboul, Kelly M. Martyniuk, Joseph M. Villarin, Yulong Li, Jonathan A. Javitch, Peter D. Balsam, Christoph Kellendonk
Summary: Cholinergic interneurons in the striatum respond to salient stimuli with a pause in activity, which is regulated by dopamine D2 receptors. Upregulation of D2Rs in these neurons leads to a prolonged pause in activity and an enhanced decrease in acetylcholine levels during behavior, resulting in a deficit in learning inhibitory responses. This study highlights the important role of CIN D2Rs in modulating responses to salient stimuli and their impact on inhibitory learning.
MOLECULAR PSYCHIATRY
(2022)
Article
Cell Biology
Adithya Gopinath, Phillip M. Mackie, Leah T. Phan, Rosa Mirabel, Aidan R. Smith, Emily Miller, Stephen Franks, Ohee Syed, Tabish Riaz, Brian K. Law, Nikhil Urs, Habibeh Khoshbouei
Summary: The dopamine transporter (DAT) is not only expressed in the central nervous system and involved in neurological and neuropsychiatric diseases, but also in peripheral immune cells where it regulates immune responses. Blocking DAT activity enhances immune stimulation in macrophages, leading to increased inflammatory response and altered T and B cell populations.
Article
Endocrinology & Metabolism
Jacob Emil Petersen, Maria Hauge Pedersen, Oksana Dmytriyeva, Emilie Nellemose, Tulika Arora, Maja Storm Engelstoft, Wesley B. Asher, Jonathan A. Javitch, Thue W. Schwartz, Mette Trauelsen
Summary: The activation of FFAR1 can induce both IP3/Ca2+ signaling pathway and cAMP signaling pathway, and the co-activation of these two pathways is required for the highly efficient hormone secretion induced by second-generation FFAR1 agonists. Adcy2 gene is highly expressed in enteroendocrine cells of the intestine and may mediate Gq-driven cAMP signaling response.
MOLECULAR METABOLISM
(2023)
Article
Chemistry, Physical
S. Tori Ellison, Senthilkumar Duraivel, Vignesh Subramaniam, Fredrik Hugosson, Bo Yu, Joseph J. Lebowitz, Habibeh Khoshbouei, Tanmay P. Lele, Mark Q. Martindale, Thomas E. Angelini
Summary: Cell type variation plays a crucial role in tissue physiology. To better understand the relationship between tissue structure and function, and to engineer accurate tissues, it is necessary to assemble 3D cellular structures with detailed precision. In this study, a method of 3D cell assembly with subcellular precision is introduced. The authors demonstrate the ability to create detailed cellular patterns and show functional characteristics after assembly.
Article
Biochemistry & Molecular Biology
Jianjun Fan, Yang Xiao, Matthias Quick, Yuwei Yang, Ziyi Sun, Jonathan A. Javitch, Xiaoming Zhou
Summary: The neurotransmitter:sodium symporter (NSS) homolog LeuT from Aquifex aeolicus is a valuable model for studying the transport mechanism of the NSS family. Crystal structures and studies on substrate binding dynamics suggest a potential competition between outward-open and outward-occluded states during substrate transport. The interplay between the protonation state of Glu290 and Na1 binding may regulate the outward-open-to-occluded transition.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)