Article
Immunology
Ming-long Cai, Lan Gui, He Huang, Yu-kun Zhang, Li Zhang, Zhu Chen, Yu-jun Sheng
Summary: This study revealed heterogeneity in the pathogenesis of SLE between male and female patients, with male SLE showing higher levels of neutrophil activation. These findings provide a basis for the development of gender-specific treatments.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Marie-Helene Paclet, Salome Laurans, Sophie Dupre-Crochet
Summary: This article reviews the multiple roles of NOX2 in neutrophil functions, with a focus on the description of its components and their assembly mechanisms. It also explains the role of energy metabolism and phosphoinositides in regulating NADPH oxidase activity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Immunology
Aleida Susana Castellanos Gutierrez, Francesc Figueras, Diana M. Morales-Prieto, Ekkehard Schleussner, Gerard Espinosa, Nuria Banos
Summary: Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease that mainly affects women of childbearing age. During pregnancy, SLE is associated with a higher risk of perinatal morbidity and mortality. Several studies have suggested that placental dysfunction may play a crucial role in this association.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Haoguang Li, Xiuling Zhang, Jingjing Shang, Xueqin Feng, Le Yu, Jie Fan, Jie Ren, Rongwei Zhang, Xinwang Duan
Summary: This study investigated the molecular characteristics of NETs-related genes (NRGs) in systemic lupus erythematosus (SLE) through bioinformatics analysis. Eight differentially expressed NRGs were identified and HMGB1, ITGB2, and CREB5 were selected as hub genes. These hub genes showed significant diagnostic value for SLE and three distinct NETs-related sub-clusters were identified. This study provides new insights into the molecular characteristics of NRGs in SLE and identifies potential biomarkers and molecular clusters.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Paul Curtiss, Amanda M. Walker, Benjamin F. Chong
Summary: This study reviewed patient cohorts and populations to investigate the progression of cutaneous lupus to systemic lupus. The study found variations in the progression rates between adult and pediatric groups, which were attributed to differences in patient populations, study design, diagnostic criteria, and follow-up time. Risk factors associated with the development of systemic lupus included positive anti-nuclear antibodies, hematologic abnormalities, and a higher number of lupus classification criteria at baseline.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Sze-Ming Law, Shuji Akizuki, Akio Morinobu, Koichiro Ohmura
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disorder, and somatic mutations of certain genes, such as KRAS, may cause the refractoriness of SLE.
INFLAMMATION AND REGENERATION
(2022)
Article
Cell Biology
Simon Lind, Yanling Wu, Martina Sundqvist, Huamei Forsman, Claes Dahlgren
Summary: Signals generated by ATP/P2Y2R can activate FFA2R and induce the activation of neutrophils by increasing the cytosolic concentration of ionized calcium.
CELLULAR SIGNALLING
(2023)
Article
Dermatology
Mingfang Li, Luobei Weng, Datang Yu, Guofei Yang, Jin Hao
Summary: Abnormal death of neutrophils and ineffective clearance of cell fragments contribute to autoantigen production, resulting in systemic lupus erythematosus (SLE). Excessive formation of neutrophil extracellular traps (NETs) triggers the synthesis of pro-inflammatory cytokines and leads to tissue damage and immune dysfunction in SLE patients. In this study, a decrease in neutrophil counts was associated with clinical parameters in SLE patients, and targeting the autophagy-related gene HIF1A could be a potential therapeutic approach.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Cell Biology
Enrica Pellegrino, Beren Aylan, Claudio Bussi, Antony Fearns, Elliott M. Bernard, Natalia Athanasiadi, Pierre Santucci, Laure Botella, Maximiliano G. Gutierrez
Summary: Peroxisomes play a role in restricting cytosolic Mycobacterium tuberculosis (Mtb) infection in human macrophages by increasing ROS levels.
JOURNAL OF CELL BIOLOGY
(2023)
Review
Oncology
Kaichi Kaneko, Hao Chen, Matthew Kaufman, Isaak Sverdlov, Emily M. Stein, Kyung-Hyun Park-Min
Summary: Osteonecrosis is a complex and devastating complication of systemic lupus erythematosus, with variable prevalence in SLE patients. The use of high-dose glucocorticoid therapy is strongly associated with the development of osteonecrosis in SLE patients, although the exact pathophysiology and risk factors for osteonecrosis in this population are not fully understood.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Valeria Rella, Cinzia Rotondo, Alberto Altomare, Francesco Paolo Cantatore, Addolorata Corrado
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a wide range of clinical manifestations. Dysregulation of the immune system due to genetic, hormonal, and environmental factors can lead to various complications, including bone involvement such as osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Shih-Yao Chen, Chung-Teng Wang, Ching-Yi Chen, Pin-Yu Kuo, Chrong-Reen Wang, Ai-Li Shiau, Cheng-Hsi Chang, Chao-Liang Wu
Summary: In this study, researchers found that the expression levels of galectin-3 were higher in the peripheral blood mononuclear cells of SLE patients compared with normal individuals and positively correlated with lupus nephritis and SLE disease activity index. They also observed NETosis in normal individuals, SLE patients, and galectin-3 knockout mice. Furthermore, galectin-3 was found to be associated with NETs and immune complex deposition in SLE patients. These findings provide clinical relevance of galectin-3 in SLE and offer insights into the underlying mechanisms of galectin-3-mediated NETosis for developing novel therapeutic strategies targeting galectin-3 for SLE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Shunxiang Li, Huihua Ding, Ziheng Qi, Jing Yang, Jingyi Huang, Lin Huang, Mengji Zhang, Yuanjia Tang, Nan Shen, Kun Qian, Qiang Guo, Jingjing Wan
Summary: Serum metabolic fingerprints can be used for disease diagnosis and biomarker discovery. By analyzing the serum metabolic fingerprints of systemic lupus erythematosus (SLE) patients and healthy controls, early diagnosis and precision medicine for SLE can be achieved. This study identified the unique metabolic pattern of SLE patients and screened out a panel of metabolic biomarkers.
Article
Cell Biology
Jasmin Knopf, Johanna Sjowall, Martina Frodlund, Jorma Hinkula, Martin Herrmann, Christopher Sjowall
Summary: The severity of COVID-19 is related to immune response, which raises concerns for patients with autoimmune disorders. Thromboembolism, characterized by the occlusion of vessels by NETs, is a complication of COVID-19. This study suggests that an imbalance in NET formation and clearance may exacerbate autoimmunity and disease severity. Serologic evidence of SARS-CoV-2 exposure has minor impact on the course of SLE.
Review
Medicine, General & Internal
Helena Enocsson, Jesper Karlsson, Hai-Yun Li, Yi Wu, Irving Kushner, Jonas Wettero, Christopher Sjowall
Summary: C-reactive protein (CRP) is a sensitive but nonspecific biomarker of inflammation, with increased levels potentially predicting cardiovascular events and playing a beneficial role in autoimmune diseases. Autoimmune conditions characterized by the Type I interferon gene signature are exceptions to the general rule that CRP levels correlate with inflammation severity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Niyati Jhaveri, Fabienne Agasse, Don Armstrong, Lilei Peng, Deborah Commins, Weijun Wang, Rachel Rosenstein-Sisson, Vijaya Pooja Vaikari, Shayane V. Santiago, Tiago Santos, Ligang Chen, Axel H. Schoenthal, Thomas C. Chen, Florence M. Hofman
Article
Developmental Biology
Don L. Armstrong, Michael R. McGowen, Amy Weckle, Priyadarshini Pantham, Jason Caravas, Dalen Agnew, Kurt Benirschke, Sue Savage-Rumbaugh, Eviatar Nevo, Chong J. Kim, Gunter P. Wagner, Roberto Romero, Derek E. Wildman
Article
Rheumatology
Bahram Namjou, Andrea L. Sestak, Don L. Armstrong, Raphael Zidovetzki, Jennifer A. Kelly, Noam Jacob, Voicu Ciobanu, Kenneth M. Kaufman, Joshua O. Ojwang, Julie Ziegler, Francesco P. Quismorio, Andreas Reiff, Barry L. Myones, Joel M. Guthridge, Swapan K. Nath, Gall R. Bruner, Ruth Mehrian-Shai, Earl Silverman, Marisa Klein-Gitelman, Deborah McCurdy, Linda Wagner-Weiner, James J. Nocton, Chaim Putterman, Sang-Cheol Bae, Yun Jung Kim, Michelle Petri, John D. Reveille, Timothy J. Vyse, Gary S. Gilkeson, Diane L. Kamen, Marta E. Alarcon-Riquelme, Patrick M. Gaffney, Kathy L. Moser, Joan T. Merrill, R. Hal Scofield, Judith A. James, Carl D. Langefeld, John B. Harley, Chaim O. Jacob
ARTHRITIS AND RHEUMATISM
(2009)
Article
Neurosciences
Jennifer A. Sumner, Natalie L. Colich, Monica Uddin, Don Armstrong, Katie A. McLaughlin
BIOLOGICAL PSYCHIATRY
(2019)
Article
Biophysics
Don Armstrong, Raphael Zidovetzki
BIOPHYSICAL JOURNAL
(2008)
Article
Biochemical Research Methods
Don L. Armstrong, Chaim O. Jacob, Raphael Zidovetzki
BMC BIOINFORMATICS
(2008)
Article
Genetics & Heredity
D. L. Armstrong, A. Reiff, B. L. Myones, F. P. Quismorio, M. Klein-Gitelman, D. McCurdy, L. Wagner-Weiner, E. Silverman, J. O. Ojwang, K. M. Kaufman, J. A. Kelly, J. T. Merrill, J. B. Harley, S-C Bae, T. J. Vyse, G. S. Gilkeson, P. M. Gaffney, K. L. Moser, C. Putterman, J. C. Edberg, E. E. Brown, J. Ziegler, C. D. Langefeld, R. Zidovetzki, C. O. Jacob
GENES AND IMMUNITY
(2009)
Article
Genetics & Heredity
D. L. Armstrong, R. Zidovetzki, M. E. Alarcon-Riquelme, B. P. Tsaos, L. A. Criswell, R. P. Kimberly, J. B. Harley, K. L. Sivils, T. J. Vyse, P. M. Gaffney, C. D. Langefeld, C. O. Jacob
GENES AND IMMUNITY
(2014)
Article
Clinical Neurology
Christopher J. Stapleton, Don L. Armstrong, Raphael Zidovetzki, Charles Y. Liu, Steven L. Giannotta, Florence M. Hofman
Article
Multidisciplinary Sciences
Chaim O. Jacob, Jiankun Zhu, Don L. Armstrong, Mei Yan, Jie Han, Xin J. Zhou, James A. Thomas, Andreas Reiff, Barry L. Myones, Joshua O. Ojwang, Kenneth M. Kaufman, Marisa Klein-Gitelman, Deborah McCurdy, Linda Wagner-Weiner, Earl Silverman, Julie Ziegler, Jennifer A. Kelly, Joan T. Merrill, John B. Harley, Rosalind Ramsey-Goldman, Luis M. Vila, Sang-Cheol Bae, Timothy J. Vyse, Gary S. Gilkeson, Patrick M. Gaffney, Kathy L. Moser, Carl D. Langefeld, Raphael Zidovetzki, Chandra Mohan
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2009)
Article
Multidisciplinary Sciences
Chaim O. Jacob, Miriam Eisenstein, Mary C. Dinauer, Wenyu Ming, Qiang Liu, Sutha John, Francesco P. Quismorio, Andreas Reiff, Barry L. Myones, Kenneth M. Kaufman, Deborah McCurdy, John B. Harley, Earl Silverman, Robert P. Kimberly, Timothy J. Vyse, Patrick M. Gaffney, Kathy L. Moser, Marisa Klein-Gitelman, Linda Wagner-Weiner, Carl D. Langefeld, Don L. Armstrong, Raphael Zidovetzki
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2012)
Article
Zoology
Laren Narapareddy, Derek E. Wildman, Don L. Armstrong, Amy Weckle, Aleeca F. Bell, Crystal L. Patil, Suzette D. Tardif, Corinna N. Ross, Julienne N. Rutherford
AMERICAN JOURNAL OF PRIMATOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Don L. Armstrong, Omer Markovitch, Raphael Zidovetzki, Doron Lancet
Article
Rheumatology
Chaim O. Jacob, Andreas Reiff, Don L. Armstrong, Barry L. Myones, Earl Silverman, Marisa Mein-Gitelman, Deborah McCurdy, Linda Wagner-Weiner, James J. Nocton, Aaron Solomon, Raphael Zidovetzki
ARTHRITIS AND RHEUMATISM
(2007)