Proteasome-mediated Proteolysis of the Polyglutamine-expanded Androgen Receptor Is a Late Event in Spinal and Bulbar Muscular Atrophy (SBMA) Pathogenesis
Published 2015 View Full Article
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Title
Proteasome-mediated Proteolysis of the Polyglutamine-expanded Androgen Receptor Is a Late Event in Spinal and Bulbar Muscular Atrophy (SBMA) Pathogenesis
Authors
Keywords
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Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 290, Issue 20, Pages 12572-12584
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Online
2015-03-21
DOI
10.1074/jbc.m114.617894
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Note: Only part of the references are listed.- Dynamic recruitment of active proteasomes into polyglutamine initiated inclusion bodies
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- Linear and extended: a common polyglutamine conformation recognized by the three antibodies MW1, 1C2 and 3B5H10
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- Disease-Associated Polyglutamine Stretches in Monomeric Huntingtin Adopt a Compact Structure
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- Methylene Blue Modulates Huntingtin Aggregation Intermediates and Is Protective in Huntington's Disease Models
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- SIRT1 Modulates Aggregation and Toxicity through Deacetylation of the Androgen Receptor in Cell Models of SBMA
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- Identifying polyglutamine protein species in situ that best predict neurodegeneration
- (2011) Jason Miller et al. Nature Chemical Biology
- Mutant Huntingtin Fragments Form Oligomers in a Polyglutamine Length-dependent Mannerin Vitroandin Vivo
- (2010) Justin Legleiter et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- An Interdomain Interaction of the Androgen Receptor Is Required for Its Aggregation and Toxicity in Spinal and Bulbar Muscular Atrophy
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- Acute Polyglutamine Expression in Inducible Mouse Model Unravels Ubiquitin/Proteasome System Impairment and Permanent Recovery Attributable to Aggregate Formation
- (2010) Z. Ortega et al. JOURNAL OF NEUROSCIENCE
- Native Functions of the Androgen Receptor Are Essential to Pathogenesis in a Drosophila Model of Spinobulbar Muscular Atrophy
- (2010) Natalia B. Nedelsky et al. NEURON
- Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy
- (2009) Heather L. Montie et al. HUMAN MOLECULAR GENETICS
- Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease
- (2009) Kirupa Sathasivam et al. HUMAN MOLECULAR GENETICS
- Polyglutamine-Expanded Androgen Receptor Truncation Fragments Activate a Bax-Dependent Apoptotic Cascade Mediated by DP5/Hrk
- (2009) J. E. Young et al. JOURNAL OF NEUROSCIENCE
- FOXO3a Is Broadly Neuroprotective In Vitro and In Vivo against Insults Implicated in Motor Neuron Diseases
- (2009) J. Mojsilovic-Petrovic et al. JOURNAL OF NEUROSCIENCE
- Single Neuron Ubiquitin-Proteasome Dynamics Accompanying Inclusion Body Formation in Huntington Disease
- (2008) Siddhartha Mitra et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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