Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor

Atomic Structure of GRK5 Reveals Distinct Structural Features Novel for G Protein-coupled Receptor Kinases

(2015) Konstantin E. Komolov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Basis for Small Molecule Inhibition of G Protein-Coupled Receptor Kinases

(2014) Kristoff T. Homan et al.   ACS Chemical Biology

Identification and Structure–Function Analysis of Subfamily Selective G Protein-Coupled Receptor Kinase Inhibitors

(2014) Kristoff T. Homan et al.   ACS Chemical Biology

Regulation of G Protein-Coupled Receptor Kinases by Phospholipids

(2013) K.T. Homan et al.   CURRENT MEDICINAL CHEMISTRY

Nuclear Translocation of Cardiac G Protein-Coupled Receptor Kinase 5 Downstream of Select Gq-Activating Hypertrophic Ligands Is a Calmodulin-Dependent Process

(2013) Jessica I. Gold et al.   PLoS One

Membrane Orientation and Binding Determinants of G Protein-Coupled Receptor Kinase 5 as Assessed by Combined Vibrational Spectroscopic Studies

(2013) Pei Yang et al.   PLoS One

Paroxetine Is a Direct Inhibitor of G Protein-Coupled Receptor Kinase 2 and Increases Myocardial Contractility

(2012) David M. Thal et al.   ACS Chemical Biology

Structure of a monomeric variant of rhodopsin kinase at 2.5 Å resolution

(2012) John J. G. Tesmer et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Determining the Absolute Requirement of G Protein–Coupled Receptor Kinase 5 for Pathological Cardiac Hypertrophy

(2012) Jessica I. Gold et al.   CIRCULATION RESEARCH

The Origin and Evolution of G Protein-Coupled Receptor Kinases

(2012) Arcady Mushegian et al.   PLoS One

Molecular structure and target recognition of neuronal calcium sensor proteins

(2012) James B. Ames et al.   Frontiers in Molecular Neuroscience

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A Myristoyl/Phosphoserine Switch Controls cAMP-Dependent Protein Kinase Association to Membranes

(2011) Ece C. Gaffarogullari et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors

(2011) D. M. Thal et al.   MOLECULAR PHARMACOLOGY

G protein-coupled receptor kinases: More than just kinases and not only for GPCRs

(2011) Eugenia V. Gurevich et al.   PHARMACOLOGY & THERAPEUTICS

Molecular basis for activation of G protein-coupled receptor kinases

(2010) Cassandra A Boguth et al.   EMBO JOURNAL

Structure of Human G Protein-Coupled Receptor Kinase 2 in Complex with the Kinase Inhibitor Balanol

(2010) John J. G. Tesmer et al.   JOURNAL OF MEDICINAL CHEMISTRY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A Surface of the Kinase Domain Critical for the Allosteric Activation of G Protein-coupled Receptor Kinases

(2009) Chih-chin Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GRK mythology: G-protein receptor kinases in cardiovascular disease

(2009) Gerald W. Dorn   JOURNAL OF MOLECULAR MEDICINE-JMM

Structures of Rhodopsin Kinase in Different Ligand States Reveal Key Elements Involved in G Protein-coupled Receptor Kinase Activation

(2008) Puja Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of a β1-adrenergic G-protein-coupled receptor

(2008) Tony Warne et al.   NATURE

Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes

(2008) J. S. Martini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA