Journal
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
Volume 28, Issue 2, Pages 229-246Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.berh.2014.05.002
Keywords
JIA; Bench to bedside; Translational research; Personalized medicine
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Funding
- 7th Framework programme of the EU, SP3-People, support for training and career development for researchers (Marie Curie), Network for Initial Training (ITN), under the Marie Sklodowska-Curie grant [FP7-PEOPLE-2011-ITN, 289903]
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Despite the enormous progress in the treatment of juvenile idiopathic arthritis (JIA), innovations based on true bench-to-bedside research, performed in JIA patients, are still scarce. This chapter describes novel developments in which clinical innovations go hand in hand with basic discoveries. For the purpose of this review, we will mainly focus on developments in severe forms of JIA, most notably systemic JIA and polyarticular JIA. However, also in less severe forms of JIA, such as oligoarticular JIA, better insight will help to improve diagnosis and treatment. Facilitating the transition from bench to bedside will prove crucial for addressing the major challenges in JIA management. If successful, it will set new standards for a safe, targeted and personalized therapeutic approach for children with JIA. (C) 2014 Elsevier Ltd. All rights reserved.
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