Alternative Activation Mechanisms of Protein Kinase B Trigger Distinct Downstream Signaling Responses

Fine-tuning the intensity of the PKB/Akt signal enables diverse physiological responses

(2014) Xiangyu Zhou et al.   CELL CYCLE

Diverse Mechanisms of AKT Pathway Activation in Human Malignancy

(2013) Mitchell Cheung et al.   CURRENT CANCER DRUG TARGETS

Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P3-dependent mechanisms leading to resistance to PDK1 inhibitors

(2012) Ayaz Najafov et al.   BIOCHEMICAL JOURNAL

Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor

(2012) Sonia Martínez González et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Biological characterization of ETP-46321 a selective and efficacious inhibitor of phosphoinositide-3-kinases

(2012) Teresa G. Granda et al.   INVESTIGATIONAL NEW DRUGS

Interaction of PDK1 with Phosphoinositides Is Essential for Neuronal Differentiation but Dispensable for Neuronal Survival

(2012) T. Zurashvili et al.   MOLECULAR AND CELLULAR BIOLOGY

Activation of mTORC2 by Association with the Ribosome

(2011) Vittoria Zinzalla et al.   CELL

Akt signalling in health and disease

(2011) Ingeborg Hers et al.   CELLULAR SIGNALLING

Evidence for Direct Activation of mTORC2 Kinase Activity by Phosphatidylinositol 3,4,5-Trisphosphate

(2011) Xiaoqing Gan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition

(2010) Wen-I Wu et al.   PLoS One

Phosphoinositide (3,4,5)-Triphosphate Binding to Phosphoinositide-Dependent Kinase 1 Regulates a Protein Kinase B/Akt Signaling Threshold That Dictates T-Cell Migration, Not Proliferation

(2009) C. Waugh et al.   MOLECULAR AND CELLULAR BIOLOGY

Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance

(2008) J. R. Bayascas et al.   MOLECULAR AND CELLULAR BIOLOGY

PKBα/Akt1 Acts Downstream of DNA-PK in the DNA Double-Strand Break Response and Promotes Survival

(2008) Lana Bozulic et al.   MOLECULAR CELL