Journal
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
Volume 26, Issue 1, Pages 5-11Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.berh.2012.01.010
Keywords
Autoimmunity; Autoimmune diseases; Vaccinations; Systemic lupus erythematosus; Rheumatoid arthritis
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Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico - CNPQ [300665/2009-1]
- Federico Foundation
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The immune system must be able to discriminate between self and non-self. However, mechanisms of doing so sometimes fail, causing the activation and clonal expansion of autoreactive lymphocytes and the development of autoimmune conditions. Although some autoimmune diseases have heritable components, these components are not sufficient to develop an autoimmune condition. A.variety of environmental factors have been described as possible triggers of autoimmune diseases, including drugs, infectious agents, smoking, vaccination and adjuvants. The aim of this chapter is to review the most common environmental factors associated with autoimmune diseases. (C) 2012 Elsevier Ltd. All rights reserved.
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