Article
Anesthesiology
Han Tong, Thomas C. Maloney, Michael F. Payne, Maria Sunol, Jonathan A. Dudley, Christopher D. King, Tracy V. Ting, Susmita Kashikar-Zuck, Robert C. Coghill, Marina Lopez-Sola
Summary: Juvenile fibromyalgia (JFM) is a chronic pain condition that primarily affects adolescent girls. This study found that girls with JFM showed heightened sensitivity to noxious pressure stimuli and increased activation in the sensorimotor cortex, which may be related to central sensitization or amplified nociceptive input.
Article
Biochemistry & Molecular Biology
Santiago Navarro-Ledesma, Maria Aguilar-Garcia, Ana Gonzalez-Munoz, Leo Pruimboom, Maria Encarnacion Aguilar-Ferrandiz
Summary: There is evidence of a correlation between psychological factors and the elastic properties of tissue in fibromyalgia patients, particularly in non-dominant body parts that may be neglected and underused.
Article
Rheumatology
A. Piarulli, C. Conversano, R. Ciacchini, M. Miniati, L. Marchi, L. Bazzichi, A. Gemignani, G. Orru
Summary: In comparison to healthy controls, fibromyalgia and rheumatoid arthritis patients exhibit significant differences in pain perception, pain catastrophising, sexual functioning, and overall quality of life, with fibromyalgia patients showing the poorest outcomes.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Article
Orthopedics
J. S. Teunissen, M. J. W. van der Oest, D. E. van Groeninghen, R. Feitz, S. E. R. Hovius, E. P. A. van der Heijden
Summary: This study aimed to investigate the impact of pain catastrophising, psychological distress, illness perception, and patients' outcome expectations on patient-reported pain and hand function before and after surgery for ulnar-sided wrist pathology. Results showed that psychosocial variables were associated with preoperative and postoperative PRWHE scores. However, patients with negative psychosocial profiles still showed improvement in treatment outcomes. Therefore, surgical treatment should not be withheld solely based on preoperative psychosocial profiles, and boosting treatment expectations may further enhance treatment outcomes.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Multidisciplinary Sciences
Carmen M. Galvez-Sanchez, Pablo de la Coba, Jose M. Colmenero, Gustavo A. Reyes del Paso, Stefan Duschek
Summary: The study compared attentional performance between patients with FMS and RA, finding that FMS patients exhibited longer reaction times and more errors in attention tests compared to RA patients and healthy individuals. The differences in performance did not vary by experimental conditions, suggesting a general attentional deficit in FMS rather than specific impairments in different attention domains.
Article
Environmental Sciences
Juan Luis Leon-Llamas, Santos Villafaina, Alvaro Murillo-Garcia, Narcis Gusi
Summary: This study found that women with FM have lower volumes of hippocampal subfields compared to healthy women. Regression models revealed that various covariates, such as age, cognitive impairment, or depression, are associated with specific subfields.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Clinical Neurology
Santiago Navarro-Ledesma, James Carroll, Patricia Burton, Gonzalez-Munoz Ana
Summary: This study compared the effects of whole-body PBM and placebo PBM on pain, functionality, and psychological symptoms in patients suffering from FM. The results showed that whole-body PBM treatment significantly reduced pain, improved quality of life, and had positive effects on psychological factors such as kinesiophobia and self-efficacy.
Article
Clinical Neurology
Roland Staud, Melyssa M. Godfrey, Michael E. Robinson
Summary: This study found that the hypersensitivity of fibromyalgia patients extends beyond painful stimuli to innocuous stimuli like sound. The results suggest that abnormal brain mechanisms may be responsible for the increased sensitivity of FM patients.
Article
Chemistry, Multidisciplinary
Victor Riquelme-Aguado, Antonio Gil-Crujera, Josue Fernandez-Carnero, Ferran Cuenca-Martinez, Francisco Gomez Esquer
Summary: The main objective of this study was to assess the status of body schema and its relationship with somatosensory variables in patients with fibromyalgia syndrome (FMS). The study found that patients with FMS have a longer reaction time and lower accuracy for limb laterality discrimination, increased mechanical hyperalgesia, and decreased response to conditioned pain modulation compared to healthy subjects. Furthermore, there is a positive correlation between greater laterality discrimination ability and better conditioned pain modulation function in patients with FMS.
APPLIED SCIENCES-BASEL
(2022)
Article
Biology
Maria M. Cobo, Caroline Hartley, Deniz Gursul, Foteini Andritsou, Marianne van der Vaart, Gabriela Schmidt Mellado, Luke Baxter, Eugene P. Duff, Miranda Buckle, Ria Evans Fry, Gabrielle Green, Amy Hoskin, Richard Rogers, Eleri Adams, Fiona Moultrie, Rebeccah Slater
Summary: Despite the high burden of pain in hospitalised neonates, few analgesics have proven efficacy. Testing analgesics in neonates comes with challenges, both experimentally and ethically; however, EEG-derived measures of noxious-evoked brain activity can help assess efficacy. A new experimental paradigm accounting for individual differences in noxious-evoked baseline sensitivity was developed and tested across four studies, providing evidence of the efficacy of gentle brushing and paracetamol in neonates. This work represents an important step towards safe and cost-effective clinical trials of analgesics in neonates.
Article
Multidisciplinary Sciences
Nurcan Ueceyler, Mira Schliesser, Dimitar Evdokimov, Jakub Radziwon, Betty Feulner, Stefan Unterecker, Florian Rimmele, Uwe Walter
Summary: The echogenicity of the midbrain raphe area is reduced in patients with FMS and in patients with depression and physical pain, regardless of the presence or severity of pain, FMS, and depressive symptoms.
Article
Medicine, General & Internal
Giorgia Varallo, Paolo Pitera, Jacopo Maria Fontana, Michele Gobbi, Marco Arreghini, Emanuele Maria Giusti, Christian Franceschini, Giuseppe Plazzi, Gianluca Castelnuovo, Paolo Capodaglio
Summary: This study aimed to evaluate the effects of adding WBC intervention to a multidisciplinary rehabilitation program for FM patients with obesity. The results showed that the group that underwent WBC intervention had greater improvements in pain severity, depressive symptoms, disease impact, and sleep quality. However, no significant differences were found in performance-based physical functioning between the two groups.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Daniela Monteiro-Fernandes, Joana Margarida Silva, Carina Soares-Cunha, Christina Dalla, Nikolaos Kokras, Francois Arnaud, Rodolphe Billiras, Viktoriya Zhuravleva, Clarissa Waites, Sylvie Bretin, Nuno Sousa, Ioannis Sotiropoulos
Summary: Despite progress in understanding AD neuropathology, there is no effective treatment for the memory deficits caused by A beta and Tau protein accumulation. However, positive allosteric modulation of AMPA receptors shows promise in restoring memory and synaptic signaling in non-transgenic animal models.
MOLECULAR PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Cristina Munoz Ladron de Guevara, Gustavo A. Reyes del Paso, Maria Jose Fernandez Serrano, Casandra I. Montoro
Summary: This study analyzed the influence of body mass index (BMI) and primary clinical symptoms on cognitive function in fibromyalgia patients. The findings showed that patients with fibromyalgia have deficits in attention, memory, and processing speed, and BMI is a significant predictor of these cognitive deficits.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
Sudha Raghunath, Emma K. Guymer, Yifat Glikmann-Johnston, Vera Golder, Rangi Kandane Rathnayake, Eric F. Morand, Julie C. Stout, Alberta Hoi
Summary: Cognitive symptoms are common in SLE patients, but they are not directly associated with objective cognitive dysfunction. Depression, anxiety, and fibromyalgia are more consistently related to patient-reported cognitive symptoms. These factors have a significant impact on the quality of life of patients. Understanding the discrepancy between patient-reported cognitive symptoms and cognitive test performance is crucial for improving care in this area of unmet need.