Review
Pediatrics
Antonio F. Corno
Summary: Following prenatal diagnosis of congenital heart defects, parents and families experience a psychological crisis and counseling may be influenced by cultural and educational backgrounds. The type and quality of information transmitted by caregivers are crucial in the counseling process.
TRANSLATIONAL PEDIATRICS
(2021)
Article
Public, Environmental & Occupational Health
Tingting Wang, Qiongxuan Li, Lizhang Chen, Bin Ni, Xiaoqi Sheng, Peng Huang, Senmao Zhang, Letao Chen, Jiabi Qin
Summary: This study suggests that maternal alcohol consumption in the 3 months before pregnancy and in early pregnancy is associated with an increased risk of offspring congenital heart disease (CHD). Specifically, the highest risk was observed for Tetralogy of Fallot in offspring exposed to maternal alcohol consumption in the 3 months before pregnancy. These findings highlight the importance of public health efforts to raise awareness of the potential risks of alcohol consumption prior to or during pregnancy.
PREVENTIVE MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Mengting Sun, Senmao Zhang, Yihuan Li, Letao Chen, Jingyi Diao, Jinqi Li, Jianhui Wei, Xinli Song, Yiping Liu, Jing Shu, Tingting Wang, Peng Huang, Jiabi Qin
Summary: The study found that maternal antidepressant use in the 3 months before pregnancy and early pregnancy were both associated with an increased risk of congenital heart disease in their offspring, emphasizing the importance for pregnant women to plan for pregnancy after their condition improves or receive the minimum effective dose of medication.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Obstetrics & Gynecology
Shannon L. Son, Lauren L. Hosek, Miranda C. Stein, Amanda A. Allshouse, Anna B. Catino, Arvind K. Hoskoppal, Daniel A. Cox, Kevin J. Whitehead, Ian M. Lindsay, Sean Esplin, Torri D. Metz
Summary: This retrospective longitudinal cohort study found an association between pregnancy and subsequent long-term adverse cardiovascular outcomes in individuals with congenital heart disease. These findings can provide important information for counseling and guidance of individuals with congenital heart disease who are considering pregnancy.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Astrid Elisabeth Lammers, Gerhard-Paul Diller, Rieke Lober, Mareike Moellers, Renate Schmidt, Robert M. Radke, Fernando De-Torres-Alba, Gerrit Kaleschke, Ursula Marschall, Ulrike M. Bauer, Joachim Gerss, Dominic Enders, Helmut Baumgartner
Summary: This population-based study reveals a reassuringly low maternal mortality rate in a highly developed healthcare system. However, maternal and neonatal morbidity/mortality were significantly increased in women with adult congenital heart disease (ACHD) and their offspring compared to non-ACHD controls, highlighting the importance of specialized care and pre-pregnancy counseling.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Astrid Elisabeth Lammers, Gerhard-Paul Diller, Rieke Lober, Mareike Moellers, Renate Schmidt, Robert M. Radke, Fernando De-Torres-Alba, Gerrit Kaleschke, Ursula Marschall, Ulrike M. Bauer, Joachim Gerss, Dominic Enders, Helmut Baumgartner
Summary: This population-based study revealed a reassuringly low maternal mortality rate in a highly developed healthcare system. However, maternal morbidity and neonatal morbidity/mortality were significantly increased in women with ACHD and their offspring compared to non-ACHD controls, highlighting the need for specialized care and pre-pregnancy counselling.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Nathalie Denayer, Els Troost, Beatrice Santens, Pieter De Meester, Leen Roggen, Philip Moons, Kristel Van Calsteren, Werner Budts, Alexander Van De Bruaene
Summary: This study compared the accuracy of four commonly used risk models for predicting maternal cardiac complications in pregnant women with CHD. It found that all models overestimated maternal cardiac risk, with the ZAHARA model being closer to the actual risk level. Further research on a larger study population is needed to validate these findings.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Ansley M. Morrish, Janine Smith, Annabelle Enriquez, Gary F. Sholler, Jonathan Mervis, Sally L. Dunwoodie, Edwin P. Kirk, David S. Winlaw, Gillian M. Blue
Summary: Genetic and genomic testing in pediatric CHD is increasingly common, with significant implications in psychosocial, clinical, and reproductive aspects. Proper genetic counseling, integration of clinical genetics and cardiology workflows, and the establishment of a dedicated genetics clinic are essential for managing the information arising from genetic testing effectively.
TRENDS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Obstetrics & Gynecology
Yoshihito Morimoto, Kiyotaka Go, Hidenori Yamamoto, Yoshie Fukasawa, Michikazu Nakai, Eiji Morihana, Kazushi Yasuda, Hiroshi Nishikawa, Naoki Ohashi, Yoshiyuki Takahashi, Taichi Kato
Summary: This study investigated the proportion of infants born through ART in different types of CCHD in a Japanese population and found that the proportion of ART in CCHD infants, especially UVH, was high. These findings could provide a rationale for conducting fetal echocardiography in fetuses conceived through ART.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Biochemistry & Molecular Biology
Jennifer A. Courtney, Rebecca L. Wilson, James Cnota, Helen N. Jones
Summary: The study demonstrates the essential role of the Hand1 gene in placental development during early pregnancy, with mutations potentially leading to embryonic lethality and abnormal vascular development. Additionally, in late pregnancy, fetuses with the Cdh5(Cre+);Hand1(A126fs/+) genotype showed reduced fetal and placental weights, as well as decreased vascular density. This indicates the critical role of the Hand1 gene in maintaining pregnancy and fetal growth processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Psychiatry
Madhuri H. Nanjundaswamy, Shayanth Manche, Sundarnag Ganjekar, Harish Thippeswamy, Geetha Desai, Prabha S. Chandra
Summary: This study aims to analyze the clinical and sociodemographic characteristics of women with mental illness seeking conception counseling. The results show that 58.1% of women sought preconception counseling, while 41.9% had exposure to psychotropics without planning for pregnancy.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Cardiac & Cardiovascular Systems
Karishma P. Ramlakhan, Daniel Tobler, Matthias Greutmann, Markus Schwerzmann, Lucia Baris, Anji T. Yetman, Petros Nihoyannopoulos, Pravin Manga, Eric Boersma, Aldo P. Maggioni, Mark R. Johnson, Roger Hall, Jolien W. Roos-Hesselink
Summary: The study examined outcomes of pregnancy in women with aortic coarctation and found low rates of MACE and hypertensive disorders, suggesting pregnancy in these women may be safer and better tolerated than previously appreciated.
Article
Cardiac & Cardiovascular Systems
Yang Liu, Yanna Li, Jun Zhang, Wenjuan Zhao, Zhaoliang Bao, Xiaolong Ma, Yichen Zhao, Cheng Zhao, Kemin Liu, Qing Ye, Lixiao Su, Yao Yang, Jing Yang, Gang Li, Xiangming Fan, Jiangang Wang
Summary: This study conducted a comparative analysis of complications and outcomes in pregnant women with and without congenital heart disease (CHD) in Beijing. The results indicated that women with CHD had longer hospital stays, higher death rates, and greater risks of comorbidities and adverse events compared to women without CHD. Greater attention should be paid to pregnant women with CHD and their infants.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Xuelian Yuan, Fengchao Liang, Jun Zhu, Keyong Huang, Li Dai, Xiaohong Li, Yanping Wang, Qi Li, Xiangfeng Lu, Jianfeng Huang, Lihui Liao, Yang Liu, Dongfeng Gu, Hanmin Liu, Fangchao Liu
Summary: This study investigated the association between maternal exposure to fine particulate matter (PM2.5) and fetal congenital heart defects (CHDs) in China. The results showed that higher maternal PM2.5 exposure, especially during the preconception period, increased the risk of certain types of CHDs in offspring. The findings highlight the importance of improving air quality in China and other highly polluted regions for CHD prevention.
Article
Medical Laboratory Technology
Yiwei Fang, Zheng Zhang, Yun Zhao, Guoqiang Sun, Meilin Peng, Chunyan Liu, Guilin Yi, Kai Zhao, Hui Yang
Summary: The study aimed to explore maternal metabolic changes in fetal congenital heart disease (FCHD) and screen metabolic markers to establish a practical diagnostic model. Maternal peripheral serum samples from 17 FCHD and 63 non-FCHD pregnant women were analyzed using UPLC-MS/MS. The study identified 132 metabolites, including 35 differential metabolites enriched in various metabolic pathways. Two metabolites, (+/-)9,10-dihydroxy-12Z-octadecenoic acid and 11,12-epoxy-(5Z,8Z,11Z)-icosatrienoic acid, were incorporated into a logistic regression model, which showed superior diagnostic performance compared to previously reported markers.
CLINICA CHIMICA ACTA
(2023)
Article
Obstetrics & Gynecology
Anna Collins, Annie Jacob, Esther Moss
Summary: This article reviews the current evidence on minimally-invasive surgery in high-risk endometrial cancer patients and identifies areas that require further research.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Editorial Material
Obstetrics & Gynecology
Thomas D'Hooghe
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Editorial Material
Obstetrics & Gynecology
Thomas M. D'Hooghe
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Article
Obstetrics & Gynecology
Lina Youssef, Lea Testa, Francesca Crovetto, Fatima Crispi
Summary: Preeclampsia is a pregnancy-specific disease with an unknown precise cause. Multi-omics approaches have been used to study the molecular mechanisms of preeclampsia, and various genetic variants, altered gene expressions, potential biomarkers, and metabolic changes have been identified. Microbiomics studies have also found dysbiosis in the microbiota of pregnant women with preeclampsia. Further research is needed to integrate and translate these findings into clinical practice.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
