Review
Health Care Sciences & Services
Edoardo Di Naro, Matteo Loverro, Ilaria Converti, Maria Teresa Loverro, Elisabetta Ferrara, Biagio Rapone
Summary: Menopause affects periodontal status through estrogen deficiency, which impairs osteogenic differentiation of periodontal ligament cells. Further research is needed to elucidate the physiological link between menopause and periodontal disease.
Article
Clinical Neurology
Nelsan Pourhadi, Amani Meaidi, Soren Friis, Christian Torp-Pedersen, Lina S. Morch
Summary: The study aimed to investigate the association between vaginal oestradiol use and the development of meningioma and glioma. The results showed a slightly increased incidence of meningioma but no significant association with glioma in women using vaginal oestradiol tablets.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Obstetrics & Gynecology
Sunila Khandelwal, Meeta Meeta, Tanvir Tanvir
Summary: Migraine is a common and disabling form of headache, predominantly affecting females. It is classified into migraines with and without aura and is associated with sex hormones. Migraine with aura has been linked to stroke, especially among younger individuals. Smoking and high-dose oral estrogens may increase the risk of stroke. Early diagnosis and treatment are crucial.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2022)
Article
Medicine, General & Internal
Nuria Chic, Francesco Schettini, Fara Braso-Maristany, Esther Sanfeliu, Barbara Adamo, Maria Vidal, Debora Martinez, Patricia Galvan, Blanca Gonzalez-Farre, Javier Cortes, Joaquin Gavila, Cristina Saura, Mafalda Oliveira, Sonia Pernas, Olga Martinez-Saez, Jesus Soberino, Eva Ciruelos, Lisa A. Carey, Montserrat Munoz, Charles M. Perou, Tomas Pascual, Meritxell Bellet, Aleix Prat
Summary: Chemotherapy has different biological effects on patients with hormone receptor-positive breast cancer with different menopausal statuses. Specific estrogen-regulated genes exhibited varied expression levels under different treatment regimens in these patients.
Article
Cell Biology
Shao-Yong Xu, Peng Shi, Rui-Ming Zhou
Summary: This study identified a negative regulatory relationship between HOTAIR and miR-138 in post-menopausal females, as well as the ability of miR-138 to bind to TIMP1 mRNA and decrease its expression. It was also found that estrogen could modulate cell survival and apoptosis by regulating the HOTAIR/miR-138/TIMP1 signaling axis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biophysics
Bruna Carletto, Adriana Yuriko Koga, Andressa Novatski, Rubiana Mara Mainardes, Leandro Cavalcante Lipinski, Paulo Vitor Farago
Summary: The study demonstrates that ursolic acid-loaded, lipid-core nanocapsules can effectively alleviate skin aging acceleration in women due to menopause, assisting in promoting healing processes and reducing inflammatory responses.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Dermatology
Erin Kamp, Mariha Ashraf, Esra Musbahi, Claudia DeGiovanni
Summary: Menopause has an impact on the hair cycle and can lead to hair loss in postmenopausal women. Female pattern hair loss and frontal fibrosing alopecia are commonly associated with the perimenopausal and postmenopausal states. Further research is needed to understand the therapeutic targets and role of hormonal therapy.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Article
Clinical Neurology
Lorena Lorefice, Giuseppe Fenu, Marzia Fronza, Federica Murgia, Jessica Frau, Giancarlo Coghe, Maria Antonietta Barracciu, Luigi Atzori, Stefano Angioni, Eleonora Cocco
Summary: This study investigates the influence of menopause on multiple sclerosis (MS), showing that menopause is associated with MS progression and brain atrophy.
FRONTIERS IN NEUROLOGY
(2023)
Article
Endocrinology & Metabolism
Jessica J. Steventon, Thomas M. Lancaster, Emily Simmonds Baker, Matthew Bracher-Smith, Valentina Escott-Price, Katherine S. Ruth, William Davies, Xavier Caseras, Kevin Murphy
Summary: This study investigated the relationship between reproductive hormone exposure, polygenic scores for Alzheimer's disease (AD) risk, estradiol concentration, medial temporal lobe (MTL) anatomy, and cognitive performance in postmenopausal women. The results showed that longer use of hormone replacement therapy (HRT) was associated with larger parahippocampal volumes. Later age of natural menopause and longer reproductive span were associated with larger volumes of multiple MTL structures and better prospective memory performance.
PSYCHONEUROENDOCRINOLOGY
(2023)
Reprint
Materials Science, Multidisciplinary
Andrei Pissarenko, Marc A. Meyers
Summary: Skin, as the primary protective barrier of the body, regulates body temperature and stores water and lipids for healthy metabolism. Research on the mechanical behavior and deformation mechanisms of skin has led to the development of experimental techniques and models for various applications.
PROGRESS IN MATERIALS SCIENCE
(2021)
Article
Dermatology
Wei Zhou, Elizabeth Fleming, Guylaine Legendre, Lauriane Roux, Julie Latreille, Gaelle Gendronneau, Sandra Forestier, Julia Oh
Summary: Two major arms of skin ageing, biophysical conditions and the skin microbiome, were studied separately to understand their interaction. Using shotgun metagenomics, researchers explored how skin microbial species, strains, and gene content interact with biophysical traits in ageing skin. The study found associations between skin biophysical traits, such as collagen diffusion coefficient, and the composition and functional potential of the skin microbiome, including antibiotic resistance genes. This research provides important insights into the associations between skin biophysical features and ageing-related changes in the skin microbiome.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Biochemical Research Methods
Max Dooley, Jeni Luckett, Morgan R. Alexander, Pavel Matousek, Hamid Dehghani, Amir M. Ghaemmaghami, Ioan Notingher
Summary: Numerical modeling was used to improve the design of a Diffuse Raman Spectroscopy (DRS) instrument, maximizing the signal-to-noise ratio (SNR) while ensuring safe laser exposure parameters. Experimental validation showed significant reduction in laser exposure and improved SNR.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Oncology
Romy Aarnoutse, Lars E. Hillege, Janine Ziemons, Judith De Vos-Geelen, Maaike de Boer, Elvira M. E. R. Aerts, Birgit E. P. J. Vriens, Yvonne van Riet, Jeroen Vincent, Agnes J. van de Wouw, Giang N. Le, Koen Venema, Sander S. Rensen, John Penders, Marjolein L. Smidt
Summary: The study found that there were no differences in intestinal microbiota richness, diversity, and composition between postmenopausal breast cancer patients and controls. However, an increased relative abundance of Dialister and Veillonellaceae was observed in breast cancer patients scheduled for adjuvant treatment, which may be caused by a relative decrease in other bacteria rather than an absolute increase. Further research on a more homogeneous group of treatment-naive patients is advised for future studies on the role of intestinal microbiota in breast cancer.
Review
Biology
Andrea Marie E. Matinong, Yusuf Chisti, Kim L. Pickering, Richard G. Haverkamp
Summary: Collagen, the most abundant structural protein in animals, is widely used in various applications. This review focuses on the extraction and purification methods of collagen from animal skins, particularly those of commonly consumed meat animals. Different pretreatment and extraction techniques, including enzymatic, acid or alkaline methods, are discussed. Post-extraction purification methods are also explained. This compilation will be helpful for individuals interested in utilizing collagen as a resource and improving extraction and purification methods.
Article
Dermatology
Yasushi Kikuchi, Tomoki Tamakoshi, Ryuichi Ishida, Ryosuke Kobayashi, Shiho Mori, Akemi Ishida-Yamamoto, Manabu Fujimoto, Yasufumi Kaneda, Katsuto Tamai
Summary: In this study, researchers developed an ex vivo gene therapy for recessive dystrophic epidermolysis bullosa (RDEB) using autologous mesenchymal stromal cells (MSCs). The gene-modified MSCs were injected into mice with type VII collagen deficiency, leading to continuous and widespread expression of type VII collagen. The therapy showed successful application in both early blistering skin and advanced ulcerative lesions in the RDEB mouse model.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Review
Obstetrics & Gynecology
Sarah Cuschieri, Jean Calleja Agius
Summary: Type 2 diabetes and climate change are interconnected through direct and indirect pathways, impacting susceptibility, diagnosis, and treatment outcomes. Shared predisposing vectors such as sedentary lifestyle and unhealthy diets contribute to their progressive development. An integrated action plan targeting these common factors is essential for supporting a sustainable and equitable future.
EARLY HUMAN DEVELOPMENT
(2021)
Review
Biochemistry & Molecular Biology
Riccardo Di Fiore, Sherif Suleiman, Francesca Pentimalli, Sharon A. O'Toole, John J. O'Leary, Mark P. Ward, Neil T. Conlon, Maja Sabol, Petar Ozretic, Ayse Elif Erson-Bensan, Nicholas Reed, Antonio Giordano, C. Simon Herrington, Jean Calleja-Agius
Summary: Gynecological cancers are a significant public health issue with high incidence among females. While rare gynecological cancers often have poor prognosis and risk delayed diagnosis, there is growing interest in using miRNAs to improve diagnosis, therapy and prognosis, although research on rare gynecological cancers is limited.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Letter
Anatomy & Morphology
Christian Zammit, Pierre Schembri Wismayer, Jean Calleja Agius
ANATOMICAL SCIENCE INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Riccardo Di Fiore, Sherif Suleiman, Ana Felix, Sharon A. O'Toole, John J. O'Leary, Mark P. Ward, James Beirne, Maja Sabol, Petar Ozretic, Angel Yordanov, Mariela Vasileva-Slaveva, Stoyan Kostov, Margarita Nikolova, Ian Said-Huntingford, Duncan Ayers, Bridget Ellul, Francesca Pentimalli, Antonio Giordano, Jean Calleja-Agius
Summary: Choriocarcinoma is a rare and aggressive tumor, with effective treatment in early stages and good prognosis in advanced stages. Long non-coding RNAs play crucial roles in tumor development and have potential for cancer diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Riccardo Di Fiore, Sherif Suleiman, Rosa Drago-Ferrante, Ana Felix, Sharon A. O'Toole, John J. O'Leary, Mark P. Ward, James Beirne, Angel Yordanov, Mariela Vasileva-Slaveva, Yashwanth Subbannayya, Francesca Pentimalli, Antonio Giordano, Jean Calleja-Agius
Summary: Gynecological cancers are major threats to female health, and long non-coding RNAs (lncRNAs) play critical roles in tumorigenesis and could be potential therapeutic targets. ZNF667-AS1, identified as a tumor-related lncRNA, is silenced by DNA hypermethylation in several cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Electrical & Electronic
S. Di Meo, J. Bonello, I Farhat, L. Farrugia, M. Pasian, M. T. Camilleri Podesta, S. Suleiman, J. Calleja-Agius, C. Sammut
Summary: This study aimed to analyze the correlation between tissue dielectric data variability and sample hydration by measuring samples from different sources. Results showed that sample hydration level directly influences intra- and inter-organ variability for both animal and human tissues.
JOURNAL OF ELECTROMAGNETIC WAVES AND APPLICATIONS
(2022)
Letter
Surgery
Christian Camenzuli, Pierre Schembri Wismayer, Jean Calleja-Agius
SURGICAL INNOVATION
(2022)
Article
Oncology
Angel Yordanov, Stoyan Kostov, Stanislav Slavchev, Strahil Strashilov, Assia Konsoulova, Jean Calleja-Agius, Riccardo Di Fiore, Sherif Suleiman, Paul Kubelac, Catalin Vlad, Patriciu Achimas-Cadariu, Mariela Vasileva-Slaveva
Summary: The study analyzed the epidemiology and prognosis of all Bulgarian patients with adenosquamous carcinoma (ASC), comparing patients treated at a large specialized institution with those treated at a local hospital. Results showed that ASC accounted for 3.2% of all registered cervical cancer cases and 4.97% of stage I patients, with lymph node status significantly affecting patient survival rates.
CANCER MANAGEMENT AND RESEARCH
(2021)
Review
Hematology
Nicoletta Riva, Laura Maria Attard, Kevin Vella, Alessandro Squizzato, Alex Gatt, Jean Calleja-Agius
Summary: The study evaluated the diagnostic accuracy of D-dimer in patients at high risk of SVT, showing high sensitivity but low specificity. There is a call for more robust evidence on this topic.
THROMBOSIS RESEARCH
(2021)
Article
Environmental Sciences
Olga Gouni, Gabija Jarasiunaite-Fedosejeva, Burcu Komurcu Akik, Annaleena Holopainen, Jean Calleja-Agius
Summary: The purpose of this concept analysis is to explore childlessness and provide understanding to professionals involved in infertility. The analysis defines childlessness as the absence of children in an individual's life, which can be voluntary or involuntary. A deeper analysis of the concept considers cultural, psychological, biological, philosophical, theological, sociological, anthropological, and linguistic factors throughout history. The experience of childlessness has long-term impacts on both individuals and society, causing pain to those who are involuntarily childless.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Oncology
Maja Sabol, Jean Calleja-Agius, Riccardo Di Fiore, Sherif Suleiman, Sureyya Ozcan, Mark P. Ward, Petar Ozretic
Summary: Ovarian cancers are the most lethal form of gynecological tumors, with rare OCs having distinct molecular characteristics, prognosis, and therapeutic approaches. Late diagnosis due to the lack of specific symptoms is a common problem for all ovarian malignancies.
Review
Biochemistry & Molecular Biology
Yashwanth Subbannayya, Riccardo Di Fiore, Silvana Anna Maria Urru, Jean Calleja-Agius
Summary: Rare ovarian cancers have a low incidence rate and poor prognosis; exploring their molecular mechanisms is challenging due to their rarity and fragmented research efforts; omics approaches offer detailed insights into the underlying mechanisms and potential biomarkers for diagnosis and treatment.
Review
Biochemistry & Molecular Biology
Riccardo Di Fiore, Sherif Suleiman, Rosa Drago-Ferrante, Yashwanth Subbannayya, Francesca Pentimalli, Antonio Giordano, Jean Calleja-Agius
Summary: Cervical cancer is the fourth most common gynecological malignancy worldwide, mostly associated with high-risk human papillomavirus infection. While cervical Pap smear screening and vaccines have effectively reduced the incidence and death rate of cervical cancer, their accessibility varies across different societies. Prognosis for advanced or recurrent cervical cancer is poor, with a maximum one-year relative survival rate of 20%. Cancer stem cells may play a crucial role in the tumorigenesis, metastasis, relapse, and resistance to treatment of cervical cancer, highlighting their potential as therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Rosa Drago-Ferrante, Riccardo Di Fiore, Fathi Karouia, Yashwanth Subbannayya, Saswati Das, Begum Aydogan Mathyk, Shehbeel Arif, Ana Paula Guevara-Cerdan, Allen Seylani, Aman Singh Galsinh, Weronika Kukulska, Joseph Borg, Sherif Suleiman, David Marshall Porterfield, Andrea Camera, Lane K. Christenson, April Elizabeth Ronca, Jonathan G. Steller, Afshin Beheshti, Jean Calleja-Agius
Summary: This review focuses on the effects of microgravity and radiation on the female reproductive system, particularly gynecological cancer. By summarizing the existing research, it provides guidance for safer exploration class missions and postflight screening and management of women astronauts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
David Pisani, Jean Calleja-Agius, Riccardo Di Fiore, John J. O'Leary, James P. Beirne, Sharon A. O'Toole, Ana Felix, Ian Said-Huntingford
Summary: Epithelioid trophoblastic tumours are rare neoplasms that often arise from previous normal pregnancies, characterized by slow growth and typically confined to the uterus for extended periods. This case describes a 49-year-old female with asymptomatic uterine mass confirmed as epithelioid trophoblastic tumour, treated successfully with pembrolizumab without recurrence.
Article
Obstetrics & Gynecology
Anna Collins, Annie Jacob, Esther Moss
Summary: This article reviews the current evidence on minimally-invasive surgery in high-risk endometrial cancer patients and identifies areas that require further research.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Editorial Material
Obstetrics & Gynecology
Thomas D'Hooghe
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Editorial Material
Obstetrics & Gynecology
Thomas M. D'Hooghe
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Article
Obstetrics & Gynecology
Lina Youssef, Lea Testa, Francesca Crovetto, Fatima Crispi
Summary: Preeclampsia is a pregnancy-specific disease with an unknown precise cause. Multi-omics approaches have been used to study the molecular mechanisms of preeclampsia, and various genetic variants, altered gene expressions, potential biomarkers, and metabolic changes have been identified. Microbiomics studies have also found dysbiosis in the microbiota of pregnant women with preeclampsia. Further research is needed to integrate and translate these findings into clinical practice.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
