Article
Obstetrics & Gynecology
K. Phan, Y. H. Gomez, J. Gorgui, A. El-Messidi, R. Gagnon, H. A. Abenhaim, E. Rahme, S. S. Daskalopoulou
Summary: This study aimed to evaluate the ability of arterial stiffness parameters to predict pre-eclampsia early compared with peripheral blood pressure, uterine artery Doppler, and established angiogenic biomarkers. The results showed that arterial stiffness predicted pre-eclampsia more accurately than blood pressure, ultrasound indices, and angiogenic biomarkers.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Acoustics
D. L. Rolnik, A. Syngelaki, N. O'Gorman, D. Wright, L. C. Poon, K. H. Nicolaides
Summary: This study aimed to investigate the effects of aspirin on mean arterial pressure (MAP) and mean uterine artery pulsatility index (UtA-PI) in women at increased risk of preterm pre-eclampsia. The results showed that aspirin did not significantly affect MAP, but it was associated with a significant decrease in mean UtA-PI, particularly before 20 weeks of gestation.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Acoustics
N. Sokratous, M. Bednorz, P. Sarli, O. E. Morillo Montes, A. Syngelaki, A. Wright, K. H. Nicolaides
Summary: This study aimed to examine the performance of screening for preterm and term pre-eclampsia (PE) using maternal factors and combinations of maternal serum glycosylated fibronectin (GlyFn), mean arterial pressure (MAP), uterine artery pulsatility index (UtA-PI), and serum placental growth factor (PlGF) during early pregnancy. The findings suggest that GlyFn may be a useful biomarker for screening preterm PE in the first trimester. However, the performance of screening for term PE or gestational hypertension at 11-13 weeks' gestation using any combination of biomarkers is poor. Prospective screening studies are needed to validate the results of this case-control study.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Erika Bonacina, Pablo Garcia-Manau, Monica Lopez, Sara Caamina, Angels Vives, Eva Lopez-Quesada, Marta Ricart, Anna Maroto, Laura de Mingo, Elena Pintado, Laura Castillo-Ribelles, Lourdes Martin, Alicia Rodriguez-Zurita, Esperanza Garcia, Mar Pallarols, Laia Vidal-Sagnier, Mireia Teixidor, Carmen Orizales-Lago, Adela Perez-Gomez, Vanesa Ocana, Linda Puerto, Pilar Millan, Merce Alsius, Sonia Diaz, Nerea Maiz, Elena Carreras, Anna Suy, Manel Mendoza
Summary: The study aimed to assess whether aspirin treatment could be discontinued in pregnancies with a normal uterine artery pulsatility index (≤90th percentile) at 24-28 weeks. The results showed that discontinuing aspirin treatment was non-inferior to continuing aspirin treatment for preventing preterm pre-eclampsia in women with a uterine artery pulsatility index ≥90th percentile at 24-28 weeks.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Acoustics
M. Litwinska, E. Litwinska, K. Lisnere, A. Syngelaki, A. Wright, K. H. Nicolaides
Summary: The study aimed to evaluate the predictive value of uterine artery pulsatility index (UtA-PI) at 19-24 weeks' gestation for pre-eclampsia (PE) and to stratify pregnancy care based on estimated risks of PE from UtA-PI and combinations of maternal factors with UtA-PI and mean arterial pressure (MAP). The findings suggest that early screening for PE at 20 weeks can help identify subgroups for additional monitoring, and screening by a combination of maternal factors and MoM values of UtA-PI and MAP is superior to other screening methods.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
G. P. Guy, K. Leslie, D. Diaz Gomez, K. Forenc, E. Buck, A. Khalil, B. Thilaganathan
Summary: The study evaluates the clinical effectiveness of implementing a first-trimester combined pre-eclampsia screening program in a public healthcare setting. The results show a significant reduction in screen-positive rate, increased aspirin use, and effective identification of preterm pre-eclampsia.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Obstetrics & Gynecology
Anna Meroni, Margaret Mascherpa, Monica Minopoli, Benjamin Lambton, Rawan Elkalaawy, Alexander Frick, Basky Thilaganathan
Summary: Routine mid-gestational uterine artery Doppler can modify the risk for preterm pre-eclampsia after first-trimester combined pre-eclampsia screening. Women at low risk in the first trimester but with high mid-gestational uterine artery Doppler resistance had a higher prevalence of preterm pre-eclampsia. This suggests that pregnancy care should not be de-escalated for women at high risk in the first trimester with low mid-gestational uterine artery Doppler resistance, and escalation of care may be justified for women at low risk but with high mid-gestational uterine artery Doppler resistance.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Acoustics
Y. M. I. Wah, D. S. Sahota, P. Chaemsaithong, L. Wong, A. H. W. Kwan, Y. H. Ting, K. M. Law, T. Y. Leung, L. C. Poon
Summary: This study aimed to assess the performance of pregnancy-associated plasma protein-A (PAPP-A) compared to placental growth factor (PlGF) in screening for preterm pre-eclampsia (PE) during early pregnancy. The adoption of PAPP-A instead of PlGF may result in a reduced detection rate of preterm PE.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Acoustics
N. Gana, M. Sarno, N. Vieira, A. Wright, M. Charakida, K. H. Nicolaides
Summary: This study aimed to evaluate the potential value of ophthalmic artery Doppler at 11-13 weeks' gestation as a predictive marker for pre-eclampsia (PE) and compare it with other first-trimester biomarkers. The results showed that ophthalmic artery PSV ratio may be helpful in predicting the development of preterm PE. However, larger studies are still needed to validate this finding.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Review
Medicine, General & Internal
Serena Resta, Gaia Scandella, Ilenia Mappa, Maria Elena Pietrolucci, Pavjola Maqina, Giuseppe Rizzo
Summary: The number of pregnancies achieved through IVF is increasing globally, with improved chances of success due to technological advances. However, pregnancies conceived through IVF have a higher risk of adverse maternal and perinatal outcomes, mainly related to hypertensive diseases, pre-eclampsia, and fetal growth restriction. Advances in ultrasound technology allow for the evaluation of placental volume and hemodynamics, with differences observed between fresh and frozen-thawed embryos.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Acoustics
I Sapantzoglou, A. Wright, M. Gallardo Arozena, R. Vallenas Campos, M. Charakida, K. H. Nicolaides
Summary: The study showed that the ophthalmic artery PSV ratio at 19-23 weeks' gestation could be used to predict the development of PE, especially preterm PE. Combining the PSV ratio with other biomarkers improved the accuracy of predicting PE, but larger studies are needed to validate these findings.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Acoustics
L. Frei, A. Wright, A. Syngelaki, R. Akolekar, K. H. Nicolaides
Summary: In pregnancies complicated by preterm PE, a high proportion of neonates are small-for-gestational age, and sonographic EFW at mid-gestation can improve the prediction of early and preterm PE provided by maternal risk factors and MAP but not the prediction provided by a combination of maternal risk factors, MAP and UtA-PI.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Acoustics
M. Sarno, A. Wright, N. Vieira, I Sapantzoglou, M. Charakida, K. H. Nicolaides
Summary: The study indicates that maternal ophthalmic artery Doppler combined with established biomarkers can enhance the prediction of pre-eclampsia at 35-37 weeks of gestation, especially for imminent pre-eclampsia within 3 weeks after assessment. Further validation studies are needed to confirm this finding.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Meng Li, Chaoyan Yue
Summary: This study aims to evaluate whether abnormal uterine artery Doppler ultrasound during weeks 21-23 of pregnancy is associated with an increased risk of pre-eclampsia. The results suggest that abnormal uterine artery ultrasound indices are closely associated with the development of pre-eclampsia.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Acoustics
M. Mendoza, P. Garcia-Manau, S. Arevalo, M. Aviles, B. Serrano, M. A. Sanchez-Duran, I Garcia-Ruiz, E. Bonacina, E. Carreras
Summary: This study compared the prediction of early-onset and preterm PE when serum biomarkers were assessed before vs after 11 weeks of gestation, finding similar predictive abilities in both scenarios. This suggests that a two-step approach for PE risk assessment can be used, allowing for immediate risk calculation at the time of the first-trimester scan.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Acoustics
J. Gutierrez Henares, R. Gutierrez Henares, H. Perry, A. Khalil, B. Thilaganathan
Summary: Objective non-invasive assessment of maternal cardiovascular potential and kinetic energy using PKR and SMII may help distinguish pregnancies affected by specific placental disorders and those exhibiting healthy cardiovascular adaptation to pregnancy. Women with HDP and/or SGA have distinctive PKR and SMII profiles, reflecting low kinetic energy in pregnancies with SGA and high potential energy in pregnancies affected by HDP. Non-invasive assessment of potential and kinetic cardiovascular energy demonstrates high-flow and low-resistance adaptation in uncomplicated pregnancies.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Acoustics
G. P. Guy, K. Leslie, D. Diaz Gomez, K. Forenc, E. Buck, A. Bhide, B. Thilaganathan
Summary: This retrospective cohort study evaluated the impact of a first-trimester combined screening program for pre-eclampsia using the FMF algorithm. The results showed a significant reduction in the rate of term small-for-gestational age (SGA) birth below the 10th percentile, but no effect on SGA birth below the 5th or 3rd percentile.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Editorial Material
Acoustics
J. Deng, A. T. Papageorghiou, M. Xie
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Review
Peripheral Vascular Disease
Veronica Giorgione, Gwyneth Jansen, Jamie Kitt, Chahinda Ghossein-Doha, Paul Leeson, Basky Thilaganathan
Summary: There is an increased occurrence of cardiovascular diseases in women within 1 to 2 decades after a preeclamptic pregnancy. Recent evidence suggests that the abnormal biochemical and echocardiographic findings in preeclamptic women do not resolve after giving birth. Many women remain hypertensive in the immediate postnatal period, with some showing signs of cardiac dysfunction. Close monitoring and effective blood pressure control in the immediate postnatal period may lead to persistently lower blood pressures in women years after stopping medication. This review emphasizes the importance of delivering effective medical care in the fourth trimester of pregnancy to improve long-term cardiovascular health after a preeclamptic birth.
Article
Obstetrics & Gynecology
Anna Meroni, Margaret Mascherpa, Monica Minopoli, Benjamin Lambton, Rawan Elkalaawy, Alexander Frick, Basky Thilaganathan
Summary: Routine mid-gestational uterine artery Doppler can modify the risk for preterm pre-eclampsia after first-trimester combined pre-eclampsia screening. Women at low risk in the first trimester but with high mid-gestational uterine artery Doppler resistance had a higher prevalence of preterm pre-eclampsia. This suggests that pregnancy care should not be de-escalated for women at high risk in the first trimester with low mid-gestational uterine artery Doppler resistance, and escalation of care may be justified for women at low risk but with high mid-gestational uterine artery Doppler resistance.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Amarnath Bhide, Anna Meroni, Alexander Frick, Basky Thilaganathan
Summary: This study examines the significance of not meeting Dawes-Redman criteria on computerised cardiotocography in high-risk pregnancies. The results show that the risk of stillbirth is higher in the group that does not meet the criteria, even after excluding cases with low short-term variation. Therefore, pregnancies that do not meet the criteria should be closely monitored.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
E. Kalafat, B. Liu, I. Barratt, R. Bhate, A. Papageorghiou, A. Khalil
Summary: This study investigated the perinatal outcomes of dichorionic twin pregnancies complicated by selective fetal growth restriction (sFGR). The umbilical artery Z-scores were found to be associated with both intrauterine death and adverse perinatal outcomes.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Acoustics
B. Liu, B. Thilaganathan, A. Bhide
Summary: This study compared the short-term variation (STV) outputs of a novel self-applied non-invasive fetal electrocardiography (NIFECG) device with those obtained from computerized cardiotocography (cCTG). The study found that, after appropriate filtering, removal of poor-quality traces, and correction for signal loss, NIFECG was able to produce STV values strongly correlated with those of cCTG.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Acoustics
B. Liu, B. Thilaganathan, A. Bhide
Summary: The study found that there is a correlation between phase-rectified signal averaging (PRSA) and computerized cardiotocography (cCTG), as well as a relationship between PRSA and short-term variation (STV). PRSA may be an equivalent method of fetal assessment to STV and can generate interpretable non-invasive fetal electrocardiography (NIFECG) traces with high accuracy. These findings raise the possibility of self-applied at-home or remote fetal heart-rate monitoring, increasing surveillance in high-risk women without impacting service demand.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Cell Biology
Clara Apicella, Camino S. M. Ruano, Basky Thilaganathan, Asma Khalil, Veronica Giorgione, Geraldine Gascoin, Louis Marcellin, Cassandra Gaspar, Sebastien Jacques, Colin E. Murdoch, Francisco Miralles, Celine Mehats, Daniel Vaiman
Summary: In this study, we aimed to identify genetic variants affecting gene expression in the human placenta, specifically in normal and pathological situations. The analysis was constrained by the fact that placental tissue samples from diseased individuals are typically obtained at an earlier gestational age compared to control samples, leading to confounding factors in transcriptome regulation. To address this issue, we implemented a novel approach that accounted for gestational age and identified disease-specific cis-eQTLs. Through statistical correction and analysis, we identified a list of e-genes that significantly influenced expression levels, demonstrating the validity of our methodology for future research purposes.
Review
Cardiac & Cardiovascular Systems
Veronica Giorgione, Matthew Cauldwell, Basky Thilaganathan
Summary: Hypertensive disorders of pregnancy (HDP) occur in approximately 10% of pregnancies and are associated with multiorgan manifestations related to endothelial dysfunction. Women with HDP have an increased risk of cardiovascular disease during delivery hospitalisation and are more likely to develop cardiovascular risk factors and major cardiovascular disease in the long term. Chronic hypertension, obesity, hypercholesterolaemia, and diabetes are the main mediators of cardiovascular disease in women with a history of HDP. Optimising blood pressure levels in the immediate postpartum period can improve long-term cardiovascular health. Peripartum screening based on maternal demographics and clinical and echocardiographic data can help identify high-risk HDP women who would benefit from targeted cardiovascular prevention.
EUROPEAN CARDIOLOGY REVIEW
(2023)
Article
Public, Environmental & Occupational Health
Diego F. Wyszynski, Aris T. Papageorghiou, Cheryl Renz, Torri D. Metz, Sonia Hernandez-Diaz
Summary: This study aims to assess the relative risk of obstetric, neonatal, and infant outcomes associated with the use of drugs specifically indicated for COVID-19 treatment compared with other drug treatment strategies. The COVID-PR is a noninterventional, postmarketing cohort study designed to evaluate the safety profile of each studied drug and its potential effects on neonatal outcomes.
Article
Engineering, Biomedical
Bing Zhang, Yang Wang, Caifu Ding, Ziqing Deng, Linwei Li, Zesheng Qin, Zhao Ding, Lifeng Bian, Chen Yang
Summary: Medical image segmentation is crucial in diagnostic and clinical research. This article proposes a Multi-Scale Feature Pyramid Fusion Network (MS-Net) that combines Multi-Scale Attention Module (MSAM) and Stacked Feature Pyramid Module (SFPM) to improve the accuracy of segmentation. Experimental results show that the proposed MS-Net achieves better segmentation results on different datasets.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2023)
Article
Endocrinology & Metabolism
Elizabeth M. Curtis, Rebecca J. Moon, Stefania D'Angelo, Sarah R. Crozier, Nicholas J. Bishop, Jaya Sujatha Gopal-Kothandapani, Stephen H. Kennedy, Aris T. Papageorghiou, Robert Fraser, Saurabh Gandhi, Inez Schoenmakers, Ann Prentice, Hazel M. Inskip, Keith M. Godfrey, M. Kassim Javaid, Richard Eastell, Cyrus Cooper, Nicholas C. Harvey
Summary: In the Maternal Vitamin D Osteoporosis Study (MAVIDOS) randomized trial, vitamin D supplementation during pregnancy did not have a significant effect on neonatal bone mass overall, but it did increase bone mass among babies born in winter. A follow-up study examined the impact of antenatal vitamin D supplementation on early childhood bone mineralization. The study found that maternal vitamin D supplementation during pregnancy resulted in greater bone mineral density in children at the age of 4.
Article
Engineering, Biomedical
Yipei Wang, Qianye Yang, Lior Drukker, Aris Papageorghiou, Yipeng Hu, J. Alison Noble
Summary: This paper explores the effectiveness of frame classification and skill assessment networks for ultrasound biometry tasks. By using neural networks for frame classification and skill assessment, a more objective evaluation method can be provided.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2022)
Article
Obstetrics & Gynecology
Anna Collins, Annie Jacob, Esther Moss
Summary: This article reviews the current evidence on minimally-invasive surgery in high-risk endometrial cancer patients and identifies areas that require further research.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Editorial Material
Obstetrics & Gynecology
Thomas D'Hooghe
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Editorial Material
Obstetrics & Gynecology
Thomas M. D'Hooghe
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Article
Obstetrics & Gynecology
Lina Youssef, Lea Testa, Francesca Crovetto, Fatima Crispi
Summary: Preeclampsia is a pregnancy-specific disease with an unknown precise cause. Multi-omics approaches have been used to study the molecular mechanisms of preeclampsia, and various genetic variants, altered gene expressions, potential biomarkers, and metabolic changes have been identified. Microbiomics studies have also found dysbiosis in the microbiota of pregnant women with preeclampsia. Further research is needed to integrate and translate these findings into clinical practice.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
