Substrate-induced Unlocking of the Inner Gate Determines the Catalytic Efficiency of a Neurotransmitter:Sodium Symporter
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Substrate-induced Unlocking of the Inner Gate Determines the Catalytic Efficiency of a Neurotransmitter:Sodium Symporter
Authors
Keywords
-
Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 290, Issue 44, Pages 26725-26738
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Online
2015-09-12
DOI
10.1074/jbc.m115.677658
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The Aromatic and Charge Pairs of the Thin Extracellular Gate of the γ-Aminobutyric Acid Transporter GAT-1 Are Differently Impacted by Mutation
- (2014) Oshrat Dayan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Conformational dynamics of ligand-dependent alternating access in LeuT
- (2014) Kelli Kazmier et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters
- (2014) Lina Malinauskaite et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- NbIT - A New Information Theory-Based Analysis of Allosteric Mechanisms Reveals Residues that Underlie Function in the Leucine Transporter LeuT
- (2014) Michael V. LeVine et al. PLoS Computational Biology
- Structural basis for action by diverse antidepressants on biogenic amine transporters
- (2013) Hui Wang et al. NATURE
- X-ray structure of dopamine transporter elucidates antidepressant mechanism
- (2013) Aravind Penmatsa et al. NATURE
- Evolutionary relationship between 5+5 and 7+7 inverted repeat folds within the amino acid-polyamine-organocation superfamily
- (2013) Åke Västermark et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- X-ray structures of LeuT in substrate-free outward-open and apo inward-open states
- (2012) Harini Krishnamurthy et al. NATURE
- Experimental conditions can obscure the second high-affinity site in LeuT
- (2012) Matthias Quick et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Insights into transport mechanism from LeuT engineered to transport tryptophan
- (2011) Chayne L Piscitelli et al. EMBO JOURNAL
- MATCH: An atom-typing toolset for molecular mechanics force fields
- (2011) Joseph D. Yesselman et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- Dopamine Transport by the Serotonin Transporter: A Mechanistically Distinct Mode of Substrate Translocation
- (2011) M. B. Larsen et al. JOURNAL OF NEUROSCIENCE
- Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue
- (2011) Yongfang Zhao et al. NATURE
- SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation
- (2011) A. S. Kristensen et al. PHARMACOLOGICAL REVIEWS
- Conformational Rearrangements to the Intracellular Open States of the LeuT and ApcT Transporters Are Modulated by Common Mechanisms
- (2010) Lei Shi et al. BIOPHYSICAL JOURNAL
- Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types
- (2010) Jeffery B. Klauda et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Single-molecule dynamics of gating in a neurotransmitter transporter homologue
- (2010) Yongfang Zhao et al. NATURE
- Neurotransmitter/sodium symporter orthologue LeuT has a single high-affinity substrate site
- (2010) Chayne L. Piscitelli et al. NATURE
- Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters
- (2010) Derek P Claxton et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Investigating the disorder-order transition of calmodulin binding domain upon binding calmodulin using molecular dynamics simulation
- (2009) Yong Zhang et al. JOURNAL OF MOLECULAR RECOGNITION
- Structure of a prokaryotic virtual proton pump at 3.2 Å resolution
- (2009) Yiling Fang et al. NATURE
- Molecular basis of transport and regulation in the Na+/betaine symporter BetP
- (2009) Susanne Ressl et al. NATURE
- Unlocking the molecular secrets of sodium-coupled transporters
- (2009) Harini Krishnamurthy et al. NATURE
- Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation
- (2009) M. Quick et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure and Mechanism of an Amino Acid Antiporter
- (2009) X. Gao et al. SCIENCE
- Structure and Mechanism of a Na+-Independent Amino Acid Transporter
- (2009) P. L. Shaffer et al. SCIENCE
- An Intracellular Interaction Network Regulates Conformational Transitions in the Dopamine Transporter
- (2008) Julie Kniazeff et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Mechanism of a Neurotransmitter:Sodium Symporter—Inward Release of Na+ and Substrate Is Triggered by Substrate in a Second Binding Site
- (2008) Lei Shi et al. MOLECULAR CELL
- The binding sites for cocaine and dopamine in the dopamine transporter overlap
- (2008) Thijs Beuming et al. NATURE NEUROSCIENCE
- Mechanism for alternating access in neurotransmitter transporters
- (2008) L. R. Forrest et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Competitive Inhibitor Traps LeuT in an Open-to-Out Conformation
- (2008) S. K. Singh et al. SCIENCE
- Structure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family Transporter
- (2008) S. Weyand et al. SCIENCE
- The Crystal Structure of a Sodium Galactose Transporter Reveals Mechanistic Insights into Na+/Sugar Symport
- (2008) S. Faham et al. SCIENCE
- Neurotransmitter transporters and their impact on the development of psychopharmacology
- (2006) Leslie Iversen BRITISH JOURNAL OF PHARMACOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now