Article
Medicine, General & Internal
Ronnie Fass, Guy E. Boeckxstaens, Hashem El-Serag, Rachel Rosen, Daniel Sifrim, Michael F. Vaezi
Summary: Gastro-oesophageal reflux disease is common in adults and children, with diagnosis primarily based on history, physical examination, and treatment varying with age. Treatment options include medications, endoscopic interventions, or surgery.
NATURE REVIEWS DISEASE PRIMERS
(2021)
Review
Gastroenterology & Hepatology
Chamara Basnayake, Annelies Geeraerts, Ans Pauwels, Ger Koek, Michael Vaezi, Tim Vanuytsel, Jan Tack
Summary: The prevalence of duodenogastroesophageal reflux (DGER) increases with more advanced esophageal lesions in patients with gastroesophageal reflux disease (GERD) and persists in patients on proton pump inhibitor (PPI) therapy. PPIs appear to be effective in treating DGER, but further research is needed for future therapies.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Gastroenterology & Hepatology
Leonardo Frazzoni, Lorenzo Fuccio, Rocco Maurizio Zagari
Summary: Gastro-esophageal reflux disease (GERD) is a common condition that primary care physicians and gastroenterologists frequently encounter. Improving the management of GERD is vital for optimizing patient care and resource utilization. This review aims to provide a comprehensive update on the clinical management of GERD patients through a literature review on diagnosis and treatment.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Agriculture, Dairy & Animal Science
Ioannis Savvas, Kiriaki Pavlidou, Tilemachos Anagnostou, Eugenia Flouraki, George Kazakos, Dimitrios Raptopoulos
Summary: This systematic review investigates the effect of preoperative fasting duration and drugs on gastro-oesophageal reflux (GOR) in dogs and cats during anaesthesia. The study found that many factors seem to affect the development of GOR, but due to the limited number of studies and low level of evidence, no reliable conclusions can be drawn.
Review
Gastroenterology & Hepatology
Leonardo H. Eusebi, Andrea Telese, Giovanna G. Cirota, Rehan Haidry, Rocco M. Zagari, Franco Bazzoli, Alexander C. Ford
Summary: Gastro-oesophageal reflux is the main risk factor for Barrett's oesophagus, with alcohol consumption and hiatal hernia showing the strongest association with its development. Other potential risk factors such as smoking and obesity did not show significant correlation.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Gastroenterology & Hepatology
Rena Yadlapati, Alexander M. Kaizer, Daniel R. Sikavi, Madeline Greytak, Jennifer X. Cai, Thomas L. Carroll, Samir Gupta, Sachin Wani, Paul Menard-Katcher, Tsung-Chin Wu, Philip Weissbrod, Andrew M. Vahabzadeh-Hagh, John E. Pandolfino, Walter W. Chan
Summary: The study identified different clinicophysiologic phenotypes of patients with laryngeal symptoms referred for reflux evaluation, including LPR and GERD with hiatal hernia, mild LPR/GERD, no LPR/No GERD, reflex cough, and mixed/possible obstructive esophagogastric junction, which may inform targeted clinical trial design and improve outcomes.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Medicine, General & Internal
Zoe Kopsaftis, Hooi Shan Yap, Kyi Saw Tin, Khin Hnin, Kristin Carson-Chahhoud
Summary: The effectiveness of GORD treatment on reducing acute asthma exacerbations remains uncertain, though it may provide small benefits for certain secondary outcomes related to asthma management. Further research is needed to assess outcomes in children and compare surgical intervention with medical therapy.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Gastroenterology & Hepatology
Ans Pauwels, Karlien Raymenants, Annelies Geeraerts, Veerle Boecxstaens, Imke Masuy, Charlotte Broers, Tim Vanuytsel, Jan Tack
Summary: Baclofen has shown efficacy in reducing reflux parameters in patients with PPI refractory GERD symptoms, but only SAP+ patients experience clinical benefit after 4 weeks of treatment. pH-impedance monitoring is necessary before treatment.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Loren Laine, Kenneth DeVault, Philip Katz, Stefan Mitev, John Lowe, Barbara Hunt, Stuart Spechler
Summary: This study found that vonoprazan, a potassium-competitive acid blocker, was noninferior and superior to the PPI lansoprazole in healing and maintenance of erosive esophagitis, particularly in patients with more severe cases.
Review
Agriculture, Dairy & Animal Science
Anna Carolina Fernandez Alasia, Olivier Levionnois, Mathieu Raillard
Summary: Regurgitation and gastro-oesophageal reflux (GOR) are common complications in dogs under anaesthesia. Studies on these complications showed inconsistencies in definitions and assessment methods, making meaningful comparisons difficult. Standardization and re-evaluation of methods may be necessary to address these discrepancies.
Article
Gastroenterology & Hepatology
Kentaro Sugano, Stuart Jon Spechler, Emad M. El-Omar, Kenneth E. L. McColl, Kaiyo Takubo, Takuji Gotoda, Mitsuhiro Fujishiro, Katsunori Iijima, Haruhiro Inoue, Takashi Kawai, Yoshikazu Kinoshita, Hiroto Miwa, Ken-ichi Mukaisho, Kazunari Murakami, Yasuyuki Seto, Hisao Tajiri, Shobna Bhatia, Myung-Gyu Choi, Rebecca C. Fitzgerald, Kwong Ming Fock, Khean-Lee Goh, Khek Yu Ho, Varocha Mahachai, Maria O'Donovan, Robert Odze, Richard Peek, Massimo Rugge, Prateek Sharma, Jose D. Sollano, Michael Vieth, Justin Wu, Ming-Shiang Wu, Duowu Zou, Michio Kaminishi, Peter Malfertheiner
Summary: This study aims to achieve international consensus on the new definitions of Barrett's esophagus, gastro-esophageal junction, and gastro-esophageal junctional zone, which will provide support for future research addressing many issues concerning this important anatomical area and hopefully lead to improved classification and management of diseases related to the gastro-esophageal junction.
Article
Respiratory System
Sufyan Shakir, Carlos Echevarria, Simon Doe, Malcolm Brodlie, Christopher Ward, Stephen J. Bourke
Summary: Upper gastrointestinal and upper airway diseases are common in cystic fibrosis (CF) and may contribute to lower airway infection and inflammation. A longitudinal cohort study showed that treatment with CFTR modulators can improve respiratory reflux symptoms and sinonasal symptoms, as well as improve lung function and weight in patients with advanced CF.
JOURNAL OF CYSTIC FIBROSIS
(2022)
Review
Gastroenterology & Hepatology
Reidar Fossmark, Eivind Ness-Jensen, Oystein Sordal
Summary: There is a debate on the causal relationship between GERD and EE manifestations, as well as the pathophysiology and diagnostic criteria. Evidence-based treatment recommendations are challenging to provide.
BMC GASTROENTEROLOGY
(2023)
Article
Multidisciplinary Sciences
Gaston Arnolda, Harriet Hiscock, David Moore, Glen Farrow, Peter D. Hibbert, Louise K. Wiles, Hseun P. Ting, Charlotte J. Molloy, Meagan Warwick, Jeffrey Braithwaite
Summary: A study assessing adherence to clinical practice guidelines for managing GOR/GORD in Australian pediatric care found low adherence rates to recommended indicators, particularly in performing differential diagnostic tests and avoiding prescription of acid-suppression medication for infants. Therefore, there is a need for a guideline targeting health professionals in Australia, emphasizing the importance of differential diagnostic testing and avoidance of acid-suppression medication in infants with GOR/GORD.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Adam Frankel, Hock Soo Ong, B. Mark Smithers, Les K. Nathanson, David C. Gotley
Summary: This study evaluated the efficacy of laparoscopic fundoplication in patients with chronic cough without asthma and pathologic gastro-oesophageal reflux. It found that 61% of the patients experienced relief in cough after the surgery, while predictors of cough response to fundoplication were not accurately predicted by typical GORD symptoms or pH study variables.