Review
Biochemistry & Molecular Biology
Ahsen Ustaoglu, Philip Woodland
Summary: Gastroesophageal reflux disease (GORD) affects a significant portion of Western populations and the mechanisms behind heartburn pathogenesis are not fully understood. Recent studies have highlighted the role of neurochemical, inflammatory, and cellular changes in the esophageal mucosa itself. The localization and neurochemical characterization of sensory nerve endings differ among GORD phenotypes and may explain why patients with similar levels of reflux experience different symptoms. This review investigates the role of peripheral mechanisms in sensitizing esophageal sensitivity in GORD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Agriculture, Dairy & Animal Science
Ioannis Savvas, Kiriaki Pavlidou, Tilemachos Anagnostou, Eugenia Flouraki, George Kazakos, Dimitrios Raptopoulos
Summary: This systematic review investigates the effect of preoperative fasting duration and drugs on gastro-oesophageal reflux (GOR) in dogs and cats during anaesthesia. The study found that many factors seem to affect the development of GOR, but due to the limited number of studies and low level of evidence, no reliable conclusions can be drawn.
Article
Medicine, General & Internal
Antoni Stadnicki, Jozef Kurek, Ewa Klimacka-Nawrot, Anna Stadnicka, Katarzyna Rerych
Summary: The study compared the effectiveness of high-resolution manometry (HRM) and upper gastrointestinal (GI) endoscopy in detecting sliding hiatus hernia in patients with gastro-oesophageal reflux disease (GORD) symptoms. The results showed that both modalities were not reliable tools for diagnosing sliding hiatus hernia due to their poor sensitivity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Agriculture, Dairy & Animal Science
Anna Carolina Fernandez Alasia, Olivier Levionnois, Mathieu Raillard
Summary: Regurgitation and gastro-oesophageal reflux (GOR) are common complications in dogs under anaesthesia. Studies on these complications showed inconsistencies in definitions and assessment methods, making meaningful comparisons difficult. Standardization and re-evaluation of methods may be necessary to address these discrepancies.
Article
Gastroenterology & Hepatology
Kentaro Sugano, Stuart Jon Spechler, Emad M. El-Omar, Kenneth E. L. McColl, Kaiyo Takubo, Takuji Gotoda, Mitsuhiro Fujishiro, Katsunori Iijima, Haruhiro Inoue, Takashi Kawai, Yoshikazu Kinoshita, Hiroto Miwa, Ken-ichi Mukaisho, Kazunari Murakami, Yasuyuki Seto, Hisao Tajiri, Shobna Bhatia, Myung-Gyu Choi, Rebecca C. Fitzgerald, Kwong Ming Fock, Khean-Lee Goh, Khek Yu Ho, Varocha Mahachai, Maria O'Donovan, Robert Odze, Richard Peek, Massimo Rugge, Prateek Sharma, Jose D. Sollano, Michael Vieth, Justin Wu, Ming-Shiang Wu, Duowu Zou, Michio Kaminishi, Peter Malfertheiner
Summary: This study aims to achieve international consensus on the new definitions of Barrett's esophagus, gastro-esophageal junction, and gastro-esophageal junctional zone, which will provide support for future research addressing many issues concerning this important anatomical area and hopefully lead to improved classification and management of diseases related to the gastro-esophageal junction.
Article
Medicine, General & Internal
Dag Holmberg, Giola Santoni, My von Euler-Chelpin, Martti Farkkila, Joonas H. Kauppila, John Maret-Ouda, Eivind Ness-Jensen, Jesper Lagergren
Summary: Patients with non-erosive gastro-oesophageal reflux disease have a similar incidence of oesophageal adenocarcinoma as the general population.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Agriculture, Dairy & Animal Science
Paraskevi Tsompanidou, Joris H. Robben, Ioannis Savvas, Tilemahos Anagnostou, Nikitas N. Prassinos, George M. Kazakos
Summary: This study compares the effects of three different pre-anaesthetic fasting regimens on the incidence of gastro-oesophageal reflux (GOR) in dogs under anaesthesia. The results suggest that feeding the dogs 3 hours before anaesthesia does not reduce the GOR incidence compared to feeding them 12 hours before anaesthesia. However, the 3-hour fasting resulted in a lower oesophageal pH.
Article
Medicine, General & Internal
Anna Plocek, Beata Gebora-Kowalska, Wojciech Fendler, Ewa Toporowska-Kowalska
Summary: Diagnosis of gastro-oesophageal reflux disease in children with chronic neurological impairment remains a clinical challenge. This study validated reference values for assessing GOR in these children and determined the optimal cut-off level of the pH-impedance parameter for predicting endoscopic outcomes. Endoscopic findings showed that even with a low number of GOR episodes recorded by pH-impedance, children with chronic NI may still have endoscopic lesions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Deepika Razia, Sumeet K. Mittal, Sarah Fournier, Rajat Walia, Michael A. Smith, Ross M. Bremner, Jasmine L. Huang
Summary: Gastro-oesophageal reflux disease after lung transplantation may contribute to chronic lung allograft dysfunction. Antireflux surgery can improve long-term allograft function and show a survival benefit. This study compares outcomes between medical and surgical management of reflux in lung recipients.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Allergy
Bronwyn K. Brew, Catarina Almqvist, Cecilia Lundholm, Anna Andreasson, Kelli Lehto, Nicholas J. Talley, Tong Gong
Summary: GERD is a common comorbidity in adults with asthma, hay fever, and/or eczema. There is evidence for shared mechanisms suggesting common underlying causes that may involve affective traits requiring further investigation.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Gastroenterology & Hepatology
Benjamin D. Rogers, Luis R. Valdovinos, Michael D. Crowell, Reginald Bell, Marcelo F. Vela, C. Prakash Gyawali
Summary: The reduction of reflux episodes to physiological levels on pH-impedance monitoring is associated with improved outcomes in patients with regurgitation-predominant GERD. Treatment with magnetic sphincter augmentation significantly improved symptom and satisfaction scores, while also reducing acid exposure time and reflux episodes. Improvement in regurgitation score remained independently predictive of satisfaction with therapy, and a reduction to <40 reflux episodes was significantly associated with symptom response.
Review
Gastroenterology & Hepatology
Leonardo H. Eusebi, Andrea Telese, Giovanna G. Cirota, Rehan Haidry, Rocco M. Zagari, Franco Bazzoli, Alexander C. Ford
Summary: Gastro-oesophageal reflux is the main risk factor for Barrett's oesophagus, with alcohol consumption and hiatal hernia showing the strongest association with its development. Other potential risk factors such as smoking and obesity did not show significant correlation.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Surgery
Rachel Xue Ning Lee, Nayer Rizkallah, Sonja Chiappetta, Christine Stier, Sjaak Pouwels, Nasser Sakran, Rishi Singhal, Kamal Mahawar, Brijesh Madhok
Summary: Revisional surgery after OAGB for GORD is rare, and the conversion to Roux-en-Y configuration is the most common choice when required.
Article
Nutrition & Dietetics
Yuanlin Sun, Xueyuan Cao, Donghui Cao, Yingnan Cui, Kaisheng Su, Zhifang Jia, Yanhua Wu, Jing Jiang
Summary: This study systematically elucidated the modifiable factors causally associated with the risk of GORD from multifaceted perspectives, which provided implications for prevention and treatment of GORD.
FRONTIERS IN NUTRITION
(2022)
Review
Pharmacology & Pharmacy
N. Padayachee, V Bangalee, N. Schellack
Summary: Gastro-oesophageal reflux disease (GORD) is a condition where acid from the stomach continuously flows back into the oesophagus, causing discomfort. If left untreated, it can lead to serious complications. The main symptoms of GORD are heartburn and regurgitation. Treatment options include antacids, H2 antagonists, and other medications.
SA PHARMACEUTICAL JOURNAL
(2022)
Review
Anesthesiology
Qasim Aziz, Maria Adele Giamberardino, Antonia Barke, Beatrice Korwisi, Andrew P. Baranowski, Ursula Wesselmann, Winfried Rief, Rolf-Detlef Treedel, Michael Bennett, Rafael Benoliel, Milton Cohen, Stefan Evers, Nanna B. Finnerup, Michael First, Stein Kaasa, Eva Kosek, Patricia Lavand'homme, Michael Nicholas, Serge Perrot, Joachim Scholz, Stephan Schug, Blair H. Smith, Peter Svensson, Johannes Vlaeyen, Shuu-Jiun Wang
Article
Gastroenterology & Hepatology
Emeran A. Mayer, Jennifer Labus, Qasim Aziz, Irene Tracey, Lisa Kilpatrick, Sigrid Elsenbruch, Petra Schweinhardt, Lukas Van Oudenhove, David Borsook
Letter
Anesthesiology
Rolf-Detlef Treede, Winfried Rief, Beatrice Korwisi, Qasim Aziz, Maria Adele Giamberardino, Antonia Barke
Article
Psychology, Biological
Ali Gholamrezaei, Ilse Van Diest, Qasim Aziz, Johan W. S. Vlaeyen, Lukas Van Oudenhove
Review
Gastroenterology & Hepatology
Tamara Mogilevski, Rebecca Burgell, Qasim Aziz, Peter R. Gibson
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2019)
Article
Gastroenterology & Hepatology
Kenichiro Nakagawa, Ken Hara, Asma Fikree, Shahab Siddiqi, Philip Woodland, Atsushi Masamune, Qasim Aziz, Daniel Sifrim, Etsuro Yazaki
JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Gastroenterology & Hepatology
Adam D. Farmer, Ahmed Albusoda, Gehanjali Amarasinghe, James K. Ruffle, Heather E. Fitzke, Ruqaya Idrees, Ron Fried, Christina Brock, Qasim Aziz
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2020)
Article
Gastroenterology & Hepatology
Florencia Carbone, Nick Goelen, Asma Fikree, Qasim Aziz, Jan Tack
Summary: Functional dyspepsia (FD) often co-exists with joint hypermobility syndrome (JHS), characterized by decreased gastric accommodation and lower nutrient tolerance compared to FD patients with JHS.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Tim Klaassen, Fabienne G. M. Smeets, Lisa Vork, Jan Tack, Nicholas J. Talley, Magnus Simren, Qasim Aziz, Alexander C. Ford, Joanna W. Kruimel, Jose M. Conchillo, Carsten Leue, Adrian A. M. Masclee, Daniel Keszthelyi
Summary: This study demonstrated the good validity and reliability of a novel ESM-based PROM for assessing gastrointestinal symptoms in FD patients. The novel PROM allows evaluation of individual symptom patterns and interactions between symptoms and environmental/contextual factors. ESM has the potential to increase patients' disease insight, provide tools for self-management, and improve shared decision making, aiding in the transition toward personalized health care for FD patients.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Ali Gholamrezaei, Ilse Van Diest, Qasim Aziz, Ans Pauwels, Jan Tack, Johan W. S. Vlaeyen, Lukas Van Oudenhove
Summary: The study found that slow, deep breathing can reduce visceral pain intensity, which is not specific to the frequency of slow breathing and is not mediated by autonomic or emotional responses.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Psychology, Biological
Ali Gholamrezaei, Ilse Van Diest, Qasim Aziz, Johan W. S. Vlaeyen, Lukas Van Oudenhove
Summary: The study did not support the hypothesis that adding an inspiratory load to slow, deep breathing enhances its hypoalgesic effects. While pain intensity was slightly lower during SDB with load compared to normal-frequency controlled breathing, the difference was minimal. Heart rate variability was higher during SDB, but emotional responses were less favorable when using load.
Article
Anesthesiology
Abraham B. Beckers, Lukas van Oudenhove, Zsa Zsa R. M. Weerts, Heidi I. L. Jacobs, Nikos Priovoulos, Benedikt A. Poser, Dimo Ivanov, Ali Gholamrezaei, Qasim Aziz, Sigrid Elsenbruch, Ad A. M. Masclee, Daniel Keszthelyi
Summary: The study found that subjects with abdominal pain had more pronounced brain activation during infusion, while activation at the NTS level was independent of subjective pain ratings. These findings contribute to understanding the fundamental mechanism necessary for developing novel therapies aimed at correcting disturbances in visceral afferent pain processing.
Review
Gastroenterology & Hepatology
Christopher Roberts, Ahmed Albusoda, Adam D. Farmer, Qasim Aziz
Summary: This study aimed to determine whether individuals with irritable bowel syndrome (IBS) have lower pain thresholds compared to healthy individuals. The results showed that reduced rectal pain threshold is more common in IBS patients than in healthy controls. Further research is needed to understand the pathophysiological and therapeutic implications of rectal sensitivity in IBS.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Psychology, Biological
Ali Gholamrezaei, Ilse Van Diest, Qasim Aziz, Johan W. S. Vlaeyen, Lukas Van Oudenhove
Summary: This study compared four deep breathing techniques and found that loaded breathing was associated with better cardiovascular effects, while pursed-lips breathing had better emotional responses. The findings suggest that different deep breathing techniques may have varying impacts on physiological and emotional states.
Article
Rehabilitation
Jane V. Simmonds, Anthony Herbland, Alan Hakim, Nelly Ninis, William Lever, Qasim Aziz, Mindy Cairns
DISABILITY AND REHABILITATION
(2019)