Article
Multidisciplinary Sciences
Lance D. Erickson, David S. White, Pierce Bassett, Shawn D. Gale, Bruce L. Brown, Dawson Hedges
Summary: This study used data from the UK Biobank to investigate the associations between H. pylori seropositivity and serointensity and cognitive function in adults aged 40-70. The results showed that H. pylori seropositivity and serointensity were associated with worse performance on Numeric memory, Reasoning, and errors on the Pairs matching test, but better performance on the Tower rearrangement task. These findings suggest that H. pylori seropositivity and serointensity might be linked to impaired cognitive function in this age group.
Article
Gastroenterology & Hepatology
M. C. Mommersteeg, I Simovic, B. Yu, S. A. van Nieuwenburg, I. M. J. Bruno, M. Doukas, E. J. Kuipers, M. C. W. Spaander, M. P. Peppelenbosch, N. Castano-Rodriguez, G. M. Fuhler
Summary: The SNP in the ATG16L1 gene is associated with increased intestinal endoplasmic reticulum stress and progression of gastric cancer induced by H. pylori. Individuals with the G-allele are more prone to developing gastric cancer.
Article
Gastroenterology & Hepatology
Samuel Tanner, Jeffry Katz, Fabio Cominelli, Miguel Regueiro, Gregory Cooper, Emad Mansoor
Summary: This article examines the prevalence of inflammatory bowel disease in patients with gastritis, duodenitis, and peptic ulcer disease, taking into consideration the presence of Helicobacter pylori infection. It is found that inflammatory bowel disease is less common in patients with H. pylori, and there is no increased risk of developing IBD after undergoing H. pylori eradication therapy.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Multidisciplinary Sciences
Hidenori Matsu, Emiko Rimbara, Masato Suzuki, Kengo Tokunaga, Hidekazu Suzuki, Masaya Sano, Takashi Ueda, Hitoshi Tsugawa, Sohachi Nanjo, Akira Takeda, Makot Sakshi, Shuich Terao, Tsuyosh Suda, Sae Aoki, Keigo Shibayama, Hiroyosh Ota, Katsuhiro Mabe
Summary: Helicobacter suis, the most common gastric non-Helicobacter pylori Helicobacter species found in humans, has been suggested to cause many cases of gastric disease, but the transmission route from hogs remains unclear. Diagnostic methods for H. suis infection often yield negative results, making it difficult to diagnose without gastric biopsy specimens. This study introduces the use of whole-bacterial cell ELISA to simultaneously assess H. suis and H. pylori infections, with high accuracy and sensitivity.
Review
Medicine, Research & Experimental
Yi-Chia Lee, Maria Pina Dore, David Y. Graham
Summary: The past 5 years have witnessed significant changes in the testing and treatment of Helicobacter pylori infection. Peptic ulcer has transitioned from a chronic disease to an acute condition, and countries with high incidence of gastric cancer have started implementing population-wide screening and treatment. A proactive approach to testing and treatment, including outreach to family members and high-risk populations, is now recommended. The rise in antimicrobial resistance has led to a decline in treatment success, necessitating a reconsideration of treatment guidelines and adherence to principles of antibiotic usage and antimicrobial stewardship.
ANNUAL REVIEW OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Iyad Ali, Qusay Abdo, Shayma'a M. Al-Hihi, Ansam Shawabkeh
Summary: This study investigated the association between Helicobacter pylori (H. pylori) colonization and ulcerative colitis (UC) in Palestine. The results showed a significantly lower H. pylori infection rate in patients with UC compared to the control group, suggesting a potential protective role of H. pylori against UC occurrence.
Article
Gastroenterology & Hepatology
Young Jae Hwang, Yonghoon Choi, Nayoung Kim, Hye Seung Lee, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee
Summary: The study found that both endoscopic and histologic improvements of atrophic gastritis and intestinal metaplasia were observed after H. pylori eradication, with endoscopic improvement taking significantly longer time than histologic improvement.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Review
Medicine, General & Internal
Irena Mladenova
Summary: Helicobacter pylori is a pathogenic bacterium that infects approximately 50% of the world population, playing a role in chronic gastritis, ulcers, and gastric cancer. Treatment should be based on local antibiotic use and resistance, while diagnostic methods depend on clinical indications.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Alain P. Gobert, Mohammad Asim, Thaddeus M. Smith, Kamery J. Williams, Daniel P. Barry, Margaret M. Allaman, Kara M. McNamara, Caroline V. Hawkins, Alberto G. Delgado, M. Blanca Piazuelo, John A. Rathmacher, Keith T. Wilson
Summary: Stomach cancer is a leading cause of cancer death, primarily caused by Helicobacter pylori infection, which induces inflammation and DNA damage. 2-hydroxybenzylamine (2-HOBA), derived from buckwheat seeds, is effective in reducing gastritis, gastric dysplasia, and carcinogenesis caused by H. pylori infection in mice and gastric epithelial cells.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, General & Internal
Maidina Abuduwaili, Hidehiko Takigawa, Ryo Yuge, Hajime Teshima, Takahiro Kotachi, Yuji Urabe, Masanori Ito, Kazuhiro Sentani, Naohide Oue, Shiro Oka, Yasuhiko Kitadai, Shinji Tanaka
Summary: This study aimed to investigate the relationship between NHPH infection and gastritis and gastric cancer development. The results showed no significant difference in NHPH infection rates based on different Hp infection statuses, and the NHPH infection rates in gastric cancer patients were similar to those in patients with gastritis-related diseases reported in previous studies. A comparison between NHPH-positive and negative patients showed no significant differences in atrophic gastritis status, serum gastritis markers, or clinicopathological characteristics of gastric cancer.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Massimo Rugge, Ludovica Bricca, Stefano Guzzinati, Diana Sacchi, Marco Pizzi, Edoardo Savarino, Fabio Farinati, Manuel Zorzi, Matteo Fassan, Angelo Paolo Dei Tos, Peter Malfertheiner, Robert M. Genta, David Y. Graham
Summary: The study found that autoimmune gastritis (AIG) patients exhibit oxyntic-predominant-mononuclear inflammation, PPM (more than IM), and ECL-cell hyperplasia/neoplasia as histological hallmarks. Over a cumulative follow-up time of 10,541 person years, there was no excess risk of gastric or other malignancies found, except for a (marginally significant) risk of thyroid cancer.
Review
Oncology
Sarah Killcoyne, Rebecca C. Fitzgerald
Summary: Cancer cells evolve through DNA mutation, cell selection, and population expansion, driven by mutated driver genes and structural alterations to the genome. Early genomic instability in Barrett's esophagus (BE) may lead to esophageal adenocarcinoma (EAC). Understanding these patterns and genomic changes can improve early detection of EAC and provide insights into cancer evolution.
NATURE REVIEWS CANCER
(2021)
Article
Gastroenterology & Hepatology
Peter Malfertheiner, Francis Megraud, Theodore Rokkas, Javier P. Gisbert, Jyh-Ming Liou, Christian Schulz, Antonio Gasbarrini, Richard H. Hunt, Marcis Leja, Colm O'Morain, Massimo Rugge, Sebastian Suerbaum, Herbert Tilg, Kentaro Sugano, Emad M. El-Omar
Summary: Helicobacter pylori infection is recognized as an infectious disease and requires optimized management to prevent complications and gastric cancer. Continuous updates in treatment strategies and testing methods are necessary due to rising antibiotic resistance and the impact on gut microbiota.
Article
Gastroenterology & Hepatology
Naoki Sumi, Ken Haruma, Tomoari Kamada, Mitsuhiko Suehiro, Noriaki Manabe, Takashi Akiyama, Akiko Shiotani, Yoshiyuki Yamanaka, Sohachi Fujimoto, Toshihiro Takao
Summary: The study aimed to determine the normal number of inflammatory cells, including eosinophils, in the normal mucosae of pyloric and fundic glands in patients without inflammation. The findings showed significant differences in the abundance of inflammatory cells between the pyloric and fundic gland mucosae, providing important information for defining gastric mucosal inflammation, including eosinophilic gastritis diagnosis.
DIGESTIVE DISEASES
(2021)
Review
Gastroenterology & Hepatology
Alain P. Gobert, Keith T. Wilson
Summary: Gastric cancer is the fifth most common cancer and the fourth most common cause of cancer-related death worldwide. The key factor in the development of gastric inflammation and disease progression is Helicobacter pylori infection, although only a small percentage of infected individuals develop gastric adenocarcinoma.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
