Journal
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
Volume 24, Issue 1, Pages 13-24Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.beha.2010.11.003
Keywords
mesenchymal stroma cell (MSC); mesenchymal progenitor cell (MPC); sca-1; multipotent differentiation; pericyte advenmial reticular cell; vascular smooth muscle cell (VSMC)
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Funding
- Cancer Research UK Funding Source: Medline
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Enormous confusion still exists in the scientific community regarding the in vivo identity of putative bone marrow (BM) multipotent mesenchymal progenitor cells (MPCs). There is still lack of consensus between laboratories on this issue but recent advancements in this field have shed light on the identity of these cells in humans. However, in mice there are limited and reproducible data available that convincingly define prospectively these cells in vivo. In this review we will critically address: 1) important considerations on how to interpret MPC nomenclature, heterogeneity and differentiation abilities; 2) potential surface antigens that could aid in the isolation of MPC from mouse BM; 3) and their topography and prospective cellular relationship with pericytes, adventitial reticulocytes (ARCs) and vascular smooth muscle cells (VSMCs). (C) 2010 Elsevier Ltd. All rights reserved.
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