Journal
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
Volume 23, Issue 3, Pages 319-331Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.beha.2010.07.002
Keywords
phosphoflow; multiparameter flow cytometry; diagnostic, signal transduction; biological characterization; standardization; leukemia; pharmacodynamics
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The advent of modulated multiparameter phosphoflow cytometry allows insight into the complexity of signal transduction networks in distinct cell subsets within a complex tissue sample. The application of this technology to hematopoietic malignancies can reveal pathogenic signaling profiles in intact tumor cells. Here, we review recent studies demonstrating the advantages and utility of this technology to inform the biological characterization of tumor cells and its applications to clinical medicine and drug development. Further, we discuss standardization and quality control approaches necessary for the adoption of this technique into clinical flow cytometry laboratories. (C) 2010 Elsevier Ltd. All rights reserved.
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