Article
Endocrinology & Metabolism
Gladys Wojciechowska, Lukasz Szczerbinski, Marek Kretowski, Magdalena Niemira, Hady Razak Hady, Adam Kretowski
Summary: This study suggests that four serum miRNAs may serve as predictive biomarkers for type 2 diabetes remission 12 months after sleeve gastrectomy. Further validation studies are needed to confirm the findings.
Article
Surgery
Xinqiang Zhu, Gang Zhou, Xingwei Gu, Xuetong Jiang, Hailong Huang, Sainan You, Gong Zhang
Summary: This study aimed to compare the clinical outcomes of bariatric surgery and medical treatment for obese adolescents with type 2 diabetes. The results showed that bariatric surgery was more effective than medical treatment in controlling weight loss and type 2 diabetes, with LRYGB surgery having better effects on weight loss and glycemic control.
ASIAN JOURNAL OF SURGERY
(2023)
Editorial Material
Endocrinology & Metabolism
Samuel Klein, Randy J. Seeley
Summary: Many individuals with obesity and type 2 diabetes experience diabetes remission after Roux-en-Y gastric bypass surgery, but there is disagreement regarding the underlying mechanisms. We present our perspective on conflicting datasets suggesting that the remission could be attributed solely to weight loss or weight loss-independent factors.
Review
Endocrinology & Metabolism
Rexiati Ruze, Tiantong Liu, Xi Zou, Jianlu Song, Yuan Chen, Ruiyuan Xu, Xinpeng Yin, Qiang Xu
Summary: The prevalence of obesity and diabetes mellitus (DM) is increasing globally due to shared genetic and environmental factors. Obesity amplifies the impact of genetic susceptibility and environmental factors on DM by interfering with metabolic balance and causing insulin resistance. The dysregulation of immunometabolism through low-grade systemic inflammation leads to the loss of functional beta-cells and elevated blood glucose. Treatment approaches for obesity and type 2 DM have interconnected effects, and surgical procedures like bariatric surgery are more effective. More research is needed to improve the efficacy and safety of available and new treatments.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Brianna N. Lauren, Francesca Lim, Abraham Krikhely, Elsie M. Taveras, Jennifer A. Woo Baidal, Brandon K. Bellows, Chin Hur
Summary: This study evaluated the cost-effectiveness of medical therapy, sleeve gastrectomy (SG), and Roux-en-Y gastric bypass (RYGB) in patients with severe obesity and type 2 diabetes (T2D). The results showed that RYGB is the most cost-effective treatment strategy, resulting in the highest number of quality-adjusted life-years (QALYs) gained.
Article
Endocrinology & Metabolism
Rinki Murphy, Lindsay D. Plank, Michael G. Clarke, Nicholas J. Evennett, James Tan, David D. W. Kim, Richard Cutfield, Michael W. C. Booth
Summary: SR-LRYGB provided superior diabetes remission and weight loss compared with LSG at 5 years, with similar low risks of complications.
Article
Endocrinology & Metabolism
Maddalena Ardissino, Francesca Watson, Ravi Amin, Peter Collins, Osama Moussa, Sanjay Purkayastha
Summary: This study demonstrates that bariatric surgery can improve atherosclerotic cardiovascular disease outcomes and reduce mortality in patients with obesity and type 2 diabetes.
JOURNAL OF DIABETES
(2021)
Article
Chemistry, Multidisciplinary
Arianna Bonizzi, Marta Sevieri, Leopoldo Sitia, Andrea Rizzi, Lorenzo Conti, Fabio Corsi, Carlo Morasso, Serena Mazzucchelli
Summary: The study revealed that despite the improvements in weight, glycemic control, and lipid profile of type 2 diabetes mellitus patients after bariatric surgery, Raman spectroscopy indicated that their metabolic profiles were not fully restored post-surgery.
APPLIED SCIENCES-BASEL
(2021)
Review
Endocrinology & Metabolism
Paolo Gentileschi, Emanuela Bianciardi, Domenico Benavoli, Michela Campanelli
Summary: Bariatric surgery has been shown to promote remission or significant improvement of Type II Diabetes Mellitus and related comorbidities in obese patients. Different gastrointestinal procedures may have varying effects and mechanisms of action on glucose metabolism. Metabolic surgery integrates knowledge and multidisciplinary expertise to provide a combination of conservative and surgical treatments for Type II diabetes.
ACTA DIABETOLOGICA
(2021)
Article
Endocrinology & Metabolism
Kaisheng Yuan, Bing Wu, Ruiqi Zeng, Fuqing Zhou, Ruixiang Hu, Cunchuan Wang
Summary: This study aimed to investigate factors influencing diabetes remission (DR) in patients with obesity and T2DM after bariatric metabolic surgery (BMS), and develop a predictive model using a nomogram. Glycated haemoglobin, triglycerides, duration of diabetes, insulin requirement, and hypercholesterolaemia were identified as independent factors for DR. The nomogram showed good efficacy in both training and validation cohorts.
DIABETES OBESITY & METABOLISM
(2023)
Review
Biology
Yanmin Du, Jianlu Zhang, Guanyang Chen, Zhipeng Sun
Summary: Bariatric surgery has undergone a long and difficult development process, gradually becoming the gold standard for treating morbid obesity with metabolic diseases. Constant improvement and evolving procedures, along with the in-depth study of the mechanism of metabolic weight loss surgery, are effectively promoting the rapid development of bariatric surgery.
Review
Endocrinology & Metabolism
Zhang-Liu Jin, Wei Liu
Summary: The global incidence of type 2 diabetes is on the rise, and bariatric surgical procedures are effective in providing relief. The mechanisms of these surgeries involve increased satiety and alterations in gastrointestinal hormones. Understanding these mechanisms can aid in developing better non-surgical treatments for type 2 diabetes.
WORLD JOURNAL OF DIABETES
(2021)
Article
Cell Biology
Filipa P. Ferreira, Sofia S. Pereira, Madalena M. Costa, Marta Guimaraes, Nicolai J. Wewer Albrechtsen, Jens J. Holst, Mario Nora, Mariana P. Monteiro
Summary: This study aims to investigate the distribution of neurotensin in the human small intestine and compare the density of neurotensin-expressing cells in individuals with and without type 2 diabetes undergoing bariatric surgery for obesity treatment. The results show that the density of neurotensin-expressing cells increases along the human small intestine, and individuals with type 2 diabetes have a higher density of these cells. This finding suggests a potential role for neurotensin in the mechanisms of disease and type 2 diabetes improvement observed after bariatric surgery.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Guanhua Lu, Huanhuan Gao, Zhiyong Dong, Shuwen Jiang, Ruixiang Hu, Cunchuan Wang
Summary: This study investigated the differences in miRNA expression in obese patients with and without T2DM, as well as before and after bariatric surgery in obese T2DM patients. The study found 16 up-regulated and 32 down-regulated miRNAs in T2DM patients compared to non-T2DM patients. Improvement in metabolic metrics after bariatric surgery was correlated with changes in miRNA expression. Seven intersecting miRNAs with opposite changes were identified, and their target genes were enriched in pathways associated with T2DM. These miRNAs and their target genes may be potential targets for regulating T2DM.
DIABETES & METABOLISM JOURNAL
(2023)
Article
Endocrinology & Metabolism
John P. Kirwan, Anita P. Courcoulas, David E. Cummings, Allison B. Goldfine, Sangeeta R. Kashyap, Donald C. Simonson, David E. Arterburn, William F. Gourash, Ashley H. Vernon, John M. Jakicic, Mary Elizabeth Patti, Kathy Wolski, Philip R. Schauer
Summary: The objective of this study is to assess the durability and longer-term effectiveness of metabolic surgery compared with medical/lifestyle management in patients with type 2 diabetes. The results demonstrate that metabolic/bariatric surgery is more effective and durable than medical/lifestyle intervention in remission of type 2 diabetes, with significant improvements in glycemic control, body weight, and biomarkers.
Article
Surgery
Khadija Nasser, Kevin Verhoeff, Valentin Mocanu, Janice Y. Kung, Kieran Purich, Noah J. Switzer, Daniel W. Birch, Shahzeer Karmali
Summary: Increasing evidence suggests surgical patients, particularly those undergoing bariatric surgery, are at risk for developing new, persistent opioid use. Little is known about the rate of opioid use and factors associated with it in bariatric surgery patients.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Surgery
Andrea Lin, Kevin Verhoeff, Valentin Mocanu, Kieran Purich, Khadija Nasser, Janice Y. Kung, Daniel W. Birch, Shahzeer Karmali, Noah J. Switzer
Summary: This study aimed to characterize opioid prescribing practices and use following bariatric surgery. The results showed that nearly 90% of the evaluated patients were prescribed excessive opioids at discharge. Further research on this phenomenon can help guide the development of standardized post-bariatric surgery prescription guidelines.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Valentin Mocanu, Kevin Verhoeff, Hayley Forbes, Daniel W. Birch, Shahzeer Karmali, Noah J. Switzer
Summary: Compared to Roux-en-Y gastric bypass, patients undergoing single anastomosis gastric bypass tend to be younger with slightly higher BMI. After adjusting for comorbidities, single anastomosis gastric bypass is associated with a lower incidence of serious complications.
Article
Surgery
Valentin Mocanu, Kevin Verhoeff, Kirk Sinclair, Daniel W. Birch, Shahzeer Karmali, Noah J. Switzer
Summary: The study aims to determine the prevalence of atrial dysrhythmias in elective bariatric surgery patients and investigate their impact on postoperative outcomes. Data was extracted from the MBSAQIP data registry from 2015 to 2019. The results showed that atrial dysrhythmias were the greatest independent predictors of serious complications and 30-day mortality.
SURGERY FOR OBESITY AND RELATED DISEASES
(2023)
Letter
Surgery
Valentin Mocanu, Kevin Verhoeff, Daniel W. Birch, Shahzeer Karmali, Noah J. Switzer
Article
Surgery
Hillary A. A. Wilson, Valentin Mocanu, Cheynne McLean, Daniel W. W. Birch, Shahzeer Karmali, Noah J. J. Switzer
Summary: The impact of the COVID-19 pandemic on early postoperative follow-up after bariatric surgery was examined. The study found that follow-up rates significantly increased during the COVID era in 2020. Older patients with more medical comorbidities and higher BMI were more likely to achieve 30-day follow-up.
Article
Surgery
Lauren Hampton, Valentin Mocanu, Kevin Verhoeff, Daniel W. Birch, Shahzeer Karmali, Noah J. Switzer
Summary: This study analyzed the database of the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) from 2015 to 2019 to characterize Asian patients undergoing bariatric surgery and assess their postoperative outcomes. The results showed that Asian patients were younger and had a lower BMI compared to White patients, but there were no significant differences in terms of complications and mortality.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Surgery
Valentin Mocanu, Hillary Wilson, Kevin Verhoeff, Janice Kung, Caolan Walsh, Nicole Koloszvari, Amy Neville, Shahzeer Karmali
Summary: TXA administration during bariatric surgery significantly reduces post-operative bleeding without observed differences in thromboembolic events or mortality. Further studies are needed to determine the optimal bariatric population for TXA use, as well as the ideal timing, dose, and duration of TXA therapy.
Article
Surgery
Valentin Mocanu, Kevin Verhoeff, Jerry Dang, Daniel W. W. Birch, Shahzeer Karmali, Noah J. Switzer
Summary: This study aimed to investigate the impact of pre- and post-operative COVID-19 diagnosis on bariatric surgery outcomes. The results showed that post-operative COVID-19 diagnosis was associated with significant complications and mortality. Therefore, a more liberal strategy of performing surgery soon after COVID-19 infection is recommended to address the current backlog of bariatric surgeries.
Article
Surgery
Jerry T. Dang, Tiffany Vaughan, Valentin Mocanu, Hadika Mubashir, Juan S. Barajas-Gamboa, Ricard Corcelles Codina, John Rodriguez, Shahzeer Karmali, Matthew Kroh
Summary: Conversion from sleeve gastrectomy (SG) to Roux-en-Y gastric bypass (RYGB) is often necessary due to gastroesophageal reflux disease (GERD) or weight regain. Limited evidence exists regarding the safety and indications of SG-RYGB conversion. A retrospective analysis of the MBSAQIP database was conducted to compare the outcomes of primary RYGB (P-RYGB) and SG-RYGB. The study found that SG-RYGB had higher rates of serious complications, including anastomotic leak, bleeding, and reoperation, but no significant increase in mortality compared to P-RYGB.
Article
Surgery
Sukhdeep Jatana, Kevin Verhoeff, Valentin Mocanu, Uzair Jogiat, Daniel W. Birch, Shahzeer Karmali, Noah J. Switzer
Summary: By analyzing the 2021 MBSAQIP database, we found a significant risk of substance abuse among patients undergoing bariatric surgery. It is important to use validated screening tools to identify patients at risk for substance abuse in order to minimize risk and plan the surgery accordingly. The study revealed that patients who underwent substance abuse screening were more likely to be white, non-smokers, and have more comorbidities. However, there was no significant association between substance abuse screening and postoperative complications.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Sukhdeep Jatana, Kevin Verhoeff, Valentin Mocanu, Uzair Jogiat, Daniel W. W. Birch, Shahzeer Karmali, Noah J. J. Switzer
Summary: This study aimed to evaluate the utility of risk stratification using ASA class for bariatric surgery patients and assessed predictive factors of postoperative complications. The analysis of the 2020 MBSAQIP database revealed that high-risk patients were more likely to be older, male, have a higher BMI, and have more comorbidities. While elevated ASA class correlates with increased serious complications, pre-operative functional status appears to have a much greater contribution to odds of serious complications and mortality. These findings question the utility of using ASA to risk stratify patients peri-operatively and provides evidence for using a simpler and more practical functional status approach.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Steffane McLennan, Kevin Verhoeff, Valentin Mocanu, Uzair Jogiat, Daniel W. Birch, Shahzeer Karmali, Noah J. Switzer
Summary: Revisional bariatric surgery is an option for patients with weight regain or inadequate weight loss after primary elective procedures. However, the safety outcomes of revisional procedures are conflicting. This study aims to characterize the patient demographics, procedure types, and safety outcomes for those undergoing revisional compared to initial bariatric interventions.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Samantha Albacete, Kevin Verhoeff, Valentin Mocanu, Daniel W. Birch, Shahzeer Karmali, Noah J. Switzer
Summary: The North American population with severe obesity is aging, and the number of elderly patients (>= 65 years) meeting indications for metabolic surgery is increasing. However, trends in bariatric delivery and outcomes in this population are poorly characterized, which hinders the potential uptake and delivery of these surgeries.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Surgery
Alexander Hajjar, Kevin Verhoeff, Uzair Jogiat, Valentin Mocanu, Daniel W. Birch, Noah J. Switzer, Clarence Wong, Shahzeer Karmali
Summary: This systematic review and meta-analysis compared endoscopic plication and laparoscopic fundoplication for the treatment of gastroesophageal reflux disease (GERD). The results showed that laparoscopic fundoplication was more likely to achieve PPI cessation compared to endoscopic plication, with similar post-procedural risk.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)