Article
Endocrinology & Metabolism
Isaac. W. W. Shaw, Phoebe. M. M. Kirkwood, Diane Rebourcet, Fiona. L. L. Cousins, Rebecca. J. J. Ainslie, Dawn E. W. Livingstone, Lee. B. B. Smith, Philippa T. K. Saunders, Douglas. A. A. Gibson
Summary: This study reveals the importance of intracrine androgen signaling in endometrial decidualization and its role in regulating the vascular development through the modulation of vascular endothelial growth factor (VEGF) pathway. These findings provide new opportunities for improving age-related deficits in fertility and pregnancy health.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Plant Sciences
Ja Yeon Park, Woo Yong Park, Jinbong Park, Kwang Seok Ahn, Jun Hee Lee, Hyun Jeong Kwak, Jae-Young Um
Summary: This study found that a water extract of Glycyrrhiza uralensis Fischer has potential therapeutic effects on BPH by inhibiting AR-5AR2 signaling and activating apoptosis signaling to reduce BPH development. Unlike finasteride, GUWE does not impact sperm count, suggesting lower toxicity and a safer alternative option for BPH treatment.
Article
Oncology
Jane B. Vaselkiv, Carl Ceraolo, Kathryn M. Wilson, Claire H. Pernar, Emily M. Rencsok, Konrad H. Stopsack, Sydney T. Grob, Anna Plym, Edward L. Giovannucci, Aria F. Olumi, Adam S. Kibel, Mark A. Preston, Lorelei A. Mucci
Summary: The use of 5-alpha reductase inhibitor (5-ARI) is not associated with an increased risk of lethal prostate cancer or cancer-specific death, but is instead linked to a reduced risk of overall and localized disease. These findings suggest that 5-ARI use is safe in terms of prostate cancer mortality.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Pharmacology & Pharmacy
Yani Zhao, Yan Zhang, Yao Li, Min Yang, Jiani Yuan, Yu Cao, Lu Xu, Xuexinyu Ma, Sisong Lin, Junming An, Siwang Wang
Summary: The study found that different doses of yohimbine effectively inhibited the increase in prostate index in BPH rats, and reduced the levels of dihydrotestosterone, prostatic acid phosphatase, prostate-specific antigen, proliferating cell nuclear antigen, and steroid 5 alpha-reductase, indicating that it exerts beneficial effects against BPH by modulating the steroid 5 alpha-reductase pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Urology & Nephrology
David Julian Arias-Chavez, Patrick Mailloux-Salinas, Jessica Ledesma-Aparicio, Elihu Campos-Perez, Omar Noel Medina-Campos, Jose Pedraza-Chaverri, Guadalupe Bravo
Summary: The therapeutic effect of a combination of tomato lipidic extract (STE) and selenium (Se) on rats with prostatic hyperplasia (PH) was evaluated, and its possible mechanisms of action and synergism versus finasteride were observed. The results demonstrated that the combination of STE + Se had a greater therapeutic effect in reducing prostate weight, glandular hyperplasia, oxidative stress, dihydrotestosterone (DHT) and androgen receptor (AR) expression compared to finasteride.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Urology & Nephrology
David Julian Arias-Chavez, Patrick Mailloux-Salinas, Jessica Ledesma-Aparicio, Elihu Campos-Perez, Omar Noel Medina-Campos, Jose Pedraza-Chaverri, Guadalupe Bravo
Summary: This study evaluated the therapeutic effect of a tomato lipidic extract in combination with selenium on rats with prostatic hyperplasia, and observed its possible mechanisms of action and synergism with finasteride. The results showed that the combination of tomato lipidic extract and selenium had a greater therapeutic effect compared to finasteride, without increasing prooxidant activity.
WORLD JOURNAL OF UROLOGY
(2023)
Review
Dermatology
Mariana Escamilla-Cruz, Mario Magana, Sabrina Escandon-Perez, Omar Yaxmehen Bello-Chavolla
Summary: Finasteride and dutasteride are 5-alpha reductase selective inhibitors used in the treatment of benign prostatic hyperplasia and androgenetic alopecia. They block the conversion of testosterone to dihydrotestosterone, which has several therapeutic implications in dermatology. This review discusses the application of these inhibitors in various dermatological conditions and evaluates their efficacy and safety profile.
DERMATOLOGY AND THERAPY
(2023)
Article
Urology & Nephrology
Matthew B. Harrell, Kaylee Ho, Alexis E. Te, Steven A. Kaplan, Bilal Chughtai
Summary: Analysis of FAERS data suggests that adverse effects of 5ARIs are dose-independent, with a higher likelihood of occurrence in younger patients, particularly in the sexual and mental domains. Further prospective studies are needed to determine the true rates of adverse events.
WORLD JOURNAL OF UROLOGY
(2021)
Editorial Material
Oncology
Robert J. Hamilton
Summary: Vaselkiv and colleagues provide strong evidence for the long-term safety of 5-alpha reductase inhibitor (5-ARI) use, showing no association with advanced prostate cancer development or mortality. However, with increasing use of active surveillance for low-grade prostate cancer and advancements in technologies focusing on detecting clinically significant cancers, the role of 5-ARIs in chemoprevention may have become less important.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Endocrinology & Metabolism
Jordan J. Kramer, Lin Gu, Daniel Moreira, Gerald Andriole, Stephen J. Freedland, Ilona Csizmadi
Summary: In older men, smoking does not increase the risk of developing lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) in asymptomatic men, nor does it affect the progression of LUTS in symptomatic men.
Article
Medicine, Research & Experimental
Jaekwon Seok, Hee Jeong Kwak, Yeonjoo Kwak, Moonjung Lee, Kyoung Sik Park, Aram Kim, Ssang-Goo Cho
Summary: This study investigates the effects of androgen suppression therapy on bladder cancer progression and identifies potential therapeutic targets. It is found that dutasteride, a 5 alpha-reductase inhibitor, can inhibit cell proliferation and migration of bladder cancer cells by regulating the expression of cancer progression proteins. Additionally, the study reveals the role of the target gene SRD5A1 in bladder cancer and its correlation with patient survival.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Subin Oh, Moon Ho Do, Jin A. Shin, Min Jee Lee, Hua Li, Su Yeon Cho, Jong-Moon Jeong
Summary: This study investigated the protective effects of a natural product mixture called BenPros on benign prostatic hyperplasia (BPH). BenPros exhibited inhibitory ability on the expression of androgen receptor, prostate-specific antigen, and 5 alpha-reductase protein, as well as anti-inflammatory effects. The mixture also reduced levels of hormones associated with BPH and showed regulatory effects on BPH markers, leading to a decrease in prostate size and epithelial thickness.
APPLIED SCIENCES-BASEL
(2022)
Article
Medical Laboratory Technology
Yoshitaka Hobo, Jun Nishikawa, Noriko Taniguchi Asai, Keisuke Yoneyama, Yoko Watanabe, Yoshimichi Miyashiro, Akira Fujikata
Summary: In this study, a method to measure the concentrations of 5ARI medications finasteride and dutasteride in hair was developed, and their effective action in hair follicle tissues was confirmed. Compared to the non-detection group, significant decreases in dihydrotestosterone (DHT) concentrations were observed in both finasteride and dutasteride groups, with the dutasteride group showing the lowest concentrations. Measurement of finasteride, dutasteride, and DHT concentrations in hair could help evaluate the pharmacokinetics and therapeutic effects of these drugs on patients with androgenetic alopecia.
CLINICA CHIMICA ACTA
(2023)
Article
Plant Sciences
Hyo-Jung Kim, Bo -Ram Jin, Hyo-Jin An
Summary: This study confirmed the efficacy of Psoralea corylifolia L. seed against BPH by regulating prostate cell proliferation and apoptosis, showing therapeutic potential in both in vitro cell lines and in vivo rat models.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ja Yeon Park, Woo Yong Park, Gahee Song, Se Jin Jung, Beomsu Kim, Minji Choi, Sang Hee Kim, Jinbong Park, Hyun Jeong Kwak, Kwang Seok Ahn, Jun Hee Lee, Jae-Young Um
Summary: This study aimed to investigate the therapeutic effects of Panax ginseng water extract (PGWE) on benign prostatic hyperplasia (BPH) and its potential in treating side effects related to finasteride (Fi), an FDA-approved drug for BPH. The results showed that PGWE alleviated BPH symptoms and downregulated androgen-related factors. PGWE also induced prostatic cell apoptosis and improved sperm count in BPH rats. Furthermore, PGWE protected against Fi-induced sperm loss without compromising the therapeutic effects of Fi on BPH. These findings suggest that PGWE could be an alternative therapeutic agent for BPH.
FRONTIERS IN PHARMACOLOGY
(2023)