Review
Engineering, Biomedical
Qiao Sun, Xiao Xie, Yujie Song, Litao Sun
Summary: The investigation of the interaction between metal ions and DNA has always been a topic of great interest in the fields of bioinorganic chemistry, supramolecular coordination chemistry, and DNA nanotechnology. The interaction can be divided into non-specific electrostatic adsorption and specific covalent binding. This article focuses on the mechanism of action between Ag+ and DNA mismatch pair C-C, and summarizes the characterization methods and applications. It aims to provide a reference for the field of biological devices. The development of cryo-electron microscopy and liquid-cell TEM is expected to further characterize the structure of C-Ag+-C and enhance its application.
BIOMATERIALS RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Antonio Perez-Romero, Alicia Dominguez-Martin, Simona Galli, Noelia Santamaria-Diaz, Oscar Palacios, Jose A. Dobado, May Nyman, Miguel A. Galindo
Summary: The study demonstrates that 1Pd-DNA molecules with a continuous single chain of Pd-II ions can be prepared by a simple self-assembly reaction between complex [Pd(Cheld)(CH3CN)] (1Pd_CH3CN) and single-stranded DNA homopolymers containing adenine (A) or 7-deazaadenine (X). The resulting structures resemble natural Watson-Crick base pairs and double-stranded DNA, with one strand being replaced by a supramolecular stack of continuous Pd-II complexes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Ge Mu, Ryan B. Gaynor, Baylee N. Mcintyre, Bruno Donnadieu, Sidney E. Creutz
Summary: Metalloenzymes extensively use manganese centers for oxidative catalysis, such as water oxidation. The development of bioinspired manganese complexes as improved synthetic catalysts for these processes has been a long-standing motivation. In this study, we report a series of bpy-(imidazole)(n) (n = 1 or 2) (bpy = 2,2 '-bipyridyl) ligands and their Mn2+ complexes. The structures of four Mn2+ complexes are characterized using single-crystal X-ray diffraction, revealing different coordination modes of tridentate and tetradentate ligands. Cyclic voltammetry results indicate ligand-centered reductions and metal-centered oxidations, while UV-vis spectroscopy and TD-DFT calculations show primarily ligand-centered transitions in the complexes. ESI-MS studies in solution provide evidence of ligand reorganization, suggesting complex speciation behavior. However, the low stability of the complexes in aqueous solution prevents their ultimate application as aqueous electrocatalysts. Possible reasons for the low stability and suggestions for improvement are discussed.
Article
Chemistry, Inorganic & Nuclear
Daniela Escher, Jens Mueller
Summary: The study investigated the ability of DNA duplexes containing artificial nucleobases to form silver(I)-mediated base pairs. It was found that the stability of resulting silver(I)-mediated base pairs is strongly sequence-dependent. The most stable silver(I)-mediated base pairs are formed when specific artificial nucleobases are located opposite to certain natural nucleobases in the DNA duplex.
ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE
(2021)
Review
Chemistry, Multidisciplinary
Joern Bargstedt, Martin Reinschmidt, Leon Tydecks, Theresa Kolmar, Christoph M. Hendrich, Andres Jaeschke
Summary: Photochromic nucleosides have emerged as a promising approach for manipulating and studying complex processes in living organisms. This review highlights recent advancements in this field, including design principles, synthetic strategies, analytical challenges, and applications. The incorporation of photoswitchable moieties into biological macromolecules allows for light-responsive behavior, offering advantages in cellular and tissue applications due to its non-invasive nature. This field holds great potential for precise control of gene expression and modulation of biomolecular structure and function.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Organic
Misa Shoji, Yasufumi Fuchi, Takashi Osawa, Han Kim, Yuta Ito, Yoshiyuki Hari
Summary: In this study, a unique consecutive three-acetal-containing nucleic acid (TaNA) was designed and its methylated derivatives were synthesized. The modified oligonucleotides showed higher stability when forming duplexes or triplexes compared to natural and other modified oligonucleotides, and also exhibited enhanced nuclease resistance.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Daniele Rosa-Gastaldo, Andrea Dalla Valle, Tommaso Marchetti, Luca Gabrielli
Summary: A new family of duplex-forming recognition encoded oligomers was developed with the ability of sequence selective duplex formation and template directed synthesis. The duplex formation and assembly properties were studied by F-19 and H-1 NMR experiments. The use of dynamic combinatorial chemistry demonstrated the templated synthesis of complementary oligomers. The H-bond recognition played a key role in discriminating mutated donor monomers. The combination of sequence-selective duplex formation and template effect makes this system a promising target for further studies.
Article
Chemistry, Multidisciplinary
Nils Lefringhausen, Victoria Seiffert, Catharina Erbacher, Uwe Karst, Jens Mueller
Summary: It has been discovered that by incorporating ligands capable of forming chiral metal complexes into a DNA double helix, it is possible to selectively form enantiomers of metal-mediated base pairs depending on the number of consecutive pairs. The chirality of the metal complex formed inside the DNA duplex remains the same for up to five neighboring pairs, regardless of the enantiomer used. However, with six pairs, the chirality of the metal complex is inverted for one enantiomer but not the other, suggesting a delicate balance between the metal-centered chirality and the DNA helical chirality in determining the configuration of the metal complex.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Osamu Nakagawa, Hiroshi Aoyama, Akane Fujii, Yuki Kishimoto, Satoshi Obika
Summary: The study focused on the crystallographic structure of a non-canonical DNA/DNA duplex containing metal-mediated base pairs, revealing a novel type of Ag-I-mediated base pair and its potential application in DNA nanotechnology. This bent duplex structure induced by Ag-I ions could be a powerful tool for dynamic structural changes in DNA nanotechnology applications.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Laia Vicens, Giorgio Olivo, Miquel Costas
Summary: This study presents a supramolecular strategy for enzyme-like H2O2 activation at a biologically inspired manganese catalyst, allowing for catalytic asymmetric epoxidation. Modulation of both amino acid and catalyst structure can tune the efficiency and enantioselectivity of the reaction, and an investigation on the oxidative degradation pathway of the system is provided.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Biotechnology & Applied Microbiology
Gan Zhu, Ping Song, Jing Wu, Minglan Luo, Zhipeng Chen, Tingjian Chen
Summary: Nucleic acids play a crucial role in storing and retrieving genetic information in all living organisms, as well as providing materials for artificial nanostructures and scaffolds for constructing high-performance multi-enzyme systems. Introducing unnatural moieties into nucleic acids significantly increases their diversity, expanding the toolbox for making nanomaterials and multi-enzyme system scaffolds.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bernhard Lippert
Summary: This commentary discusses the distinction between nucleobase pairs and pairs of basic ligands, and highlights the potential issues with metal ion cross-linking.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Nikita Brodyagin, Aubrey L. Maryniak, Ilze Kumpina, John M. Talbott, Martins Katkevics, Eriks Rozners, James A. MacKay
Summary: Peptide nucleic acids (PNA) with extended isoorotamides containing nucleobases (I-o) were designed to bind A-U base pairs in double-stranded RNA. Isothermal titration calorimetry and UV thermal melting experiments showed improved affinity for A-U using the Io scaffold in PNA, with PNAs having four sequential Io extended nucleobases maintaining high binding affinity.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Chemistry, Inorganic & Nuclear
Xiao-Wei Zhu, Dong Luo, Xiao-Ping Zhou, Dan Li
Summary: The review explores the synthetic methods and functional applications of imidazole-based metal-organic cages (IMOCs). Various types of IMOCs with diverse structures and coordination are categorized by using self-assembly strategies. The relationship between the structures and properties of IMOCs is elucidated, providing inspiration for designing new metal-organic cages with advanced functions.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Biotechnology & Applied Microbiology
Rachael Putman, Adele S. Ricciardi, Kelly E. W. Carufe, Elias Quijano, Raman Bahal, Peter M. Glazer, W. Mark Saltzman
Summary: Gene editing using nanoparticle delivery system has been demonstrated to be effective in correcting gene mutations during early embryonic development, potentially offering a cure or prevention for genetic diseases.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Chemistry, Multidisciplinary
Shuvankar Naskar, Rweetuparna Guha, Jens Mueller
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Biochemistry & Molecular Biology
Biswarup Jash, Jens Mueller
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Marie Flamme, Fabienne Levi-Acobas, Susanne Hensel, Shuvankar Naskar, Pascal Rothlisberger, Ivo Sarac, Gilles Gasser, Jens Mueller, Marcel Hollenstein
Article
Chemistry, Multidisciplinary
Daniela Escher, Jens Muller
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Biochemistry & Molecular Biology
Jim Bachmann, Isabell Schoenrath, Jens Mueller, Nikos L. Doltsinis
Article
Chemistry, Organic
Marius H. Heddinga, Jens Mueller
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Chemistry, Inorganic & Nuclear
Daniela Escher, Jens Mueller
Summary: The study investigated the ability of DNA duplexes containing artificial nucleobases to form silver(I)-mediated base pairs. It was found that the stability of resulting silver(I)-mediated base pairs is strongly sequence-dependent. The most stable silver(I)-mediated base pairs are formed when specific artificial nucleobases are located opposite to certain natural nucleobases in the DNA duplex.
ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE
(2021)
Article
Biochemistry & Molecular Biology
Daniela Escher, M. Nur Hossain, Heinz-Bernhard Kraatz, Jens Mueller
Summary: Films of different DNA quadruplex-forming sequences were studied on gold surfaces using electrochemical impedance spectroscopy, showing unique electrochemical responses that allow for their identification. This method could be an alternative means for determining G4 sequences of unknown structure.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
(2021)
Article
Biochemical Research Methods
Catharina Erbacher, Nils Flothkoetter, Marcel Macke, C. Derrick Quarles, Michael Sperling, Jens Mueller, Uwe Karst
Summary: A fast and automated method for separation and quantification of bromide and 5-BrdU via IC and ICP-MS was developed, relevant for monitoring electron transfer efficiency along DNA. With a LOD of 30 ng/L, the method is suitable for screening applications with a multitude of samples.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Chemistry, Inorganic & Nuclear
Shuvankar Naskar, Jens Mueller
Summary: Metal-mediated base pairs allow for the site-specific incorporation of transition metal ions into nucleic acid structures, creating nucleic acid-metal complexes with metal-based functionality. The design of nucleic acids with externally triggered metal-binding affinity, such as copper(II) ions upon light irradiation, can lead to the regulation of functionality in nucleic acids.
INORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Isabell Schoenrath, Hanne Aukam, Beate Jasper-Peter, Jens Mueller
Summary: The study reports the first metal-mediated base pair containing an S-glycosidic nucleoside analogue, and describes the synthesis of the phosphoramidite for solid-phase synthesis of DNA oligonucleotides. The results showed that in DNA duplexes containing a 4S:C mismatch, the addition of silver ions can lead to the formation of a silver(I)-mediated base pair with significant thermal stabilization.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
(2022)
Article
Chemistry, Inorganic & Nuclear
Ivan Maisuls, Felix Boisten, Marian Hebenbrock, Julian Alfke, Lina Schurmann, Beate Jasper-Peter, Alexander Hepp, Melanie Esselen, Jens Mueller, Cristian A. Strassert
Summary: This study successfully synthesized a family of Pt(II) complexes with luminophoric units, and investigated their photophysical properties in relation to the structure and substitution pattern of the ligands. By comparing the photoluminescence under different conditions, the correlation between the properties and substitution pattern was analyzed. In addition, density functional theory calculations were performed to gain a deeper understanding of the electronic states responsible for the optical properties. The cytotoxicity evaluation showed that the cationic complexes exhibited strong antitumor activity, while the neutral species had potential for bioimaging applications.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Marvin Nyenhuis, Isabell Schonrath, Polina N. Kamzeeva, Timofei S. Zatsepin, Jens Mueller, Nikos Doltsinis, Andrey Aralov
Summary: A benzothiazole-substituted derivative was evaluated for its ability to form Ag(I)-mediated homo base pairs in DNA duplexes, and the study revealed that even bulky non-planar artificial nucleobases can form stable metal-mediated base pairs.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Organic
Marius H. Heddinga, Jens Mueller
Summary: This study modifies the structure of aptamers to modulate their function through the addition of Cu(ii). By introducing synthetic nucleoside substitutes into the oligonucleotide sequence, the binding of aptamers to their target molecules can be influenced.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Nikolas Sandmann, Jim Bachmann, Alexander Hepp, Nikos L. Doltsinis, Jens Mueller
DALTON TRANSACTIONS
(2019)
