Journal
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
Volume 9, Issue -, Pages 2344-2353Publisher
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.9.269
Keywords
green chemistry; pyrrole-fused isocoumarin; reusable solid support; silica sulfuric acid; solvent-free condition
Categories
Funding
- CSIR
- UGC, New Delhi, India
- CSIR, New Delhi [02(0007)/11/EMR-II]
- DST-FIST, India
Ask authors/readers for more resources
A convenient and efficient methodology for the synthesis of densely substituted pyrrole-fused isocoumarins, which employs solid-supported silica sulfuric acid (SSA) as catalyst, has been developed. When the mixture of ninhydrin adducts of acetylacetone/ethyl acetoacetate and primary amines was heated on the solid surface of SSA under solvent-free conditions, the pyrrole-fused isocoumarins were formed in good yields. This synthetic method has several advantages such as the employment of solvent-free reaction conditions without the use of any toxic reagents and metal catalysts, the ease of product isolation, the use of a recyclable catalyst, the low cost, the easy availability of the starting materials, and the excellent yields of products.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available