Article
Chemistry, Physical
M. Xing, Jeotikanta Mohapatra, J. Beatty, J. Elkins, Nil Kanatha Pandey, A. Chalise, W. Chen, M. Jin, J. Ping Liu
Summary: Localized heat generation using iron carbide nanoparticles with a thin carbon shell shows promising magnetothermal and photothermal effects when irradiated with a NIR laser, and exhibits enhanced specific absorption rate under an alternating magnetic field due to high magnetization and coercivity.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Chemistry, Analytical
Hyung Joon Kim, Sung Wook Hyun, So Hee Kim, Hyunkyung Choi
Summary: Mn-Zn ferrite nanoparticles for magnetic hyperthermia applications were synthesized using a high temperature thermal decomposition method, with a maximum saturation magnetization of 83.2 emu/g. The results suggest that these synthesized nanoparticles have potential applications in the field of magnetic hyperthermia.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
David Serantes, Daniel Baldomir
Summary: This study explores how the threshold size for magnetic agglomeration varies depending on the magnetic anisotropy constant K, finding that small variations in K may shift the threshold size by a few nanometers. A comparison with usual superparamagnetic estimation and energy competition approach is provided, while also analyzing the key role of anisotropy in hyperthermia performance.
Article
Chemistry, Analytical
Eylem Turan, Adem Zengin, Zekiye Suludere, Nurhan Onal Kalkan, Ugur Tamer
Summary: A novel analytical method for selective and sensitive detection of prostate specific antigen (PSA) was developed by combining molecularly-imprinted polymers and surface-enhanced Raman spectroscopy (SERS). The method showed high sensitivity, selectivity, low cost, simplified detection procedure, fast response, and potential for clinical applications in determining tumor markers of prostate cancer.
Article
Biochemistry & Molecular Biology
Masataka Nakagawa, Yui Tomioka, Chiaki Sakuma, Ryo Sato, Takashi Shibata, Yasunori Kurosawa, Yoshinori Sato, Yasuo Ono, Tsutomu Arakawa, Teruo Akuta
Summary: In this study, silver staining of proteins and nucleic acids separated by agarose gel electrophoresis was examined using five commercial kits. The Silver Stain Plus from Bio-Rad was found to be the most suitable due to its minimal background staining and reasonable band staining. Additionally, silver staining showed the ability to stain nucleic acids and worked well on vertical agarose gels prepared with technological modifications. This optimized silver staining method could enable future analysis of biological samples with limited quantity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Chemistry, Medicinal
Carl A. Mieczkowski
Summary: This article reviews the US and EU approved antibody formulations and evaluates their nature and composition over time. Significant trends have been observed, including a decrease in average formulation pH and increased use of certain excipients and buffers. The formulation space has become more homogenous and there has been a convergence in terms of pH and excipient preferences. These trends may be driven by advancements in computational and analytical technologies, increased understanding of developability attributes and formulation principles, and the adoption of low-risk development platform approaches.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Elena-Alina Moaca, Claudia-Geanina Watz, Vlad Socoliuc, Roxana Racoviceanu, Cornelia Pacurariu, Robert Ianos, Simona Cinta-Pinzaru, Lucian Barbu Tudoran, Fran Nekvapil, Stela Iurciuc, Codruta Soica, Cristina-Adriana Dehelean
Summary: This study presents a method for preparing a highly stable and biocompatible magnetic colloidal suspension, which has significant effects on breast adenocarcinoma cells in hyperthermia treatment, while exhibiting minimal impact on non-tumorigenic cells. Further research is needed to explore the clinical biological potential of the synthesized magnetic colloidal suspension for magnetically triggered hyperthermia.
Article
Chemistry, Multidisciplinary
Armando Ramos-Sebastian, So-Jung Gwak, Sung Hoon Kim
Summary: Magnetic microrobots are highly promising for biomedical applications, but magnetic actuation alone is not enough. This study introduces a multimodal electromagnetic system that enables various modes of locomotion and heating control of magnetic microrobots, as well as the manipulation of magnetic nanoparticles.
Article
Chemistry, Analytical
Junjie Zhang, Xuemeng Tian, Xihui Cui, Aqun Zheng, Jianjun Li, Yanhong Bai, Yuansuo Zheng
Summary: The separation and purification of proteins is crucial for proteomics research. This study presents a facile method to synthesize magnetic nanomaterials with dendritic structure and unique electrostatic effect, enabling selective adsorption of proteins. The materials exhibit stable crystal shape, superparamagnetic properties, fast adsorption kinetics, high adsorption capacity, and reusability, showing great potential for special protein adsorption.
Article
Biochemistry & Molecular Biology
Y. Jabalera, M. Montalban-Lopez, J. J. Vinuesa-Rodriguez, G. R. Iglesias, M. Maqueda, C. Jimenez-Lopez
Summary: The study aimed to develop an innovative nanoformulation for local antibacterial therapy, delivering the drug at the target while minimizing side effects to enhance effectiveness. The nanoassembly showed strong bactericidal effects on Gram-positive bacteria, E. coli, P. aeruginosa, and K. pneumoniae, particularly when combined with magnetic hyperthermia. The results suggest that this new formulation could be a promising tool in the fight against bacteria.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Materials Science, Multidisciplinary
Musa Mutlu Can, Chasan Bairam, Seda Aksoy, Durdane Serap Kuruca, Satoru Kaneko, Zerrin Aktas, Mustafa Oral Oncul
Summary: This study investigated the relationship between the doping amount of titanium (Ti) and the magnetic heating performance of magnetite (Fe3O4). Ti-doped magnetite nanoparticles were synthesized using the sol-gel technique. SiO2 coated nanoparticles were also produced to study the effects of silica coating on the magnetic properties. The results showed that SiO2 coated (Fe-0.97,Ti-0.03)(3)O-4 nanoparticles had an increased temperature difference of up to 22°C in 10 minutes, which was similar to the uncoated Fe3O4 nanoparticles.
Article
Chemistry, Multidisciplinary
Pavel Kim, Nikita Serov, Aleksandra Falchevskaya, Ilia Shabalkin, Andrei Dmitrenko, Daniil Kladko, Vladimir Vinogradov
Summary: A machine learning-based approach has been developed to predict the efficacy of magnetic nanoparticles in biomedicine applications such as magnetic resonance imaging (MRI) and hyperthermia treatment. A database of over 980 magnetic nanoparticles was assembled and tree-based ensemble models were trained to predict specific absorption rate (SAR) for hyperthermia and r(1)/r(2) relaxivities in MRI. The models showed promising performances, with R-2 values of 0.86, 0.78, and 0.75 for SAR, r(1), and r(2) respectively.
Article
Chemistry, Physical
Lluis Lopez-Conesa, Carlos Martinez-Boubeta, David Serantes, Sonia Estrade, Francesca Peiro
Summary: The nanoscale magnetic configuration of self-assembled groups of 40 nm cubic magnetite nanoparticles was investigated using electron holography in the transmission electron microscope (TEM). The arrangement of the cubes in chains driven by the alignment of their dipoles of single nanocubes was assessed by measured in-plane magnetic induction maps, showing good agreement with theoretical calculations.
Article
Chemistry, Multidisciplinary
Xiang Yu, Tianyu Yang, Ruoshui Liu, Di'an Wu, Daming Tian, Tianshi Zhou, Haitao Yan, Shuli He, Hao Zeng
Summary: In this study, the efficiency of alternating current magnetic field and near-infrared heating is enhanced by co-doping Zn and Co in magnetite nanoparticles. Optimum magnetic anisotropy is achieved by tuning the doping concentration to maximize the loss power under each magnetic field. The specific loss power of the nanoparticles greatly exceeds previous levels, making it a promising nanoplatform for multi-modal local hyperthermia therapy.
Article
Physics, Applied
Zs Iszaly, I Gresits, I. G. Marian, Gy Thuroczy, O. Sagi, B. G. Markus, F. Simon, I Nandori
Summary: Magnetic hyperthermia is an adjuvant therapy that uses magnetic nanoparticles to transfer energy and increase the local temperature of the human body. The combination of static and alternating magnetic fields can enhance this localization effect. Research shows a significant polarization effect in superlocalization for small frequencies and large field strengths, which is important for practical applications.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2022)
Article
Gastroenterology & Hepatology
Bartlomiej Zapotoczny, Karolina Szafranska, Edyta Kus, Filip Braet, Eddie Wisse, Stefan Chlopicki, Marek Szymonski
Article
Biochemistry & Molecular Biology
Aleksandra Kopacz, Damian Kloska, Marta Targosz-Korecka, Bartlomiej Zapotoczny, Dominik Cysewski, Nicolas Personnic, Ewa Werner, Karolina Hajduk, Alicja Jozkowicz, Anna Grochot-Przeczek
Article
Chemistry, Physical
Maciej Marc, Lidia Najder-Kozdrowska, Nikos Guskos, Grzegorz Zolnierkiewicz, Ana Maria Montero, Miroslaw Roman Dudek
Article
Cell Biology
Eddie Wisse, Filip Braet, Gerald J. Shami, Bartlomiej Zapotoczny, Celien Vreuls, Pauline Verhaegh, Peter Frederik, Peters J. Peters, Steven Olde Damink, Ger Koek
Summary: Adapted fixation methods for electron microscopy were used to study liver cell fine structure in 217 biopsies over 10 years, revealing that single, huge fat droplets cause necrosis and inflammation in single parenchymal cells. These fat droplets also collect Mallory substance and give rise to sinusoidal fat emboli.
HISTOCHEMISTRY AND CELL BIOLOGY
(2022)
Article
Physics, Condensed Matter
Krzysztof K. Dudek, Maciej Marc, Wiktor Wolak, Andrzej Drzewinski, Miroslaw R. Dudek
Summary: The study analyzes the effect of magnetic dipole interactions on the heating process of single-domain magnetic nanoparticles subjected to an external radiofrequency magnetic field. The mechanical deformation of the thin film causes displacement of nanoparticles and affects their interactions, resulting in different heating powers at different stages. The theoretical model proposed in the study demonstrates that the stretchable magnetic film can sense mechanical deformation in the presence of a uniform RF magnetic field, which could be utilized in designing sensors for medical applications.
PHYSICA STATUS SOLIDI B-BASIC SOLID STATE PHYSICS
(2021)
Review
Physiology
Karolina Szafranska, Larissa D. Kruse, Christopher Florian Holte, Peter McCourt, Bartlomiej Zapotoczny
Summary: The porosity of liver sinusoidal endothelial cells (LSEC) plays a crucial role in the bidirectional passive transport of lipoproteins, drugs, and solutes between liver capillaries and parenchyma. Various factors, including aging and liver disorders, can severely reduce LSEC porosity and affect their filtration properties. Recent research suggests that certain medications may have a beneficial effect on LSEC re-fenestration in aging populations, highlighting the importance of understanding and regulating LSEC porosity for overall liver health.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Maciej Marc, Andrzej Drzewinski, Wiktor W. Wolak, Lidia Najder-Kozdrowska, Miroslaw R. Dudek
Summary: The study examined the rapid aggregation of single-domain magnetic iron oxide nanoparticles in stable aqueous colloidal suspensions under the influence of a radio-frequency (RF) magnetic field. It was found that the RF field caused localized heating, leading to the destabilization of the colloid and faster agglomeration of nanoparticles. These findings have implications for biomedical applications and wastewater treatment.
Article
Engineering, Biomedical
Magdalena Giergiel, Bartlomiej Zapotoczny, Izabela Czyzynska-Cichon, Jerzy Konior, Marek Szymonski
Summary: In this study, a method utilizing convolutional neural networks to find and characterize transmembrane porous structures in high resolution AFM images of murine liver sinusoidal endothelial cells (LSECs) was presented. Through evaluation, proposing network structure, optimizing loss functions, and rough calculation steps, the method achieved an accuracy exceeding 90%, is fast, insensitive to image contrast choices, and easily modifiable for different objects of interest, promoting neural networks as a universal tool for analyzing microscopy images.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2022)
Article
Microscopy
K. Szafranska, C. F. Holte, L. D. Kruse, H. Mao, C. I. Oie, M. Szymonski, B. Zapotoczny, P. A. G. McCourt
Summary: This study utilized three super resolution techniques to obtain images of liver sinusoidal endothelial cell fenestrations and compared three different methods of fenestration image analysis. In addition to comparing analysis methods, user bias was also studied through comparison of data obtained by different users.
Article
Biochemistry & Molecular Biology
Bartlomiej Zapotoczny, Karolina Szafranska, Malgorzata Lekka, Balpreet Singh Ahluwalia, Peter McCourt
Summary: This study demonstrates the regulation of fenestration diameter and porosity in liver sinusoidal endothelial cells through Rho-ROCK and MLCK-dependent phosphorylation of MLC. The Rho-ROCK pathway controls fenestration diameter, while inhibition of MLCK prevents the formation of new fenestrations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Andrzej Drzewinski, Maciej Marc, Wiktor W. Wolak, Miroslaw R. Dudek
Summary: Stable aqueous suspension of magnetic nanoparticles is crucial for magnetic hyperthermia and other applications. Magnetic field-induced agglomeration can deteriorate the material's magnetic properties. Proper sonication treatment can enhance stability and heating efficiency.
Article
Multidisciplinary Sciences
M. Marc, W. Wolak, A. Drzewinski
Summary: This study investigates the mechanism of ring-shaped stains formed from dried liquid colloidal droplets and demonstrates the self-assembly of magnetic nanoparticles into a multi-ring deposit structure under magnetic field control. These findings have promising implications for applications such as ink-jet printing and 2D printed electronics.
SCIENTIFIC REPORTS
(2022)
Article
Mathematics
Wiktor W. Wolak, Andrzej Drzewinski, Maciej Marc, Miroslaw R. Dudek
Summary: This article analyzes the behavior of magnetic nanoparticles in aqueous solutions and their impact on the formation of aggregates. The study is important for selecting magnetic suspensions with desired properties.
JOURNAL OF APPLIED MATHEMATICS AND COMPUTATIONAL MECHANICS
(2022)
Article
Chemistry, Multidisciplinary
Sylwia Hajdasz, Adam Kempski, Krzysztof Solak, Maciej Marc, Jacek Rusinski, Pawel Szczesniak
Summary: Superconducting fault current limiters (SFCL) using high-temperature superconducting tapes of the second generation (HTS 2G) can replace traditional devices in power systems to limit short-circuit currents. The critical current of the HTS tape determines the activation of the SFCL and should remain constant to ensure proper cooperation with power system protection devices. The article presents research results on the degradation processes of 2G HTS tapes due to prospective short-circuit currents exceeding the critical current, including the decrease in critical current value and determination of limitation values of voltage drop that do not cause accelerated degradation processes.
APPLIED SCIENCES-BASEL
(2023)
Article
Nanoscience & Nanotechnology
Karolina Szafranska, Tanja Neuman, Zbigniew Baster, Zenon Rajfur, Oskar Szelest, Christopher Holte, Agata Kubisiak, Edyta Kus, Deanna L. Wolfson, Stefan Chlopicki, Balpreet S. Ahluwalia, Malgorzata Lekka, Marek Szymonski, Peter McCourt, Bartlomiej Zapotoczny
Summary: In this study, different types of microscopy techniques were compared to analyze fenestrations in liver sinusoidal endothelial cells (LSEC). Sample dehydration was found to alter fenestration diameters, and a combination of atomic force microscopy (AFM) with conventional microscopy was proposed to observe cell dynamics and obtain chemical information more effectively.
