Article
Neurosciences
Rosa A. M. Marino, Kasey S. Girven, Antonio Figueiredo, Jovana Navarrete, Carolyn Doty, Dennis R. Sparta
Summary: Changes in brain regions involved in reward-seeking may contribute to persistent behaviors associated with alcohol-use disorder. The BNST is a critical node linked to alcohol consumption and anxiety-related disorders. Previous research suggests that the IC-vBNST projection is important in emotional and reward-seeking processes.
Article
Psychology, Multidisciplinary
Judith Andre, Momar Diouf, Margaret P. Martinetti, Olivia Ortelli, Fabien Gierski, Frederic Furst, Olivier Pierrefiche, Mickael Naassila
Summary: This study aims to identify homogeneous drinking groups and develop a new tool to assess the severity of binge drinking regardless of gender. Through clustering analysis and a partial proportional odds model, key factors of drinking and behavior were identified, and homogeneous drinking groups were created. The results show a progressive severity in the drinking pattern, and frequency of drinking behavior and drunkenness are central features of binge drinking.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jerome Jeanblanc, Pierre Sauton, Charles Houdant, Sandra Fernandez Rodriguez, Sofia Vilelas de Sousa, Virginie Jeanblanc, Sandra Bodeau, Laurence Labat, Marion Soichot, Florence Vorspan, Mickael Naassila
Summary: This study examined the effects of different forms of Baclofen on alcohol intake and dopamine release in the nucleus accumbens of male and female rats. Results showed that RS(+/-)-Baclofen reduced alcohol intake in both sexes, but more females were non-responders. R(+)-Baclofen reduced alcohol intake in both sexes, but females were less sensitive than males. S(-)-Baclofen did not have any overall effect, but increased alcohol intake in some individuals, especially females.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Psychiatry
Elizabeth A. A. Sneddon, Brianna M. M. Masters, Kiara D. D. Ream, Kaila A. A. Fennell, Jenelle N. N. DeMedio, Miranda M. M. Cash, Brynn P. P. Hollingsworth, Sai Pandrangi, Chloe M. M. Thach, Haifei Shi, Anna K. K. Radke
Summary: Research suggests that sex chromosomes play a role in regulating ethanol consumption, preference, and aversion resistance in mice, and sex chromosome complement may be an important contributor to alcohol drinking behaviors.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Neurosciences
Sonia Aroni, Rosa A. M. Marino, Kasey S. Girven, James M. Irving, Joseph F. Cheer, Dennis R. Sparta
Summary: Binge ethanol drinking is a major financial burden in the United States and leads to significant neuroplasticity changes in the brain. Corticotropin releasing factor (CRF) neurons in the central amygdala are believed to play a key role in modulating binge drinking. Research shows that these neurons exhibit diverse responses and enhanced electrical activity during binge drinking sessions.
Article
Psychology, Clinical
Maria-Teresa Cortes-Tomas, Jose-Antonio Gimenez-Costa, Patricia Motos-Selles, Maria-Dolores Sancerni-Beitia
Summary: Despite the negative consequences of alcohol use, it remains prevalent among college students, particularly among women. This study explores the variables of expectancies and motives to understand their influence on risky drinking patterns among female university students. The findings show that negative expectancies and enhancement motives play a significant role in risky drinking behavior.
INTERNATIONAL JOURNAL OF MENTAL HEALTH AND ADDICTION
(2022)
Article
Substance Abuse
Leandro Ruiz Leyva, Agustin Salguero, Miriam Beatriz Virgolini, Veronica Leonor Romero, Leonardo Marengo, Maria Carolina Fabio, Ignacio Moron, Cruz Miguel Cendan, Ricardo Marcos Pautassi
Summary: The study reveals a significant interaction between adolescent ethanol exposure and binge eating behavior in female rats, leading to increased ethanol consumption. This finding provides valuable insights into the underlying mechanisms of alcohol intake and the long-term consequences of binge drinking.
DRUG AND ALCOHOL DEPENDENCE
(2023)
Article
Family Studies
Yang Yang, Manyu Li, Hung-Chu Lin
Summary: This study found that parental psychological control and perceived social capital have different impacts on health-risk behaviors in college students of different genders, highlighting the importance of gender-specific parenting skills. Social capital can mitigate the negative effects of parental psychological control in certain cases.
JOURNAL OF CHILD AND FAMILY STUDIES
(2022)
Article
Psychiatry
Chelsea R. Kasten, Eleanor B. Holmgren, Mollie R. Lerner, Tiffany A. Wills
Summary: Adolescent alcohol use is strongly associated with the development of alcohol use disorder, particularly affecting women with affective disorders. Stress plays a significant role in relapse during abstinence. Knocking down mGlu5 receptors in the bed nucleus of the stria terminalis enhances anhedonia-like behavior, especially in females.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Manuel Herrero-Montes, Cristina Alonso-Blanco, Maria Paz-Zulueta, Amada Pellico-Lopez, Laura Ruiz-Azcona, Carmen Sarabia-Cobo, Ester Boixadera-Planas, Paula Paras-Bravo
Summary: A study conducted among nursing students in a university in northern Spain found that excessive alcohol consumption is common among university students, especially those who practice binge drinking.
Article
Neurosciences
Nathan W. Burnham, Corryn N. Chaimowitz, Cortland C. Vis, Ana Paula Segantine Dornellas, Montserrat Navarro, Todd E. Thiele
Summary: This study found that increased NE tone in a circuit from the LC to the LH can reduce binge-like ethanol consumption in mice, providing a potential novel approach for treating binge drinking before the development of dependence.
Article
Substance Abuse
Tien T. Tong, Jatin G. Vaidya, John R. Kramer, Samuel Kuperman, Douglas R. Langbehn, Daniel S. O'Leary
Summary: The study explored the longitudinal effects of standard and extreme binge drinking on resting-state functional connectivity. It was found that greater standard binge drinking was negatively associated with changes in connectivity between specific brain networks. However, no significant correlation was observed between longitudinal binge drinking and cognitive performance changes, and a predictive model could not be established using CPM.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Review
Chemistry, Medicinal
Bruno Goncalves Pinheiro, Diandra Araujo Luz, Sabrina de Carvalho Cartagenes, Luanna de Melo Pereira Fernandes, Sarah Viana Farias, Natalia Harumi Correa Kobayashi, Eneas Andrade Fontes-Junior, Samira G. Ferreira, Rodrigo A. Cunha, Rui Daniel Prediger, Cristiane do Socorro Ferraz Maia
Summary: This review comprehensively discusses the role of the adenosinergic system in emotional and cognitive disturbances induced by alcohol consumption during adolescence, and explores the potential benefits of caffeine as a non-selective antagonist of adenosine receptors.
Article
Pharmacology & Pharmacy
Pierre Sauton, Jerome Jeanblanc, Farid Benzerouk, Fabien Gierski, Mickael Naassila
Summary: Binge drinking is a predictive factor for alcohol addiction and is harmful to health. Weak decision-making capacities may contribute to vulnerability to binge drinking, leading to impaired decision-making and perpetuating binge drinking. Longitudinal preclinical studies are lacking in understanding this complex relationship.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Beatriz Rodrigues Risuenho Peinado, Walessa Alana Braganca Aragao, Cristian dos Santos Pereira, Diane Cleydes Baia da Silva, Railson de Oliveira Ferreira, Antonio Hernandes Chaves-Neto, Luanna Melo Pereira Fernandes, Rafael Rodrigues Lima
Summary: This study aims to investigate whether moderate exercise can reduce the damage generated by ethanol consumption in salivary glands and saliva. The results showed that moderate physical exercise can significantly recover antioxidant activity, reducing the damage caused by ethanol.