Article
Neurosciences
Laura Fenton, S. Duke Han, Carolyn G. DiGuiseppi, Nicole R. Fowler, Linda Hill, Rachel L. Johnson, Ryan A. Peterson, Christopher E. Knoepke, Daniel D. Matlock, Ryan Moran, Jason Karlawish, Marian E. Betz
Summary: The study found that mild cognitive impairment has a negative impact on decision-making abilities in older adults. Compared to cognitively normal older adults, those with mild cognitive impairment performed worse in various decision-making contexts.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Stefano Giuseppe Grisanti, Federico Massa, Andrea Chincarini, Stefano Pretta, Roberto Rissotto, Carlo Serrati, Fiammetta Monacelli, Gianluca Serafini, Pietro Calcagno, Andrea Brugnolo, Matteo Pardini, Flavio Nobili, Nicola Girtler
Summary: Apathy and awareness of apathy can predict the progression and timing of dementia in patients with amnesic mild cognitive impairment (aMCI).
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Haitham Salem, Robert Suchting, Mitzi M. Gonzales, Sudha Seshadri, Antonio L. Teixeira
Summary: This study aimed to detect conversion rates from mild cognitive impairment (MCI) to Alzheimer's disease (AD) and determine the effect of apathy on the progression to AD in patients with MCI. The study found that 17.3% of individuals had conversion from MCI to AD over a period of 8.21 years. Patients with apathy had a higher conversion rate and shorter time-to-conversion. Age and cognitive performance were found to moderate the relationship between apathy and time-to-conversion.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Geriatrics & Gerontology
Mu-Hsing Ho, Hui-Chen (Rita) Chang, Megan F. Liu, Hui-Wen Chien, Li-Yu Tang, Su-Yuan Chan, Su-Hui Liu, Shibu John, Victoria Traynor
Summary: This study summarized the applicability of various decision-making tools for individuals with dementia or mild cognitive impairment and their families. The review identified different types of decision-making tools and validated tools that can facilitate the decision-making process for everyday activities and medical treatment decisions.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Baichuan Li, Shuming Ji, Anjiao Peng, Na Yang, Xia Zhao, Peimin Feng, Yunwu Zhang, Lei Chen
Summary: This study aimed to develop a risk prediction model for MCI based on gastrointestinal myoelectrical activity. The model showed good prediction ability and clinical usability in predicting the risk of MCI.
Article
Medicine, General & Internal
Camilla Elefante, Giulio Emilio Brancati, Zahinoor Ismail, Sara Ricciardulli, Maria Francesca Beatino, Vittoria Lepri, Antonella Fama, Elisabetta Ferrari, Linda Giampietri, Filippo Baldacci, Roberto Ceravolo, Icro Maremmani, Lorenzo Lattanzi, Giulio Perugi
Summary: This study aimed to investigate the prevalence and differentiating features of Mild Behavioral Impairment (MBI) with respect to major neurocognitive disorders (MNDs) and primary psychiatric disorders (PPDs). The results showed that patients with MBI had higher scores of psychopathology, specifically in terms of negative symptoms, compared to patients with PPDs. Additionally, MBI patients frequently reported higher severity of apathy and motor retardation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Benjamin M. Hampstead, Anthony Y. Stringer, Alexandru D. Iordan, Robert Ploutz-Snyder, K. Sathian
Summary: Cognitive training is a potential technique for treating cognitive impairment caused by neurological injury and disease. Different training methods have different mechanisms of action and engage distinct brain regions. Mnemonic strategy training (MST) showed superior effects in the short term and increased activation and functional connectivity in multiple brain regions.
ALZHEIMERS & DEMENTIA
(2023)
Review
Behavioral Sciences
Carina Fernandes, Ines Macedo, Fernando Barbosa, Joao Marques-Teixeira
Summary: The impact of pathological aging on economic decision-making is significant, as impairments in this domain increase the vulnerability of older adults to financial abuse. Evidence suggests that both Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD) affect economic decision-making, with healthy older adults outperforming patients and MCI patients demonstrating better performance than AD patients. Financial capacity measures provide more robust findings compared to behavioral tasks, highlighting the need for further research in this area.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Geriatrics & Gerontology
Michal S. Beeri, Sue E. Leugrans, Osvaldo Delbono, David A. Bennett, Aron S. Buchman
Summary: In this study, poor muscle function, rather than reduced lean muscle mass, was found to be associated with late-life cognitive impairment, including incident Alzheimer's dementia, mild cognitive impairment, and cognitive decline. Further research is needed to identify muscle structure features that may enhance the specificity of sarcopenia in identifying older adults at risk for late-life cognitive impairment.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Editorial Material
Cell Biology
Zhuang-Yao D. Wei, Ashok K. Shetty
Summary: This article discusses a recent study that suggests using a miRNA triad, consisting of miR-181a-5p, miR-146a-5p, and miR-148a-3p, for diagnosing ACI, MCI, and AD. The study explores the impact of elevated levels of this miRNA triad on neural plasticity and cognitive function in the brain and the potential of inhibiting it to improve cognitive function in MCI and AD.
Article
Neurosciences
Marina Botello-Marabotto, M. Carmen Martinez-Bisbal, Miguel Calero, Andrea Bernardos, Ana B. Pastor, Miguel Medina, Ramon Martinez-Manez
Summary: This study employed 1H NMR spectroscopy to conduct a metabolomic study in serum samples from patients with Alzheimer's disease (AD), mild cognitive impairment (MCI), and cognitively healthy controls (HC). The aim was to search for potential metabolite biomarkers. The results highlight the potential of 1H NMR metabolomics to support the diagnosis of dementia in a less invasive way, and provide a starting point for the study of potential biomarkers to identify MCI or HC subjects at risk of developing AD in the future.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Neurosciences
Zhiyuan Yang, Xiaoning Sheng, Ruomeng Qin, Haifeng Chen, Pengfei Shao, Hengheng Xu, Weina Yao, Hui Zhao, Yun Xu, Feng Bai
Summary: Stimulating superficial brain regions associated with the hippocampus can improve memory in Alzheimer's disease patients. This study used neuro-navigated rTMS to stimulate the left angular gyrus and observed neuroplasticity of brain networks and improvement in cognitive abilities.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Psychology, Clinical
Michael H. Connors, Armando Teixeira-Pinto, David Ames, Michael Woodward, Henry Brodaty
Summary: Apathy is a common symptom in patients with mild cognitive impairment (MCI) and may indicate progression to dementia. However, there is limited research on the longitudinal trajectory of apathy in MCI patients and its clinical correlates when controlled for depression, which can mimic apathy. This study aimed to address these issues.
INTERNATIONAL PSYCHOGERIATRICS
(2023)
Article
Clinical Neurology
Allan I. Levey, Deqiang Qiu, Liping Zhao, William T. Hu, Duc M. Duong, Lenora Higginbotham, Eric B. Dammer, Nicholas T. Seyfried, Thomas S. Wingo, Chadwick M. Hales, Malu Gamez Tansey, David S. Goldstein, Anees Abrol, Vince D. Calhoun, Felicia C. Goldstein, Ihab Hajjar, Anne M. Fagan, Doug Galasko, Steven D. Edland, John Hanfelt, James J. Lah, David Weinshenker
Summary: The study demonstrated that atomoxetine, a clinically approved noradrenaline reuptake inhibitor, improved multiple Alzheimer's disease biomarkers in individuals with mild cognitive impairment. Treatment with atomoxetine significantly reduced CSF levels of Tau and pTau, normalized CSF protein biomarker panels linked to synaptic function, brain metabolism, and glial immunity, and increased brain activity and metabolism in key temporal lobe circuits.
Article
Clinical Neurology
Deepika Dinesh, Qing Shao, Madhuri Palnati, Sarah McDannold, Quanwu Zhang, Amir Abbas Tahami Monfared, Guneet K. Jasuja, Heather Davila, Weiming Xia, Lauren R. Moo, Donald R. Miller, Natalia Palacios
Summary: Based on electronic health records data, a study found that US veterans have a unique dementia risk profile that may be changing over time. From 2000 to 2019, the incidence and prevalence of Alzheimer's disease (AD) and related dementias (ADRD) decreased, while ADRD prevalence increased primarily due to an increase in dementia not otherwise specified. The prevalence and incidence of mild cognitive impairment (MCI) sharply increased, especially after 2010. The highest prevalence and incidence of AD, ADRD, and MCI were observed in the oldest veterans, female veterans, and African American and Hispanic veterans.
ALZHEIMERS & DEMENTIA
(2023)
Article
Psychiatry
Stephane Raffard, Cindy Lebrun, Yasmine Laraki, Delphine Capdevielle
Summary: The study validated a French version of the MacCAT-T in a sample of individuals with schizophrenia in France, demonstrating high inter-rater reliability and strong psychometric properties. Decision-making capacity was found to be positively associated with insight and the severity of psychotic symptoms, but not with sociodemographic variables except for education.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2021)
Article
Psychiatry
Catherine Bortolon, Delphine Capdevielle, Julien Dubreucq, Stephane Raffard
Summary: The study found that the impact of lockdown on psychotic symptoms needs further investigation, with factors such as socio-demographic variables, loneliness, cognitive bias, and anxiety playing a role in paranoia and hallucinations.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Multidisciplinary Sciences
Caroline Novara, Cindy Lebrun, Alexandra Macgregor, Bruno Vivet, Pierre Therouanne, Delphine Capdevielle, Stephane Raffard
Summary: The study investigates a counter-conditioning intervention for treating disgust-related emotional responses in individuals with high and low contamination concerns. Results show that the counter-conditioning procedure significantly reduces both expectations and conditioned disgust, with a lower reduction in individuals with high contamination concerns.
Article
Psychiatry
Delphine Capdevielle, Joanna Norton, Bruno Aouizerate, Fabrice Berna, Isabelle Chereau, Thierry D'Amato, Caroline Dubertret, Julien Dubreucq, Guillaume Fond, C. Lancon, Jasmina Mallet, David Misdrahi, Catherine Passerieux, Romain Rey, Franck Schurhoff, Mathieu Urbach, Pierre-Michel Llorca, Stephane Raffard
Summary: This study aimed to compare the performance of three different instruments measuring clinical and cognitive dimensions of insight. The findings showed improvements in clinical insight but decreases in cognitive insight. There was moderate agreement between cognitive and clinical insight, yet considerable variability was found for similar insight dimensions measured by different instruments.
PSYCHIATRY RESEARCH
(2021)
Article
Psychiatry
Catherine Bortolon, Martin J. Dorahy, Rachel Brand, Clement Donde, Sophie Slovak, Stephane Raffard
Summary: The study found that simulated neutral and negative voices can trigger higher levels of shame and other negative emotions, compared to ambient sound. Participants in the simulated voice conditions also exhibited higher levels of maladaptive coping strategies and negative beliefs about voices.
COGNITIVE NEUROPSYCHIATRY
(2022)
Article
Psychiatry
Amandine Decombe, Lionel Brunel, Vincent Murday, Francois Osiurak, Delphine Capdevielle, Stephane Raffard
Summary: Studies have shown that schizophrenia patients, like nonclinical participants, tend to overestimate the benefits and underestimate the effort required when mentally simulating a task involving the use of tools. However, there was no association found between movement durations and psychotic symptoms. This opens up new perspectives on the issue of effort in schizophrenia.
Article
Psychiatry
A. Schandrin, M. -c. Picot, G. Marin, M. Andre, J. Gardes, A. Leger, B. O'Donoghue, S. Raffard, M. Abbar, D. Capdevielle
Summary: This clinical trial aimed to assess the effect of video self-confrontation on insight in patients with psychosis. The results showed that video self-confrontation did not change levels of insight, but it may have a therapeutic impact on self-care and adherence to treatment. Further research is needed on this innovative therapeutic tool.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Clinical Neurology
Stephane Raffard, Sophie Bayard, Margot Eisenblaetter, Philippe Tattard, Jerome Attal, Yasmine Laraki, Delphine Capdevielle
Summary: Recent evidence suggests that people with schizophrenia are at high risk for severe COVID-19 and impaired decision-making capacities could negatively affect their uptake of COVID-19 vaccination. A study found that 56.3% of outpatients with schizophrenia had diminished capacity to consent to COVID-19 vaccination, which was associated with lower vaccination rates, poorer cognition, and higher levels of psychotic symptoms. It is urgent to develop interventions for enhancing informed consent for vaccination within this population.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Article
Psychiatry
Stephane Raffard, Joanna Norton, Martial Van der Linden, Christophe Lancon, Michel Benoit, Delphine Capdevielle
Summary: The aim of this study was to validate the self-report BIRT Motivation Questionnaire (BMQ-S) in schizophrenia, examine its agreement with the informant-report version, and assess its ability to predict real-world outcomes. The findings indicate that the BMQ-S has satisfactory psychometric properties and that self-evaluation of avolition should be considered in the overall prediction of real-world functioning in schizophrenia.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychiatry
Yasmine Laraki, Cindy Lebrun, Marine Merenciano, Margot Eisenblaetter, Jerome Attal, Alexandra Macgregor, Amandine Decombe, Delphine Capdevielle, Stephane Raffard
Summary: The aim of this study was to translate and validate a French version of the Clinical Assessment Interview for Negative Symptoms (CAINS) in French patients diagnosed with schizophrenia or schizoaffective disorder. The results showed that the French CAINS has robust psychometric properties and is a valid tool for evaluating negative symptoms in French-speaking individuals diagnosed with schizophrenia.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Behavioral Sciences
Juliette Lozano-Goupil, Stephane Raffard, Delphine Capdevielle, Emilie Aigoin, Ludovic Marin
Summary: The study found that individuals with schizophrenia showed preserved spontaneous gesture-speech synchrony but impaired intentional finger tapping-speech synchrony. In a sensorimotor synchronization task, the schizophrenia group displayed greater asynchronies between finger tapping and syllable uttering, as well as lower stability of coordination patterns.
Article
Immunology
Stephane Raffard, Sophie Bayard, Margot Eisenblaetter, Jerome Attal, Christelle Andrieu, Isabelle Chereau, Guillaume Fond, Sylvain Leignier, Jasmina Mallet, Philippe Tattard, Mathieu Urbach, David Misdrahi, Yasmine Laraki, Delphine Capdevielle
Summary: Schizophrenia patients have lower COVID-19 vaccination rates despite similar general attitudes and higher willingness to be vaccinated. Negative attitudes towards vaccines in patients are associated with higher levels of psychotic symptoms and paranoid ideation. Disparities in vaccination rates among schizophrenia patients seem to be related to structural barriers rather than attitudinal.
Article
Immunology
Margot Eisenblaetter, Clarisse Madiouni, Yasmine Laraki, Delphine Capdevielle, Stephane Raffard
Summary: Vaccination has been proven beneficial to global health. However, there is a rise in anti-vaccination attitudes and vaccine refusal in France. The study translated and adapted the Vaccination Attitudes Examination scale into French and tested its psychometric properties. The French version of the scale showed good validity, reliability, and differentiated vaccinees from non-vaccinee respondents, providing insight into vaccine hesitancy factors in France.
Review
Psychiatry
Stephane Raffard, Clarisse Madouini, Yasmine Laraki, Margot Eisenblaetter, Guillaume Broc, Delphine Capdevielle, Sophie Bayard
Summary: This study aimed to validate a brief version of the revised Green et al., Paranoid Thoughts Scale (R-GPTS) in individuals diagnosed with schizophrenia. The brief 8-item version of the R-GPTS (GPTS-8) demonstrated good psychometric properties, including a two-factor structure, internal consistency, and convergent/divergent validities. The GPTS-8 also showed clinical validity by distinguishing patients with schizophrenia from non-clinical controls.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychology, Clinical
Catherine Bortolon, Stephane Raffard
Summary: In a nonclinical sample, rumination was found to maintain grandiose ideas and positive affect, while distraction reduced grandiose ideas levels. The study suggests that interventions targeting rumination might be useful in treating grandiose delusions in clinical samples.
JOURNAL OF BEHAVIOR THERAPY AND EXPERIMENTAL PSYCHIATRY
(2021)
