Article
Clinical Neurology
Marco Pisa, Tommaso Croese, Gloria Dalla Costa, Simone Guerrieri, Su-Chun Huang, Annamaria Finardi, Lorena Fabbella, Francesca Sangalli, Bruno Colombo, Lucia Moiola, Vittorio Martinelli, Giancarlo Comi, Roberto Furlan, Letizia Leocani
Summary: Optical coherence tomography (OCT) is increasingly important in evaluating patients with multiple sclerosis, showing neuro-retinal changes indicative of inflammatory and disease burden. Subclinical optic nerve involvement and thinning of ganglion cell layer in eyes without acute optic neuritis are associated with greater disease burden, reflecting early disease phases.
Article
Biochemistry & Molecular Biology
Milagros Hidalgo de la Cruz, Paola Valsasina, Sarlota Mesaros, Alessandro Meani, Jovana Ivanovic, Vanja Martinovic, Jelena Drulovic, Massimo Filippi, Maria A. Rocca
Summary: In the study, it was found that abnormalities in sub-regional thalamic resting state functional connectivity in clinically isolated syndrome patients were associated with clinical disability and evolved over time. Some patients experienced multiple clinical relapses, but the median EDSS score remained stable.
MOLECULAR PSYCHIATRY
(2021)
Review
Clinical Neurology
Massimiliano Calabrese, Damiano Marastoni, Francesco Crescenzo, Antonio Scalfari
Summary: This review discusses the challenges in diagnosing patients with the first demyelinating attack or RIS, focusing on the updated diagnostic criteria, considering neuroinflammatory conditions in the differential diagnosis, and identifying factors that predict MS development. Accurate interpretation of demyelinating attacks, MRI results, and the importance of cerebrospinal fluid examination are emphasized for an early and precise MS diagnosis to start timely disease-modifying therapy and improve long-term outcomes.
CURRENT OPINION IN NEUROLOGY
(2021)
Article
Clinical Neurology
Michelle H. Chen, Nancy D. Chiaravalloti, John DeLuca
Summary: Cognitive impairment is a common and disabling symptom in multiple sclerosis, with limited evidence supporting the efficacy of disease-modifying therapies in treating cognitive dysfunction. Cognitive rehabilitation in MS has shown promise in the past decade, with both restorative and compensatory programs proving efficacious. Clinicians should consider this low-cost, low-risk, yet effective treatment approach for their patients.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Tehila Eilam-Stock, Pamela Best, Kathleen Sherman, Michael T. Shaw, Joseph Ventura, Lauren B. Krupp, Leigh E. Charvet
Summary: The study utilized the Cognitive Assessment Interview (CAI) to assess individuals with MS, finding that processing speed, working memory, and learning and memory problems were most commonly reported. CAI ratings showed moderate correlation with self-report measures, but only mild correlation with objective neuropsychological measures specific to executive functions.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Renata Silva, Pedro Coelho, Mafalda Seabra, Ines Laranjinha, Daniela Vieira, Octavia Costa, Jennifer Jesus, Ana Claudia Fonseca, Sonia Costa, Ines Ferreira, Joao Lemos, Claudia Sousa, Jose Vale, Maria Jose Sa, Luis Ruano
Summary: This study aimed to evaluate the relationship between retinal atrophy and cognitive performance in early multiple sclerosis (MS) patients. The results showed that cognitive impairment was frequent in early MS, but not associated with retinal atrophy.
NEUROLOGICAL SCIENCES
(2022)
Article
Neurosciences
Martin Sjogard, Vincent Wens, Jeroen Van Schependom, Lars Costers, Marie D'hooghe, Miguel D'haeseleer, Mark Woolrich, Serge Goldman, Guy Nagels, Xavier De Tiege
Summary: This study found that multiple sclerosis has a significant impact on resting-state functional brain connectivity and is related to disability, disease duration, and specific cognitive functioning changes. Healthy subjects and patients showed significant differences in cognitive fatigue and verbal fluency scores, with distinct correlation patterns between rsFC and these cognitive functions.
HUMAN BRAIN MAPPING
(2021)
Article
Clinical Neurology
Damiano Mistri, Nicolo Tedone, Diana Biondi, Carmen Vizzino, Elisabetta Pagani, Maria A. Rocca, Massimo Filippi
Summary: This study identified five cognitive phenotypes with varying degrees of impairment in multiple sclerosis (MS) patients and described their characteristics. The findings suggest potential variations in the neural substrates of dysfunction throughout disease stages in MS.
JOURNAL OF NEUROLOGY
(2023)
Article
Medicine, General & Internal
Jiri Motyl, Lucie Friedova, Manuela Vaneckova, Jan Krasensky, Balazs Lorincz, Jana Blahova Dusankova, Michaela Andelova, Tom A. Fuchs, Eva Kubala Havrdova, Ralph H. B. Benedict, Dana Horakova, Tomas Uher
Summary: Only a small proportion of MS patients experience isolated cognitive decline (ICD) over short-term follow-up. Patients with severe MS are more prone to cognitive decline, but those with normal cognitive performance and mild MS may benefit the most from early detection of cognitive decline.
Article
Clinical Neurology
Foraysa Talaat, Sahar Abdelatty, Christine Ragaie, Ahmed Dahshan
Summary: This study aimed to measure the level of CHI3L1 in the CSF of patients with multiple sclerosis (MS) and correlate it with disability measures for its potential role as a biomarker for disease progression. The results showed that patients with MS had higher levels of CHI3L1 in their CSF compared to controls, and patients with progressive forms of MS had higher levels than those with relapsing forms. There were positive correlations between disease duration, number of attacks, EDSS score, and CSF level of CHI3L1. A cut-off value of 154 ng/mL was found between RRMS and PMS patients.
NEUROLOGICAL SCIENCES
(2023)
Review
Clinical Neurology
Elizabeth S. Gromisch, Zaenab Dhari
Summary: Multiple sclerosis (MS) is a debilitating disease that primarily affects the central nervous system and is commonly seen in early to middle adulthood, but can also impact children and older adults. Cognitive impairment may become more significant as the disease progresses, with signs possibly appearing early on. Early MS presents a variety of cognitive impairment types and prevalence rates, with numerous clinical factors potentially associated with cognitive involvement.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Immunology
Klaus Berek, Gabriel Bsteh, Michael Auer, Franziska Di Pauli, Anne Zinganell, Thomas Berger, Florian Deisenhammer, Harald Hegen
Summary: The study found that the CSF parameters in MS patients varied across disease courses, with less frequent blood-CSF-barrier dysfunction and intrathecal IgA/IgM synthesis when the novel RL were applied.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Maria-Eleftheria Evangelopoulos, Georgios Koutsis, Fotini Boufidou, Manolis Markianos
Summary: Cholesterol levels may be associated with disease characteristics in multiple sclerosis, particularly with demyelination and immune response. This study found lower levels of plasma and cerebrospinal fluid cholesterol in patients with multiple sclerosis. Patients with positive oligoclonal bands had even lower cerebrospinal fluid cholesterol levels, which may be related to disease progression and enhanced humoral immune response.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Clinical Neurology
Alessandro Dinoto, Sara Baldini, Maria Elisa Morelli, Fulvio Pasquin, Alessio Bratina, Antonio Bosco, Arianna Sartori, Paolo Manganotti
Summary: Fatigue in multiple sclerosis patients is closely related to autonomic nervous system symptoms, with orthostatic intolerance potentially playing a predominant role, while cognitive impairment seems to be unrelated to autonomic nervous system symptoms.
NEUROLOGICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Siddhesh P. Thakur, Matthew K. Schindler, Michel Bilello, Spyridon Bakas
Summary: This article introduces a computational approach that utilizes computer-aided detection (CAD) software to play a vital role in the diagnosis and treatment monitoring of Multiple Sclerosis (MS). The software can accurately detect disease activity and determine the necessity for injecting Gadolinium Based Contract Agents (GBCAs), providing reproducible and accurate clinical assessments, reducing adverse effects, and decreasing healthcare costs.
FRONTIERS IN MEDICINE
(2022)
Article
Clinical Neurology
Cavit Boz, Murat Terzi, Bilge Ozer, Recai Turkoglu, Rana Karabudak, Husnu Efendi, Aysun Soysal, Serhan Sevim, Ayse Altintas, Asli Kurne, Aylin Akcali, Gulsen Akman, Nur Yuceyar, Belgin Petek Balci, Ozgul Ekmekci, Serap Zengin Karahan, Meltem Demirkiran, Burcu Altunrende, Omer Faruk Turan, Gokcen GozubatikCelik, Nilufer Kale, Mesrure Koseoglu, Serkan Ozakbas
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2019)
Article
Endocrinology & Metabolism
Erhan Canbay, Melisa Vural, Sema Kalkan Ucar, Ebru Demirel Sezer, Hatice Karasoy, Ayse Nur Yuceyar, Mahmut Coker, Eser Yildirim Sozmen
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2020)
Article
Clinical Neurology
Onur Akan, Leyla Baysal-Kirac
Summary: This study found that 11.6% of ALS patients were associated with cancer. ALS patients with cancer have lower survival rates, and in most cases, cancer is diagnosed before ALS.
ACTA NEUROLOGICA BELGICA
(2021)
Article
Clinical Neurology
Oznur Erbay, Oznur Usta Yesilbalkan, Nur Yuceyar, Meltem Baklan, Ayfer Karadakovan, Mustafa Agah Tekindal
JOURNAL OF NEUROSCIENCE NURSING
(2020)
Article
Medicine, General & Internal
Stephen L. Hauser, Amit Bar-Or, Jeffrey A. Cohen, Giancarlo Comi, Jorge Correale, Patricia K. Coyle, Anne H. Cross, Jerome de Seze, David Leppert, Xavier Montalban, Krzysztof Selmaj, Heinz Wiendl, Cecile Kerloeguen, Roman Willi, Bingbing Li, Algirdas Kakarieka, Davorka Tomic, Alexandra Goodyear, Ratnakar Pingili, Dieter A. Haring, Krishnan Ramanathan, Martin Merschhemke, Ludwig Kappos
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Article
Clinical Neurology
Serhan Sevim, Meltem Demirkiran, Murat Terzi, Nur Yuceyar, Bahar Tasdelen, Egemen Idiman, Murat Kurtuncu, Cavit Boz, Deniz Tuncel, Rana Karabudak, Aksel Siva, Abdulcemal Ozcan, Munife Neyal, Basak Karakurum Goksel, Mehmet Balal, Sedat Sen, Ozgul Ekmekci, Nevra Oksuz, Derya Kaya
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2020)
Article
Clinical Neurology
Gulden Akdal, Koray Kocoglu, Tural Tanriverdizade, Elcin Bora, Fikret Bademkiran, Ayse Nur Yuceyar, Ozgul Ekmekci, Ihsan Sukru Sengun, Hatice Karasoy
Summary: The study aimed to investigate the postural balance of CMT patients with both vestibular and somatosensory impairments compared to those with only one type of impairment. Results showed that half of the patients had some degree of vestibular impairment, which correlated with their mCTSIB scores and vertical VOR gain.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Onur Akan, Leyla Baysal-Kirac
Summary: The study investigated ophthalmologic manifestations in patients with myasthenia gravis, finding a high prevalence of ocular onset MG. Some patients with extraocular muscle weakness responded partially to immunosuppressive treatments. Patients with ocular onset MG were more likely to develop secondary GMG if younger at disease onset, and the presence of thymoma was associated with a poor outcome.
ACTA NEUROLOGICA BELGICA
(2021)
Article
Behavioral Sciences
Leyla Baysal-Kirac, Merve Melodi Cakar, Gunes Altiokka-Uzun, Zuhal Guncan, Baburhan Guldiken
Summary: This study retrospectively reviewed clinical and EEG data of 45 NCSE patients, indicating that potentially fatal etiology, multiple status patterns on EEG, and non-reactive EEG may carry greater risk for short-term mortality.
EPILEPSY & BEHAVIOR
(2021)
Letter
Cardiac & Cardiovascular Systems
Caglar Kaya, Hulya Ozkan, Mustafa Yilmaztepe, Yuksel Aksoy, Leyla Baysal-Kirac, Candan Gurses
ACTA CARDIOLOGICA SINICA
(2022)
Letter
Clinical Neurology
Leyla Baysal-Kirac, Ibrahim Aydogdu
EPILEPSY & BEHAVIOR REPORTS
(2020)
Article
Clinical Neurology
Oznur Usta Yesilbalkan, Oznur Erbay, Ayse Nur Yuceyar
NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
(2019)
Article
Clinical Neurology
Leyla Baysal-Kirac, Elisabeth Hartl, Christian Vollmar, Katharina Ernst, Hannah Lohr, Soheyl Noachtar
EPILEPTIC DISORDERS
(2018)
Article
Clinical Neurology
Elif Kocasoy Orhan, Leyla Baysal Kirac, Pinar Yalinay Dikmen, Zeliha Matur, Mustafa Ertas, A. Emre Oge, Feza Deymeer, Jale Yazici, M. Baris Baslo
NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
(2018)
Review
Neurosciences
Leyla Baysal-Kirac, Hilmi Uysal
NEUROLOGICAL SCIENCES AND NEUROPHYSIOLOGY
(2020)