Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 243, Issue -, Pages 171-175Publisher
ELSEVIER
DOI: 10.1016/j.bbr.2013.01.004
Keywords
Orbitofrontal; Fasudil; Learning; ROCK; Dependence; Sensitization
Categories
Funding
- Children's Healthcare of Atlanta
- Emory Egleston Children's Research Center
- National Center for Research Resources [P51RR165]
- Office of Research Infrastructure Programs/OD [P510D11132]
- NINDS [P30NS055077]
Ask authors/readers for more resources
Prefrontal cortical dendritic spine remodeling during adolescence may open a window of vulnerability to pathological stimuli that impact long-term behavioral outcomes, but causal mechanisms remain unclear. We administered the Rho-kinase inhibitor HA-1077 during three adolescent periods in mice to destabilize dendritic spines. In adulthood, cocaine-induced locomotor activity was exaggerated. By contrast, when administered in adulthood, HA-1077 had no psychomotor consequences and normalized food-reinforced instrumental responding after orbitofrontal-selective knockdown of Brain-derived neurotrophic factor, a potential factor in addiction. Thus, early-life Rho-kinase inhibition confers cocaine vulnerability, but may actually protect against pathological reward-seeking - particularly in cases of diminished neurotrophic support - in adulthood. (C) 2013 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available