Article
Psychology, Biological
Sabrina Sghirripa, Lynton Graetz, Ashley Merkin, Nigel C. Rogasch, John G. Semmler, Mitchell R. Goldsworthy
Summary: The study demonstrates that when verbal working memory performance is matched across age groups, alpha power and frequency are modulated in a similar task- and load-dependent manner in both young and older adults.
Article
Neurosciences
Barour H. Joensen, Daniel Bush, Umesh Vivekananda, Aidan J. Horner, James A. Bisby, Beate Diehl, Anna Miserocchi, Andrew W. McEvoy, Matthew C. Walker, Neil Burgess
Summary: In this study, the researchers investigated the predictive role of hippocampal theta activity during encoding on subsequent associative memory performance. They found that theta power in the hippocampus increased during encoding and that this increase was related to successful retrieval of pairs in the memory task. These findings help to clarify the role of theta oscillations in associative memory formation and suggest that results from epilepsy patients undergoing intracranial electroencephalography recordings can be extended to healthy participants undergoing magnetoencephalography recordings.
Article
Multidisciplinary Sciences
Elena Plog, Martin I. I. Antov, Philipp Bierwirth, Ursula Stockhorst
Summary: Oscillatory synchronization in the theta-frequency band was found to play a causal role in binding information of different modalities in declarative memory. The study also provided evidence that theta-synchronized multimodal input resulted in better discrimination of threat-associated stimuli compared to similar stimuli not associated with aversive unconditioned stimulus. The study found that phase synchronization enhanced CS-US contingency knowledge regardless of frequency.
Article
Neurosciences
Rose Nasrawi, Sage E. P. Boettcher, Freek van Ede
Summary: In order for visual working memory to serve future behavior, it is important to prepare for the potential use of working memory contents ahead of time. Recent studies show that the planning for upcoming manual actions starts early after visual encoding and occurs alongside visual retention. This study explores whether such output planning in visual working memory can flexibly adapt to different visual-motor mappings, and if it occurs even for actions that may only potentially become relevant for behavior.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Psychology, Multidisciplinary
Siyuan Huang, David R. White, Ksenija Marinkovic
Summary: This study found that binge drinkers showed lower event-related theta power during successful memory encoding compared to light drinkers, and theta synchronous activity between frontal and left posterior regions successfully predicted memory recognition in light drinkers, which was negatively correlated with high-intensity drinking in the previous year. No gender differences were observed in any analysis.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Neurosciences
Syanah C. Wynn, Erika Nyhus, Ole Jensen
Summary: This study found that both older and younger adults were able to encode targets paired with distractors, and the level of alpha power modulation during encoding predicted recognition success. Older adults showed signs of higher distractibility, but this did not harm their episodic memory for target information. The research also demonstrated that older adults only modulated alpha power during high distraction, indicating that both age groups can successfully employ inhibitory control mechanisms but older adults fail to do so when distraction is minimal.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Jimin Park, Sangjun Lee, Seonghun Park, Chany Lee, Sungshin Kim, Chang-Hwan Im
Summary: Recent research has shown that systematic phase delays between cortical regions reflect the direction of communications between them. This study proposed a new noninvasive brain stimulation method called msmp-tACS to modulate the direction of communication between distant brain areas. The results suggest that msmp-tACS is a promising method to effectively modulate cortical networks that cannot be readily modulated with conventional multi-site stimulation methods.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Yi-Fang Hsu, Jarmo A. Hamalainen
Summary: This study investigates the relationship between alpha suppression and working memory performance, and finds that alpha suppression increases with higher working memory load and is more prominent in individuals with poor working memory capacity.
Article
Multidisciplinary Sciences
Anais Llorens, Ludovic Bellier, Alejandro O. Blenkmann, Jugoslav Ivanovic, Pal G. Larsson, Jack J. Lin, Tor Endestad, Anne-Kristin Solbakk, Robert T. Knight
Summary: This study investigates the spatiotemporal dynamics in the insula during a verbal working memory task using intracranial EEG. The results show robust effects for theta, beta, and high frequency activity during probe presentation requiring a decision. The study also reveals differential involvement of different insula subregions in decision-making and response monitoring.
Article
Neurosciences
Yuanjun Xie, Yanyan Li, Haidan Duan, Xiliang Xu, Wenmo Zhang, Peng Fang
Summary: Working memory is a memory system that involves the short-term storage and processing of information. Research has shown that theta oscillations are prominent and widely distributed across multiple cortical regions during multisensory encoding, indicating significant neural connectivity in these areas.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Psychiatry
Molly A. Erickson, Britta Hahn, John E. Kiat, Luz Maria Alliende, Steven J. Luck, James M. Gold
Summary: Research has found that individuals with schizophrenia exhibit shallow modulation patterns in working memory tasks, with both alpha suppression and posterior parietal BOLD activity increasing as the number of items stored in working memory increases. In individuals with schizophrenia, the magnitude of alpha suppression modulation is correlated with the magnitude of BOLD signal modulation.
SCHIZOPHRENIA RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Andrew Yang, Gulce N. Dikecligil, Heidi Jiang, Sandhitsu R. Das, Joel M. Stein, Stephan U. Schuele, Joshua M. Rosenow, Kathryn A. Davis, Timothy H. Lucas, Jay A. Gottfried
Summary: This study reveals a novel link between endogenous replay orchestrated by the theta rhythm and short-term retention of sequential memories in the human brain. During encoding, odors time-stamped their positions in the sequence by eliciting greater gamma at distinct theta phases in both regions, while during maintenance, stimulus-driven patterns of theta-coupled gamma were spontaneously reinstated in the piriform cortex, recapitulating the order of the initial sequence.
Article
Biochemistry & Molecular Biology
Oliver Ratcliffe, Kimron Shapiro, Bernhard P. Staresina
Summary: This study reports on the role of frontal-midline theta oscillations (FMT) in working memory (WM) content. The findings suggest that FMT plays a crucial role in coordinating the maintenance of memory content in posterior regions and that the observed frequency slowing supports phase coding in WM.
Article
Neurosciences
Rong Yao, Jiayue Xue, Pengfei Yang, Qianshan Wang, Peng Gao, Xiaofeng Yang, Hongxia Deng, Shuping Tan, Haifang Li
Summary: This research aims to distinguish brain functional networks of schizophrenia patients from healthy participants during working memory tasks using a method involving microstates. Results show decreased neuronal activity in certain brain regions of schizophrenia patients. The use of microstates significantly reduces the time needed to construct brain functional networks.
Article
Neurosciences
Gaia Bonassi, Marianna Semprini, Paola Mandich, Lucia Trevisan, Roberta Marchese, Giovanna Lagravinese, Federico Barban, Elisa Pelosin, Michela Chiappalone, Dante Mantini, Laura Avanzino
Summary: Using high-density electroencephalography, we found decreased modulation of neural oscillations in early symptomatic HD and pre-HD, even though the dynamics of modulation were preserved.
Article
Psychology, Clinical
Hannah J. Jones, Gemma Hammerton, Tayla McCloud, Lindsey A. Hines, Caroline Wright, Suzanne H. Gage, Peter Holmans, Peter B. Jones, George Davey Smith, David E. J. Linden, Michael C. O'Donovan, Michael J. Owen, James T. Walters, Marcus R. Munafo, Jon Heron, Stanley Zammit
Summary: This study found that genetic risk for schizophrenia is associated with patterns of cannabis use during adolescence, but not mediated through cognitive, emotional, and behavioral phenotypes during childhood. Further investigation of pathways other than those examined in this study is needed to identify modifiable targets for reducing the public health burden of cannabis use.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychology, Clinical
Rachael L. Adams, Alister Baird, Jacqueline Smith, Nigel Williams, Marianne B. M. van den Bree, David E. J. Linden, Michael J. Owen, Jeremy Hall, Stefanie C. Linden
Summary: Adult CNV carriers have a significantly increased rate of anxiety and personality disorders. In addition, they have a high rate of psychiatric multimorbidity. These findings support comprehensive psychiatric and medical assessments for CNV carriers and the establishment of multidisciplinary clinical services.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Clara A. Moreau, Annabelle Harvey, Kuldeep Kumar, Guillaume Huguet, Sebastian G. W. Urchs, Elise A. Douard, Laura M. Schultz, Hanad Sharmarke, Khadije Jizi, Charles-Olivier Martin, Nadine Younis, Petra Tamer, Thomas Rolland, Jean-Louis Martineau, Pierre Orban, Ana Isabel Silva, Jeremy Hall, Marianne B. M. van den Bree, Michael J. Owen, David E. J. Linden, Aurelie Labbe, Sarah Lippe, Carrie E. Bearden, Laura Almasy, David C. Glahn, Paul M. Thompson, Thomas Bourgeron, Pierre Bellec, Sebastien Jacquemont
Summary: Polygenicity and genetic heterogeneity pose challenges in studying psychiatric disorders. This study estimated and compared the effect sizes on brain connectivity of different genetic risk factors and found that psychiatric CNVs had the largest effect sizes, followed by psychiatric conditions, neuroticism and fluid intelligence, and PRSs. The effect sizes of CNVs on connectivity were correlated with their effects on cognition and disease risk.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Clinical Neurology
Clara A. Moreau, Kuldeep Kumar, Annabelle Harvey, Guillaume Huguet, Sebastian G. W. Urchs, Laura M. Schultz, Hanad Sharmarke, Khadije Jizi, Charles-Olivier Martin, Nadine Younis, Petra Tamer, Jean-Louis Martineau, Pierre Orban, Ana Isabel Silva, Jeremy Hall, Marianne B. M. van den Bree, Michael J. Owen, David E. J. Linden, Sarah Lippe, Carrie E. Bearden, Laura Almasy, David C. Glahn, Paul M. Thompson, Thomas Bourgeron, Pierre Bellec, Sebastien Jacquemont
Summary: This study uses large-scale resting-state functional MRI data to investigate the influence of genetic variants on large-scale brain networks and their correlations with psychiatric disorders and cognitive traits. The findings suggest a substantial genetic component for shared connectivity profiles across conditions and traits, providing new avenues for understanding and treating psychiatric disorders.
Article
Neurosciences
Chaira Serrarens, Sriranga Kashyap, Laura Riveiro-Lago, Maarten Otter, Bea C. M. Campforts, Constance T. R. M. Stumpel, Henk Jansma, David E. J. Linden, Therese A. M. J. van Amelsvoort, Claudia Vingerhoets
Summary: This study investigated the effects of triple X syndrome (47,XXX) on functional connectivity in the brain. The results showed abnormal increase in resting-state functional connectivity in patients. However, these changes were not associated with intelligence quotient (IQ) or social cognition function.
Article
Psychiatry
Mouhamed Alsaqati, Brittany A. Davis, Jamie Wood, Megan M. Jones, Lora Jones, Aishah Westwood, Olena Petter, Anthony R. Isles, David Linden, Marianne Van den Bree, Michael Owen, Jeremy Hall, Adrian J. Harwood
Summary: Genetic evidence suggests that disrupted epigenetic regulation is a major risk factor for psychiatric disorders. This study reveals that EHMT1, an epigenetic repressor, indirectly regulates NRSF/REST through repression of miRNA, leading to abnormal neuronal gene expression and neurodevelopment timing. The findings highlight the broad molecular interaction between H3K9 demethylation, NSRF/REST regulation, and the risk for intellectual disability and schizophrenia.
TRANSLATIONAL PSYCHIATRY
(2022)
Review
Genetics & Heredity
Yelyzaveta Snihirova, David E. J. Linden, Therese van Amelsvoort, Dennis van der Meer
Summary: 22q11.2 deletion syndrome (22q11DS) is associated with a wide range of neuropsychiatric symptoms, and the clinical presentation is likely influenced by environmental factors. This review explores the role of the environment in 22q11DS and finds that parental factors, stress, and substance use have significant effects on the clinical profile. However, case-control studies have not found significant moderating effects of the environment. The study suggests specific environmental measures that may interact with the 22q11 deletion based on genes and molecular pathways.
Article
Neurosciences
Xi Yang, Xinqi Zhou, Fei Xin, Benjamin Becker, David Linden, Dennis Hernaus
Summary: Age-related changes in brain function have an important role in neurodegenerative diseases. Previous studies have mainly focused on static functional connectivity, but emerging evidence suggests that aging is associated with dynamic changes in brain interactions and transitions. This study replicates the finding of age-associated changes in dynamic functional connectivity using fMRI data from two cultures (Western European and Chinese). Older participants consistently exhibit a lower occurrence and duration of a specific connectivity state (state I) compared to younger participants, as well as more transitions between networks and greater variance in global efficiency.
Article
Psychiatry
Corinna Haenschel, Dino Krupic, Antonia Hoff, Philip J. Corr, Sebastian Gaigg, Anne-Kathrin Fett
Summary: This study investigated the association between two different measures of schizotypy and symptoms of depression and anxiety in a sample of university students. The results indicated that persecutory ideation was a strong predictor of anxiety, depression, and stress sensitivity, while the dimensions of no close friends and social anxiety predicted psychological distress and stress.
EARLY INTERVENTION IN PSYCHIATRY
(2023)
Article
Clinical Neurology
Ruben L. Andriessen, Mayke Oosterloo, Angelique Hollands, David E. J. Linden, Bianca T. A. de Greef, Albert F. G. Leentjens
Summary: The study found that psychotropic medication is widely prescribed in HD patients, with antidepressant use decreasing proportionally and antipsychotic use increasing with advancing disease stages. This suggests a relative decrease in prevalence of anxiety and depression, and a relative increase in irritability and delusions over disease stages.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Neurosciences
Duncan James McLauchlan, David E. J. Linden, Anne E. Rosser
Summary: In Huntington's disease, irritability is mainly mediated by excessive response to provocation rather than a failure of motor inhibition, while impulsive behavior is associated with irritability.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Joanne L. Doherty, Adam C. Cunningham, Samuel J. R. A. Chawner, Hayley M. Moss, Diana C. Dima, David E. J. Linden, Michael J. Owen, Marianne B. M. van den Bree, Krish D. Singh
Summary: The study utilized magnetoencephalography to investigate the electrophysiological markers of brain activity in individuals with 22q11.2 deletion syndrome. The findings revealed alterations in local and global network function, which may contribute to the increased vulnerability to neurodevelopmental and psychiatric disorders in this population.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Vasileios Ioakeimidis, Laura Lennuyeux-Comnene, Nareg Khachatoorian, Sebastian B. Gaigg, Corinna Haenschel, Marinos Kyriakopoulos, Danai Dima
Summary: This study used the auditory roving oddball paradigm to investigate the impact of self-reported anxiety on event-related potential (ERP) activity related to sensory gating and mismatch negativity (MMN). The findings suggest that individuals with high trait anxiety demonstrate increased vigilance towards deviant tones, while increased state anxiety is associated with a reduced ability to filter out irrelevant stimuli.
Meeting Abstract
Biochemistry & Molecular Biology
Yanq Xiao, Tijs Louwies, Kristen Smith-Edwards, Arthur Beyder, David Linden, Gianrico Farrugia, Purna Kashyap
Article
Clinical Neurology
Duncan James McLauchlan, Thomas Lancaster, David Craufurd, David E. J. Linden, Anne E. Rosser
Summary: Depression is more common in neurodegenerative diseases like Huntington's disease, and the choice of antidepressant treatment for Huntington's disease lacks sufficient evidence. This study used propensity score analyses and cognitive battery assessments to determine the best treatment choices for depression in Huntington's disease and identified the main mechanisms underlying depression.
BRAIN COMMUNICATIONS
(2022)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)
