Article
Chemistry, Physical
Khalil Chennit, Yannick Coffinier, Shuo Li, Nicolas Clement, Agnes Anne, Arnaud Chovin, Christophe Demaille
Summary: This paper reports the fabrication and electrochemical interrogation of very high density single-antibody nanoarrays. The occupancy of nanodots by single antibody molecules is demonstrated using ensemble scale interrogation and nanoscale interrogation techniques. The possibility of using single-antibody nanoarrays for digital electrochemical immunoassays is evidenced by experiments involving competitive adsorption of antibodies.
Review
Chemistry, Physical
Huaxu Zhou, Kele Chen, Ru-Jia Yu, Yi-Lun Ying, Qianjin Chen, Yi-Tao Long
Summary: This review focuses on the recent advances in single nanobubble electrochemistry achieved through the utilization of nanopipettes, with new insights into fundamental electrochemistry and electroanalytical applications of single gas nanobubbles.
CURRENT OPINION IN ELECTROCHEMISTRY
(2023)
Review
Chemistry, Physical
Chunlei Yang, Tianhui Su, Yanbo Hua, Liming Zhang
Summary: This review summarizes the latest results of electrochemical scanning probe microscopy techniques in studying the interfacial properties of electrocatalysts and photoelectrodes, and offers some perspectives on future research directions.
Review
Chemistry, Multidisciplinary
Mali Zhao, Dohyun Kim, Young Hee Lee, Heejun Yang, Suyeon Cho
Summary: This paper introduces critical advances in the field of quantum sensing of thermopower, ranging from atomic to several-hundred-nanometer scales, and discusses the roles of low-dimensionality, defects, spins, and relativistic effects in optimized power generation. Investigating the microscopic nature of thermopower in quantum materials can provide insights for the design of advanced materials for future thermoelectric applications, while quantum sensing techniques for thermopower can pave the way for practical and novel energy devices towards a sustainable society.
ADVANCED MATERIALS
(2023)
Article
Biophysics
Xiaocui Zhao, Renkang Zhu, Max Anikovskiy, Qingxi Wu, Zhifeng Ding
Summary: This study utilized scanning electrochemical microscopy (SECM) to quantitatively determine the extracellular H2O2 released from single COS-7 cells with high spatial resolution. The SECM mode allowed for efficient recording of probe approach curves (PACs) and visualization of cell topography simultaneously. The H2O2 concentration at the membrane surface of intact COS-7 cells was determined to be 0.020 mM using experimental PACs and a simulated PAC with a known H2O2 release value. Additionally, confocal microscopy was used to demonstrate the intracellular H2O2 profile, showing that H2O2 generation is centered at the endoplasmic reticula.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Andreas Karg, Sebastian Goedrich, Philipp Dennstedt, Nicolas Helfricht, Markus Retsch, Georg Papastavrou
Summary: Scanning electrochemical microscopy (SECM) is a versatile technique for monitoring electrochemical reactions on a highly resolved local scale. This research presents a novel approach to implement a three-electrode setup for SECM in any fluid cell, allowing for high-resolution imaging and equivalent electrochemical performance to macroscopic electrodes.
Article
Chemistry, Multidisciplinary
Dongho Kim, Jaejin Hwang, Pilgyu Byeon, Wonsik Kim, Dong Gyu Kang, Hyung Bin Bae, Sang-Gil Lee, Seung Min Han, Jaekwang Lee, Sung-Yoon Chung
Summary: Since the recognition of the significant oxygen-redox contribution to Li transition-metal oxide cathodes' capacity enhancement, the issues of oxygen release, structural variations, and capacity fading have become critical for achieving better electrochemical performance. This study utilizes nanoindentation and surface polishing to investigate the local variations of atomic structure and oxygen content in LiCoO2 and Li2MnO3. The findings provide direct evidence of oxygen release due to lattice strain and suggest the importance of efficient strain relaxation for the longevity of the anion framework in layered oxide cathodes.
ADVANCED MATERIALS
(2023)
Article
Physics, Applied
Liuxia Ruan, Junwei Tong, Wenzhen Yang, Fubo Tian, Xianmin Zhang
Summary: DyPc2 and (DyPc2CH2Cl2)-C-center dot were prepared using the solvent thermal method. X-ray diffractometer and Fourier transform infrared spectrometer were used to explore the structure changes between DyPc2 and (DyPc2CH2Cl2)-C-center dot. The different molecular environment affects the structure and magnetism of single-molecule magnets, as demonstrated by the twist angles and magnetic relaxation measurements.
JOURNAL OF APPLIED PHYSICS
(2023)
Article
Chemistry, Analytical
Ruimin Li, Weiwei Guo, Zhijun Zhu, Yanling Zhai, Guanwen Wang, Zheng Liu, Lei Jiao, Chengzhou Zhu, Xiaoquan Lu
Summary: A single-atom indium anchored on nitrogen-doped carbon (In1-N-C) catalyst was prepared for sensitive electrochemical sensing of dopamine (DA). The In1-N-C catalyst exhibited high catalytic performance for DA oxidation, showing enhanced intrinsic activity with atomically dispersed In-N4 sites. The concept application of an electrochemical sensor for DA detection with high sensitivity and selectivity was established.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Baran Sarac, Tolga Karazehir, Eray Yuce, Marlene Muehlbacher, A. Sezai Sarac, Juergen Eckert
Summary: Improving the efficiency of hydrogen storage and release using metallic glass nanofilms offers green solutions for nanoscale energy applications. Specific sizes and configurations of the hydrogen storage components demonstrate high electrochemical performance, with high specific pseudocapacitance and conductive behavior.
ACS APPLIED ENERGY MATERIALS
(2021)
Article
Chemistry, Analytical
Yirong Xia, Wei Ni, Xiaorong Wang, Yougui Yu, Qing Zheng, Ximing Huang
Summary: This study constructed a specific molecular switch that can control the oxidation and non-oxidation states of dopamine, which is expected to play an important role in cellular physiology research.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Article
Electrochemistry
Gregorio Bonazza, Hubert H. Girault, Andreas Lesch, Salvatore Daniele
Summary: A method for the fabrication of dual soft microelectrodes for Soft-Probe-SECM is presented, which involves encapsulating electrode wires in a dielectric material to create two individually addressable microdisc electrodes. The thickness of the dielectric material can be controlled, resulting in variation in the inter-distance between the microelectrodes. The dual soft probes allow for the detection of electro-active analytes at solid/solution interfaces.
ELECTROCHIMICA ACTA
(2023)
Article
Chemistry, Physical
Junjie Zhang, Yulin Liu, Yabei Li, Tong Zhu, Jinbin Qiu, Feng Xu, Hua Zhang, Fei Li
Summary: Understanding the oxidative state and damage of neurons under heat stress is crucial for studying heat-related neuronal injury. In this study, a temperature-controlled scanning electrochemical microscopy platform was developed for in situ and quantitative monitoring of neuronal oxygen consumption, extracellular hydrogen peroxide levels, and cell membrane permeability under thermal microenvironment. The results contribute to a better understanding of the heat-related cellular injury mechanism.
Article
Materials Science, Multidisciplinary
Shinji Ootsuka, Flavien Vucko, Varvara Shubina Helbert, Andrei Nazarov, Dominique Thierry
Summary: The scanning Kelvin probe (SKP) can be used to map subsurface hydrogen in steels, but it has poor quantification. On the other hand, the electrochemical permeation technique (EPT) is highly sensitive to hydrogen flux but has low spatial resolution. To overcome this, a local hydrogen quantification method using SKP measurements calibrated by EPT was developed. The method was applied to map subsurface hydrogen in steel corroding under various atmospheric corrosion conditions.
Article
Radiology, Nuclear Medicine & Medical Imaging
Saad Abbasi, Kevan Bell, Benjamin Ecclestone, Parsin Haji Reza
Summary: This study introduces a method with low computational overhead for image rendering, resulting in a live display capable of real-time frame rates. 3D imaging with a non-contact label-free reflection-mode technique based on PARS is demonstrated, showing high resolution and sensitivity.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Article
Chemistry, Multidisciplinary
Mengjie Chen, Si-Min Lu, Hao-Wei Wang, Yi-Tao Long
Summary: By statistically analyzing time-resolved current transients, we can quantitatively determine the dynamic chemical potential difference and interparticle communication between populations of large and small Ag NPs, enabling in situ investigation of chemical communication-dependent transformation kinetics of NPs in the photochemical process with the high sensitivity of stochastic collision electrochemistry, shedding light on designing nanomaterials.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Editorial Material
Chemistry, Multidisciplinary
Yi-Tao Long, Meni Wanunu, Mathias Winterhalter
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Shijia Li, Xinyi Li, Yong-Jing Wan, Yi-Lun Ying, Ru-Jia Yu, Yi-Tao Long
Summary: RNA modifications have a significant impact on cellular functions, but identifying and quantifying these modifications is challenging. To address this issue, we developed a machine-learning algorithm called SmartImage that combines improved graph conversion methods and deep neural networks to accurately identify and classify nanopore electrochemical signals. SmartImage overcomes the limitations of current nanopore algorithms, demonstrating an overall accuracy of over 90% for identifying three types of RNAs. Moreover, our algorithm successfully recognizes one modified RNA molecule from 1000 normal RNAs with an accuracy exceeding 90%. This proposed model and algorithm hold great potential for clinical applications.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Chemistry, Physical
Si -Min Lu, Jian-Fu Chen, Hai-Feng Wang, Peijun Hu, Yi-Tao Long
Summary: Single entity measurements based on stochastic collision electrochemistry offer a promising and versatile approach to study single molecules, particles, droplets, etc. This perspective demonstrates how controllable stochastic collision electrochemistry can be achieved by effectively modifying the mass transport and electron transfer processes at the electrochemically confined interface. Future challenges and opportunities in stochastic collision electrochemistry are also discussed.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Multidisciplinary Sciences
Jie Ren, Hao-Wen Li, Liang Chen, Min Zhang, Yan-Xiang Liu, Bo-Wen Zhang, Rui Xu, Yan-Yan Miao, Xue-Mei Xu, Xin Hua, Xiao-Gang Sun, Ru-Jia Yu, Yi-Tao Long, Sheng-Shou Hu
Summary: Heart failure (HF), a leading cause of death, is a serious global public health issue. Metabolomics of single cardiomyocytes (CMs) has the potential to revolutionize our understanding of HF pathogenesis, as metabolic remodeling in the human heart plays a vital role in disease progression. However, current metabolic analysis is often limited by the dynamic features of metabolites and the requirement for high-quality isolated CMs.
Article
Chemistry, Physical
Xinmei Song, Xiaolan Xue, Hailun Xia, Li Jin, Anyang Tao, Yaoda Wang, Junchuan Liang, Yuzhu Liu, Pengbo Zhang, Zuoxiu Tie, Yitao Long, Zhong Jin
Summary: This article reports that pyrrole-based redox-active organic monomers can be instantly converted into pi-conjugated polymer derivatives via in-situ chemical polymerization without tedious fabrication procedures during battery assembly. The resulting poly(N-anthraquinoyl pyrrole) (PAQPy) cathode material exhibits high specific capacity, good rate performance, and ultralong cycling stability. The work also demonstrates an effective strategy of stabilizing redox-active organic electrode materials via electrolyte initiated in-situ chemical polymerization.
ENERGY STORAGE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Xue-Yuan Wu, Meng-Yin Li, Shao-Jun Yang, Jie Jiang, Yi-Lun Ying, Peng R. Chen, Yi-Tao Long
Summary: Conventional methods for protein nanopore engineering are limited by the 20 natural amino acids, which restricts the diversity of nanopores. To overcome this, we used the genetic code expansion technique to incorporate unnatural amino acids into aerolysin nanopores. Molecular dynamics simulations and single-molecule sensing experiments showed that the newly incorporated amino acids provided a favorable environment for target molecule interactions. This work provides a new framework for creating nanopores with unique sensing properties.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Wei Liu, Chao-Nan Yang, Zhong-Lin Yang, Ru-Jia Yu, Yi-Tao Long, Yi-Lun Ying
Summary: In this study, a protein-nanopore inside a glove box is used to control local O-2 for single-molecule reaction, as well as a single-molecule sensor for real-time monitoring of the reversible thiol/disulfide cycle. The results demonstrate that the local O-2 molecules in protein nanopores could facilitate the redox cycle of disulfide formation and cleavage by promoting a higher fraction of effective reactant collisions owing to nanoconfinement. The unexpectedly strong oxidation ability of confined local O-2 may play an essential role in cellular redox signaling and enzyme reactions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Jie Jiang, Meng-Yin Li, Xue-Yuan Wu, Yi-Lun Ying, Huan-Xing Han, Yi-Tao Long
Summary: A nanopore framework is used to quantitatively monitor the crosstalk effects between angiotensin-converting enzyme (ACE) and angiotensin-converting enzyme 2 (ACE2) on the renin-angiotensin system (RAS). ACE2 selectively inhibits ACE to prevent cleavage of angiotensin I, even at a higher concentration of ACE. The spike protein of SARS-CoV-2 suppresses the activity of ACE2, leading to the accumulation of angiotensin II and relaxation of ACE. The Delta variant has a greater impact on the crosstalk than the wild type.
Meeting Abstract
Biophysics
Jie Jiang, Junge Li, Yan Gao, Meng-Yin Li, Yi-Tao Long
BIOPHYSICAL JOURNAL
(2023)
Meeting Abstract
Biophysics
Hongyan Niu, Meng-Yin Li, Xue-yuan Wu, Yi-Tao Long
BIOPHYSICAL JOURNAL
(2023)
Meeting Abstract
Biophysics
Kele Chen, Yuhuang Xie, Ru-Jia Yu, Yi-Lun Ying, Yi-Tao Long
BIOPHYSICAL JOURNAL
(2023)
Meeting Abstract
Biophysics
Yan Gao, Jie Jiang, Meng-Yin Li, Yi-Tao Long
BIOPHYSICAL JOURNAL
(2023)
Meeting Abstract
Biophysics
Jia-Hong Wang, Zheng-Li Hu, Kai-Li Xin, Jun-Ge Li, Yi-Lun Ying, Yi-Tao Long
BIOPHYSICAL JOURNAL
(2023)
Meeting Abstract
Biophysics
Kai-Li Xin, Zheng-Li Hu, Yi-Lun Ying, Yi-Tao Long
BIOPHYSICAL JOURNAL
(2023)
