Article
Neurosciences
Megane Missaire, Nicolas Fraize, Jean-Christophe Comte, Bruno Truchet, Regis Parmentier, Paul-Antoine Salin, Gael Malleret
Summary: Long-term storage of information in memory relies on long-term synaptic plasticity processes. Studies have shown synaptic changes after training in long-term/reference memory and working memory tasks. Consolidation of long-term information leads to delayed synaptic potentiation, while optimal information processing into working memory triggers synaptic depression.
Article
Psychology, Biological
William A. Roberts, Krista Macpherson, Sophia Robinson, Abagail Hennessy, Bram Richmond
Summary: Three experiments were conducted to investigate spatial memory in rats using a new test. Rats were tested in a dual eight-arm radial maze, where they had to remember the location of food rewards. The results showed that rats were able to form reference and working memory, and they displayed a preference for the maze with a known food reward or a cue indicating the reward location. These findings suggest that rats use a two-step strategy to navigate the maze.
LEARNING & BEHAVIOR
(2023)
Article
Behavioral Sciences
Victoria E. Bernaud, Ryoko Hiroi, Mallori L. Poisson, Arthur J. Castaneda, Ziv Z. Kirshner, Robert B. Gibbs, Heather A. Bimonte-Nelson
Summary: Rodent aging research often uses spatial mazes to evaluate cognition, with evidence suggesting interference between reference and working memory especially at high working memory load. Young rats outperformed aged rats on tasks testing solely working memory, but their performances were similar when a reference memory component was added. The relationship between cholinergic activity and maze performance varied by age, demonstrating the complex role of the cholinergic system in memory and attention processes.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Neurosciences
Price Obot, Galadu Subah, Antonia Schonwald, Jian Pan, Libor Velisek, Jana Veliskova, Patric K. Stanton, Eliana Scemes
Summary: Pannexin 1 (Panx1) is a widely expressed protein that forms plasma membrane channels allowing the passage of anions and moderate-sized signaling molecules. Previous studies have shown that activation of Panx1 channels contributes to various neurological disorders, and limited research suggests their involvement in hippocampus dependent learning. In this study, Panx1-null mice were used to investigate their role in working and reference memory and it was found that Panx1 channels in both astrocytes and neurons are critical for long-term spatial reference memory formation and consolidation. Recordings in hippocampal slices of Panx1-null mice showed a decrease in long-term potentiation and long-term depression, without affecting basal synaptic transmission or pre-synaptic paired-pulse facilitation.
Article
Behavioral Sciences
Hiroko Mochizuki-Kawai, Yukio Ichitani, Saho Ayabe-Kanamura, Kazuo Yamada
Summary: Odor stimuli can promote relaxation and reduce anxiety. This study compared the effects of a novel odor and a familiar odor associated with a positive experience on anxiety-like behaviors in rats. The results showed that exposure to the familiar odor reduced anxiety, especially in females.
Article
Behavioral Sciences
Joel Kohler, Jie Mei, Stefanie Banneke, York Winter, Matthias Endres, Julius Valentin Emmrich
Summary: The radial arm maze is a common test to study spatial learning and memory in rodents. A newly developed refined maze showed advantages in detecting long-term cognitive impairment and quantifying exploratory behavior compared to the classic method.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Fateme Khodabande, Esmaeil Akbari, Motahareh Rouhi Ardeshiri
Summary: The orexin 1 receptors in the dorsal raphe nucleus play a significant role in the consolidation of spatial reference memory in rats, while the orexin 2 receptors do not have an effect.
Article
Neurosciences
NaYoung So, Michael N. Shadlen
Summary: Neurons in the lateral intraparietal cortex can represent the formation of a decision, but not across actions. However, by passing information between active and future active neurons, the ensemble achieves continuity of the decision process.
Article
Mathematical & Computational Biology
Wenhao Cao, Lianne Siege, Jincheng Zhou, Motao Zhu, Tiejun Tong, Yong Chen, Haitao Chu
Summary: Reference intervals are used to determine whether a measurement is typical of a healthy individual. Meta-analysis combines results from multiple studies to provide a general reference interval, while the fixed effects model is useful for estimating reference intervals with only a few studies.
RESEARCH SYNTHESIS METHODS
(2021)
Article
Behavioral Sciences
Juan M. J. Ramos, Ignacio Moron
Summary: The study found that there are different roles between the dorsal hippocampus (DHip) and ventral hippocampus (VHip) in spatial learning and memory. Specifically, DHip-lesioned rats showed an acquisition deficit, while VHip-lesioned rats only exhibited deficits under specific training protocols.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Behavioral Sciences
Soniya Assudani Patel, Karyn M. Frick, Paul A. Newhouse, Robert S. Astur
Summary: The study examined the role of estradiol in hippocampal-dependent spatial memory in women. Results showed that the high estradiol group demonstrated superior spatial reference memory, while the low estradiol group exhibited the poorest probe trial performance. There were no group differences in performance on the virtual memory tasks.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Behavioral Sciences
Juan M. J. Ramos
Summary: This study compares the effects of dorsal and ventral hippocampus lesions on long-term spatial memory retention and finds that both lesioned groups show significant impairment in spatial memory 24 days after learning.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Multidisciplinary Sciences
Haziq Kamal, Khidhir Kamii, Nelson Tan Kar Wai, Abdul Latif Noor Bin Amiruddin, Manmeet Kaur Prithviraj Singh, Nurul Aina Binti Johaniff, Nursyahirah Binti Abdul Halim, Azmawati Mohammed Nawi, Chua Kien Hui, Jaya Kumar
Summary: Consumption of edible bird's nest (EBN) has a believed health benefit. This study aimed to investigate the effects of both traditional edible bird's nest (TEBN) and convenient edible bird's nest (CEBN) on the spatial learning of male Sprague Dawley rats in a radial arm maze (RAM). The results suggested that TEBN may work better than CEBN in improving spatial learning.
Article
Chemistry, Medicinal
Bianca Romero-Delgado, Marcela Cardenas-Tueme, Jose de Jesus de la Rosa, Alberto Camacho-Morales, Heriberto Castro, Ana Laura de la Garza
Summary: The study suggests that maternal intake of high-sucrose diet during gestation and lactation may lead to increased blood glucose levels and deficient memory performance in adult female offspring rats.
JOURNAL OF MEDICINAL FOOD
(2021)
Article
Psychology, Biological
Adnan M. Massadeh, Karem H. Alzoubi, Amal M. Milhem, Abeer M. Rababa'h, Omar F. Khabour
Summary: Chronic sleep deprivation impairs both short-term and long-term memory, while chronic selenium administration can prevent this impairment by normalizing antioxidant enzyme activities in the hippocampus.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Neurosciences
S. B. Taylor, L. R. Watterson, P. R. Kufahl, N. E. Nemirovsky, S. E. Tomek, C. D. Conrad, M. P. Olive
Article
Critical Care Medicine
Ann N. Hoffman, Pooja R. Paode, Hazel G. May, J. Bryce Ortiz, Salma Kemmou, Jonathan Lifshitz, Cheryl D. Conrad, Theresa Currier Thomas
JOURNAL OF NEUROTRAUMA
(2017)
Article
Behavioral Sciences
Kenji J. Nishimura, J. Bryce Ortiz, Cheryl D. Conrad
NEUROBIOLOGY OF LEARNING AND MEMORY
(2017)
Review
Psychology, Biological
Cheryl D. Conrad, J. Bryce Ortiz, Jessica M. Judd
PHYSIOLOGY & BEHAVIOR
(2017)
Review
Endocrinology & Metabolism
J. Bryce Ortiz, Cheryl D. Conrad
FRONTIERS IN NEUROENDOCRINOLOGY
(2018)
Article
Neurosciences
J. Bryce Ortiz, Julia M. Anglin, Eshaan J. Daas, Pooja R. Paode, Kenji Nishimura, Cheryl D. Conrad
Article
Genetics & Heredity
Michael C. Holter, Lauren T. Hewitt, Stephanie Koebele, Jessica M. Judd, Lei Xing, Heather A. Bimonte-Nelson, Cheryl D. Conrad, Toshiyuki Araki, Benjamin G. Neel, William D. Snider, Jason M. Newbern
Article
Behavioral Sciences
Tanya A. Gupta, Carter W. Daniels, J. Bryce Ortiz, McAllister Stephens, Paula Overby, Korinna Romero, Cheryl D. Conrad, Federico Sanabria
BEHAVIOURAL BRAIN RESEARCH
(2019)
Article
Behavioral Sciences
Stephanie V. Koebele, Kenji J. Nishimura, Heather A. Bimonte-Nelson, Salma Kemmou, J. Bryce Ortiz, Jessica M. Judd, Cheryl D. Conra
HORMONES AND BEHAVIOR
(2020)
Biographical-Item
Neurosciences
Liisa A. M. Galea, Roberta D. Brinton, Heather A. Cameron, Cheryl D. Conrad, Sonia J. Lupien, Rebecca M. Shansky, Catherine S. Woolley, Elizabeth Gould
TRENDS IN NEUROSCIENCES
(2020)
Article
Behavioral Sciences
Dylan N. Peay, Hovhannes M. Saribekyan, Priscilla A. Parada, Elizabeth M. Hanson, Bryce S. Badaruddin, Jessica M. Judd, Megan E. Donnay, Diego Padilla-Garcia, Cheryl D. Conrad
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Neurosciences
J. Bryce Ortiz, Jason Newbern, Cheryl D. Conrad
Summary: Chronic stress affects the inhibitory GABA circuitry in distinct hippocampal subregions without altering the total number of GABAergic neurons. It reduces the expression of CR+ in the CA3 region and DG region of the hippocampus, especially in males, but these changes reverse after a rest period. Chronic stress also decreases the proportion of hippocampal SOM+ neurons, and this reduction persists even with a rest period.
Article
Endocrinology & Metabolism
Camila de Avila, Sandrine Chometton, Juliane Calvez, Genevieve Guevremont, Alan Kania, Lola Torz, Christophe Lenglos, Anna Blasiak, Mette M. Rosenkilde, Birgitte Holst, Cheryl D. Conrad, John D. Fyer, Elena Timofeeva, Andrew L. Gundlach, Carlo Cifani
Summary: Food intake varies during the ovarian hormone/estrous cycle in humans and rodents, mediated mainly by estradiol. The RLN3/RXFP3 system is modulated by the estrous cycle, suggesting its involvement in food intake fluctuations observed in female rats. Further studies are needed to elucidate the cellular and molecular mechanisms of estradiol signaling.
NEUROENDOCRINOLOGY
(2021)
Editorial Material
Neurosciences
Cheryl D. Conrad
Summary: This study provides a descriptive analysis of biological, psychological, and socioemotional markers of stress in individuals who self-identify as being either 'very stressed out' or 'zen'.
NEUROBIOLOGY OF STRESS
(2022)
Article
Neurosciences
Jessica M. Judd, Elliot A. Smith, Jinah Kim, Vrishti Shah, Federico Sanabria, Cheryl D. Conrad