Article
Neurosciences
F. R. Fiocchi, S. Dijkhuizen, S. K. E. Koekkoek, C. I. De Zeeuw, H. J. Boele
Summary: In this study, the researchers investigated stimulus generalization in a cerebellar learning paradigm called eyeblink conditioning. They found that mice showed a strong generalization gradient, with the probability and amplitude of conditioned eyelid responses decreasing as the tones' dissimilarity to the 10-kHz tone increased. The researchers also discovered that lower frequency tones resulted in conditioned responses that peaked earlier after tone onset compared to higher frequency tones.
Article
Biochemistry & Molecular Biology
Ling Li, Li Li, Ying Shao, Runyu Du, Ling Li, Xiaoguang Shi, Yu Bai
Summary: Insulin resistance (IR) plays a significant role in glucose metabolic disturbance and placental dysplasia in gestational diabetes mellitus (GDM). Calcium/calmodulin dependent protein kinase IV (CAMK4) has been shown to improve insulin IR induced by a high-fat diet (HFD). This study aimed to investigate the role and potential mechanism of CAMK4 in GDM.
MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Shuhang Dai, Elisa Venturini, Saveg Yadav, Xiaoxuan Lin, Dylan Clapp, Martin Steckiewicz, Angela M. Gocher-Demske, Arthur M. Edelman, D. Grahame Hardie
Summary: This study reveals the important role of CaMKK2 in mediating EGFR signaling in cancer cells, with regulation mechanisms involving both calcium-dependent and calcium-independent pathways. Additionally, CaMKK2 regulates transcription of key genes, impacting cell survival and proliferation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Mathematical & Computational Biology
Matthew Ricci, Junkyung Kim, Fredrik Johansson
Summary: The cerebellar Purkinje cell controls eyeblinks and can learn, remember, and reproduce the timing of stimuli in a classical conditioning paradigm. Previous models suggest that the perception of time is represented in upstream networks, but direct stimulation of the Purkinje cell during conditioning still results in a well-timed response. Furthermore, experimental findings indicate that the acquired Purkinje cell response is insensitive to variations in the temporal structure of probe stimulation, motivating the development of alternative models.
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Sofia Beghi, Malgorzata Furmanik, Armand Jaminon, Rogier Veltrop, Nikolas Rapp, Kanin Wichapong, Elham Bidar, Annamaria Buschini, Leon J. Schurgers
Summary: Cardiovascular disease remains a major cause of death worldwide, despite advancements in medication and preventive measures. Calcium plays a vital role in the cardiovascular system, regulating events from action potentials to muscle contraction. Calcium calmodulin pathways are involved in the regulation of cardiac functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Michal Marcinkowski, Tomas Pilzys, Damian Garbicz, Jan Piwowarski, Kaja Przygonska, Maria Winiewska-Szajewska, Karolina Ferenc, Oleksandr Skorobogatov, Jaroslaw Poznanski, Elzbieta Grzesiuk
Summary: FTO is an N-6-methyladenosine demethylase which can remove methyl groups from nucleic acids, forming complexes with other proteins. Research indicates an interaction between FTO and calmodulin (CaM), influencing calcium-binding loops in CaM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Riku Kaneshige, Satomi Ohtsuka, Yuhei Harada, Issei Kawamata, Masaki Magari, Naoki Kanayama, Naoya Hatano, Hiroyuki Sakagami, Hiroshi Tokumitsu
Summary: This study reveals that the RP-domain is required for CaMKK isoforms to recognize and phosphorylate downstream kinases, potentially providing a promising target for specific CaMKK inhibitors.
Article
Neurosciences
Carlos Alexandre Gomes, Katharina M. Steiner, Nicolas Ludolph, Tamas Spisak, Thomas M. Ernst, Oliver Mueller, Sophia L. Goricke, Franziska Labrenz, Winfried Ilg, Nikolai Axmacher, Dagmar Timmann
Summary: The study found that cerebellar diseases directly affect the integrity of white matter in the brain and are related to behavioral performance in motor tasks.
HUMAN BRAIN MAPPING
(2021)
Article
Fisheries
Chen Huang, Jie Du, Bairu Ji, Sinan Gong, Chao Geng, Yanyang Miao, Qingchun Shen, Wei Gu, Li Wang, Qingguo Meng
Summary: EsCaMKII is highly transcribed in various tissues of E. sinensis and its over-expression promotes apoptosis and enhances resistance to S. eriocheiris infection, while RNAi knockdown results in increased pathogen copy numbers and crab mortality.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Review
Neurosciences
Kyoung-Doo Hwang, Sang Jeong Kim, Yong-Seok Lee
Summary: The cerebellum plays a critical role in modulating fear memory network and prediction, with involvement at the cellular and synaptic levels. Understanding the contributions of distinct cerebellar structures to fear learning and memory may lead to more effective treatment strategies for fear-related affective disorders.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Andrew J. Boyle, Carl Schultz, Joseph B. Selvanayagam, Stuart Moir, Richard Kovacs, Nabil Dib, David Zlotnick, Mohammed Al-Omary, Stuart Sugito, Aravinda Selvarajah, Nicholas Collins, Grant McLachlan
Summary: This study found that treatment with NP202 for 3 months after primary PCI for anterior STEMI did not improve LV remodeling in patients with residual LV dysfunction. However, the drug demonstrated good safety and tolerability.
Article
Biochemistry & Molecular Biology
Qingxi Zhang, Yin Huang, Anbiao Wu, Qingrui Duan, Peikum He, Haifeng Huang, Yuyuan Gao, Kun Nie, Qicai Liu, Lijuan Wang
Summary: We identified the pathogenic role of calcium/calmodulin-dependent serine protein kinase in Parkinson's disease, showing that it phosphorylated alpha-synuclein to activate mitochondrial calcium uniporter and increase mitochondrial calcium influx, leading to mitochondrial damage. Our findings highlight the therapeutic potential of targeting calcium/calmodulin-dependent serine protein kinase in Parkinson's disease treatment.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2023)
Article
Parasitology
Hai-Jun Gao, Xu-Dong Sun, Yan-Ping Luo, Hua-Sheng Pang, Xing-Ming Ma, Ting Zhang, Tao Jing, Wei Hu, Yu-Juan Shen, Jian-Ping Cao
Summary: The study demonstrated that verapamil has anti-parasitic effects against Echinococcus by downregulating the expression of Ca2+/CaM-CaMKII, indicating that Ca2+/CaM-CaMKII may be a novel drug target for the treatment of echinococcosis.
PARASITES & VECTORS
(2021)
Article
Multidisciplinary Sciences
Giovanna Nalesso, Anne-Sophie Thorup, Suzanne Elizabeth Eldridge, Anna De Palma, Amanpreet Kaur, Kiran Peddireddi, Kevin Blighe, Sharmila Rana, Bryony Stott, Tonia Louise Vincent, Bethan Lynne Thomas, Jessica Bertrand, Joanna Sherwood, Antonella Fioravanti, Costantino Pitzalis, Francesco Dell'Accio
Summary: The WNT/CaMKII signaling pathway plays a crucial role in osteoarthritis by affecting the expression of markers such as HMOX1 and Sox-9. Inhibition of CaMKII may exacerbate cartilage damage and bone remodeling, while also upregulating the expression of matrix remodeling enzymes in articular chondrocytes. These findings suggest the potential therapeutic implications of targeting the WNT/CaMKII pathway in osteoarthritis.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Yuki Horie, Toshiaki Arame, Naohide Hirashima, Masahiko Tanaka
Summary: The study showed that CaMKII alpha, II beta, and IV play a crucial role in the dendritic differentiation of Purkinje cells, and inhibiting all three CaMKs simultaneously significantly affects dendritic branching development and phosphorylation of CREB in Purkinje cells.
Article
Immunology
Aziz Bousfiha, Leila Jeddane, Capucine Picard, Fatima Ailal, H. Bobby Gaspar, Waleed Al-Herz, Talal Chatila, Yanick J. Crow, Charlotte Cunningham-Rundles, Amos Etzioni, Jose Luis Franco, Steven M. Holland, Christoph Klein, Tomohiro Morio, Hans D. Ochs, Eric Oksenhendler, Jennifer Puck, Mimi L. K. Tang, Stuart G. Tangye, Troy R. Torgerson, Jean-Laurent Casanova, Kathleen E. Sullivan
JOURNAL OF CLINICAL IMMUNOLOGY
(2018)
Article
Immunology
Capucine Picard, H. Bobby Gaspar, Waleed Al-Herz, Aziz Bousfiha, Jean-Laurent Casanova, Talal Chatila, Yanick J. Crow, Charlotte Cunningham-Rundles, Amos Etzioni, Jose Luis Franco, Steven M. Holland, Christoph Klein, Tomohiro Morio, Hans D. Ochs, Eric Oksenhendler, Jennifer Puck, Mimi L. K. Tang, Stuart G. Tangye, Troy R. Torgerson, Kathleen E. Sullivan
JOURNAL OF CLINICAL IMMUNOLOGY
(2018)
Article
Allergy
A. Abdel-Gadir, L. Schneider, A. Casini, L. -M. Charbonnier, S. V. Little, T. Harrington, D. T. Umetsu, R. Rachid, T. A. Chatila
CLINICAL AND EXPERIMENTAL ALLERGY
(2018)
Article
Immunology
Pinar Gur Cetinkaya, Deniz Cagdas Ayvaz, Betul Karaatmaca, Rahsan Gocmen, Figen Soylemezoglu, Wayne Bainter, Janet Chou, Talal A. Chatila, Ilhan Tezcan
CLINICAL IMMUNOLOGY
(2018)
Article
Allergy
Mingcan Xia, Hani Harb, Arian Saffari, Constantinos Sioutas, Talal A. Chatila
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Article
Allergy
Peggy S. Lai, Amir H. Massoud, Mingcan Xia, Carter R. Petty, Amparito Cunningham, Talal A. Chatila, Wanda Phipatanakul
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Article
Allergy
Charlotte Schwab, Annemarie Gabrysch, Peter Olbrich, Virginia Patino, Klaus Warnatz, Daniel Wolff, Akihiro Hoshino, Masao Kobayashi, Kohsuke Imai, Masatoshi Takagi, Ingunn Dybedal, Jamanda A. Haddock, David M. Sansom, Jose M. Lucena, Maximilian Seidl, Annette Schmitt-Graeff, Veronika Reiser, Florian Emmerich, Natalie Frede, Alla Bulashevska, Ulrich Salzer, Desiree Schubert, Seiichi Hayakawa, Satoshi Okada, Maria Kanariou, Zeynep Yesim Kucuk, Hugo Chapdelaine, Lenka Petruzelkova, Zdenek Sumnik, Anna Sediva, Mary Slatter, Peter D. Arkwright, Andrew Cant, Hanns-Martin Lorenz, Thomas Giese, Vassilios Lougaris, Alessandro Plebani, Christina Price, Kathleen E. Sullivan, Michel Moutschen, Jiri Litzman, Tomas Freiberger, Frank L. van de Veerdonk, Mike Recher, Michael H. Albert, Fabian Hauck, Suranjith Seneviratne, Jana Pachlopnik Schmid, Antonios Kolios, Gary Unglik, Christian Klemann, Carsten Speckmann, Stephan Ehl, Alan Leichtner, Richard Blumberg, Andre Franke, Scott Snapper, Sebastian Zeissig, Charlotte Cunningham-Rundles, Lisa Giulino-Roth, Olivier Elemento, Gregor Dueckers, Tim Niehues, Eva Fronkova, Veronika Kanderova, Craig D. Platt, Janet Chou, Talal A. Chatila, Raif Geha, Elizabeth McDermott, Su Bunn, Monika Kurzai, Ansgar Schulz, Laia Alsina, Ferran Casals, Angela Deya-Martinez, Sophie Hambleton, Hirokazu Kanegane, Kjetil Tasken, Olaf Neth, Bodo Grimbacher
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Article
Allergy
Fayhan J. Alroqi, Louis-Marie Charbonnier, Safa Baris, Ayca Kiykim, Janet Chou, Craig D. Platt, Abdulrahman Algassim, Sevgi Keles, Bandar K. Al Saud, Fowzan S. Alkuraya, Michael Jordan, Raif S. Geha, Talal A. Chatila
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Article
Allergy
Hassan Abolhassani, Janet Chou, Wayne Bainter, Craig D. Platt, Mahmood Tavassoli, Tooba Momen, Marzieh Tavakol, Mohammad Hossein Eslamian, Mohammad Gharagozlou, Masoud Movahedi, Mohsen Ghadami, Amir Ali Hamidieh, Gholamreza Azizi, Reza Yazdani, Mohsen Afarideh, Alireza Ghajar, Arash Havaei, Zahra Chavoshzadeh, Seyed Alireza Mahdaviani, Taher Cheraghi, Nasrin Behniafard, Reza Amin, Soheila Aleyasin, Reza Faridhosseini, Farahzad Jabbari-Azad, Mohammamd Nabavi, Mohammad Hassan Bemanian, Saba Arshi, Rasol Molatefi, Roya Sherkat, Mahboubeh Mansouri, Mehrnaz Mesdaghi, Delara Babaie, Iraj Mohammadzadeh, Javad Ghaffari, Alireza Shafiei, Najmeddin Kalantari, Hamid Ahanchian, Maryam Khoshkhui, Habib Soheili, Abbas Dabbaghzadeh, Afshin Shirkani, Rasoul Nasiri Kalmarzi, Seyed Hamidreza Mortazavi, Javad Tafaroji, Abbas Khalili, Javad Mohammadi, Babak Negahdari, Mohammad-Taghi Joghataei, Basel K. al-Ramadi, Capucine Picard, Nima Parvaneh, Nima Rezaei, Talal A. Chatila, Michel J. Massaad, Sevgi Keles, Lennart Hammarstrom, Raif S. Geha, Asghar Aghamohammadi
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Article
Immunology
Mindy S. Lo, Meghan Towne, Grace E. VanNoy, Catherine A. Brownstein, Andrew A. Lane, Talal A. Chatila, Pankaj B. Agrawal
JOURNAL OF AUTOIMMUNITY
(2018)
Article
Multidisciplinary Sciences
Amlan Biswas, Dror S. Shouval, Alexandra Griffith, Jeremy A. Goettel, Michael Field, Yu Hui Kang, Liza Konnikova, Erin Janssen, Naresh Singh Redhu, Adrian J. Thrasher, Talal Chatila, Vijay K. Kuchroo, Raif S. Geha, Luigi D. Notarangelo, Sung-Yun Pai, Bruce H. Horwitz, Scott B. Snapper
NATURE COMMUNICATIONS
(2018)
Article
Allergy
David C. Thomas, Louis-Marie Charbonnier, Andrea Schejtman, Hasan Aldhekri, Eve L. Coomber, Elizabeth R. Dufficy, Anne E. Beenken, James C. Lee, Simon Clare, Anneliese O. Speak, Adrian J. Thrasher, Giorgia Santilli, Hamoud Al-Mousa, Fowzan S. Alkuraya, Talal A. Chatila, Kenneth G. C. Smith
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2019)
Article
Immunology
Ayca Kiykim, Louis Marie Charbonnier, Arzu Akcay, Elif Karakoc-Aydiner, Ahmet Ozen, Gulyuz Ozturk, Talal A. Chatila, Safa Baris
JOURNAL OF CLINICAL IMMUNOLOGY
(2019)
Article
Immunology
Vivien Beziat, Juan Li, Jian-Xin Lin, Cindy S. Ma, Peng Li, Aziz Bousfiha, Isabelle Pellier, Samaneh Zoghi, Safa Baris, Sevgi Keles, Paul Gray, Ning Du, Yi Wang, Yoann Zerbib, Romain Levy, Thibaut Leclercq, Fredegonde About, Ai Ing Lim, Geetha Rao, Kathryn Payne, Simon J. Pelham, Danielle T. Avery, Elissa K. Deenick, Bethany Pillay, Janet Chou, Romain Guery, Aziz Belkadi, Antoine Guerin, Melanie Migaud, Vimel Rattina, Fatima Ailal, Ibtihal Benhsaien, Matthieu Bouaziz, Tanwir Habib, Damien Chaussabel, Nico Marr, Jamel El-Benna, Bodo Grimbacher, Orli Wargon, Jacinta Bustamante, Bertrand Boisson, Ingrid Mueller-Fleckenstein, Bernhard Fleckenstein, Marie-Olivia Chandesris, Matthias Titeux, Sylvie Fraitag, Marie-Alexandra Alyanakian, Marianne Leruez-Ville, Capucine Picard, Isabelle Meyts, James P. Di Santo, Alain Hovnanian, Ayper Somer, Ahmet Ozen, Nima Rezaei, Talal A. Chatila, Laurent Abel, Warren J. Leonard, Stuart G. Tangye, Anne Puel, Jean-Laurent Casanova
SCIENCE IMMUNOLOGY
(2018)
Article
Allergy
Vanitha Sampath, Dana Tupa, Michelle Toft Graham, Talal A. Chatila, Jonathan M. Spergel, Kari C. Nadeau
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2017)