Journal
BEHAVIORAL NEUROSCIENCE
Volume 122, Issue 3, Pages 570-575Publisher
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0735-7044.122.3.570
Keywords
antipsychotic; cognition; muscarinic; M-1 receptor; schizophrenia
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AC-260584 (4-[3-(4-butylpiperidin-1-yl)-propyll-7-fluoro-4H-benzo[1,4]oxazin-3-one) is a potent and selective muscarinic M, receptor agonist. AC-260584 was evaluated in animal models: antipsychotic-like effects were tested by the ability to reduce amphetamine- and MK-801-induced hyperactivity and apomorphine-induced climbing; catalepsy was assessed by measuring step-down latency; spatial memory was tested by using the Morris water maze. AC-260584 reduced amphetamine- and MK-801-induced hyperactivity and apomorphine-induced climbing. In contrast to haloperidol, AC-260584 did not produce catalepsy. AC-260584 enhanced performance in the water maze during a probe test without a platform after 6 days of training, similar to the positive control tacrine. These data indicate that AC-260584 has a behavioral profile consistent with antipsychotic-like efficacy with the potential to improve cognitive performance and shows reduced liability for extrapyramidal symptoms.
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