Article
Clinical Neurology
Naohiko Okabe, Mary Hovanesyan, Srbui Azarapetian, Weiye Dai, Batsheva Weisinger, Ana Parabucki, Shira Reznik Balter, Esther Shohami, Yaron Segal, S. Thomas Carmichael
Summary: Extremely low-frequency, low-intensity electromagnetic field therapy is a non-invasive brain stimulation method that can enhance functional recovery in stroke patients. The efficacy of ELF-EMF depends on the specific frequency used, and further research is needed to understand the underlying mechanisms and optimize the treatment parameters.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Multidisciplinary Sciences
Melissa Antons, Magdalena Lindner, Maximilian Grosch, Rosel Oos, Giovanna Palumbo, Matthias Brendel, Sibylle Ziegler, Peter Bartenstein, Marianne Dieterich, Andreas Zwergal
Summary: This study compared the serial whole-brain measurements of functional and structural synaptic plasticity before and after bilateral labyrinthectomy in rats. The results revealed complex spatial and temporal patterns of structure-function coupling in networks for vestibular, multisensory, and motor control. Locomotor training was found to improve neuroplasticity and reduce body rotations.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Cunzheng Li, Ji-an Wei, Diyang Wang, Zhihua Luo, Chaoqin Pang, Kai Chen, Juan Duan, Bailing Chen, Libing Zhou, Fadel Tissir, Lei Shi, Kwok-Fai So, Li Zhang, Yibo Qu
Summary: Celsr2 plays an important role in maintaining the structural and functional integrity of adult neocortex, as well as synaptic function and motor learning.
PROGRESS IN NEUROBIOLOGY
(2022)
Review
Psychology, Multidisciplinary
Jacopo Lamanna, Mattia Ferro, Sara Spadini, Gabriella Racchetti, Antonio Malgaroli
Summary: Tourette Syndrome (TS) is a neuropsychiatric disorder characterized by motor and vocal tics. The origin of TS involves strong genetic, perinatal, and immunological influences. The pathophysiology of TS is not fully understood, but it is thought to be related to structural and functional abnormalities in neural circuits, particularly in the basal ganglia.
BEHAVIORAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Wuzhou Yang, Harsh Kanodia, Silvia Arber
Summary: The study reveals the anatomical and functional connections between the cortical regions and medulla in mice, showing that distinct cortical regions generate synaptic columns in the lateral medulla that match the positions of postsynaptic neurons tuned to specific forelimb action phases. Additionally, cortical neurons extend collaterals to other subcortical structures through a segregated channel interaction logic. The findings clarify the interaction principles between the cortical and medulla structures.
Article
Neurosciences
Emily R. Olafson, Keith W. Jamison, Elizabeth M. Sweeney, Hesheng Liu, Danhong Wang, Joel E. Bruss, Aaron D. Boes, Amy Kuceyeski
Summary: Motor recovery after ischemic stroke is dependent on the brain's ability to compensate for damaged tissue through functional reorganization. Research has shown that regions in the cerebellar/subcortical networks undergo the most frequent functional reorganization, and that areas with more disruption due to stroke experience more remapping over time. Additionally, greater motor impairment at baseline correlates with more extensive early subacute functional reorganization, leading to better motor recovery at 6 months.
Article
Clinical Neurology
Theresa Paul, Valerie M. Wiemer, Lukas Hensel, Matthew Cieslak, Caroline Tscherpel, Christian Grefkes, Scott T. Grafton, Gereon R. Fink, Lukas J. Volz
Summary: This study used diffusion spectrum imaging (DSI) and a novel compartment-wise analysis approach to investigate the structural connectivity between bilateral cortical core motor regions in chronic stroke patients. The results showed that the structural connectivity between these regions is associated with both basal and complex motor control. Specifically, the recovery of basal motor control may be supported by an alternative pathway through the contralesional primary motor cortex (M1) and non-crossing fibers of the contralesional corticospinal tract (CST). These findings help explain conflicting interpretations of the functional role of the contralesional M1 and suggest the potential of cortico-cortical structural connectivity as a biomarker for motor recovery post-stroke.
ANNALS OF NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Noor Sajid, Emma Holmes, Thomas M. Hope, Zafeirios Fountas, Cathy J. Price, Karl J. Friston
Summary: Functional recovery after brain damage varies depending on factors such as lesion site and extent. Recovery can occur by engaging residual components or utilizing intact neural structures, with different types of lesions having different effects.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Nathan G. Hedrick, Zhongmin Lu, Eric Bushong, Surbhi Singhi, Peter Nguyen, Yessenia Magana, Sayyed Jilani, Byung Kook Lim, Mark Ellisman, Takaki Komiyama
Summary: Learning induces the formation of new dendritic spines, which bind new presynaptic inputs into preexisting clusters, generating locally coherent inputs representing learned behaviors. Successful connections are selected based on co-activity with nearby task-related spines, ensuring the functional clustering of new spines. Furthermore, a majority of new spines synapse with previously unrepresented axons, suggesting the binding of new information into functional synaptic clusters.
NATURE NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Ziyang Cui, Hope Wei, Colin Goding, Rutao Cui
Summary: Stem cell pools are homogeneous cell populations that possess self-renewal and differentiation potential. While they exhibit limited heterogeneity during homeostasis, their plasticity becomes apparent under stress, leading to changes in phenotype, constitution, metabolism, and function. Manipulating these factors offers better control of stem cell behavior and has the potential to revolutionize regenerative medicine.
Article
Neurosciences
Wei-wei Deng, Guang-yan Wu, Ling-xia Min, Zhou Feng, Hui Chen, Ming-liang Tan, Jian-feng Sui, Hong-liang Liu, Jing-ming Hou
Summary: Activation of glutamate neurons in the primary motor cortex can significantly improve motor function scores in rats, shorten the incubation period of motor evoked potentials, and increase motor potentials' amplitude. Accurate activation of the primary motor cortex can effectively promote tissue recovery and neurofilament growth, while also increasing the content of some growth-related proteins at the injured site. These findings suggest that selective activation of glutamate neurons in the primary motor cortex may play a significant role in promoting functional recovery after SCI and understanding the neural cell mechanism involved in recovery induced by motor cortex stimulation.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Nelson Johansen, Hongru Hu, Gerald Quon
Summary: Multi-modal single cell RNA assays capture RNA content as well as other data modalities, such as spatial cell position or the electrophysiological properties of cells. Compared to dedicated scRNA-seq assays however, they may unintentionally capture RNA from multiple adjacent cells, exhibit lower RNA sequencing depth compared to scRNA-seq, or lack genome-wide RNA measurements. We present scProjection, a method for mapping individual multi-modal RNA measurements to deeply sequenced scRNA-seq atlases to extract cell type-specific, single cell gene expression profiles. Therefore, scProjection combines the advantages of both multi-modal and scRNA-seq assays to yield precise multi-modal measurements of single cells.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Simon Borgognon, Eric M. Rouiller
Summary: The premotor (PM) and primary motor (M1) cortical areas contribute to the corticorubral pathway that transmits voluntary motor commands. Motor disorders and injuries lead to a decrease in corticorubral projections from PM and M1. The red nucleus may promote functional recovery after spinal cord injury, Parkinson's disease, and primary motor cortex injury by reducing direct cortical influence.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Cell Biology
Marco Bonizzato, Marina Martinez
Summary: Most rehabilitation interventions post-SCI target sublesional spinal networks, but mammalian locomotion involves more than just that. Recovery of cortical control is essential for voluntary movement and gait modulation. Neurostimulation delivered in phase coherence with ongoing locomotion immediately alleviated primary deficits in rats with incomplete SCI.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Ling Guo, Sravani Kondapavulur, Stefan M. Lemke, Seok Joon Won, Karunesh Ganguly
Summary: The study reveals the importance of consistent neural activity patterns across brain structures during recovery poststroke, and suggests that modulation of cross-area coordination can be a therapeutic target for enhancing motor function.
Article
Neurosciences
Arthur Giraidi-Guimaraes, Maira Rezende-Lima, Fernando Pereira Bruno, Rosalia Mendez-Otero
Article
Neurosciences
Andreia de Vasconcelos dos Santos, Juliana da Costa Reis, Bruno Diaz Paredes, Louise Moraes, Arthur Giraldi-Guimaraes, Rosalia Mendez-Otero
Article
Neurosciences
Arthur Giraldi-Guimaraes, Helder Teixeira de Freitas, Barbara de Paula Coelho, Hugo Macedo-Ramos, Rosalia Mendez-Otero, Leny A. Cavalcante, Wagner Baetas-da-Cruz
Article
Neurosciences
Maria de Fatima dos Santos Sampaio, Fralini dos Santos Marcilio, Arthur Giraldi-Guimaraes
Article
Neurosciences
Amelia Miranda Gomes Rodrigues, Fralini dos Santos Marcilio, Michelle Frazao Muzitano, Arthur Giraldi-Guimaraes
Review
Neurosciences
Arthur Giraidi-Guimaraes, Claudia M. C. Batista, Katia Carneiro, Frank Tenorio, Leny A. Cavalcante, Rosalia Mendez-Otero
BRAIN RESEARCH REVIEWS
(2007)
Article
Biochemistry & Molecular Biology
A Giraldi-Guimaraes, R Mendez-Otero
JOURNAL OF CHEMICAL NEUROANATOMY
(2005)
Article
Neurosciences
A Giraldi-Guimaraes, R Mendez-Otero
MOLECULAR BRAIN RESEARCH
(2005)
Article
Biology
A Giraldi-Guimaräes, RE Bittencourt-Navarrete, R Mendez-Otero
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2004)
Article
Developmental Biology
RE de Bittencourt-Navarrete, A Giraldi-Guimaraes, R Mendez-Otero
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2004)
Article
Multidisciplinary Sciences
F Tenório, A Giraldi-Guimaraes, R Mendez-Otero
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2002)
Article
Neurosciences
A Giraldi-Guimaraes, RE De Bittencourt-Navarrete, ICC Nascimento, PR Salazar, D Freitas-Campos, R Mendez-Otero