Novel aspects of excitation–contraction coupling in heart failure

Epac2 Mediates Cardiac β1-Adrenergic–Dependent Sarcoplasmic Reticulum Ca 2+ Leak and Arrhythmia

(2013) Laëtitia Pereira et al.   CIRCULATION

Crucial Role for Ca 2+ /Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation

(2013) Nazha Hamdani et al.   CIRCULATION RESEARCH

Diabetes increases mortality after myocardial infarction by oxidizing CaMKII

(2013) Min Luo et al.   JOURNAL OF CLINICAL INVESTIGATION

While systolic cardiomyocyte function is preserved, diastolic myocyte function and recovery from acidosis are impaired in CaMKIIδ-KO mice

(2013) Stefan Neef et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

RAnoLazIne for the Treatment of Diastolic Heart Failure in Patients With Preserved Ejection Fraction

(2013) Lars S. Maier et al.   JACC-Heart Failure

Cardiac FKBP12.6 overexpression protects against triggered ventricular tachycardia in pressure overloaded mouse hearts

(2012) Laurent Vinet et al.   BASIC RESEARCH IN CARDIOLOGY

Cell-to-cell variability in troponin I phosphorylation in a porcine model of pacing-induced heart failure

(2012) Dániel Czuriga et al.   BASIC RESEARCH IN CARDIOLOGY

Impaired left ventricular function in the presence of preserved ejection in chronic hypertensive conscious pigs

(2012) Mario Rienzo et al.   BASIC RESEARCH IN CARDIOLOGY

Constitutive phosphorylation of inhibitor-1 at Ser67 and Thr75 depresses calcium cycling in cardiomyocytes and leads to remodeling upon aging

(2012) Stela Florea et al.   BASIC RESEARCH IN CARDIOLOGY

JTV519 (K201) reduces sarcoplasmic reticulum Ca2+leak and improves diastolic functionin vitroin murine and human non-failing myocardium

(2012) M Sacherer et al.   BRITISH JOURNAL OF PHARMACOLOGY

New Therapeutic Targets in Cardiology

(2012) Adam G. Rokita et al.   CIRCULATION

Targeted Sarcoplasmic Reticulum Ca 2+ ATPase 2a Gene Delivery to Restore Electrical Stability in the Failing Heart

(2012) Michael J. Cutler et al.   CIRCULATION

Enhanced Sarcoplasmic Reticulum Ca 2+ Leak and Increased Na + -Ca 2+ Exchanger Function Underlie Delayed Afterdepolarizations in Patients With Chronic Atrial Fibrillation

(2012) Niels Voigt et al.   CIRCULATION

Late Sodium Current Inhibition Reverses Electromechanical Dysfunction in Human Hypertrophic Cardiomyopathy

(2012) Raffaele Coppini et al.   CIRCULATION

Ryanodine Receptor S2808 Phosphorylation in Heart Failure

(2012) Donald M. Bers   CIRCULATION RESEARCH

Hyperphosphorylation of the Cardiac Ryanodine Receptor at Serine 2808 Is Not Involved in Cardiac Dysfunction After Myocardial Infarction

(2012) Hongyu Zhang et al.   CIRCULATION RESEARCH

Role of RyR2 Phosphorylation at S2814 During Heart Failure Progression

(2012) Jonathan L. Respress et al.   CIRCULATION RESEARCH

The multidimensional role of calcium in atrial fibrillation pathophysiology: mechanistic insights and therapeutic opportunities

(2012) S. Nattel et al.   EUROPEAN HEART JOURNAL

Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) Regulates Cardiac Sodium Channel NaV1.5 Gating by Multiple Phosphorylation Sites

(2012) Nicole M. Ashpole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular [Na+] modulates synergy between Na+/Ca2+ exchanger and L-type Ca2+ current in cardiac excitation–contraction coupling during action potentials

(2011) Rafael J. Ramirez et al.   BASIC RESEARCH IN CARDIOLOGY

The relationship between arrhythmogenesis and impaired contractility in heart failure: role of altered ryanodine receptor function

(2011) Andriy E. Belevych et al.   CARDIOVASCULAR RESEARCH

Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID)

(2011) Mariell Jessup et al.   CIRCULATION

Systolic and Diastolic Heart Failure Are Overlapping Phenotypes Within the Heart Failure Spectrum

(2011) Gilles W. De Keulenaer et al.   CIRCULATION

Reactive Oxygen Species–Activated Ca/Calmodulin Kinase IIδ Is Required for Late I Na Augmentation Leading to Cellular Na and Ca Overload

(2011) Stefan Wagner et al.   CIRCULATION RESEARCH

CaMKII-dependent SR Ca leak contributes to doxorubicin-induced impaired Ca handling in isolated cardiac myocytes

(2011) Can M. Sag et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Overexpression of CaMKIIδc in RyR2R4496C+/− Knock-In Mice Leads to Altered Intracellular Ca2+ Handling and Increased Mortality

(2011) Nataliya Dybkova et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A Radical View on the Contractile Machinery in Human Heart Failure⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.

(2011) Gerd Heusch et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Oxidation of CaMKII determines the cardiotoxic effects of aldosterone

(2011) B Julie He et al.   NATURE MEDICINE

Diastolic dysfunction and arrhythmias caused by overexpression of CaMKIIδC can be reversed by inhibition of late Na+ current

(2010) Samuel Sossalla et al.   BASIC RESEARCH IN CARDIOLOGY

Differential Cardiac Remodeling in Preload Versus Afterload

(2010) Karl Toischer et al.   CIRCULATION

Heart Rate and Heart Failure

(2010) Gerd Heusch   CIRCULATION JOURNAL

Inhibition of Elevated Ca 2+ /Calmodulin-Dependent Protein Kinase II Improves Contractility in Human Failing Myocardium

(2010) Samuel Sossalla et al.   CIRCULATION RESEARCH

CaMKII-Dependent Diastolic SR Ca 2+ Leak and Elevated Diastolic Ca 2+ Levels in Right Atrial Myocardium of Patients With Atrial Fibrillation

(2010) Stefan Neef et al.   CIRCULATION RESEARCH

A Common MLP (Muscle LIM Protein) Variant Is Associated With Cardiomyopathy

(2010) Ralph Knöll et al.   CIRCULATION RESEARCH

Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice

(2010) Jian Shan et al.   JOURNAL OF CLINICAL INVESTIGATION

A βIV-spectrin/CaMKII signaling complex is essential for membrane excitability in mice

(2010) Thomas J. Hund et al.   JOURNAL OF CLINICAL INVESTIGATION

Limitations of FKBP12.6-directed treatment strategies for maladaptive cardiac remodeling and heart failure

(2010) Tim Seidler et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Altered Na+Currents in Atrial Fibrillation

(2010) Samuel Sossalla et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Risk Factors for Heart Failure: A Population-Based Case-Control Study

(2009) Shannon M. Dunlay et al.   AMERICAN JOURNAL OF MEDICINE

Diastolic heart failure: a misNOmer

(2009) Gerd Heusch   BASIC RESEARCH IN CARDIOLOGY

K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum

(2009) Karl Toischer et al.   BASIC RESEARCH IN CARDIOLOGY

From the Ryanodine Receptor to Cardiac Arrhythmias

(2009) D. A. Eisner et al.   CIRCULATION JOURNAL

Ca/Calmodulin Kinase II Differentially Modulates Potassium Currents

(2009) Stefan Wagner et al.   Circulation-Arrhythmia and Electrophysiology

Calcium/Calmodulin-Dependent Protein Kinase II Contributes to Cardiac Arrhythmogenesis in Heart Failure

(2009) Can M. Sag et al.   Circulation-Heart Failure

Requirement for Ca2+/calmodulin–dependent kinase II in the transition from pressure overload–induced cardiac hypertrophy to heart failure in mice

(2009) Haiyun Ling et al.   JOURNAL OF CLINICAL INVESTIGATION

The   isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload

(2009) J. Backs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes

(2008) Sabine Huke et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation

(2008) Jeffrey R. Erickson et al.   CELL

Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts — Role of late sodium current and intracellular ion accumulation

(2008) Samuel Sossalla et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Heart Failure-Related Hospitalization in the U.S., 1979 to 2004

(2008) Jing Fang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY