Article
Cell Biology
Qing Ye, Quan Liu, Xiaolong Ma, Shuyun Bai, Pengfei Chen, Yichen Zhao, Chen Bai, Yang Liu, Kemin Liu, Meng Xin, Caiwu Zeng, Cheng Zhao, Yan Yao, Yue Ma, Jiangang Wang
Summary: The study revealed the correlation between miR-146b-5p regulation of TIMP4 and atrial fibrosis in AF. Experimental results showed that miR-146b-5p transfection increased collagen synthesis, while inhibition of miR-146b-5p helped reduce cardiac fibrosis phenotypes.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Xixiao Li, Anna Garcia-Elias, Begona Benito, Stanley Nattel
Summary: This article reviews the direct effects of stretch on cardiac fibroblasts, discussing the similarities and differences among studies in observed effects, the signaling pathways involved, and the factors affecting stretch-related phenotypes. The evidence regarding direct fibroblast activation by stretch is deemed weak and inconsistent, and further research is needed to clarify this issue.
CARDIOVASCULAR RESEARCH
(2022)
Article
Physiology
Lisa A. Gottlieb, Fanny Vaillant, Emma Abell, Charly Belterman, Virginie Loyer, Dounia El Hamrani, Jerome Naulin, Marion Constantin, Bruno Quesson, Bastiaan J. Boukens, Ruben Coronel, Lukas R. C. Dekker
Summary: Localized pulmonary vein scar only facilitates the inducibility of atrial fibrillation in combination with increased left atrial pressure. This is associated with changes in tissue excitability remote from the pulmonary vein scar.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Medicine, Research & Experimental
Chang Yi Li, Jing Rui Zhang, Wan Ning Hu, Song Nan Li
Summary: Atrial fibrillation (AF) is closely linked with fibrosis, which is a key factor in structural changes that impact the occurrence and persistence of AF. Despite the complexity of this process, advancements in technology now allow for non-invasive evaluation of fibrosis, facilitating the selection of personalized treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Gregory F. Michaud, William G. Stevenson
Summary: A 63-year-old healthy male with atrial fibrillation presents with symptoms of dyspnea and irregular heartbeat. Physical examination reveals high blood pressure, irregular pulse, and ECG confirms atrial fibrillation. Further evaluation and treatment plan are needed.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Multidisciplinary Sciences
Woo-Keun Kwon, Chang Hwa Ham, Hyuk Choi, Seung Min Baek, Jae Won Lee, Youn-Kwan Park, Hong Joo Moon, Woong Bae Park, Joo Han Kim
Summary: In this study, a novel multi-torsional mechanical stretch stress loading device was developed to investigate the influence of mechanical stress on the development of ligamentum flavum hypertrophy. The results showed that mechanical stress enhanced the production of inflammatory cytokines and angiogenic factors, and altered the expression of ECM-regulating enzymes, suggesting its potential role in triggering ligamentum flavum hypertrophy.
Article
Cardiac & Cardiovascular Systems
Yi Zhang, Ying Qi, Jing-Jing Li, Wen-Jin He, Xiao-Hang Gao, Yu Zhang, Xia Sun, Jie Tong, Jianbao Zhang, Xiu-Ling Deng, Xiao-Jun Du, Wenjun Xie
Summary: This study aimed to investigate the role of diastolic sarcoplasmic reticulum (SR) Ca2+ leak induced by mechanical stretch in atrial myocytes due to elevated pressure in the left atrium (LA) in the development of atrial fibrillation (AF). The results demonstrated that increased SR Ca2+ leak mediated by enhanced oxidative stress in left atrial myocytes is causatively associated with higher AF susceptibility in pressure-overloaded hearts.
CARDIOVASCULAR RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Anna Surowka, Piotr Prowans, Michal Zolnierczuk, Marek Miskiewicz, Tomasz Wawrowski, Marika Skodda, Marta Markowska, Karolina Kedzierska-Kapuza
Summary: This review discusses the role of metalloproteinases in myocardial injury in various diseases, examining changes in their expression and serum levels, as well as the impact of immunosuppressive treatment. The study focuses on the use of calcineurin inhibitors and their potential side effects on the cardiovascular system. The research emphasizes the importance of expanding knowledge on this subject and minimizing negative effects of post-transplant therapy. It also analyzes the effects of specific heart diseases on myocardial remodeling through the involvement of matrix metalloproteinases and their inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Guangling Li, Jing Yang, Demei Zhang, Xiaomei Wang, Jingjing Han, Xueya Guo
Summary: This article explores the importance of myocardial fibrosis in the occurrence and maintenance of atrial fibrillation and discusses the methods of evaluating myocardial fibrosis and the existing issues. The article proposes new ideas for evaluating and treating myocardial fibrosis and atrial fibrillation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Helena Laronha, Ines Carpinteiro, Jaime Portugal, Ana Azul, Mario Polido, Krasimira T. Petrova, Madalena Salema-Oom, Isabel Barahona, Jorge Caldeira
Summary: A new class of MMP inhibitors has been discovered, which can be co-polymerized with other vinyl compounds in commercial dental resins, limiting release and potential toxicity, and increasing safety. These inhibitors show unique properties towards various MMPs and did not significantly decrease cell viability at high concentrations.
Article
Medicine, Research & Experimental
Aneesh Bapat, Guoping Li, Ling Xiao, Ashish Yeri, Maarten Hulsmans, Jana Grune, Masahiro Yamazoe, Maximilian J. Schloss, Yoshiko Iwamoto, Justin Tedeschi, Xinyu Yang, Matthias Nahrendorf, Anthony Rosenzweig, Saumya Das, Patrick T. Ellinor, David Milan
Summary: This study validates the role of SGK1 in obesity-related atrial fibrillation using a mouse model. It demonstrates the impact of SGK1 on atrial electrophysiology, structural remodeling, inflammation, and sodium current in obesity-related AF.
Article
Clinical Neurology
Adnan Mujanovic, Christoph C. Kurmann, Tomas Dobrocky, Marta Olive-Gadea, Christian Maegerlein, Laurent Pierot, Vitor Mendes Pereira, Vincent Costalat, Marios Psychogios, Patrik Michel, Morin Beyeler, Eike I. Piechowiak, David J. Seiffge, Pasquale Mordasini, Marcel Arnold, Jan Gralla, Urs Fischer, Johannes Kaesmacher, Thomas R. Meinel
Summary: This study analyzed the safety and functional outcome of bridging intravenous thrombolysis (IVT) in acute ischemic stroke patients. Patients with atrial fibrillation and those taking oral anticoagulants had a higher risk of intracranial hemorrhage, but receiving bridging IVT was associated with good 90-day outcome.
FRONTIERS IN NEUROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ange Maguy, Yuvaraj Mahendran, Jean-Claude Tardif, David Busseuil, Jin Li
Summary: This study explores the association between autoantibodies targeting cardiac ion channels and unexplained AF. They found a common autoantibody response against K(ir)3.4 protein in patients with AF, even before the development of clinically apparent AF. Functional studies and a mouse model of K(ir)3.4 autoimmunity support the causal relationship between K(ir)3.4 autoantibodies and AF.
Article
Nanoscience & Nanotechnology
Kun Man, Jiafeng Liu, Cindy Liang, Christopher Corona, Michael D. Story, Brian Meckes, Yong Yang
Summary: Determining the mechanistic causes of lung diseases and developing new treatments would benefit from a clinically relevant preclinical human lung alveolar interstitium model. Existing models fail to replicate the key physiological characteristics of human alveoli. A human lung alveolar interstitium chip was developed to imitate the microenvironmental factors of alveoli and showed improved epithelial barrier function compared to transwell models. The chip sustained interstitial integrity and enhanced the epithelial barrier, resulting in a longevity that extended beyond eight weeks. The chip also provided accurate assessment of multiwalled carbon nanotube toxicity.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Cardiac & Cardiovascular Systems
Lisa A. Gottlieb, Ruben Coronel, Lukas R. C. Dekker
Summary: Atrial fibrillation (AF) is a common cardiac arrhythmia associated with increased mortality. Heart failure, hypertension, valvular disease, and obstructive sleep apnea are risk factors for AF as they increase atrial wall stretch. Experimental studies confirm the proarrhythmic effect of atrial stretch, suggesting that targeted reduction of atrial stretch could be a therapeutic target for AF prevention.
Review
Medicine, General & Internal
C. A. Bonfiglio, C. Weber, D. Atzler, E. Lutgens
Summary: Current therapies for cardiovascular disease primarily focus on lipid lowering and face residual risk. Inflammation, along with lipids, plays a significant role in atherosclerosis. Clinical trials targeting the interleukin-1 beta-inflammasome pathway have successfully reduced cardiovascular events but not overall CVD mortality. Novel and improved immunotherapeutics for CVD are eagerly anticipated.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Virginia Egea, Remco Theodorus Adrianus Megens, Donato Santovito, Sarawuth Wantha, Richard Brandl, Wolfgang Siess, Sajjad Khani, Oliver Soehnlein, Alexander Bartelt, Christian Weber, Christian Ries
Summary: let-7f promotes hMSC tropism towards atheromas through the LL-37/FPR2 axis and demonstrates that hMSCs develop a potentially athero-protective signature upon contact with the human plaque environment.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Laura A. Bosmans, Claudia M. van Tiel, Suzanne A. B. M. Aarts, Lisa Willemsen, Jeroen Baardman, Bram W. van Os, Myrthe den Toom, Linda Beckers, David J. Ahern, Johannes H. M. Levels, Aldo Jongejan, Perry D. Moerland, Sanne G. S. Verberk, Jan van den Bossche, Menno M. P. J. de Winther, Christian Weber, Dorothee Atzler, Claudia Monaco, Norbert Gerdes, Annelie Shami, Esther Lutgens
Summary: This study investigates the role of CD40 in atherosclerosis and shows that inhibiting CD40 signaling can reduce atherosclerosis. The researchers used myeloid-specific CD40-deficient mice and found that the absence of CD40 in myeloid cells reduces atherosclerosis and systemic inflammation by preventing pro-inflammatory macrophage polarization.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Christian Heiss, Ana Rodriguez-Mateos, Mariam Bapir, Simon S. Skene, Helmut Sies, Malte Kelm
Summary: This study aims to assess Flow-Mediated Dilation (FMD) values in healthy individuals and provides reference values for cardiovascular health measurement. The study found that FMD values are inversely correlated with age, body mass index (BMI), glucose, cholesterol, and blood pressure. Individuals with higher FMD values are younger and have smaller brachial artery diameter, lower blood pressure and cholesterol. Comparisons with coronary artery disease (CAD) patients also showed that FMD values can be used to exclude cardiovascular disease and determine the health status. The meta-analysis results showed that the average FMD in healthy individuals is 6.4%, with a decline trend associated with age.
CARDIOVASCULAR RESEARCH
(2023)
Article
Hematology
Christian Weber, Xavier Blanchet, Gregory Y. H. Lip
THROMBOSIS AND HAEMOSTASIS
(2023)
Editorial Material
Hematology
Gregory Y. H. Lip, Anne Rigby, Christian Weber
THROMBOSIS AND HAEMOSTASIS
(2023)
Review
Cell Biology
Sarajo K. Mohanta, Changjun Yin, Christian Weber, Andreas J. R. Habenicht
Summary: Two pairs of biological systems, namely the nervous and vascular systems, and the nervous and immune systems, have been defined as major participants in the regulation of physiological and pathological tissue reactions. The interactions between these systems have led to the concepts of neurovascular link and neuroimmunology. Recent studies on atherosclerosis have proposed the concept of neuroimmune cardiovascular interfaces (NICIs), which involve complex crosstalks between the nervous system, immune system, and cardiovascular system.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Emiel P. C. van der Vorst, Sanne L. Maas, Kosta Theodorou, Linsey J. F. Peters, Han Jin, Timo Rademakers, Marion J. Gijbels, Mat Rousch, Yvonne Jansen, Christian Weber, Michael Lehrke, Corinna Lebherz, Daniela Yildiz, Andreas Ludwig, Jacob F. Bentzon, Erik A. L. Biessen, Marjo M. P. C. Donners
Summary: This study demonstrates that endothelial ADAM10 plays a protective role in the development of murine atherosclerosis, primarily by limiting inflammation induced by oxidized low-density lipoprotein (oxLDL). The findings provide novel opportunities for treating atherosclerosis progression, but caution should be exercised when considering the use of ADAM10 inhibitors for therapy in other diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Selcan Kahveci-Tuerkoez, Katharina Blaesius, Justyna Wozniak, Cindy Rinkens, Anke Seifert, Petr Kasparek, Henrike Ohm, Shixin Oltzen, Martin Nieszporek, Nicole Schwarz, Aaron Babendreyer, Christian Preisinger, Radislav Sedlacek, Andreas Ludwig, Stefan Duesterhoeft
Summary: The structure-function relationship of the iRhom-ADAM17 complex is poorly understood. Using AI-based modelling, the researchers identified different regions in the iRhom homology domain (IRHD) that contribute differently to iRhom functions. Through various experiments, the predicted structure-function determinants were validated, and the regulatory role of IRHD in the cohesion and forward trafficking of the iRhom-ADAM17 complex was demonstrated. Overall, this study provides mechanistic insights into the shedding event mediated by iRhom-ADAM17, which is crucial for multiple cytokine and growth factor pathways.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Materials Science, Biomaterials
Ramin Nasehi, Jana Schieren, Caroline Grannemann, Alena L. Palkowitz, Aaron Babendreyer, Nicole Schwarz, Sanja Aveic, Andreas Ludwig, Rudolf E. Leube, Horst Fischer
Summary: The modality of hydrostatic pressure during nozzle-based bioprinting affects the biological response of processed cells differently. Pulsatile hydrostatic pressure leads to an immediate increase of intracellular ATP in both endothelial and epithelial cells. Bioprinting-associated hydrostatic pressure triggers a pro-inflammatory response in endothelial cells but not in epithelial cells.
BIOMATERIALS ADVANCES
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Tobias Zeus, Artur Lichtenberg, Malte Kelm
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Stephan Sachs, Anna Goetz, Brian Finan, Annette Feuchtinger, Richard D. DiMarchi, Yvonne Doering, Christian Weber, Matthias H. Tschoep, Timo D. Mueller, Susanna M. Hofmann
Summary: Long-acting acylated GIP analog (acyl-GIP) treatment can improve dyslipidemia and atherosclerosis independently of body weight loss. This treatment may improve dyslipidemia by directly modulating lipid metabolism in the inguinal fat depot.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cell Biology
Simon Ebert, Lan Zang, Noor Ismail, Michael Otabil, Adrian Frohlich, Virginia Egea, Susann Acs, Mikkel Hoeberg, Marie-Luise Berres, Christian Weber, Jose M. A. Moreira, Christian Ries, Juergen Bernhagen, Omar El Bounkari
Summary: TIMP-1 interacts with CD74 to regulate vascular inflammation and atherosclerosis. TIMP-1 binding to CD74 promotes monocyte migration and vascular smooth muscle cell proliferation, playing a crucial role in vascular inflammation and atherosclerosis.
Article
Cell Biology
Sarajo K. Mohanta, Ting Sun, Shu Lu, Zhihua Wang, Xi Zhang, Changjun Yin, Christian Weber, Andreas J. R. Habenicht
Summary: The nervous, immune, and cardiovascular systems form a tissue network that regulate cardiovascular function. The different systems interact with each other, and further research may lead to new therapies for cardiovascular diseases.
Editorial Material
Cardiac & Cardiovascular Systems
Maximilian Spieker, Malte Kelm, Verena Veulemans
EUROPEAN HEART JOURNAL-CASE REPORTS
(2023)