Selenium Cytotoxicity in Cancer

Selenium induces a multi-targeted cell death process in addition to ROS formation

(2014) Marita Wallenberg et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Contribution of Selenocysteine to the Peroxidase Activity of Selenoprotein S

(2013) Jun Liu et al.   BIOCHEMISTRY

Metabolism of selenite to selenosugar and trimethylselenonium in vivo: tissue dependency and requirement for S-adenosylmethionine-dependent methylation

(2013) Matthew I. Jackson et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Selenate inhibits adipogenesis through induction of transforming growth factor-β1 (TGF-β1) signaling

(2012) Choon Young Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The role of mitochondria in cellular iron–sulfur protein biogenesis and iron metabolism

(2012) Roland Lill et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Methylselenol Formed by Spontaneous Methylation of Selenide Is a Superior Selenium Substrate to the Thioredoxin and Glutaredoxin Systems

(2012) Aristi P. Fernandes et al.   PLoS One

Autophagy inhibition through PI3K/Akt increases apoptosis by sodium selenite in NB4 cells

(2011) Yun Ren et al.   BMB Reports

Redox regulation of calcium ion channels: Chemical and physiological aspects

(2011) Ivan Bogeski et al.   CELL CALCIUM

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Selenoprotein K Binds Multiprotein Complexes and Is Involved in the Regulation of Endoplasmic Reticulum Homeostasis

(2011) Valentina A. Shchedrina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selenium compounds are substrates for glutaredoxins: a novel pathway for selenium metabolism and a potential mechanism for selenium-mediated cytotoxicity

(2010) Marita Wallenberg et al.   BIOCHEMICAL JOURNAL

Rapamycin suppresses ROS-dependent apoptosis caused by selenomethionine in A549 lung carcinoma cells

(2010) Maiko Suzuki et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

β-Catenin/TCF pathway plays a vital role in selenium induced-growth inhibition and apoptosis in esophageal squamous cell carcinoma (ESCC) cells

(2010) Wei Zhang et al.   CANCER LETTERS

Selenium Compounds Activate Early Barriers of Tumorigenesis

(2010) Min Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparison of different selenocompounds with respect to nutritional value vs. toxicity using liver cells in culture

(2010) Carolin S. Hoefig et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Iron–sulfur proteins in health and disease

(2010) Alex Sheftel et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Exposure of human leukemia NB4 cells to increasing concentrations of selenite switches the signaling from pro-survival to pro-apoptosis

(2009) Liying Guan et al.   ANNALS OF HEMATOLOGY

Structure–Function Relations, Physiological Roles, and Evolution of Mammalian ER-Resident Selenoproteins

(2009) Valentina A. Shchedrina et al.   ANTIOXIDANTS & REDOX SIGNALING

Selenium and the Selenoprotein Thioredoxin Reductase in the Prevention, Treatment and Diagnostics of Cancer

(2009) Markus Selenius et al.   ANTIOXIDANTS & REDOX SIGNALING

Differential apoptotic response of human cancer cells to organoselenium compounds

(2009) Maiko Suzuki et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Selenite induces redox-dependent Bax activation and apoptosis in colorectal cancer cells

(2009) Fang Huang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Extracellular thiol-assisted selenium uptake dependent on the xc- cystine transporter explains the cancer-specific cytotoxicity of selenite

(2009) E. Olm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thiol-Based Redox Switches in Eukaryotic Proteins

(2008) Nicolas Brandes et al.   ANTIOXIDANTS & REDOX SIGNALING

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

Selenocystine Induces S-Phase Arrest and Apoptosis in Human Breast Adenocarcinoma MCF-7 Cells by Modulating ERK and Akt Phosphorylation

(2008) Tianfeng Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Methylation and demethylation of intermediates selenide and methylselenol in the metabolism of selenium

(2007) Yuki Ohta et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY