Article
Multidisciplinary Sciences
Alex Straiker, Michaela Dvorakova, Taryn Bosquez-Berger, Jaroslav Blahos, Ken Mackie
Summary: Autaptic hippocampal neurons are a simple model for studying neurotransmission and cannabinoid signaling. Through our research, we have discovered interesting negative findings in these neurons, which we hope will benefit other laboratories and lead to discussions on their relevance and significance.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Diane M. Bogdan, Keith Studholme, Adriana DiBua, Chris Gordon, Martha P. Kanjiya, Mei Yu, Michelino Puopolo, Martin Kaczocha
Summary: The endocannabinoid anandamide can produce both anti-pain effects and exacerbate pain. FABP5 plays a key role in regulating the levels of endocannabinoids in nociceptors, affecting pain perception. Decreasing the expression of FABP5 can increase the levels of endocannabinoids, leading to anti-pain effects.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Carol A. Gianessi, Stephanie M. Groman, Jane R. Taylor
Summary: Emerging data suggest that endocannabinoid signaling is crucial for habitual behavior formation, and inhibiting FAAH and MAGL disrupts habit formation while AM251 exposure affects response rates. Further studies are needed to clarify the role of CB1R signaling in habitual responding and the potential clinical utility of augmenting endocannabinoids.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Veterinary Sciences
Vikram Thakur, Mohammad Bashashati, Josue Enriquez, Munmun Chattopadhyay
Summary: This study assessed specific gastrointestinal symptoms in Type 1 diabetic mice and evaluated treatment options for this condition. The results showed that inhibiting endocannabinoid degradation may have a therapeutic effect on gastrointestinal dysmotility.
VETERINARY SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Diego A. Rodriguez-Soacha, Sophie A. M. Steinmueller, Ali Isbilir, Julia Fender, Marie H. Deventer, Yesid A. Ramirez, Anna Tutov, Christoph Sotriffer, Christophe P. Stove, Kristina Lorenz, Martin J. Lohse, James N. Hislop, Michael Decker
Summary: This study synthesized new agonist ligands for hCB1R through the design of different classes of photoswitchable molecules, evaluated their mechanisms of action and pharmacological properties through various experimental methods, providing a new molecular tool for studying the role of cannabinoid receptors in related diseases.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Anesthesiology
Richard A. Slivicki, Jiwon Yi, Victoria E. Brings, Phuong Nhu Huynh, Robert W. Gereau
Summary: The study found that CB-13 can alleviate pain induced by inflammation in a peripheral CB1 receptor-dependent manner, but repeated dosing may lead to analgesic tolerance and unwanted central nervous system effects.
Article
Biochemistry & Molecular Biology
Diego A. Rodriguez-Soacha, Sophie A. M. Steinmueller, Ali Isbilir, Julia Fender, Marie H. Deventer, Yesid A. Ramirez, Anna Tutov, Christoph Sotriffer, Christophe P. Stove, Kristina Lorenz, Martin J. Lohse, James N. Hislop, Michael Decker
Summary: This study designed a series of photoswitchable molecules based on an indole core for synthesizing new agonist ligands for the human cannabinoid receptor type 1 (hCB1R). Compound 27a showed high affinity for CB1R and exhibited marked affinity difference compared to its inactive form. The novel agonist 27a can be used to optically modulate cannabinoid receptors and investigate disorders associated with the endocannabinoid system.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Veterinary Sciences
Rodrigo Zamith Cunha, Augusta Zannoni, Giulia Salamanca, Margherita De Silva, Riccardo Rinnovati, Alessandro Gramenzi, Monica Forni, Roberto Chiocchetti
Summary: The study found that the CB1R, CB2R, TRPV1, GPR55, and PPAR alpha receptors are present in the synovial cells of the metacarpophalangeal joint. These findings suggest that targeting these receptors could be a potential therapeutic approach for reducing joint inflammation in horses.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Shira Hirsch, Liad Hinden, Meital Ben -David Naim, Saja Baraghithy, Anna Permyakova, Shahar Azar, Taher Nasser, Emma Portnoy, Majd Agbaria, Alina Nemirovski, Gershon Golomb, Joseph Tam
Summary: The overactivation of the endocannabinoid/CB1R system is a key feature of obesity and its related diseases. However, the use of drugs to block CB1R has been limited by their adverse effects. In this study, a nanotechnology-based drug delivery system was developed to encapsulate a CB1R antagonist for targeted treatment of obesity-related diseases.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Vaishali Satpute Janve, Lyndsey L. Anderson, Dilara Bahceci, Nicole A. Hawkins, Jennifer A. Kearney, Jonathon C. Arnold
Summary: Trpv1 may act as a genetic modifier in the DS model of mice, but its viability as an anticonvulsant drug target in DS is questionable.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alessandro Grillo, Filomena Fezza, Giulia Chemi, Roberto Colangeli, Simone Brogi, Domenico Fazio, Stefano Federico, Alessandro Papa, Nicola Relitti, Roberto Di Maio, Gianluca Giorgi, Stefania Lamponi, Massimo Valoti, Beatrice Gorelli, Simona Saponara, Mascia Benedusi, Alessandra Pecorelli, Patrizia Minetti, Giuseppe Valacchi, Stefania Butini, Giuseppe Campiani, Sandra Gemma, Mauro Maccarrone, Giuseppe Di Giovanni
Summary: Research has discovered new FAAH inhibitors with promising antiepileptic efficacy and devoid of psychotropic effects. These inhibitors showed good results in animal models, prompting further investigation for potential new antiepileptic agents.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Neurosciences
Shirley Alteba, Anna Portugalov, Cecilia J. Hillard, Irit Akirav
Summary: Early-life stress and early cannabis use may increase the risk of psychopathologies, affecting behavior in male and female rats. Chronic FAAH inhibition during mid-adolescence did not prevent the long-term effects of ELS on behavior, while it ameliorated ELS-induced depression and anxiety-like behavior during late-adolescence. Sex-dependent alterations in CB1 receptors and GRs expression in the BLA-PFC-CA1 circuit may contribute to the depressive behavioral phenotype.
Review
Behavioral Sciences
Willian Lazarini-Lopes, Gleice Kelli Silva-Cardoso
Summary: This study reviewed the neuroplastic changes in CB1 distribution, expression, and functionality in animal models of epileptic seizures, and discussed the relationship between CB1 alteration and the control of brain excitability. A better comprehension of neuroplastic and functional alterations in CB1 can improve pharmacological therapies for epilepsies.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Eric Sparkes, Elizabeth A. Cairns, Richard C. Kevin, Felcia Lai, Katharina Elisabeth Grafinger, Shuli Chen, Marie H. Deventer, Ross Ellison, Rochelle Boyd, Lewis J. Martin, Iain S. McGregor, Roy R. Gerona, David E. Hibbs, Volker Auwaerter, Michelle Glass, Christophe Stove, Samuel D. Banister
Summary: Synthetic cannabinoid receptor agonists exhibit high affinity and potency for CB1 and CB2 receptors, with different cannabimimetic activities in vivo. Structure-activity relationships (SARs) were identified for binding and functional activities at CB1 and CB2 receptors, providing insights into the pharmacological properties of these compounds.
RSC MEDICINAL CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Boyd R. Rorabaugh, Josee Guindon, Daniel J. Morgan
Summary: Cardiovascular disease is a leading cause of death, and the increasing use of cannabis raises the need to understand its effects and risks on cardiovascular health. This review explores the role of cannabinoid receptors in atherosclerosis and myocardial ischemia, and their potential as therapeutic targets for ischemic heart disease.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2023)
Editorial Material
Neurosciences
Antonio Carlos Pinheiro de Oliveira, Fabricio A. Moreira, Bernd L. Fiebich
Summary: The research demonstrates the permissive role of CB2 receptors in microglia activation mediated by TLRs. The findings suggest that signaling pathways downstream of both CB2 and TLRs converge in microglia cells.
TRENDS IN NEUROSCIENCES
(2022)
Article
Behavioral Sciences
Larissa Altoe Reboli, Renato Marciano Maciel, Jasiara Carla de Oliveira, Marcio Flavio Dutra Moraes, Cristiane Queixa Tilelli, Vinicius Rosa Cota
Summary: This study investigated the effects of nonperiodic stimulation (NPS) on neural function in animals. Results from behavioral tests and electrophysiological recordings showed that NPS did not impair neural function and may be safe for clinical studies. Additionally, the study found that NPS may have a desynchronization effect by competing with epileptic activity, which has implications for understanding neuropsychological phenomena and developing rehabilitation neurotechnology.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Flavio Afonso Goncalves Mourao, Leonardo de Oliveira Guarnieri, Paulo Aparecido Amaral Junior, Vinicius Rezende Carvalho, Eduardo Mazoni Andrade Marcal Mendes, Marcio Flavio Dutra Moraes
Summary: In this study, a new method for implanting multiple tungsten electrode arrays in the brain was described. The researchers also developed a low-cost headstage system that allows high-quality multichannel recording. This method provides a valuable alternative for small laboratories and developing countries.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Immunology
Magda L. P. Rosa, Caroline A. Machado, Laila Asth, Eliana C. B. Toscano, Bruna da Silva Oliveira, Lucas A. S. Marzano, Rodrigo N. Ferreira, Antonio L. Teixeira, Fabrico A. Moreira, Aline S. Miranda
Summary: This study investigates the influence of apparatus type on cocaine-induced conditioned place preference (CPP) and suggests that the three-compartment apparatus may be a more appropriate model to study the neuroinflammatory response related to cocaine addiction.
JOURNAL OF NEUROIMMUNOLOGY
(2022)
Review
Neurosciences
P. H. Gobira, S. R. Joca, F. A. Moreira
Summary: Addiction to psychostimulant drugs is a significant public health issue and cannabinoid receptors CB1R and CB2R play a crucial role in modulating the rewarding effects of these drugs. This review summarizes studies on pharmacological intervention targeting CB1R and CB2R and their interaction in psychostimulant responses.
ACTA NEUROPSYCHIATRICA
(2022)
Review
Neurosciences
Laila Asth, Leonardo Cardoso Cruz, Nicholas Soyombo, Pedro Rigo, Fabricio A. Moreira
Summary: This study investigates the potential of beta-caryophyllene (BCP) as a new drug for the treatment of substance use disorders in animal models. The results show that BCP can prevent or reverse behavioral changes resulting from drug exposure. The mechanism involves activation of the CB2 receptor and potentially other targets. Further research, including studies in humans, is needed to establish its therapeutic potential and mechanisms of action.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Anna Paula Marcal, Nicia Soares, Laila Asth, Fabricio A. Moreira, Adaliene V. M. Ferreira, Daniele C. Aguiar
Summary: This study investigated the effects of cannabidiol (CBD) treatment on behavior problems induced by a high-refined carbohydrate diet. The results demonstrated that sub-chronic treatment with CBD could alleviate the compulsive-like and anxiogenic-like behavior caused by long-term consumption of a high-refined carbohydrate diet.
METABOLIC BRAIN DISEASE
(2022)
Article
Neurosciences
Lia P. Iglesias, Heliana B. Fernandes, Aline S. de Miranda, Malena M. Perez, Lucia H. Faccioli, Carlos A. Sorgi, Leandro J. Bertoglio, Daniele C. Aguiar, Carsten T. Wotjak, Fabricio A. Moreira
Summary: This study found that hippocampal TRPV1 channels play a role in the modulation of fear memories. Endocannabinoid signaling may mediate the effects of TRPV1 blockers. The intensity of the aversive stimulus affects the regulation of fear memories by TRPV1 channels. TRPV1 blockers also promote the transcription of specific genes, leading to a decrease in fear memory reinstatement.
Article
Pharmacology & Pharmacy
Isabel Vieira de Assis Lima, Hyorrana Priscila Pereira Pinto, Paula Maria Quaglio Bellozi, Maria Carolina Machado da Silva, Luciano R. Vilela, Fabricio A. Moreira, Marcio Flavio Dutra Moraes, Antonio Carlos Pinheiro de Oliveira
Summary: The study suggests that the anticonvulsant effect of CBD requires the involvement of the PI3K signaling pathway. In a seizure model induced by PTZ in mice, genetic ablation of PI3K increased seizure duration and frequency, while CBD inhibited PTZ-induced seizures. Genetic deletion of PI3K or pretreatment with the selective inhibitor LY294002 prevented the anticonvulsant effects of CBD.
PHARMACOLOGICAL REPORTS
(2022)
Editorial Material
Neurosciences
Vinicius Rosa Cota, Marcio Flavio Dutra Moraes
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Neurosciences
Maria Carolina Machado da Silva, Lia Parada Iglesias, Eduardo Candelario-Jalil, Habibeh Khoshbouei, Fabricio Araujo Moreira, Antonio Carlos Pinheiro de Oliveira
Summary: The use of psychostimulant drugs can modify brain function by affecting the reward system and altering dopaminergic and glutamatergic transmissions. Microglia and other immune cells may play a role in addiction by influencing neuroplasticity and memory. Recent studies have shown that psychoactive substances can directly affect immune cells, leading to changes in their functions and the release of inflammatory mediators that impact synaptic activity. Understanding the neuroimmune axis involved in addiction can provide potential targets for pharmacotherapy.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Neurosciences
Rayssa C. Brianis, Lia P. Iglesias, Lucas G. Bedeschi, Fabricio A. Moreira
Summary: This study found that CBD did not decrease the reward memory involved in the formation of cocaine addiction. Further research is needed to investigate the involvement of CBD in other behavioral responses to cocaine and other psychostimulant drugs. However, this study characterized a 5-day CPP protocol for both female and male C57BL/6J mice.
ACTA NEUROPSYCHIATRICA
(2023)
Article
Neurosciences
Daniel de Castro Medeiros, Carina Plewnia, Renan Viana Mendes, Clarissa Anna Pisano, Laura Boi, Marcio Flavio Dutra Moraes, Cleiton Lopes Aguiar, Gilberto Fisone
Summary: Excessive daytime sleepiness (EDS) and sleep fragmentation are common in Parkinson's disease (PD) patients, but their mechanisms are not well understood. This study used a mouse model of PD to investigate these sleep disorders and tested the effects of dopamine replacement therapy. The results showed that a dopamine receptor agonist could alleviate EDS in PD mice, suggesting the involvement of impaired dopamine D2/D3 receptor transmission in EDS.
PROGRESS IN NEUROBIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Lia P. Iglesias, Lucas Bedeschi, Daniele C. Aguiar, Laila Asth, Fabricio A. Moreira
Summary: Delta(9)-THC and related cannabinoids have complex effects on anxiety-like behavior in humans and experimental animals. This study reviews previous research and finds that cannabinoids tend to reduce anxiety-like behavior at low doses, but can increase anxiety at high doses.
CANNABIS AND CANNABINOID RESEARCH
(2023)
