Journal
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
Volume 114, Issue 1, Pages 92-96Publisher
WILEY
DOI: 10.1111/bcpt.12116
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Funding
- Deutsche Forschungsgemeinschaft [GRK757, GRK1172, CEF EXC115]
- Else Kroner-Fresenius Foundation
- LOEWE Schwerpunkt Anwendungsorientierte Arzneimittelforschung (Fraunhofer-TMP)
- LOEWE Center for Cell and Gene Therapy Frankfurt (CGT Frankfurt)
- Aventis Foundation
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MicroRNAs (miRNAs) have emerged as important regulators in human physiological and pathological processes. We summarize the current knowledge about the role of miRNA involved in the control of inflammatory responses with a special focus on eicosanoid signalling. Cyclooxygenase 2 - the key enzyme of the prostanoid pathway - is regulated by different miRNAs such as miRNA-101, miR199a, miR26b and miR-146a. In contrast to this, the understanding of miRNA regulation on enzymes of the leukotriene biosynthesis is just at the beginning. The knowledge of miRNAs regulating enzymes of the eicosanoid pathway offers a new way for the development of new therapeutic concepts for the treatment of inflammatory diseases.
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