Article
Multidisciplinary Sciences
Tobias Benkel, Mirjam Zimmermann, Julian Zeiner, Sergi Bravo, Nicole Merten, Victor Jun Yu Lim, Edda Sofie Fabienne Matthees, Julia Drube, Elke Miess-Tanneberg, Daniela Malan, Martyna Szpakowska, Stefania Monteleone, Jak Grimes, Zsombor Koszegi, Yann Lanoiselee, Shannon O'Brien, Nikoleta Pavlaki, Nadine Dobberstein, Asuka Inoue, Viacheslav Nikolaev, Davide Calebiro, Andy Chevigne, Philipp Sasse, Stefan Schulz, Carsten Hoffmann, Peter Kolb, Maria Waldhoer, Katharina Simon, Jesus Gomeza, Evi Kostenis
Summary: This study provides an alternative mechanism for carvedilol's cellular signaling, demonstrating that G proteins drive all detectable signals through beta(2)-adrenoceptors.
NATURE COMMUNICATIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Qingtong Wang, Ying Wang, Toni M. West, Yongming Liu, Gopireddy R. Reddy, Federica Barbagallo, Bing Xu, Qian Shi, Bingqing Deng, Wei Wei, Yang K. Xiang
Summary: By studying the molecular signaling and positive cardiac contractility induced by beta-blockers in the heart, it was found that carvedilol can promote cardiac inotropy and have a protective effect in diabetic mice. The observations suggest a novel beta(1)AR-NOS3 signaling pathway that may be targeted in therapy for heart diseases with reduced ejection fraction.
CARDIOVASCULAR RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Peyton B. Sandroni, Kelsey H. Fisher-Wellman, Brian C. Jensen
Summary: This article reviews recent studies demonstrating the differential regulation of cardiac contractility by alpha 1- and beta-ARs in cardiomyocytes, with evidence suggesting that alpha 1-ARs may mitigate the deleterious effects of chronic beta-AR activation.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Qingtong Wang, Ying Wang, Toni M. West, Yongming Liu, Gopireddy R. Reddy, Federica Barbagallo, Bing Xu, Qian Shi, Bingqing Deng, Wei Wei, Yang K. Xiang
Summary: The study investigated the molecular signaling and effects of beta-blockers on cardiac inotropy in animal hearts. The results showed that carvedilol, a beta-blocker, can promote cardiac contractility through a specific signaling pathway, restoring heart function in diabetic mice and reducing cell apoptosis and hypertrophy in diabetic hearts.
CARDIOVASCULAR RESEARCH
(2021)
Article
Medicine, Research & Experimental
Xuemei Wei, Andi Zhang, Wenbo Yang, Yuehua Fang
Summary: Depletion of ADRB3 alleviates pressure overload-induced cardiac hypertrophy and heart failure by enhancing the innate immune response in the heart, as demonstrated in a study using ADRB3-knockout mice undergoing TAC surgery.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Ann-Kathrin Rahm, Juline Hackbarth, Mara E. Mueller, Julia Pfeiffer, Heike Gampp, Finn Petersenn, Rasmus Rivinius, Norbert Frey, Patrick Lugenbiel, Dierk Thomas, Anindita Das
Summary: Cardiac K(v)4.3 channels contribute to the transient outward K+ current, I-to, during early repolarization of the cardiac action potential. Different isoforms of K(v)4.3 in the human ventricle exhibit differential remodeling in heart failure. This study explores the pharmacological effects of betablockers on the two K(v)4.3 isoforms to potentially develop isoform-specific therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Annika M. A. Berends, Mathieu S. Bolhuis, Ilja M. Nolte, Edward Buitenwerf, Thera P. Links, Henri J. L. M. Timmers, Richard A. Feelders, Elisabeth M. W. Eekhoff, Eleonora P. M. Corssmit, Peter H. Bisschop, Harm R. Haak, Ron H. N. van Schaik, Samira El Bouazzaoui, Bob Wilffert, Michiel N. Kerstens
Summary: Genetic variability of alpha-adrenergic receptor genes might be associated with the clinically observed variation in beneficial and adverse therapeutic drug responses to alpha-adrenergic receptor blockers. Further studies are needed to confirm these observations.
Article
Cardiac & Cardiovascular Systems
Filip Berisha, Konrad R. Goetz, Joerg W. Wegener, Soeren Brandenburg, Hariharan Subramanian, Cristina E. Molina, Andre Ruffer, Johannes Petersen, Alexander Bernhardt, Evaldas Girdauskas, Christiane Jungen, Ulrike Pape, Axel E. Kraft, Svenja Warnke, Diana Lindner, Dirk Westermann, Stefan Blankenberg, Christian Meyer, Gerd Hasenfuss, Stephan E. Lehnart, Viacheslav O. Nikolaev
Summary: This study established a real-time live-cell imaging approach to visualize cAMP levels in the vicinity of cardiac RyR2 in mouse and human failing cardiomyocytes under beta-AR stimulation. The findings revealed a subcellular redistribution of PDEs in cardiac hypertrophy, along with increased beta(2)-AR-dependent RyR2 phosphorylation, sarcoplasmic reticulum calcium leak, and arrhythmia susceptibility in failing mouse and human myocytes. This imaging approach may uncover potential antiarrhythmic targets for heart failure.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Lintong Men, Junyi Guo, Yu Cao, Bingyu Huang, Qian Wang, Shengqi Huo, Moran Wang, Dewei Peng, Lulu Peng, Wei Shi, Sheng Li, Li Lin, Jiagao Lv
Summary: Prolonged activation of PERK branch of UPR promotes cardiomyocytes apoptosis in response to chronic β-adrenergic stimulation. STAT3 plays a critical role in β-adrenergic functions in the heart. This study aimed to investigate whether STAT3 contributed to β-adrenoceptor-mediated PERK activation and how β-adrenergic signaling activates STAT3. Results showed that PERK phosphorylation was positively associated with STAT3 activation. Stimulation with isoproterenol produced an increase in IL-6 level and IL-6/gp130 signaling was involved in STAT3 and PERK activation.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Chemistry, Applied
Qonita Kurnia Anjani, Akmal Hidayat Bin Sabri, Khuriah Abdul Hamid, Natalia Moreno-Castellanos, Huanhuan Li, Ryan F. Donnelly
Summary: This study developed tip microarray patches (MAPs) composed of ternary cyclodextrin (CD) complexes of carvedilol for transdermal delivery. The MAPs achieved a delivery depth of 600μm and the needle dissolved within 2 hours. In rats, the MAPs showed higher AUC levels of carvedilol than oral administration, with sustained plasma levels over several days.
CARBOHYDRATE POLYMERS
(2023)
Article
Cardiac & Cardiovascular Systems
Miles A. Tanner, Charles A. Maitz, Laurel A. Grisanti
Summary: This study demonstrates the important role of immune cell beta(2)AR in regulating inflammation and cardiac function in response to chronic catecholamine elevations. Mice lacking immune cell beta(2)AR showed decreased immune cell infiltration and improved cardiac outcomes when exposed to beta AR agonist isoproterenol. The findings suggest that beta(2)AR regulation of immune responses is crucial for the heart's response to prolonged beta adrenergic stimulation.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Zhiyuan Guan, Wanqiong Yuan, Jialin Jia, Chenggui Zhang, Junxiong Zhu, Jie Huang, Wang Zhang, Dongwei Fan, Huijie Leng, Zijian Li, Yingsheng Xu, Chunli Song
Summary: The present study supports the relationship between heart failure and bone loss, and suggests that excessive activation of sympathetic nerves contributes to this pathophysiological process. It provides a potential pathological mechanism of heart failure-related osteoporosis and new perspectives for developing strategies to address bone loss associated with heart failure.
Article
Biochemistry & Molecular Biology
Jennifer Maning, Victoria L. Desimine, Celina M. Pollard, Jennifer Ghandour, Anastasios Lymperopoulos
Summary: Carvedilol, but not metoprolol, can stimulate beta arrestin2-mediated SERCA2a SUMOylation and activity, leading to enhanced cardiac contractility. However, this effect may be opposed or masked by carvedilol-bound beta(2)AR subtype signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Shingo Takahara, Shubham Soni, Zaid H. Maayah, Mourad Ferdaoussi, Jason R. B. Dyck
Summary: When circulating glucose levels are depleted, the heart may rely on ketone bodies as an alternative energy source, which can also suppress inflammation. Therefore, increasing circulating ketones may be beneficial for the treatment of heart failure.
CARDIOVASCULAR RESEARCH
(2022)
Review
Cell Biology
Leonardo Bencivenga, Maria Emiliana Palaia, Immacolata Sepe, Giuseppina Gambino, Klara Komici, Alessandro Cannavo, Grazia Daniela Femminella, Giuseppe Rengo
Summary: Heart failure is the end-stage condition of various cardiovascular diseases, characterized by reduced myocardial pump function and increased pressure load, with neurohormonal dysregulation and high activity of ANS playing a negative role in its progression. Techniques for assessing cardiac ANS are limited in clinical practice, but biomarkers related to ANS activity could potentially support clinical management. Lymphocyte G-protein-coupled Receptor Kinase 2 (GRK2) levels reflect myocardial beta-adrenergic receptor function in HF and provide independent prognostic information related to ANS overdrive.
Review
Cardiac & Cardiovascular Systems
Damian Gatica, Mario Chiong, Sergio Lavandero, Daniel J. Klionsky
Summary: Macroautophagy/autophagy is a crucial cellular process involved in catabolic recycling, and dysregulation of autophagy is associated with cardiovascular diseases.
CARDIOVASCULAR RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Guangyu Zhang, Xiaoding Wang, Beverly A. Rothermel, Sergio Lavandero, Zhao Wang
Summary: Ischemic diseases, such as myocardial infarction and stroke, are among the deadliest and most disabling illnesses. The integrated stress response (ISR) plays a critical role in the pathogenesis and progression of ischemic diseases, making it a promising therapeutic target for alleviating symptoms and improving clinical outcomes of ischemic diseases such as ischemic heart disease, brain ischemia, ischemic liver disease, and ischemic kidney disease.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Cell Biology
David Mondaca-Ruff, Clara Quiroga, Ignacio Norambuena-Soto, Jaime A. Riquelme, Alejandra San Martin, Mario Bustamante, Sergio Lavandero, Mario Chiong
Summary: This study found that Ang II may regulate autophagy in VSMCs by transcriptional and translational mechanisms, increasing total LC3 content and LC3 processing. Additionally, Bag3 regulates Ang II-induced autophagy in VSMCs through the AT1R/ROCK signaling pathway.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Claudia Sepulveda-Quinenao, Juan M. Rodriguez, Francisco Diaz-Castro, Andrea del Campo, Roberto Bravo-Sagua, Rodrigo Troncoso
Summary: The study investigates the impact of glucocorticoid receptor beta on glucose uptake and storage in hepatocytes, showing that GR beta overexpression inhibits the induction of gluconeogenic genes by dexamethasone and has insulin-like actions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Alejandro Gonzalez-Candia, Alejandro A. Candia, Adolfo Paz, Fuad Mobarec, Rodrigo Urbina-Varela, Andrea del Campo, Emilio A. Herrera, Rodrigo L. Castillo
Summary: This study aims to investigate the response of cardiac function in a rat model to intermittent hypobaric hypoxia (IHH) exposure. The results demonstrate that IHH exposure improves cardiac function and reduces oxidative stress levels.
Letter
Cardiac & Cardiovascular Systems
Dan Tong, Gabriele G. Schiattarella, Nan Jiang, Daniel Daou, Yuxuan Luo, Mark S. Link, Sergio Lavandero, Thomas G. Gillette, Joseph A. Hill
Editorial Material
Cardiac & Cardiovascular Systems
Mario Chiong, Miles D. Houslay, Sergio Lavandero
Review
Pharmacology & Pharmacy
Mayarling F. Troncoso, Magda C. Diaz-Vesga, Fernanda Sanhueza-Olivares, Jaime A. Riquelme, Marioly Muller, Luis Garrido, Luigi Gabrielli, Mario Chiong, Ramon Corbalan, Pablo F. Castro, Sergio Lavandero
Summary: This review discusses the potential targeting of VCAM-1 in atherosclerosis, diabetes, hypertension, and ischemia/reperfusion injury, and highlights that VCAM-1 may be a promising therapeutic target for vascular diseases.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2023)
Article
Biochemistry & Molecular Biology
Lautaro Briones-Suarez, Mariana Cifuentes, Roberto Bravo-Sagua
Summary: Obesity-induced inflammation in adipose tissue has harmful effects on organs like the liver. The activation of the calcium-sensing receptor in pre-adipocytes results in the secretion of pro-inflammatory cytokines, TNF-alpha, and IL-1 beta. These cytokines promote cell senescence and mitochondrial dysfunction in HepG2 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Pia Apablaza, Juan Carlos Borquez, Rodrigo Mendoza, Monica Silva, Gladys Tapia, Alejandra Espinosa, Rodrigo Troncoso, Luis A. Videla, Nevenka Juretic, Andrea del Campo
Summary: Increase in body fat leads to changes in skeletal muscle and accelerates sarcopenia, known as sarco-obesity or sarcopenic obesity. Obesity affects the skeletal muscle's ability to oxidize glucose and causes mitochondrial dysfunction. Exercise improves mitochondrial dysfunction, but the effects on the mitochondrial unfolded protein response (UPRmt) in the skeletal muscle are not well understood. This study aimed to investigate the UPRmt response to exercise in obese mice and its association with skeletal muscle function improvement.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Physiology
Roberto Bravo-Sagua, Camila Lopez-Crisosto, Alfredo Criollo, Reiko Inagi, Sergio Lavandero
Summary: Organelles are membrane-lined structures that compartmentalize subcellular biochemical functions. Interorganelle communication is crucial for cellular responses. Evidence suggests that other organelles play important roles in pathophysiological conversation.
Article
Medicine, General & Internal
Hugo E. E. Verdejo, Adolfo Rojas, Camila Lopez-Crisosto, Fernando Baraona, Luigi Gabrielli, Vinicius Maracaja-Coutinho, Mario Chiong, Sergio Lavandero, Pablo F. F. Castro
Summary: This study investigated the role of trimetazidine in patients with PAH and found that it improved right ventricular function, remodeling, and functional class. Trimetazidine use was safe and well-tolerated, and it led to increased exercise capacity and minor improvements in RV remodeling.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Matias Monsalves-Alvarez, Teresa Jimenez, Daniel Bunout, Gladys Barrera, Sandra Hirsch, Carlos Sepulveda-Guzman, Claudio Silva, Juan M. Rodriguez, Rodrigo Troncoso, Maria Pia de la Maza
Summary: This study compares the body composition and metabolic changes in overweight and obese Chilean women and men after 3 months of weight loss treatment with a Mediterranean-type hypocaloric diet, high-intensity interval training (HIIT), or both. The results show that the hypocaloric diet mainly reduces fat mass but causes a loss of skeletal muscle mass, which can be prevented by HIIT.
FRONTIERS IN NUTRITION
(2023)
Article
Biology
Carlos Sepulveda, Juan Manuel Rodriguez, Matias Monsalves-Alvarez, Camila Donoso-Barraza, Francisco de la Fuente, Isabelle Matias, Thierry Leste-Lasserre, Philippe Zizzari, Eugenia Morselli, Daniela Cota, Miguel Llanos, Rodrigo Troncoso
Summary: The endocannabinoid system (ECS) regulates energy metabolism and is involved in the pathogenesis of metabolic diseases. Autophagy is associated with various cellular processes and its deregulation is linked to diseases. This study found that the CB1 receptor controls autophagy in the skeletal muscle of both lean and obese mice.
BIOLOGICAL RESEARCH
(2023)
