Journal
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
Volume 102, Issue 2, Pages 237-244Publisher
WILEY
DOI: 10.1111/j.1742-7843.2007.00164.x
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Early exposures to environmental chemicals are reliably associated with late neurotoxicities in children. However, substantial scatter of observations exists around the estimated dose-effect relationships. This variability has many potential sources, one of which is interindividual differences in susceptibility. Such differences imply that the long-term impacts of exposure will not the same for all individuals, but will vary depending on a variety of factors that might either aggravate or mitigate contaminant effects. These include co-exposures, genetic polymorphisms and characteristics of the social environment. The context dependence of contaminant effects has implications both for study designs and analytical approaches. In addition, a systems approach to understanding the associations among contaminant exposures, covariates and health outcomes is necessary.
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