Journal
BANGLADESH JOURNAL OF PHARMACOLOGY
Volume 6, Issue 1, Pages 8-13Publisher
BANGLADESH PHARMACOLOGICAL SOC
DOI: 10.3329/bjp.v6i1.7720
Keywords
Antibacterial; Antifungal; Ciprofloxacin; Schotten-Baumann method
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Five NH-derivatives of ciprofloxacin (2-6) have been prepared by acetylation/benzoylation on ciprofloxacin (1) in order to carry out screening for antibacterial activities on some gram-positive and gram-negative bacteria. The antifungal activity of these compounds has also been made against Candida albicans. All of the derivatives have shown enhanced activities against gram-negatives bacteria than parent antibiotic, ciprofloxacin among which compounds 2 and 6 are the most potent agents. Regarding the antifungal activity all of the compounds have shown highest activity than ciprofloxacin. All the compounds have been characterized with spectral analysis.
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