Review
Cell Biology
Devaraj Ezhilarasan, Sheeja S. Varghese
Summary: Periodontitis is the sixth most prevalent disease globally, with microbial interactions with stem cells exacerbating the condition.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ancuta Goriuc, Liliana Foia, Karina Cojocaru, Diana Diaconu-Popa, Darius Sandu, Ionut Luchian
Summary: Periodontitis is a challenging inflammatory condition characterized by the deterioration of tooth support structures. Regeneration of periodontal tissues using stem cells, such as dental mesenchymal stem cells (DMSCs), non-dental stem cells, and induced pluripotent stem cells (IPSCs), shows promise but remains a challenge in clinical practice due to their complex physiological characteristics and the surrounding inflammatory microenvironment.
Article
Anatomy & Morphology
Elnaz Mousavi, Armin Khosravi, Somaye Salari Sedigh, Sayad Ayub Tabatabaei Mayanei, Morteza Banakar, Moslem Karimzadeh, Amirhossein Fathi
Summary: Periodontitis is a complex inflammatory disorder that causes continuous destruction of teeth-supporting components and is associated with serious illnesses. Current therapies have shown limited effectiveness, but mesenchymal stem cell-derived mediators, such as exosomes, show potential as a therapeutic candidate. This study aims to review the evidence on their curative impacts for periodontitis.
Review
Immunology
Bo Yang, Xuefei Pang, Zhipeng Li, Zhuofan Chen, Yan Wang
Summary: In the treatment of periodontitis, modulating the immune microenvironment is crucial for preventing pathogen invasion and promoting periodontal regeneration. Utilizing new anti-inflammatory therapies can help generate viable local immune microenvironment, promoting tissue repair.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Zi Yang, Linsha Ma, Conglin Du, Jingsong Wang, Chunmei Zhang, Lei Hu, Songlin Wang
Summary: The crosstalk between mesenchymal stem cells (MSCs) and the host immune function is crucial for tissue regeneration and wound healing. Dental pulp stem cells (DPSCs) have superior tissue regeneration potential compared to other sources of stem cells and can induce more M2 macrophages. DPSCs promote M2 macrophage polarization through the secretion of CCL2, which enhances wound healing. However, blocking CCL2 significantly inhibits the activation of M2 macrophages induced by DPSCs.
Review
Biochemistry & Molecular Biology
Ilaria Roato, Giorgia Chinigo, Tullio Genova, Luca Munaron, Federico Mussano
Summary: The use of mesenchymal stem cells for regenerative purposes has become common in various diseases, including in the dental and maxillofacial field. Different sources of MSCs from the oral cavity have been proposed as promising candidates for tissue engineering, with potential applications in treating periodontal disease and dental pulp regeneration.
Review
Cell & Tissue Engineering
Liangrui Chen, Shasha Zhu, Shujuan Guo, Weidong Tian
Summary: Periodontitis is a common oral disease that causes damage to both hard and soft tissues of the periodontium, leading to tooth mobility and loss. Mesenchymal stem cells (MSCs) have emerged as a promising therapy for periodontitis due to their unique characteristics. Accumulating evidence suggests that the regenerative effects of MSCs are mainly mediated through paracrine signaling, including the release of extracellular vesicles (EVs) that contain bioactive substances. These MSC-EVs play a crucial role in regulating the biological functions of periodontal tissue cells, immune cells, and the local microenvironment, promoting tissue regeneration and repair. As a cell-free therapy, MSC-EVs offer advantages in terms of stability, immune rejection, and ethical concerns, making them potentially valuable for clinical applications in periodontal regeneration.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Medicine, Research & Experimental
Zheng Zhang, Minghui Wang, Youli Zheng, Yanmei Dai, Jiashu Chou, Xiaowei Bian, Pengcheng Wang, Changyi Li, Jing Shen
Summary: This study found that miR-223 is upregulated in periodontitis and downregulated during the osteogenesis of PDL-derived cells. Overexpression of miR-223 inhibits osteogenic differentiation of PDL-derived cells, potentially by targeting the growth factor receptor genes FGFR2 and TGFβR2.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Xiao Song, Yiwen Xue, Siyu Fan, Jing Hao, Runzhi Deng
Summary: This study demonstrates that in periodontitis, macrophages mediate inflammatory stimulation and inhibit the osteogenic differentiation of bone cells through the release of exosomes, providing new insights for the treatment of bone tissue regeneration in inflammatory states.
Review
Dentistry, Oral Surgery & Medicine
Junxian Li, Mojtaba Mehrabanian, Hassan Mivehchi, Morteza Banakar, Enas Abdalla Etajuri
Summary: Periodontitis, a common dental disorder, is caused by bacterial infections, dysregulated immune reactions, and environmental risk factors. Dysregulated immune response leads to inflammatory bone resorption, while the presence of anti-inflammatory cells contributes to the restoration of inflamed tissues. Experimental studies have shown the potential of targeting immune cells or manipulating their positive/negative effects for therapeutic purposes in periodontitis.
Article
Dentistry, Oral Surgery & Medicine
Yunus Emre Balaban, Sema Akbaba, Serife Buket Bozkurt, Arda Buyuksungur, E. Ece Akgun, Zeynep Burcin Gonen, Hasan Salkin, Aysen Tezcaner, Sema S. Hakki
Summary: This study evaluated the effect of local application of gingival mesenchymal stem cells (GMSC) in fibroin/chitosan oligosaccharide lactate hydrogel (F/COS) on periodontal regeneration in a rat model of experimental periodontitis. The results showed that local application of GMSC in the hydrogel promoted the formation of new periodontal ligament and alveolar bone.
JOURNAL OF PERIODONTOLOGY
(2023)
Review
Cell & Tissue Engineering
Li Liu, Lilong Zhang, Chunlei Li, Zhendong Qiu, Tianrui Kuang, Zhongkai Wu, Wenhong Deng
Summary: This review summarizes recent progress in the identification of hormones associated with intestinal stem cells, which can promote or prevent their development. Several hormones, such as thyroid hormone, glucagon-like peptide-2, androgens, insulin, leptin, growth hormone, corticotropin-releasing hormone, and progastrin, promote the development of intestinal stem cells, while somatostatin and melatonin prevent their proliferation. This provides potential new therapeutic targets for the diagnosis and treatment of intestinal illnesses.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Biochemical Research Methods
Samuele Ferrari, Stefano Beretta, Aurelien Jacob, Davide Cittaro, Luisa Albano, Ivan Merelli, Luigi Naldini, Pietro Genovese
Summary: BAR-Seq is a strategy for tracking edited cells that allows clonal tracking analyses without the need for computational resources or advanced bioinformatic skills, and can be used to investigate the clonal dynamics and behavior of edited cells in different environments.
Article
Endocrinology & Metabolism
Hanyue Li, Yu Yuan, Hongying Chen, Hongwei Dai, Jie Li
Summary: This study investigated the effects and underlying mechanism of adipose-derived stromal/stem cell (ASC) therapy in experimental periodontitis. The results showed that ASCs can alleviate periodontitis by modulating macrophage polarization through the IDO-dependent Kyn-AhR-NRF2 pathway.
MOLECULAR METABOLISM
(2022)
Review
Dentistry, Oral Surgery & Medicine
Jingwei Cao, Qiong Zhang, Qiyuan Yang, Yue Yu, Mingmei Meng, Jing Zou
Summary: Periodontitis is an inflammatory disease that causes bone loss in the alveolar region. The differentiation of periodontal ligament stem cells (PDLSCs) into osteoblasts can be regulated by epigenetic mechanisms. This review discusses the role of various epigenetic factors in the osteogenic differentiation of PDLSCs and explores the potential therapeutic applications in periodontitis. Studies on epigenetic regulation and PDLSCs were retrieved from databases, showing that epigenetic factors such as DNMT, KDM6A, HDACi, miRNAs, and lncRNAs can induce osteogenic differentiation in a noninflammatory microenvironment. However, in an inflammatory environment, DNA methylation of osteogenesis-related genes and changes in histone modification and noncoding RNA inhibit the osteogenic differentiation of PDLSCs. The use of epigenetic drugs to regulate abnormal epigenetic status in periodontitis and promote alveolar bone regeneration shows promise.
Article
Medicine, General & Internal
Z. Pesic, A. Pejcic, T. Boljevic
Summary: This report discusses the occurrence and differential diagnosis of hard palate foreign bodies in infants, using a case study of a 16-month-old girl with a plastic toy part embedded in her hard palate. The report highlights the possibilities of misdiagnosis and airway aspiration, emphasizing the importance of prevention in airway aspiration.
WEST INDIAN MEDICAL JOURNAL
(2021)
Article
Medicine, General & Internal
I. Minic, A. Pejcic
WEST INDIAN MEDICAL JOURNAL
(2016)
Article
Medicine, General & Internal
I. Minic, A. Pejcic, M. Kostic, N. Krunic, D. Mirkovic, M. Igic
WEST INDIAN MEDICAL JOURNAL
(2016)
Article
Medicine, General & Internal
Ana Pejcic, Vidojko Djordjevic, Draginja Kojovic, Vesna Zivkovic, Ivan Minic, Dimitrije Mirkovic, Mariola Stojanovic
MEDICAL PRINCIPLES AND PRACTICE
(2014)
Article
Medicine, General & Internal
Milena Kostic, Marko Igic, Tatjana Jevtovic Stoimenov, Ana Pejcic, Jana Pesic Stankovic
MEDICAL PRINCIPLES AND PRACTICE
(2019)
Article
Medicine, General & Internal
Marko Igic, Milena Kostic, Jelena Basic, Nebojsa Krunic, Ana Pejcic, Nikola Gligorijevic, Aleksandra Milic Lemic
MEDICAL PRINCIPLES AND PRACTICE
(2020)
Article
Dentistry, Oral Surgery & Medicine
Ivan Minic, Ana Pejcic, Marija Bradic-Vasic
Summary: The study aimed to investigate the use of local probiotics as an adjunctive therapy to scaling and root planning in the treatment of periodontitis. Results showed that topical application of probiotics in combination with SRP increased the effectiveness of conventional non-surgical therapy of periodontitis.
INTERNATIONAL JOURNAL OF DENTAL HYGIENE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ana Pejcic, Milena Kostic, Igic Marko, Radmila Obradovic, Ivan Minic, Marija Bradic-Vasic, Nikola Gligorijevic, Dzemil Kurtagic
Summary: This study investigated the possible relationship between the severity of periodontitis and the occurrence of cardiovascular disease. The results showed that patients with cardiovascular disease had worse periodontal status and there was a significant association between tooth loss levels and cardiovascular disease.
INTERNATIONAL JOURNAL OF DENTAL HYGIENE
(2023)
Article
Pathology
Ana Pejcic, Zlatibor Andjelkovic, Dragan Marjanovic, Ivan Minic, Vladimir Matvijenko, Zoran Arsic, Radovan Jovanovic, Ljiljana Subaric
Summary: The distribution and density of antigen-presenting cells (APCs) in healthy and inflamed human gingival tissue were compared. The results showed increased density of DCs, macrophages, and B lymphocytes, and decreased density of LCs in periodontitis patients. It was hypothesized that APCs played a major role in antigen presentation in periodontitis.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Review
Medicine, General & Internal
Marko Igic, Milena Kostic, Ana Pejcic, Nikola Gligorijevic, Marija Jovanovic, Nenad Stosic
Summary: The loss of jaw bone complicates prosthetic rehabilitation, but it can be overcome by using bone replacements, such as hydroxyapatite. However, its poor properties necessitate the research of chemically modified hydroxyapatite containing different metal ions.
ACTA FACULTATIS MEDICAE NAISSENSIS
(2023)
Article
Medicine, General & Internal
Milena Kostic, Marko Igic, Ana Pejcic
ACTA FACULTATIS MEDICAE NAISSENSIS
(2020)
Article
Medicine, General & Internal
Marko Igic, Milena Kostic, Nebojsa Krunic, Ana Pejac, Stefan Dacic, Nenad Stosic
ACTA FACULTATIS MEDICAE NAISSENSIS
(2020)
Article
Environmental Sciences
R. Obradovic, M. Igic, A. Mitic, G. Filipovic, A. Pejcic, M. Boskovic, K. Todorovic
JOURNAL OF ENVIRONMENTAL PROTECTION AND ECOLOGY
(2017)
Article
Pharmacology & Pharmacy
M. Kostic, A. Pejcic, M. Igic, N. Gligorijevic
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2017)
Article
Medicine, General & Internal
Ana Pejcic, Draginja Kojovic, Ivan Minic, Dimitrije Mirkovic, Marko Denic, Mariola Stojanovic
ACTA CLINICA CROATICA
(2015)
