Review
Chemistry, Multidisciplinary
Wu-Yeh Chang, Kuo-Cheng Wu, Ai-Lun Yang, Yi-Liang Chen
Summary: This article explores different hypoxia training protocols and their effects on sports performance. It discusses the physiological mechanisms of hypoxia training and its impact on cardiorespiratory fitness, muscle oxygen utilization, power performance, hematological adaptations, and specific physiological adaptations. The study finds that hypoxia high-intensity interval training (HHIIT) can increase maximum oxygen intake and improve overall sports performance. Incremental hypoxia training improves aerobic capacity but has fewer effects on hematological variables. Combined training in a hypoxia environment increases oxygen uptake and breathing volume and enhances hemodynamic function. Hypoxia during the recovery state also benefits sports performance. Further research is needed to optimize training protocols and understand their effects on different sports and athlete proficiency.
APPLIED SCIENCES-BASEL
(2023)
Article
Endocrinology & Metabolism
Mikkel Bo Brent, Thomas Emmanuel, Ulf Simonsen, Annemarie Bruel, Jesper Skovhus Thomsen
Summary: Hypobaric hypoxia significantly impacts femoral cortical bone and L4 trabecular bone in mice, reducing bone strength and bone mass. The skeletal response to hypobaric hypoxia differs between cortical and trabecular bone, with trabecular bone being less affected. Initial preclinical findings support future clinical studies on bone status and strength in mountaineers after prolonged high altitude exposure.
Article
Pharmacology & Pharmacy
Shengnan Jiang, Fangfang Fan, Lu Yang, Ke Chen, Zhihao Sun, Yi Zhang, Nanjia Cairang, Xiaobo Wang, Xianli Meng
Summary: Salidroside from Rhodiola crenulate can attenuate cerebral injury caused by hypobaric hypoxia at high altitude by reducing oxidative stress and inflammation, improving energy metabolism, and modulating the microglial phenotype. These mechanisms inhibit NF-kappa B/NLRP3 pathway and protect the blood-brain barrier, suggesting Sal as a promising anti-inflammatory agent for high altitude-induced brain injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Alejandro Gonzalez-Canadia, Alejandro A. Candia, Pamela Arias, Adolfo A. Paz, Emilio A. Herrera, Rodrigo L. Castillo
Summary: This study aimed to investigate the effects of chronic intermittent hypobaric hypoxia on cardiac and vascular response in adult rats simulating high-altitude working shifts. The results showed that chronic intermittent hypobaric hypoxia induced cardiac dysfunction and ventricular remodeling, increased collagen content in the right ventricle, and decreased antioxidant capacity in cardiac tissue. It also led to decreased contractile capacity and impaired vasodilation in carotid and femoral arteries. These findings highlight the importance of periodic cardiovascular evaluation in high-altitude workers.
Article
Environmental Sciences
Kwo-Tsao Chiang, Hsin Chu, Min-Yu Tu, You-Jin Lin, Sing-Hong Lin, Yu-Hsin Wen, Chung-Yu Lai
Summary: Helicopter aircrews are required to undergo altitude hypoxia training to familiarize with hypoxia symptoms. This study compared the hypoxia symptoms between altitude training and in-flight events, revealing a consistency in symptoms experienced by helicopter aircrews in both scenarios.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Jan Schmitz, Lydia J. Kolaparambil Varghese, Felix Liebold, Moritz Meyer, Lukas Nerlich, Clement Starck, Seamus Thierry, Stefanie Jansen, Jochen Hinkelbein
Summary: The present study aims to investigate the time-dependent changes in protein expression due to hypobaric hypoxia. The results show that protein expression differs based on the duration of exposure, with significant differences in proteins associated with hemostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Diana Alcantara-Zapata, Carolina Nazzal, Sergio Munoz, Nicole De Gregorio, Nella Marchetti, Claus Behn
Summary: This study investigated the prevalence of varicocele (VC) in a population shifting between different altitudes. The results showed that the association of VC with high altitude exposure may be related to blood volume centralization mediated by hypobaric hypoxia.
CURRENT VASCULAR PHARMACOLOGY
(2022)
Article
Sport Sciences
Manuel Mateo-March, Xabier Muriel, Pedro L. Valenzuela, Alexis Gandia-Soriano, Mikel Zabala, David Barranco-Gil, Jesus G. Pallares, Alejandro Lucia
Summary: Acute altitude exposure affects real-world cycling performance differently in lowlanders and altitude natives, giving altitude natives a competitive advantage in races at altitudes above 1500 meters.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Endocrinology & Metabolism
Minxia Zhu, Yaqi Lei, Kexin Zhang, Yuwen Xia, Chenjing Li
Summary: This study observed neuronal injury of ischemic stroke after hypobaric hypoxia in Tibet and found that the expression of NMDAR and CaMKII was reduced at high altitude. Increased numbers of RBCs and hemoglobin may play crucial roles in the development of ischemic stroke in such conditions.
METABOLIC BRAIN DISEASE
(2021)
Article
Physiology
Filipa Almeida, Paulino Padial, Juan Bonitch-Gongora, Blanca de la Fuente, Brad J. Schoenfeld, Antonio J. Morales-Artacho, Cristina Benavente, Belen Feriche
Summary: The study found that a 3-week power-oriented resistance training program conducted at moderate altitude can significantly improve explosive leg capacity, particularly in terms of jump height. The hypoxia group showed additional benefits in peak velocity and jump height compared to training at sea level, but had detrimental effects on execution time and acceleration in the judo technique tested.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biology
Zhiyuan Pan, Yichen Hu, Zongyu Huang, Ni Han, Yan Li, Xiaomei Zhuang, Jiye Yin, Hui Peng, Quansheng Gao, Wenpeng Zhang, Yong Huang, Yujun Cui, Yujing Bi, Zhenjiang Zech Xu, Ruifu Yang
Summary: This study investigated the dynamics of gut microbiota and their association with altitude-related illnesses using a rat model of hypobaric hypoxia challenge. The results showed significant changes in gut microbiota composition and metabolic abnormalities of short-chain fatty acids and bile acids in response to hypoxic conditions. Furthermore, fecal microbiota transplantation was found to partially restore the gut microbiota diversity and ameliorate cardiac hypertrophy in hypoxic rats. These findings shed light on the role of gut microbiota in the development of high-altitude heart disease.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Physiology
Ana Sousa, Joao L. Viana, Jaime Milheiro, Vitor M. Reis, Gregoire P. Millet
Summary: The study found that high-intensity interval training in hypoxia combined with chronic dietary nitrate supplementation did not significantly improve performance at simulated altitude compared to normoxic training. Additionally, dietary nitrate supplementation did not provide any additional benefits in enhancing endurance performance at simulated altitude.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biology
Rashmi Supriya, Kumar Purnendu Singh, Yang Gao, Dan Tao, Sarah Cheour, Frederic Dutheil, Julien S. Baker
Summary: Inhibiting COX2 can protect against hypoxia pathogenesis and reduce the risk of COVID-19. People accustomed to high altitude living are more resistant to COVID-19. COX-2 adaptation through gene-environment interaction and intermittent hypoxia training may have therapeutic potential. Further research on downstream molecules of the COX2 pathway is important for hypoxic environment adaptation.
Article
Physiology
Bing Yan, Xiaochuan Ge, Jiabei Yu, Yang Hu, Olivier Girard
Summary: While re-exposure to hypoxia can help retain the gains in hemoglobin mass from previous altitude training, there is no performance advantage observed above sea level.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Biophysics
Tobias Kammerer, Anna Walzl, Thomas Mueller, Philipp Groene, Giulia Roveri, Rachel Turner, Johanna Roche, Hannes Gatterer, Christoph Siebenmann, Simon T. Schaefer
Summary: This research aimed to evaluate the effect of isolated hypobaric hypoxia on coagulation in healthy females. Results showed that moderate hypobaric hypoxia had no significant influence on blood coagulation in healthy females.
HIGH ALTITUDE MEDICINE & BIOLOGY
(2023)
Article
Neuroimaging
Joy Perrier, Armelle Viard, Christelle Levy, Nastassja Morel, Djelila Allouache, Sabine Noal, Florence Joly, Francis Eustache, Benedicte Giffard
BRAIN IMAGING AND BEHAVIOR
(2020)
Article
Neurosciences
Marie Caillaud, Alexandre Bejanin, Mickael Laisney, Pierre Gagnepain, Malo Gaubert, Armelle Viard, Patrice Clochon, Vincent de La Sayette, Philippe Allain, Francis Eustache, Beatrice Desgranges
HUMAN BRAIN MAPPING
(2020)
Article
Clinical Neurology
Marie Caillaud, Mickael Laisney, Alexandre Bejanin, Clarisse Scherer-Gagou, Dominique Bonneau, Harmony Duclos, Francis Eustache, Christophe Verny, Beatrice Desgranges, Philippe Allain
Article
Clinical Neurology
R. Schneckenburger, M. Hainselin, F. Viader, F. Eustache, P. Quinette
REVUE NEUROLOGIQUE
(2020)
Article
Multidisciplinary Sciences
Alison Mary, Jacques Dayan, Giovanni Leone, Charlotte Postel, Florence Fraisse, Carine Malle, Thomas Vallee, Carine Klein-Peschanski, Fausto Viader, Vincent de la Sayette, Denis Peschanski, Francis Eustache, Pierre Gagnepain
Article
Psychology, Biological
Pierre Gagnepain, Thomas Vallee, Serge Heiden, Matthieu Decorde, Jean-Luc Gauvain, Antoine Laurent, Carine Klein-Peschanski, Fausto Viader, Denis Peschanski, Francis Eustache
NATURE HUMAN BEHAVIOUR
(2020)
Article
Behavioral Sciences
Melanie Ring, Berengere Guillery-Girard, Peggy Quinette, Sebastian B. Gaigg, Dermot M. Bowler
Article
Neurosciences
Alexandrine Morand, Shailendra Segobin, Gregory Lecouvey, Julie Gonneaud, Francis Eustache, Geraldine Rauchs, Beatrice Desgranges
Summary: This study found that older participants had lower gray matter volumes in several brain areas, but these did not correlate with TBPM performance. On the other hand, a decline in white matter integrity was correlated with TBPM performance, indicating a disconnection process that occurs in aging and contributes to cognitive decline.
Article
Infectious Diseases
Olivier Bylicki, David Delarbre, Aurelie Mayet, Audrey Ferrier, Anne Perisse, Carine Malle, Jacques Cobola, Antoine Bronstein, Nastasia Menoud, Elodie Valero-Biance, Olivier Ferraris, Frederic Janvier, Jean-Nicolas Tournier
Summary: Neutralizing antibody activity persists for up to 9 months following asymptomatic/mild COVID-19 among young adults, regardless of serological results.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Psychology, Multidisciplinary
Herve Platel, Marie-Loup Eustache, Renaud Coppalle, Armelle Viard, Francis Eustache, Mathilde Groussard, Beatrice Desgranges
Summary: Studies have shown that Alzheimer's Disease patients with severe dementia can maintain consistent, albeit impoverished, representations of themselves and a preserved sense of identity even at advanced stages of the illness. Participation in reminiscence workshops with familiar songs as prompts can enrich autobiographical memories and support self-representation for these patients. However, while autobiographical memories of AD patients can reach levels comparable to matched controls with repeated participation, this increase in memories does not necessarily lead to enriched sense of identity.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Oncology
Celine Auzanneau, Delphine Bacq, Carine Bellera, Helene Blons, Anne Boland, Marlene Boucheix, Aurelien Bourdon, Emmanuelle Chollet, Christine Chomienne, Jean-Francois Deleuze, Christelle Delmas, Derek Dinart, Helene Esperou, Flore Geillon, Damien Geneste, Antoine Italiano, Delphine Jean, Emmanuel Khalifa, Yec'han Laizet, Pierre Laurent-Puig, Franck Lethimonnier, Claire Levy-Marchal, Carlo Lucchesi, Carine Malle, Pierre Mancini, Simone Mathoulin-Pelissier, Vincent Meyer, Palomares Marie-Ange, Geraldine Perkins, Sabrina Sellan-Albert, Isabelle Soubeyran, Cedric Wallet