Article
Biochemistry & Molecular Biology
Vittoria Cammisotto, Francesco Baratta, Paola G. Simeone, Cristina Barale, Enrico Lupia, Gioacchino Galardo, Francesca Santilli, Isabella Russo, Pasquale Pignatelli
Summary: PCSK9 is involved in cholesterol metabolism and plays a role in the development of atherosclerosis and atherothrombotic processes, promoting plaque formation and oxidative stress.
Article
Cardiac & Cardiovascular Systems
Alex K. K. Leung, Yuan Chao Xue, Antyrah de Guzman, Guilherme Grzelkovski, HyeJin Julia Kong, Kelly R. Genga, James A. Russell, John H. Boyd, Gordon A. Francis, Keith R. Walley
Summary: This study found that PCSK9 reduces the uptake of LPS in vascular endothelial cells through LDLR-mediated endocytosis, leading to a decrease in the inflammatory response. This suggests that PCSK9 inhibition may have additional effects on vascular endothelial inflammation.
Article
Medical Laboratory Technology
Antonin Jabor, Tereza Vackova, Zdenek Kubicek, Jitka Komrskova, Marek Protus, Janka Franekova
Summary: The study evaluated the biological variation of serum PCSK9, finding a high within-subject variability in healthy individuals, suggesting that common reference intervals can be used to interpret its values.
CLINICA CHIMICA ACTA
(2021)
Article
Peripheral Vascular Disease
Ayako Kunimura, Katsuyuki Miura, Hiroyoshi Segawa, Sayuki Torii, Keiko Kondo, Takashi Hisamatsu, Aya Kadota, Akira Fujiyoshi, Yuichiro Yano, Yoshihisa Nakagawa, Tomonori Okamura, Hirotsugu Ueshima, SESSA Res Grp
Summary: This study assessed the relationship between serum PCSK9 concentration and coronary artery calcium (CAC) prevalence in the general population. It found a significant association between serum PCSK9 concentration and CAC prevalence in men aged <60 years, but not in men aged 60-69 years or ≥70 years.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Article
Pharmacology & Pharmacy
Rabia Aydogan Baykara, Pinar Diydem Yilmaz, Mevlut Hakan Goktepe, Cengiz Kadiyoran, Mustafa Ogul, Adem Kucuk, Medine Cumhur Cure, Erkan Cure
Summary: There is a strong independent association between subclinical atherosclerosis and PCSK9 in patients with Behcet's disease. However, there may be no independent association between PCSK9 and disease activity.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Review
Biochemistry & Molecular Biology
Alessandro Morotti, Cristina Barale, Elena Melchionda, Isabella Russo
Summary: This article discusses the association between oxidative stress and hypercholesterolemia, as well as platelet hyperreactivity, and explores the impact of lipid-lowering therapies on thrombogenesis, emphasizing the significance of oxidative stress-related mechanisms in platelet function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Gilberto Vargas-Alarcon, Oscar Perez-Mendez, Hector Gonzalez-Pacheco, Julian Ramirez-Bello, Rosalinda Posadas-Sanchez, Galileo Escobedo, Jose Manuel Fragoso
Summary: Genetic variants of the PCSK7 gene are significantly associated with the development of ACS and dyslipidemia, potentially increasing the risk of ACS.
Review
Cardiac & Cardiovascular Systems
Yimo Zhou, Weiqi Chen, Meng Lu, Yongjun Wang
Summary: This meta-analysis found a significant association between high circulating PCSK9 concentration and the risk of MACEs, with a linear dose-response relationship observed. However, no significant correlation was found with stroke or all-cause mortality. Further well-designed studies are needed to explore the relationships between PCSK9 concentration and stroke and mortality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Takumi Akiyama, Kazuyuki Ozaki, Toshiki Takano, Shintaro Yoneyama, Naoki Kubota, Takeshi Okubo, Ryutaro Ikegami, Makoto Hoyano, Takao Yanagawa, Takayuki Inomata
Summary: This case report describes a successful treatment of a hyperlipidemic patient using a proprotein convertase subtilisin/kexin type 9 inhibitor (PCSK9i). The medication not only reduced low-density lipoprotein cholesterol (LDL-C) levels, but also lowered lipoprotein (a) [LP-(a)] levels, resulting in a reduced risk of cardiac events.
Review
Cardiac & Cardiovascular Systems
Jiahui Liu, Fangfang Fan, Xingyu Luo, Wenjun Ji, Yaokun Liu, Yan Zhang, Bo Zheng
Summary: The study found a significant positive correlation between high PCSK9 concentrations and increased risk of cardiovascular events, especially in stable CVD patients, patients on statin therapy, and Asian patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Environmental Sciences
Anna Bizon, Grzegorz Franik, Pawel Madej
Summary: This study found significantly higher PCSK9 concentration and lower high-density lipoprotein concentration in the serum of women with PCOS compared to those without, as well as significant differences in paraoxonase 1 activities. Higher PCSK9 concentration in women with PCOS, especially those with insulin resistance, may be associated with hormonal concentrations. The study suggests that changes in paraoxonase 1 activities and lipid profile parameters in women with PCOS could be linked to metabolism disorders, but further research is needed due to the small sample size.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Ga Eun Lee, Jinjoo Kim, Jihei Sara Lee, JaeSang Ko, Eun Jig Lee, Jin Sook Yoon
Summary: The research revealed a significant role of PCSK9 in the pathogenesis of Graves' orbitopathy (GO), with PCSK9 inhibition attenuating pro-inflammatory cytokine production, oxidative stress, and fibroblast differentiation into adipocytes, suggesting PCSK9 as a potential therapeutic target and biomarker for GO.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Na-Qiong Wu, Hui-Wei Shi, Jian-Jun Li
Summary: PCSK9, in addition to lowering LDL-C levels, also plays a role in the modulation of inflammation, which may explain its reduction in cardiovascular risk. Previous studies have shown that PCSK9 is associated with inflammation, as it can induce inflammatory responses, regulate the expression of inflammatory cytokines, and interact with receptors of inflammatory mediators. The interaction between PCSK9 and LOX-1 may be involved in the inflammatory response of atherosclerosis. Understanding the relationship between PCSK9 and inflammation is crucial for the prevention and management of ASCVD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Clinical Neurology
Ayako Kunimura, Yuichiro Yano, Takashi Hisamatsu, Sayuki Torii, Keiko Kondo, Aya Kadota, Akira Fujiyoshi, Tomonori Okamura, Yoshiyuki Watanabe, Akihiko Shiino, Kazuhiko Nozaki, Hirotsugu Ueshima, Katsuyuki Miura
Summary: This study investigated the association between serum PCSK9 levels and subclinical cerebrovascular disease in a community-dwelling Japanese male population. The results showed that higher levels of circulating PCSK9 were significantly associated with an increased prevalence of intracranial artery stenosis, but not with cerebral small vessel disease. Therefore, measuring serum PCSK9 levels may help identify individuals at high risk for cerebrovascular disease in the general population.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Po-Wei Chen, Shih-Ya Tseng, Hsien-Yuan Chang, Cheng-Han Lee, Ting-Hsing Chao
Summary: The study reveals that Cilostazol can regulate the expression of PCSK9 through enhancing the PPARγ pathway, thus impacting cholesterol homeostasis. It was observed that Cilostazol significantly reduces PCSK9 levels in high-fat diet-induced obese mice and obese patients, indicating its therapeutic potential for obesity-related dyslipidemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medical Laboratory Technology
Xi Zhao, Hui-Wen Zhang, Sha Li, Yan Zhang, Rui-Xia Xu, Cheng-Gang Zhu, Na-Qiong Wu, Yuan-Lin Guo, Ping Qing, Xiao-Lin Li, Geng Liu, Qian Dong, Jing Sun, Jian-Jun Li
ANNALS OF CLINICAL BIOCHEMISTRY
(2018)
Article
Endocrinology & Metabolism
Ying Du, Sheng-Hua Yang, Sha Li, Xi Zhao, Yan Zhang, Di Sun, Cheng-Gang Zhu, Na-Qiong Wu, Yuan-Lin Guo, Rui-Xia Xu, Ping Qing, Ying Gao, Jing Sun, Jian-Jun Li
ANNALS OF NUTRITION AND METABOLISM
(2018)
Article
Cardiac & Cardiovascular Systems
Sheng-Hua Yang, Rui-Xia Xu, Chuan-Jue Cui, Yin Wang, Ying Du, Zhi-Guo Chen, Yu-Hong Yao, Chun-Yan Ma, Cheng-Gang Zhu, Yuan-Lin Guo, Na-Qiong Wu, Jing Sun, Bu-Xing Chen, Jian-Jun Li
CARDIOVASCULAR DIABETOLOGY
(2018)
Article
Peripheral Vascular Disease
Hui-Hui Liu, Ye-Xuan Cao, Sha Li, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Ying Gao, Qiu-Ting Dong, Xi Zhao, Yan Zhang, Di Sun, Jian-Jun Li
Article
Medical Laboratory Technology
Di Sun, Bing-Yang Zhou, Xi Zhao, Sha Li, Cheng-Gang Zhu, Yuan-Lin Guo, Ying Gao, Na-Qiong Wu, Geng Liu, Qian Dong, Jian-Jun Li
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2018)
Article
Medical Laboratory Technology
Qiu-Ting Dong, Ying Gao, Na-Qiong Wu, Yuan-Lin Guo, Cheng-Gang Zhu, Sha Li, Hui-Hui Liu, Ye-Xuan Cao, Hui-Wen Zhang, Xi Zhao, Geng Liu, Qian Dong, Jian-Jun Li
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2018)
Article
Endocrinology & Metabolism
Di Sun, Sha Li, Xi Zhao, Na-Qiong Wu, Cheng-Gang Zhu, Yuan-Lin Guo, Ying Gao, Ping Qing, Chuan-Jue Cui, Geng Liu, Jing Sun, Qian Dong, Jian-Jun Li
METABOLISM-CLINICAL AND EXPERIMENTAL
(2018)
Article
Cardiac & Cardiovascular Systems
H-W Zhang, X. Zhao, Y-L Guo, Y. Gao, C-G Zhu, N-Q Wu, J. J. Li
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2018)
Article
Pharmacology & Pharmacy
Bing-Yang Zhou, Xiong-Yi Gao, Xi Zhao, Ping Qing, Cheng-Gang Zhu, Na-Qiong Wu, Yuan-Lin Guo, Ying Gao, Geng Liu, Qian Dong, Jian-Jun Li
PERSONALIZED MEDICINE
(2018)
Article
Multidisciplinary Sciences
Sha Li, Hui-Wen Zhang, Yuan-Lin Guo, Na-Qiong Wu, Cheng-Gang Zhu, Xi Zhao, Di Sun, Xiong-Yi Gao, Ying Gao, Yan Zhang, Ping Qing, Xiao-Lin Li, Jing Sun, Geng Liu, Qian Dong, Rui-Xia Xu, Chuan-Jue Cui, Jian-Jun Li
SCIENTIFIC REPORTS
(2018)
Article
Cardiac & Cardiovascular Systems
Ye-Xuan Cao, Hui-Hui Liu, Di Sun, Jing-Lu Jin, Rui-Xia Xu, Yuan-Lin Guo, Na-Qiong Wu, Cheng-Gang Zhu, Sha Li, Yan Zhang, Jing Sun, Jian-Jun Li
Article
Multidisciplinary Sciences
Jie Zhang, Yun Jiang, Ying Wang, Yuanlin Guo, Hai Long, Guangbing Deng, Qian Chen, Pu Xuan
Article
Medical Laboratory Technology
Jun Wen, Qian Dong, Geng Liu, Ying Gao, Xiao-Lin Li, Jing-Lu Jin, Jian-Jun Li, Yuan-Lin Guo
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2020)
Review
Cardiac & Cardiovascular Systems
Ze-Ping Wang, Ya-Jie Wu, Ying Gao, Jie Qian, Long-Tao Liu, Yuan-Lin Guo, Jian-Jun Li, Ke-Ji Chen
Summary: Two siblings with familial hypercholesterolemia (FH) showed clinical phenotypic differences in cardiovascular manifestations, despite having similar LDL-C levels. The proband had more severe stenosis and smaller LDL particle size compared to his elder sister. This highlights the potential role of LDL particle size as a novel indicator for predicting the prognosis of FH.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Environmental Sciences
Sun Di, Zhao Xi, Li Sha, Zhang Yan, Wu Na Qiong, Zhu Cheng Gang, Guo Yuan Lin, Gao Ying, Qing Ping, Liu Geng, Dong Qian, Li Jian Jun
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
(2018)