Article
Immunology
Yanhong Zhao, Bihua Deng, Xiaoqing Pan, Jinqiu Zhang, Xiaoxin Zuo, Junning Wang, Fang Lv, Yu Lu, Jibo Hou
Summary: This study optimized the lyophilization process of a heat-resistant duck viral hepatitis vaccine, improving its quality and stability. The vaccine was found to be safe for ducklings and demonstrated good immunogenicity. These findings provide important theoretical and technical support for further research on vaccine products.
Article
Agriculture, Dairy & Animal Science
Yongsen Wen, Jie Kong, Yong Shen, Jiahui He, Guanming Shao, Keyu Feng, Qingmei Xie, Xinheng Zhang
Summary: This study identified suitable regions in the duck adenovirus type 3 (DAdV3) genome for exogenous gene insertion and generated a recombinant duck adenovirus that provides protection against DAdV3 and duck hepatitis A virus type 1 (DHAV1). These findings suggest the potential of DAdV3 as a vector for avian vector vaccine development.
Article
Infectious Diseases
Ruihua Zhang, Yupeng Yang, Jingjing Lan, Zhijing Xie, Xiansheng Zhang, Shijin Jiang
Summary: The study revealed possible vertical transmission of DHAV-1 from breeding ducks to ducklings. This finding provides new insights into the transmission mechanism of duck hepatitis A virus.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Virology
Yuanzhi Liu, Yanglin Li, Mingshu Wang, Anchun Cheng, Xumin Ou, Sai Mao, Di Sun, Ying Wu, Qiao Yang, Renyong Jia, Bin Tian, Shaqiu Zhang, Dekang Zhu, Shun Chen, Mafeng Liu, Xinxin Zhao, Juan Huang, Qun Gao, Yanling Yu, Ling Zhang
Summary: DHAV-1 infection induces cell cycle arrest in the S phase of DEFs. S phase and G0/G1 phase synchronization facilitate DHAV-1 replication, and 3D protein is one of the reasons for the S phase arrest.
Article
Microbiology
Yuanzhi Liu, Anchun Cheng, Mingshu Wang, Sai Mao, Xumin Ou, Qiao Yang, Ying Wu, Qun Gao, Mafeng Liu, Shaqiu Zhang, Juan Huang, Renyong Jia, Dekang Zhu, Shun Chen, Xinxin Zhao, Yanling Yu, Yunya Liu, Ling Zhang, Bin Tian, Leichang Pan
Summary: DHAV-1 virus inhibits cellular translation in duck embryo fibroblasts by inducing eIF2 alpha phosphorylation.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Fisheries
Hanchang Sohn, Seongdo Lee, Hyukjae Kwon, Mun Gyeong Kwon, Jee Youn Hwang, Seong Don Hwang, Jehee Lee
Summary: A multiplex PCR method was established to detect two genotypes of Megalocytivirus, RSIV and TRBIV, with optimized primer pairs for increased sensitivity and specificity. The evaluation showed successful differentiation of 21 Korean Megalocytivirus isolates, including 20 RSIV and one TRBIV, providing a convenient tool for diagnosing viral diseases in the Korean aquaculture industry.
AQUACULTURE REPORTS
(2021)
Article
Microbiology
Guige Xu, Hui Yan, Yanli Zhu, Zhijing Xie, Ruihua Zhang, Shijin Jiang
Summary: This study revealed the role of exosomes in the transmission of DHAV-1 infection and demonstrated that exosome-mediated transmission is resistant to antibody neutralization, suggesting it as an immune evasion mechanism of DHAV-1.
VETERINARY MICROBIOLOGY
(2023)
Article
Immunology
Nana Sui, Ruihua Zhang, Yue Jiang, Honglei Yu, Guige Xu, Jingyu Wang, Yanli Zhu, Zhijing Xie, Jiaqing Hu, Shijin Jiang
Summary: This study comprehensively analyzed the dynamic changes of host lncRNA profiles upon DHAV-1 infection and screened the target genes involved in the innate immune response and autophagy signaling pathway, revealing the essential roles of duck lncRNAs in the host-virus interactions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Virology
Zhen Chen, Shao-hua Shi, Yu Huang, Cui-qin Huang, Rong-chang Liu, Long-fei Cheng, Guang-hua Fu, Hong-mei Chen, Chun-he Wan, Qiu-ling Fu
Summary: The study identified significant downregulation of genes involved in glycine, serine, and threonine metabolism pathways in ducks infected with pancreatitis-associated DHAV-1 compared to those infected with classical-type DHAV-1. This suggests that intensive metabolism disorders may contribute to the different phenotypes of DHAV-1 infection.
ARCHIVES OF VIROLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Hao An, Yumei Liu, Lei Fang, Ming Shu, Qingfeng Zhai, Junhao Chen
Summary: This research suggests that duck PLAC8 plays an important immune role in the infection of duck hepatitis A virus type 1 by suppressing the expression of Toll-like receptor 7 and decreasing the levels of type I interferon and interleukin 6, thereby facilitating virus replication.
Article
Agriculture, Dairy & Animal Science
Linglin Su, Rui Wang, Tianxin Qiu, Jinli Wang, Jinwu Meng, Jinyue Zhu, Deyun Wang, Yi Wu, Jiaguo Liu
Summary: This study demonstrates that baicalin enhances antioxidant enzyme activities in the liver and mitochondria, reduces lipid peroxidation damage and iNOS activities, thereby improving the survival rate of ducklings infected with DHAV-1 and protecting the liver from viral-induced damage.
Article
Multidisciplinary Sciences
Jackson Alves da Silva Queiroz, Tarcio Peixoto Roca, Rutilene Barbosa Souza, Luiz Fellype Alves de Souza, Ana Maisa Passos-Silva, Andre Luiz Ferreira da Silva, Eugenia de Castro e Silva, Lourdes Maria Pinheiro Borzacov, Rita de Cassia Pontello Rampazzo, Soraya dos Santos Pereira, Thor Oliveira Dantas, Janaina Mazaro, Livia Melo Villar, Juan Miguel Villalobos Salcedo, Daniel Archimedes da Matta, Deusilene Vieira
Summary: This study developed a one-step RT-qPCR method for detecting hepatitis Delta virus, which was proven to be highly efficient and reproducible. The method can be used to monitor the disease progression and assess the effectiveness of treatment in hepatitis Delta patients.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Xiaoting Zhang, Ruihua Zhang, Jingyu Wang, Nana Sui, Guige Xu, Hui Yan, Yanli Zhu, Zhijing Xie, Shijin Jiang
Summary: The study developed a secretory recombinant L. lactis (MG1363-VP1) expressing the VP1-eGFP fusion protein of DHAV-1, which significantly induced specific immune responses in ducklings. Oral administration of the recombinant L. lactis stimulated both humoral and mucosal immune systems, resulting in protection against DHAV-1 infection and a reduction in mortality rates. The recombinant L. lactis provides a new approach for preventing and controlling DHAV-1 infection in duck farming.
Article
Microbiology
Nana Sui, Ruihua Zhang, Yue Jiang, Honglei Yu, Guige Xu, Jingyu Wang, Yanli Zhu, Zhijing Xie, Jiaqing Hu, Shijin Jiang
Summary: Duck hepatitis A virus type 1 (DHAV-1) interacts with the duck innate immune system by its encoded protein 2A2, which inhibits the production of IFN-beta to evade the host immune response. The 2A2 protein of DHAV-1 suppresses IFN-beta production by interacting with mitochondrial antiviral signaling (MAVS) and TANK-binding kinase 1 (TBK1). This discovery provides new insights into controlling duck hepatitis A virus.
VETERINARY MICROBIOLOGY
(2023)
Article
Immunology
Nana Sui, Ruihua Zhang, Yue Jiang, Honglei Yu, Guige Xu, Jingyu Wang, Yanli Zhu, Zhijing Xie, Jiaqing Hu, Shijin Jiang
Summary: This study reveals the changes of miRNAs and mRNAs during DHAV-1 infection and suggests miR-222a as an antiviral factor against DHAV-1.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Virology
Conny Tolf, Maria Gullberg, Jens-Ola Ekstrom, Nina Jonsson, A. Michael Lindberg
ARCHIVES OF VIROLOGY
(2009)
Article
Virology
Nina Jonsson, Kristin Wahlstrom, Lennart Svensson, Lena Serrander, A. Michael Lindberg
ARCHIVES OF VIROLOGY
(2012)
Article
Virology
Raida EL Hiar, Samir Haddad, Hela Jaidane, Didier Hober, Manel Ben M'hadheb-Gharbi, Maria Gullberg, Mohamed Neji-Guediche, A. Michael Lindberg, Jawhar Gharbi, Mahjoub Aouni
INDIAN JOURNAL OF VIROLOGY
(2012)
Article
Microbiology
W. Allan Nix, Kaija Maher, E. Susanne Johansson, Bo Niklasson, A. Michael Lindberg, Mark A. Pallansch, M. Steven Oberste
JOURNAL OF CLINICAL MICROBIOLOGY
(2008)
Article
Biotechnology & Applied Microbiology
Conny Tolf, Maria Gullberg, E. Susanne Johansson, Robert Tesh, Bjoern Andersson, A. Michael Lindberg
JOURNAL OF GENERAL VIROLOGY
(2009)
Article
Biotechnology & Applied Microbiology
Beatrice Carlsson, A. Michael Lindberg, Jesus Rodriguez-Diaz, Kjell-Olof Hedlund, Bengt Persson, Lennart Svensson
JOURNAL OF GENERAL VIROLOGY
(2009)
Article
Virology
Maria Gullberg, Conny Tolf, Nina Jonsson, Charlotta Polacek, Jana Precechtelova, Miriam Badurova, Martin Sojka, Camilla Mohlin, Stina Israelsson, Kjell Johansson, Shubhada Bopegamage, Susan Hafenstein, A. Michael Lindberg
JOURNAL OF VIROLOGY
(2010)
Article
Virology
Maria Gullberg, Conny Tolf, Nina Jonsson, Mick N. Mulders, Carita Savolainen-Kopra, Tapani Hovi, Marc Van Ranst, Philippe Lemey, Susan Hafenstein, A. Michael Lindberg
JOURNAL OF VIROLOGY
(2010)
Article
Immunology
Nina Jonsson, Maria Gullberg, A. Michael Lindberg
MICROBIOLOGY AND IMMUNOLOGY
(2009)
Article
Multidisciplinary Sciences
Malin Stoltz, Karin B. Sundstrom, Asa Hidmark, Conny Tolf, Sirkka Vene, Clas Ahlm, A. Michael Lindberg, Ake Lundkvist, Jonas Klingstrom
Article
Multidisciplinary Sciences
Fredrik Lysholm, Anna Wetterbom, Cecilia Lindau, Hamid Darban, Annelie Bjerkner, Kristina Fahlander, A. Michael Lindberg, Bengt Persson, Tobias Allander, Bjorn Andersson
Article
Immunology
Min-Chul Kim, Min-Jeong Kim, Yong-Kuk Kwon, A. Michael Lindberg, Seong-Joon Joh, Hyuk-Man Kwon, Youn-Jeong Lee, Jun-Hun Kwon
Article
Virology
Nina Jonsson, Maria Gullberg, Stina Israelsson, A. Michael Lindberg
Article
Virology
Stina Israelsson, Nina Jonsson, Maria Gullberg, Michael Lindberg
Article
Virology
Stina Israelsson, Maria Gullberg, Nina Jonsson, Merja Roivainen, Kjell Edman, A. Michael Lindberg
Article
Veterinary Sciences
Kriengwich Limpavithayakul, Nataya Charoenvisal, Somsak Pakpinyo
Summary: The PCR-RFLP molecular assay was verified as a convenient technique for detecting the MS-H vaccine strain, and the immune response mechanisms in vaccinated layer-type chickens were characterized. Vaccination stimulated immune response mechanisms in chickens with no significant difference between single and double doses.
Article
Veterinary Sciences
Doan Hoang Phu, Ruethai Narinthorn, Nguyen Thi Nhung, Niwat Chansiripornchai, Patrick J. Blackall, Conny Turni, Juan Carrique-Mas, Thotsapol Thomrongsuwannakij
Summary: Chicken in southern Thailand has different prevalence and resistance patterns of Campylobacter. Commercial broilers exhibit higher resistance to quinolones and lower resistance to macrolides and tetracycline compared to native chickens. Resistance patterns are more consistent within farms, and commercial broilers show higher homogeneity. Phenotypic and genotypic resistance have partial agreement among isolates.
Article
Veterinary Sciences
Sanjiv Kumar, Madhurendu Kumar Gupta, Sanjit Kumar, Tanmoy Rana
Summary: This study evaluated the relative efficacy of allopurinol and febuxostat, two important anti-gout agents, in controlling hyperuricemia/gout using a poultry model. The results showed that both allopurinol and febuxostat have definite potential for ameliorating hyperuricemia and gout in poultry, with febuxostat showing better effects compared to allopurinol.
Article
Veterinary Sciences
Robert Jan Molenaar, Remco Dijkman, Christiaan ter Veen, Annet Heuvelink, Fiona van Kaam, Marieke Augustijn, Anneke Feberwee
Summary: This report describes an outbreak of Salmonella Pullorum (SP) in a Dutch laying flock, causing increased mortality, decreased egg production, and neurological signs. SP was frequently isolated from various organs, and immunostaining showed cerebral granulomas in birds with neurological signs. Vaccination did not affect the detection of SP antibodies. Some clinically healthy birds had ovarian lesions associated with SP contact, but carrier status could not be confirmed. Phylogenetic analysis showed clonality of the SP isolates within the outbreak.
Article
Veterinary Sciences
Yingfei Sun, Yingjie Wang, Lulu Wang, Mengyun Zou, Xiuli Peng
Summary: This study investigates the regulation of miR-33-5p gene expression during MG infection. The researchers found an upregulation in pri-miR-33-5p and pre-miR-33-5p expression, indicating transcriptional regulation. They identified a binding motif for STAT5 in the miR-33-5p promoter element and showed that STAT5 modulates miR-33-5p transcription in response to MG infection. The overexpression of STAT5 led to increased miR-33-5p expression while suppressing JNK1 expression.