A curated census of autophagy-modulating proteins and small molecules

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

(2013) J. Y. Guo et al.   GENES & DEVELOPMENT

l-asparaginase: an effective agent in the treatment of acute lymphoblastic leukemia

(2013) Kuldeep Kumar et al.   LEUKEMIA & LYMPHOMA

Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-Driven Lung Tumors

(2013) A. M. Strohecker et al.   Cancer Discovery

Inhibition of autophagy through MAPK14-mediated phosphorylation of ATG5

(2012) Ralf Höcker et al.   Autophagy

NF-κB p65 repression by the sesquiterpene lactone, Helenalin, contributes to the induction of autophagy cell death

(2012) Chuan Bian Lim et al.   BMC Complementary and Alternative Medicine

Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC

(2012) Nicole C McKnight et al.   EMBO JOURNAL

L-asparaginase inhibits invasive and angiogenic activity and induces autophagy in ovarian cancer

(2012) Minshu Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Identification of Autophagosome-associated Proteins and Regulators by Quantitative Proteomic Analysis and Genetic Screens

(2012) Jörn Dengjel et al.   MOLECULAR & CELLULAR PROTEOMICS

Glutaminolysis Activates Rag-mTORC1 Signaling

(2012) Raúl V. Durán et al.   MOLECULAR CELL

Modulation of glutamine metabolism by the PI(3)K–PKB–FOXO network regulates autophagy

(2012) Kristan E. van der Vos et al.   NATURE CELL BIOLOGY

Abortive Autophagy Induces Endoplasmic Reticulum Stress and Cell Death in Cancer Cells

(2012) Sofie Claerhout et al.   PLoS One

Autophagy Suppresses RIP Kinase-Dependent Necrosis Enabling Survival to mTOR Inhibition

(2012) Kevin Bray et al.   PLoS One

A comprehensive siRNA screen for kinases that suppress macroautophagy in optimal growth conditions

(2011) Piotr Szyniarowski et al.   Autophagy

Microautophagy in mammalian cells: Revisiting a 40-year-old conundrum

(2011) Dalibor Mijaljica et al.   Autophagy

Autophagy modulation for cancer therapy

(2011) Zhineng J. Yang et al.   CANCER BIOLOGY & THERAPY

Bnip3 impairs mitochondrial bioenergetics and stimulates mitochondrial turnover

(2011) S Rikka et al.   CELL DEATH AND DIFFERENTIATION

Principles and Current Strategies for Targeting Autophagy for Cancer Treatment

(2011) R. K. Amaravadi et al.   CLINICAL CANCER RESEARCH

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

RIG-I RNA Helicase Activation of IRF3 Transcription Factor Is Negatively Regulated by Caspase-8-Mediated Cleavage of the RIP1 Protein

(2011) Akhil Rajput et al.   IMMUNITY

Chaperone-mediated autophagy at a glance

(2011) S. Kaushik et al.   JOURNAL OF CELL SCIENCE

Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy

(2011) Seth A. Wander et al.   JOURNAL OF CLINICAL INVESTIGATION

Bortezomib Sensitizes Malignant Human Glioma Cells to TRAIL, Mediated by Inhibition of the NF- B Signaling Pathway

(2011) E. P. Jane et al.   MOLECULAR CANCER THERAPEUTICS

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

A differential autophagic response to hyperglycemia in the developing murine embryo

(2011) Katie L Adastra et al.   REPRODUCTION

Autophagy Is a Renoprotective Mechanism During in Vitro Hypoxia and in Vivo Ischemia-Reperfusion Injury

(2010) Man Jiang et al.   AMERICAN JOURNAL OF PATHOLOGY

The RB-E2F1 Pathway Regulates Autophagy

(2010) H. Jiang et al.   CANCER RESEARCH

Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells

(2010) I. Ben Sahra et al.   CANCER RESEARCH

Stimulation of autophagy by the p53 target gene Sestrin2

(2010) Maria Chiara Maiuri et al.   CELL CYCLE

HIF1-alpha functions as a tumor promoter in cancer-associated fibroblasts, and as a tumor suppressor in breast cancer cells

(2010) Barbara Chiavarina et al.   CELL CYCLE

Autophagy in cancer associated fibroblasts promotes tumor cell survival

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

A Genome-Wide siRNA Screen Reveals Multiple mTORC1 Independent Signaling Pathways Regulating Autophagy under Normal Nutritional Conditions

(2010) Marta M. Lipinski et al.   DEVELOPMENTAL CELL

Concomitant inhibition of AKT and autophagy is required for efficient cisplatin-induced apoptosis of metastatic skin carcinoma

(2010) Sofie Claerhout et al.   INTERNATIONAL JOURNAL OF CANCER

Chemical Inducers of Autophagy That Enhance the Clearance of Mutant Proteins in Neurodegenerative Diseases

(2010) Maurizio Renna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The eIF2 Kinase GCN2 Is Essential for the Murine Immune System to Adapt to Amino Acid Deprivation by Asparaginase1–3

(2010) Piyawan Bunpo et al.   JOURNAL OF NUTRITION

The molecular mechanism of mitochondria autophagy in yeast

(2010) Tomotake Kanki et al.   MOLECULAR MICROBIOLOGY

Network organization of the human autophagy system

(2010) Christian Behrends et al.   NATURE

The Autophagy Database: an all-inclusive information resource on autophagy that provides nourishment for research

(2010) K. Homma et al.   NUCLEIC ACIDS RESEARCH

Regulation of autophagy by ATF4 in response to severe hypoxia

(2010) T Rzymski et al.   ONCOGENE

Ammonia Derived from Glutaminolysis Is a Diffusible Regulator of Autophagy

(2010) C. H. Eng et al.   Science Signaling

Inositol hexaphosphate-loaded red blood cells prevent in vitro sickling

(2010) Vanessa Bourgeaux et al.   TRANSFUSION

Activation of autophagy through modulation of 5′-AMP-activated protein kinase protects pancreatic β-cells from high glucose

(2009) Diana Han et al.   BIOCHEMICAL JOURNAL

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

The Double-Edged Sword of Autophagy Modulation in Cancer

(2009) E. White et al.   CLINICAL CANCER RESEARCH

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

(2009) Kasper M.A. Rouschop et al.   JOURNAL OF CLINICAL INVESTIGATION

The autophagy effector Beclin 1: a novel BH3-only protein

(2009) S Sinha et al.   ONCOGENE

Depletion of Kinesin 5B Affects Lysosomal Distribution and Stability and Induces Peri-Nuclear Accumulation of Autophagosomes in Cancer Cells

(2009) Carla M. P. Cardoso et al.   PLoS One

Islet Endothelial Activation and Oxidative Stress Gene Expression Is Reduced by IL-1Ra Treatment in the Type 2 Diabetic GK Rat

(2009) Grégory Lacraz et al.   PLoS One

Role of AMP-activated protein kinase in autophagy and proteasome function

(2008) Rosa Viana et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

VennMaster: Area-proportional Euler diagrams for functional GO analysis of microarrays

(2008) Hans A Kestler et al.   BMC BIOINFORMATICS

Organochlorine-mediated potentiation of the general coactivator p300 through p38 mitogen-activated protein kinase

(2008) M. R. Bratton et al.   CARCINOGENESIS

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Kinase Cθ Is Required for Autophagy in Response to Stress in the Endoplasmic Reticulum

(2008) Kenjiro Sakaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY