Journal
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
Volume 32, Issue 10, Pages 1449-1457Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10815-015-0570-7
Keywords
In vitro fertilization; IVF; Cumulative live birth rate; Young women
Funding
- Harvard Catalyst \ The Harvard Clinical and Translational Science Center (National Center for Research Resources)
- Harvard Catalyst \ The Harvard Clinical and Translational Science Center (National Center for Advancing Translational Sciences, National Institutes of Health) [UL1 TR001102]
- Harvard University
- [T32 ES 07069]
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The aim of this study is to evaluate the outcomes of in vitro fertilization (IVF), including cumulative live birth rate, among women < 25 years, 25 to < 30 years, and 30 to < 35 years. A retrospective cohort study of all women 18 to < 35 years of age at their first fresh-embryo, non-donor IVF cycle from January 1995 through December 2012 at a single center was conducted. A competing-risk regression model was used to estimate the cumulative probability and 95 % confidence interval (CI) of the first live birth in up to 6 cycles during the study period with IVF cycle number as the time metric. Among 7243 women who underwent 16,792 cycles, there were 163 (2.3 %) women < 25 years, 1691 (23.3 %) women 25 to < 30 years, and 5389 (74.4 %) women 30 to < 35 years. Women < 25 years had the lowest cumulative live birth rate after each cycle, followed by women 30 to < 35 years. In both groups, the cumulative live birth rate after 6 cycles was significantly lower than that of women 25 to < 30 years; these rates were 58 % (95 % CI 0.51-0.66) among women < 25 years, 69 % (95 % CI 0.67-0.71) among women 25 to < 30 years, and 64 % (95 % CI 0.63-0.65) among women 30 to < 35 years. Our findings are consistent with other reports of less favorable IVF treatment outcomes in women < 25 years of age following their first IVF cycle. This indicates that there are underlying factors in couples with a female < 25 years of age that should lead to different treatment counseling when they attempt IVF.
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