Article
Obstetrics & Gynecology
N. E. van Hoogenhuijze, R. van Eekelen, F. Mol, I Schipper, E. R. Groenewoud, M. A. F. Traas, C. A. H. Janssen, G. Teklenburg, J. P. de Bruin, R. H. F. van Oppenraaij, J. W. M. Maas, E. Moll, K. Fleischer, M. H. A. van Hooff, C. H. de Koning, A. E. P. Cantineau, C. B. Lambalk, M. Verberg, A. M. van Heusden, A. P. Manger, M. M. E. van Rumste, L. F. van der Voet, Q. D. Pieterse, J. Visser, E. A. Brinkhuis, J. E. den Hartog, M. W. Glas, N. F. Klijn, M. van der Zanden, M. L. Bandell, J. C. Boxmeer, J. van Disseldorp, J. Smeenk, M. van Wely, M. J. C. Eijkemans, H. L. Torrance, F. J. M. Broekmans
Summary: Endometrial scratch prior to the second fresh IVF/ICSI treatment may increase live birth rate, but comes with higher costs and uncertainty in effectiveness.
HUMAN REPRODUCTION
(2022)
Review
Biochemistry & Molecular Biology
Manizha Shekibi, Sophea Heng, Guiying Nie
Summary: The development of endometrial receptivity is crucial for successful embryo implantation and pregnancy initiation. Recent studies have focused on the role of microRNAs (miRNAs) in the regulation of endometrial receptivity. This review provides an up-to-date knowledge of the miRNAs identified in humans and mice that may play a functional role in the establishment of receptivity. The findings suggest that miRNAs could be potential biomarkers and therapeutic targets for improving endometrial receptivity in human fertility treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Obstetrics & Gynecology
Nienke E. van Hoogenhuijze, Gemma Lahoz Casarramona, Sarah Lensen, Cindy Farquhar, Mohan S. Kamath, Aleyamma T. Kunjummen, Nick Raine-Fenning, Sine Berntsen, Anja Pinborg, Shari Mackens, Zeynep Ozturk Inal, Ernest H. Y. Ng, Jennifer S. M. Mak, Sachin A. Narvekar, Wellington P. Martins, Mia Steengaard Olesen, Helen L. Torrance, Ben W. Mol, Marinus J. C. Eijkemans, Rui Wang, Frank J. M. Broekmans
Summary: This meta-analysis based on individual participant data suggests that endometrial scratching may improve live birth rates in women undergoing IVF/ICSI. However, the effectiveness of scratching may vary in different subgroups, and the timing of the procedure may also play a role. Therefore, the use of endometrial scratching in clinical practice should be done cautiously and patients should be informed about the level of evidence and uncertainties.
HUMAN REPRODUCTION UPDATE
(2023)
Article
Medicine, General & Internal
Ioannis Rigos, Vasileios Athanasiou, Nikolaos Vlahos, Nikolaos Papantoniou, Dimitrios Profer, Charalampos Siristatidis
Summary: The study found that in IVF treatment, performing hysteroscopic endometrial injury in patients with recurrent implantation failure, in conjunction with the freeze-all technique, did not significantly improve pregnancy rates, including live birth.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Health Care Sciences & Services
Amer Mahmoud Sindiani, Faheem Zayed, Eman Hussein Alshdaifat, Hasan Rawashdeh, Wesam Al-Woshah, Nada Zayed
Summary: The study found that 83.2% of couples undergoing non-medical PGD for male sex selection had a higher ratio of female embryos compared to male embryos. There was no significant difference in patient-related factors between equal and unequal embryonic groups. Patients with positive pregnancy outcomes and those treated with a short protocol were more likely to have an unequal embryonic ratio.
RISK MANAGEMENT AND HEALTHCARE POLICY
(2021)
Article
Obstetrics & Gynecology
N. E. van Hoogenhuijze, F. Mol, J. S. E. Laven, E. R. Groenewoud, M. A. F. Traas, C. A. H. Janssen, G. Teklenburg, J. P. de Bruin, R. H. F. van Oppenraaij, J. W. M. Maas, E. Moll, K. Fleischer, M. H. A. van Hooff, C. H. de Koning, A. E. P. Cantineau, C. B. Lambalk, M. Verberg, A. M. van Heusden, A. P. Manger, M. M. E. van Rumste, L. F. van der Voet, Q. D. Pieterse, J. Visser, E. A. Brinkhuis, J. E. den Hartog, M. W. Glas, N. F. Klijn, S. van der meer, M. L. Bandell, J. C. Boxmeer, J. van Disseldorp, J. Smeenk, M. van Wely, M. J. C. Eijkemans, H. L. Torrance, F. J. M. Broekmans
Summary: The study found that endometrial scratching in women with one failed IVF/ICSI treatment resulted in 4.6% more live births in the scratch group compared to the control group, with a likely certainty range between -0.7% and +9.9%. Larger studies are needed to further assess the efficacy and clinical implications of endometrial scratching.
HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Mostafa Metwally, Robin Chatters, Munya Dimairo, Stephen Walters, Clare Pye, David White, Priya Bhide, Tim Chater, Ying Cheong, Meenakshi Choudhary, Tim Child, Andrew Drakeley, Isaac Evbuomwan, Tarek Gelbaya, Jan Grace, Philip Harris, Susan Laird, Sarah Martins da Silva, Lamiya Mohiyiddeen, Kirsty Pemberton, Nick Raine-Fenning, Madhurima Rajkhowa, Tracey Young, Judith Cohen
Summary: The study found that the endometrial scratch procedure prior to the first IVF cycle in the mid-luteal phase is safe but does not significantly improve pregnancy outcomes. There were no statistical differences in pregnancy outcomes and adverse events between the group that underwent the procedure and the control group.
HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Mostafa Metwally, Stephen Walters, Robin Chatters
Summary: Endometrial scratch, a technique used to improve the success rates of IVF treatment, has been controversial despite sporadic support from studies. Recent large randomized controlled trials have presented conflicting views on the benefits of this procedure.
SEMINARS IN REPRODUCTIVE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Irem Gulfem Albayrak, Fatemeh Azhari, Ezgi Nur Colak, Burcin Karamustafaoglu Balci, Ege Ulgen, Ugur Sezerman, Ercan Bastu, Tuba Gunel
Summary: Recurrent implantation failure (RIF) is diagnosed when good-quality embryos repeatedly fail to implant after transfer, potentially due to dysregulated gene expression. This study focused on identifying significantly dysregulated genes related to implantation between healthy fertile women and RIF patients. The study found up-regulated expression of MME and WWC1 genes, and down-regulated expression of TNC gene in RIF samples compared to controls, suggesting potential mechanisms underlying RIF.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Genetics & Heredity
Benjamin P. Jones, Timothy Bracewell-Milnes, Lorraine Kasaven, Ariadne L'Heveder, Megan Spearman, Diana Marcus, Maria Jalmbrant, Joy Green, Rabi Odia, Srdjan Saso, Paul Serhal, Jara Ben Nagi
Summary: The study found that most women undergo PGT-A to increase the probability of successful pregnancy per cycle and enhance the chance of implantation. The majority of women have positive perceptions towards PGT-A, with a significant association found between successful reproductive outcomes and positive attitudes towards PGT-A.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Genetics & Heredity
Chloe Angwin, Neeti Ghali, Fleur Stephanie van Dijk
Summary: Vascular Ehlers-Danlos syndrome (vEDS) is an inherited connective tissue disorder that increases the risk of arterial dissection and organ rupture. Pregnancy and childbirth in women with vEDS are associated with significant morbidity and mortality. Pre-implantation genetic diagnosis (PGD) is approved for vEDS to prevent the implantation of affected embryos.
FRONTIERS IN GENETICS
(2023)
Review
Obstetrics & Gynecology
Mostafa Metwally, Robin Chatters, David White, Jamie Hall, Stephen Walters
Summary: There is insufficient evidence to support the effectiveness of the endometrial scratch procedure in improving pregnancy outcomes for women undergoing their first IVF cycle.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Madina Sarwari, Kiri Beilby, Karin Hammarberg, Martha Hickey, Sarah Lensen
Summary: Endometrial scratching is a common IVF add-on, but recent evidence suggests that it does not improve live birth rates. However, some fertility specialists still believe it may be beneficial for women with recurrent implantation failure.
Article
Developmental Biology
Yi-An Tu, Chia-Hung Chou, Po-Kai Yang, Chia-Tung Shun, Wen-Fen Wen, Po-Nien Tsao, Shee-Uan Chen, Jehn-Hsiahn Yang
Summary: Intentional endometrial injuries may lead to an increase in MMP-3 and MMP-9 production, which in turn stimulate angiogenesis.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Public, Environmental & Occupational Health
Stefano Palomba, Domenico Carone, Amerigo Vitagliano, Flavia Costanzi, Alice Fracassi, Tiziana Russo, Serena Del Negro, Altiero Biello, Aldo Di Filippo, Antonio Mangiacasale, Antonio Monaco, Antonio Ranieri, Beatrice Ermini, Bruno Francesco Barba, Claudio Castello, Federica Di Guardo, Francesco Pastorella, Elena Bernasconi, Ezio Michele Tricarico, Francesca Filippi, Francesco Polsinelli, Giuseppe Lo M. Monte, Loredana Sosa Fernandez, Marco Galletta, Paolo Giardina, Pasquale Totaro, Roberto Laganara, Roberto Liguori, Matteo Buccheri, Mario Montanino Oliva, Rosita Piscopo, Assunta Iuliano, Nicola Innantuoni, Irene Romanello, Francesco Sinatra, Annalisa Liprino, Roberto Thiella, Alessandra Tiezzi, Tiziana Bartolotti, Alessandra Tomasi, Valeria Finocchiaro, Mario Thiella, Giuseppa Fuggetta, Sebastiano Messineo, Francesco Isabella, Marcello Tripodi, Stefania Iaccarino, Giovanni Battista La Sala, Enrico Papaleo, Donatella Caserta, Roberto Marci, Edgardo Somigliana, Antonino Guglielmino, talian Soc Human Reprod SIRU
Summary: This study aimed to assess the views and behaviors towards endometrial scratching (ES) among fertility specialists in Italy and the relationship between these views and the attitudes towards the use of ES as an add-on in their commercial setting. The results showed that ES is still performed by fertility specialists in Italy to improve the implantation rate in IVF patients, but they have a poor attitude towards proposing ES as an add-on in the commercial setting.
Meeting Abstract
Obstetrics & Gynecology
Brent M. Hanson, Julia G. Kim, Ashley W. Tiegs, Emily K. Osman, Shelby A. Neal, Ruth B. Lathi, Richard Thomas Scott, Jason M. Franasiak
FERTILITY AND STERILITY
(2019)
Meeting Abstract
Obstetrics & Gynecology
Emily K. Osman, Tianren Wang, Min Yang, Yiping Zhan, Caroline R. Juneau, Scott J. Morin, Emre Seli, Richard Thomas Scott, Jason M. Franasiak
FERTILITY AND STERILITY
(2019)
Meeting Abstract
Obstetrics & Gynecology
Amber M. Klimczak, Christine V. Whitehead, Shelby A. Neal, Ashley W. Tiegs, Emily K. Osman, Brent M. Hanson, Julia G. Kim, Marie D. Werner, Jason M. Franasiak, Richard Thomas Scott
FERTILITY AND STERILITY
(2019)
Meeting Abstract
Obstetrics & Gynecology
Brent M. Hanson, Julia G. Kim, Emily K. Osman, Ashley W. Tiegs, Shelby A. Neal, Ruth B. Lathi, Richard Thomas Scott, Jason M. Franasiak
FERTILITY AND STERILITY
(2019)
Meeting Abstract
Obstetrics & Gynecology
Emily K. Osman, Shelby A. Neal, Ashley W. Tiegs, Brent M. Hanson, Julia G. Kim, Jason M. Franasiak, Richard Thomas Scott
FERTILITY AND STERILITY
(2019)
Meeting Abstract
Obstetrics & Gynecology
Ashley W. Tiegs, Shelby A. Neal, Emily K. Osman, Julia G. Kim, Brent M. Hanson, Jason M. Franasiak, Richard Thomas Scott, Linnea R. Goodman
FERTILITY AND STERILITY
(2019)
Meeting Abstract
Obstetrics & Gynecology
Shelby A. Neal, Xin Tao, Li Sun, Brent M. Hanson, Julia G. Kim, Emily K. Osman, Ashley W. Tiegs, Richard Thomas Scott, Jason M. Franasiak
FERTILITY AND STERILITY
(2019)
Meeting Abstract
Obstetrics & Gynecology
Julia G. Kim, George Patounakis, Caroline R. Juneau, Jason M. Franasiak, Scott J. Morin, Shelby A. Neal, Ashley W. Tiegs, Emily K. Osman, Brent M. Hanson, Emre Seli, Richard Thomas Scott
FERTILITY AND STERILITY
(2019)
Article
Obstetrics & Gynecology
Evelin E. Lara-Molina, Jason M. Franasiak, Diego Marin, Xin Tao, Patricia Diaz-Gimeno, Mireia Florensa, Marta Martin, Emre Seli, Antonio Pellicer
FERTILITY AND STERILITY
(2020)
Article
Genetics & Heredity
Katherine A. Green, George Patounakis, Michael P. Dougherty, Marie D. Werner, Richard T. Scott, Jason M. Franasiak
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2020)
Review
Obstetrics & Gynecology
Mauro Cozzolino, Jason Franasiak, Alessandra Andrisani, Guido Ambrosini, Amerigo Vitagliano
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2020)
Article
Genetics & Heredity
Andres Reig, Jason Franasiak, Richard T. Scott, Emre Seli
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2020)
Editorial Material
Obstetrics & Gynecology
Amber M. Klimczak, Jason M. Franasiak
FERTILITY AND STERILITY
(2021)
Review
Obstetrics & Gynecology
Jason M. Franasiak, Diana Alecsandru, Eric J. Forman, Laura C. Gemmell, Jeffrey M. Goldberg, Natalia Llarena, Cheri Margolis, Joop Laven, Sam Schoenmakers, Emre Seli
Summary: Implantation is a critical step in human reproduction, and recurrent implantation failure can result from various factors. Literature discussing this clinical phenomenon is increasing, and there is not a universally agreed-on definition for it.
FERTILITY AND STERILITY
(2021)
Editorial Material
Obstetrics & Gynecology
Andres Reig, Jason M. Franasiak
FERTILITY AND STERILITY
(2022)