Article
Agriculture, Dairy & Animal Science
Sylwia Mozel, Marcin B. Arciszewski
Summary: The study showed the presence of the P2X2 receptor in the neurons of the small intestine of pigs, suggesting its potential influence on the function of the small intestinal ENS. P2X2 receptor presence was observed in the myenteric plexus, outer submucosal plexus, and inner submucosal plexus neurons of all small intestinal segments in pigs, along with coexistence with certain biologically active substances.
Article
Biochemistry & Molecular Biology
Silvia Cerantola, Valentina Caputi, Gabriella Contarini, Maddalena Mereu, Antonella Bertazzo, Annalisa Bosi, Davide Banfi, Dante Mantini, Cristina Giaroni, Maria Cecilia Giron
Summary: This study evaluated the impact of DAT genetic reduction on the integrity of the enteric nervous system in mice, finding that reduced DAT activity led to increased dopamine-mediated effects, decreased cholinergic response, and altered neurochemical coding and architecture of the small intestine myenteric plexus.
Article
Gastroenterology & Hepatology
Camila Cristina Alves Machado, Paulo da Silva Watanabe, Joana D'Arc de Lima Mendes, Andreia Carla Eugenio Pupim, Silvia Miyazaki Ortigoza, Heloisa Goncalves Bergoc, Beatriz de Souza Lima Nino, Marcelo Biondaro Gois, Joao Luis Garcia, L. Ashley Blackshaw, Debora de Mello Goncales Sant'Ana, Eduardo Jose de Almeida Araujo
Summary: Toxoplasma gondii infection causes hypertrophy of the muscularis externa layer of the colon, loss of myenteric neurons, and altered motility pattern, but has no effect on gastrointestinal transit time and fecal pellet output.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Review
Physiology
Hongyi Duan, Xueqin Cai, Yingying Luan, Shuo Yang, Juan Yang, Hui Dong, Huihong Zeng, Lijian Shao
Summary: The intestine is composed of various types of cells that play important roles in digestion, absorption, neuroendocrine, and immune functions. The autonomic nervous system regulates cellular proliferation and function in the intestine. Understanding the distribution and function of the autonomic nervous system in the intestine could be helpful in treating intestinal diseases.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Zhixin Li, Elly Sau-Wai Ngan
Summary: With the rapid development of single-cell sequencing technologies, the use of single-cell multimodal sequencing has become a powerful strategy in discovering rare cells and understanding biological processes. This article summarizes recent findings in single-cell multimodal sequencing, particularly focusing on single-cell RNA sequencing (scRNA-seq) in the enteric nervous system (ENS). The studies have revealed the heterogeneity of ENS cells at different developmental stages and identified novel cell types. The application of single-cell multimodal omics techniques in profiling disease mechanisms and cellular drug responses is expected to revolutionize biomedical research.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Agriculture, Dairy & Animal Science
Katarzyna Kras, Halyna Rudyk, Siemowit Muszynski, Ewa Tomaszewska, Piotr Dobrowolski, Volodymyr Kushnir, Viktor Muzyka, Oksana Brezvyn, Marcin B. Arciszewski, Ihor Kotsyumbas
Summary: In an experiment where fumonisin was administered to pregnant rats, it was found that this mycotoxin did not significantly alter the structure of the offspring's intestine/enteric nervous system, but it did change the neurochemical profile of the enteric neurons.
Review
Biochemistry & Molecular Biology
Richard A. Guyer, Jessica L. Mueller, Allan M. Goldstein
Summary: With the advancement of technology, single-cell sequencing has become a common tool to analyze cellular diversity and reveal cellular diversity within organs. The application of these methods in the study of the enteric nervous system has provided abundant data and biological insights. As technology continues to evolve, these methods may become commonplace in enteric nervous system research and diagnostic testing.
Article
Cell Biology
Hailing Yao, Huiying Shi, Chen Jiang, Mengke Fan, Yurui Zhang, Wei Qian, Rong Lin
Summary: The study revealed that L-Fucose could promote neurogenesis and gliogenesis derived from ENPCs by inhibiting the SMAD2 signaling, facilitating ENS regeneration and gastrointestinal motility recovery in type 1 diabetic mice.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Krystyna Makowska, Kamila Szymanska, Jaroslaw Calka, Slawomir Gonkowski
Summary: Bisphenol A (BPA) is a harmful substance used in plastic manufacturing, primarily affecting the stomach and intestines through gastrointestinal intoxication, potentially increasing the co-localization of NRG1 with other substances in the nervous system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
S. B. Panza, R. Vargas, S. L. Balbo, M. L. Bonfleur, D. C. T. Granzotto, D. M. G. Sant'Ana, G. A. Nogueira-Melo
Summary: This study indicates that perinatal exposure to glyphosate combined with a high-fat diet in adulthood increases the risk of jejunum inflammation and dysfunction. Specifically, exposure changes the morphology of the intestinal wall, increases certain cell types, and affects the enteric nervous system.
Review
Biochemistry & Molecular Biology
Yue Ji, Paul Kwong-Hang Tam, Clara Sze-Man Tang
Summary: The development of the enteric nervous system relies on the interaction between enteric neural crest cells and the neural stem cell niche. Defects in ENCCs may lead to ENS dysfunction. HSCR patients may have niche defects affecting ECM-cell interaction, suggesting the need for complementary therapies involving drugs and niche-based treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Amanda Gubert Alves dos Santos, Maria Gabriela Lima da Silva, Erick Lincoln Carneiro, Lainy Leiny de Lima, Andrea Claudia Bekner Silva Fernandes, Thais Gomes Verzignassi Silveira, Debora de Mello Goncales Sant'Ana, Gessilda de Alcantara Nogueira-Melo
Summary: In this study, the immune response components, morphological changes, and effects on neurons in the ileums of hamsters infected by three different strains of L. (V.) braziliensis were evaluated. The results showed an increase in blood leukocytes after infection, histopathological changes, and alterations in the organ histoarchitecture of infected hamsters. It was concluded that L. (V.) braziliensis infection caused time-dependent alterations in hamster ileums.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jonathan D. Windster, Andrea Sacchetti, Gerben J. Schaaf, Eric M. J. Bindels, Robert M. W. Hofstra, Rene M. H. Wijnen, Cornelius E. J. Sloots, Maria M. Alves
Summary: A selective FACS protocol based on CD56/CD90/CD24 co-expression is developed to enrich and discriminate human ENS cells. Neuronal and glial selective markers are found to be co-expressed by all ENS cells, mainly driven by neuronal fragments. By applying this protocol to single-cell RNA sequencing, high-quality ENS cells are obtained for transcriptome analysis.
Review
Cell Biology
Ji Wu, Yun-Yi Wang, Xi-Wen Yang, Xiao-Tian Zhang, Jia-Yi Tang
Summary: hNP22 is a novel neuron-specific protein that interacts with actin filaments and microtubules, showing similarities to other cytoskeleton-associated proteins. It has potential biological functions in neurological disorders like schizophrenia and ARBD, making it a target for research in exploring clinical significance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Neurosciences
Luisa Seguella, Irene Palenca, Silvia Basili Franzin, Aurora Zilli, Giuseppe Esposito
Summary: Enteric glia, a unique population of peripheral neuroglia, display plastic and adaptative abilities, undergo phenotypic and functional changes, and engage in dynamic signaling with neurons and neighboring cells within the intestinal wall. They serve important roles in maintaining local homeostasis and sensing signals from luminal microbes, although further investigation is needed to fully understand this communication.
NEUROSCIENCE LETTERS
(2023)
Article
Microbiology
Andreia Carla Eugenio Pupim, Tacito Graminha Campois, Eduardo Jose de Almeida Araujo, Terezinha Inez Estivalet Svidizinski, Ionice Felipe
JOURNAL OF MEDICAL MICROBIOLOGY
(2017)
Article
Gastroenterology & Hepatology
L. C. L. Schneider, J. C. P. do Nascimento, A. R. Trevizan, M. B. Gois, S. C. Borges, E. J. Beraldi, J. L. Garcia, D. M. G. Sant'Ana, N. C. Buttow
NEUROGASTROENTEROLOGY AND MOTILITY
(2018)
Article
Medicine, Research & Experimental
Mariana Felgueira Pavanelli, Cristiane Maria Colli, Monica Lucia Gomes, Marcelo Biondaro Gois, Gessilda de Alcantara Nogueira de Melo, Eduardo Jose de Almeida Araujo, Debora de Mello Goncales Sant'Ana
BIOMEDICINE & PHARMACOTHERAPY
(2018)
Article
Parasitology
Daniele S. Rocha, Mariana G. Nilsson, Bianca M. Maciel, Hilda F. J. Pena, Bruna F. Alves, Aristeu Silva, Luis F. P. Gondim, George R. Albuquerque
JOURNAL OF PARASITOLOGY
(2018)
Article
Neurosciences
Rubina Aktar, Madusha Peiris, Asma Fikree, Vincent Cibert-Goton, Maxim Walmsley, Iain R. Tough, Paulo Watanabe, Eduardo J. A. Araujo, Sahar D. Mohammed, Jean-Marie Delalande, David C. Bulmer, S. Mark Scott, Helen M. Cox, Nicol C. Voermans, Qasim Aziz, L. Ashley Blackshaw
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Parasitology
Mariana Felgueira Pavanelli, Cristiane Maria Colli, Renata Coltro Bezagio, Marcelo Biondaro Gois, Gessilda de Alcantara Nogueira de Melo, Eduardo Jose de Almeida Araujo, Debora de Mello Goncales Sant'Ana
PARASITOLOGY RESEARCH
(2018)
Article
Gastroenterology & Hepatology
Aline Rosa Trevizan, Larissa Carla Lauer Schneider, Eduardo Jose de Almeida Araujo, Joao Luis Garcia, Nilza C. Buttow, Gessilda de Alcantara Nogueira-Melo, Debora de Mello Goncales Sant'Ana
NEUROGASTROENTEROLOGY AND MOTILITY
(2019)
Article
Chemistry, Medicinal
Camile Cecconi Cechinel-Zanchett, Thaise Boeing, Lincon Bordignon Somensi, Viviane Miranda Bispo Steimbach, Adriana Campos, Clarissa de Medeiros Amorm Krueger, Cristiany Schultz, Debora de Mello Goncales Sant'ana, Valdir Cechinel-Filho, Luisa Mota da Silva, Sergio Faloni de Andrade
PHYTOTHERAPY RESEARCH
(2019)
Article
Parasitology
Adriana Lebram von Sohsten, Aristeu Vieira da Silva, Guita Rubinsky-Elefant, Ilmara Simony Freitas Santana, Joelande Esquivel Correia, Luciara Alves da Cruz, Ellen Monteiro Ribeiro Santos, Priscylla Marcelly Vilanova Oliveira
EXPERIMENTAL PARASITOLOGY
(2020)
Article
Infectious Diseases
Tatiana Salerno, Amanda Keller Siqueira, Jose Paes de Almeida Nogueira Pinto, Maria de Lourdes Ribeiro de Souza da Cunha, Patricia Kelly Silvestre, Larissa Anuska Zeni Condas, Gustavo Henrique Batista Lara, Juliano Goncalves Pereira, Aristeu Vieira da Silva, Fernando Jose Paganini Listoni, Lorrayne de Souza Araujo Martins, Rodrigo Garcia Motta, Marcio Garcia Ribeiro
Summary: The study investigated the bacteriological and physical-chemical characteristics, as well as genotypic and phenotypic profiles of Staphylococcus species in breast milk samples from a hospital milk bank. It found that Staphylococcus and Enterobacter were the most prevalent genera, with high resistance rates to certain antimicrobials. Additionally, genes associated with toxin production and multidrug resistance were identified in the isolated bacteria. The presence of microbial multiplication inhibitory substances in a high percentage of samples highlighted the need for continuous monitoring of the quality of milk provided to infants from human milk banks.
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO
(2021)
Article
Microbiology
Thiago de Oliveira Zamprogna, Dayana Ribeiro, Vasco A. C. Azevedo, Gustavo Henrique Batista Lara, Rodrigo Garcia Motta, Rodrigo Costa da Silva, Amanda Keller Siqueira, Geraldo de Nardi Junior, Fernando Jose Paganini Listoni, Lorrayne de Souza Araujo Martins, Aristeu Vieira da Silva, Fabio Vinicius Ramos Portilho, Andre da Rocha Mota, Carolina Aparecida Rodrigues, Beatriz Oliveira de Almeida, Marcio Garcia Ribeiro
Summary: Caseous lymphadenitis in sheep is a chronic contagious disease caused by Corynebacterium pseudotuberculosis, diagnosed through cytology and microbiological testing, while molecular methods are confirmatory. The study also identified other bacteria in lymph nodes, posing potential diagnostic challenges.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Marcelo Alberto Elias, Mariana Felgueira Pavanelli, Gessilda de Alcanara Nogueira de Melo, Debora de Mello Goncales Sant'Ana
SEMINA-CIENCIAS AGRARIAS
(2020)
Meeting Abstract
Public, Environmental & Occupational Health
Ryan H. Avery, Simone S. Oliveira, Aristeu V. da Silva, Rojelio Mejia, Marta M. Silva, Rebecca C. Christofferson, Laura Rinaldi, John B. Malone
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2017)
Article
Parasitology
Pedro de Alcantara Brito Junior, Josiane Moreira Rocha, Caroline Araujo da Silva, Priscylla Marcelly Vilanova Oliveira, Joelande Esquivel Correia, Luciara Alves da Cruz, Anaia Paixao Seva, Teo Veiga de Oliveira, Aristeu Vieira da Silva, Martin Roberto del Valle Alvarez, George Rego Albuquerque
REVISTA BRASILEIRA DE PARASITOLOGIA VETERINARIA
(2020)