Article
Physiology
Rafal Pawlowski, Katarzyna Buszko, Julia L. Newton, Slawomir Kujawski, Pawel Zalewski
Summary: This study aimed to assess the cardiovascular system response to orthostatic stress in 133 healthy men using heart rate asymmetry methods. The research found that orthostatic stress affects the variability and asymmetry of human heart rate. Therefore, short-term HRA may serve as a potential tool to increase sensitivity in conditions where HUTT is a diagnostic tool.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biology
Gianfranco Piccirillo, Federica Moscucci, Ilaria Di Diego, Martina Mezzadri, Cristina Caltabiano, Myriam Carnovale, Andrea Corrao, Ilaria Lospinuso, Sara Stefano, Claudia Scinicariello, Marco Giuffre, Valerio De Santis, Susanna Sciomer, Pietro Rossi, Emiliano Fiori, Damiano Magri
Summary: The autonomic nervous system (ANS) can modulate the oscillation of electrocardiogram segments and their intervals, including the myocardial repolarization phase. This study investigates the influence of head-up/-down tilt on ECG segments, suggesting that cardiopulmonary postural reflexes can modulate ECG interval oscillations. T wave amplitude decreases during head-up tilt and correlates with left ventricular end-systolic volume. Head-up/-down tilt acutely modifies the autonomic nervous system balance through deactivation of cardiopulmonary reflexes.
Article
Engineering, Aerospace
Roman Yu Zhedyaev, Olga S. Tarasova, Anna P. Sharova, Elena S. Tomilovskaya, Olga L. Vinogradova, Anatoly S. Borovik
Summary: This study aimed to compare the effects of 7-day dry immersion on hemodynamic responses to HUT and LBNP. The results showed that dry immersion weakened autonomic blood pressure control in the HUT test, possibly due to an inappropriate increase in lower body vascular resistance.
Article
Cardiac & Cardiovascular Systems
Abrahim Mahmood, Kinza Ahmed, Youhua Zhang
Summary: Cardiac sympathetic activation and abnormal Ca2+ handling are important factors in the progression of heart failure. The interaction between beta-adrenergic receptor desensitization/down-regulation and abnormal Ca2+ handling in heart failure leads to cardiac dysfunction and arrhythmias.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Lingping Xu, Xiangqi Cao, Rui Wang, Yichao Duan, Ye Yang, Junlong Hou, Jing Wang, Bin Chen, Xianjun Xue, Bo Zhang, Hua Ma, Chaofeng Sun, Fengwei Guo
Summary: Direct drug-potentiated head-up tilt test (HUTT) is a safe and highly sensitive tool for diagnosing vasovagal syncope (VVS). It is especially important to perform HUTT in patients with precursor syncope symptoms but without actual syncope, particularly in young females presenting with weakness and sweating, to minimize the risk of misdiagnosis or missed diagnosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Vincenzo Russo, Erika Parente, Angelo Comune, Nunzia Laezza, Anna Rago, Paolo Golino, Gerardo Nigro, Michele Brignole
Summary: This study compared the positivity rate and type of responses in patients with classical and non-classical vasovagal syncope (VVS) using NTG-potentiated HUTT. The results showed that the positivity rate of HUTT was significantly higher in patients with classical VVS compared to those with non-classical VVS. Non-classical VVS patients were more likely to have a cardioinhibitory response and a history of traumatic syncope. Male sex, classical VVS, history of traumatic syncope, and use of diuretics were independent predictors of HUTT positivity.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Miles A. Tanner, Charles A. Maitz, Laurel A. Grisanti
Summary: This study demonstrates the important role of immune cell beta(2)AR in regulating inflammation and cardiac function in response to chronic catecholamine elevations. Mice lacking immune cell beta(2)AR showed decreased immune cell infiltration and improved cardiac outcomes when exposed to beta AR agonist isoproterenol. The findings suggest that beta(2)AR regulation of immune responses is crucial for the heart's response to prolonged beta adrenergic stimulation.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Isabella Kharraziha, Hannes Holm, Martin Magnusson, Per Wollmer, John Molvin, Amra Jujic, Artur Fedorowski, Erasmus Bachus, Viktor Hamrefors
Summary: Heart failure patients show lower cerebral tissue oxygenation at rest and during orthostasis compared to subjects without heart failure, with a greater decrease in SctO(2) in response to orthostatic challenge. Blood pressure remains stable during orthostasis, while heart rate and diastolic blood pressure increase in both groups.
Article
Cardiac & Cardiovascular Systems
Qingtong Wang, Ying Wang, Toni M. West, Yongming Liu, Gopireddy R. Reddy, Federica Barbagallo, Bing Xu, Qian Shi, Bingqing Deng, Wei Wei, Yang K. Xiang
Summary: By studying the molecular signaling and positive cardiac contractility induced by beta-blockers in the heart, it was found that carvedilol can promote cardiac inotropy and have a protective effect in diabetic mice. The observations suggest a novel beta(1)AR-NOS3 signaling pathway that may be targeted in therapy for heart diseases with reduced ejection fraction.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Qingtong Wang, Ying Wang, Toni M. West, Yongming Liu, Gopireddy R. Reddy, Federica Barbagallo, Bing Xu, Qian Shi, Bingqing Deng, Wei Wei, Yang K. Xiang
Summary: The study investigated the molecular signaling and effects of beta-blockers on cardiac inotropy in animal hearts. The results showed that carvedilol, a beta-blocker, can promote cardiac contractility through a specific signaling pathway, restoring heart function in diabetic mice and reducing cell apoptosis and hypertrophy in diabetic hearts.
CARDIOVASCULAR RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Dianne M. Perez
Summary: The failing heart has reduced energy generation capacity, leading to diminished functions, with defects in mitochondrial functions and oxidative phosphorylation affecting glucose and fatty acid oxidation. Early clinical studies suggest inhibitors of fatty acid oxidation and mitochondrial-targeted antioxidants may improve heart function by enhancing compensatory glucose oxidation. Adrenergic receptors play a key role in regulating cardiac function and metabolic pathways, with potential therapeutic benefits through adrenergic receptor-mediated restoration of cardiac energetics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agriculture, Dairy & Animal Science
Jinhee H. Hwang, John C. Kube, Stephen B. Smith
Summary: The study demonstrated that lubabegron fumarate acts as an antagonist to beta-adrenergic receptor subtypes in subcutaneous adipocytes and exhibits different responses to beta-AA and LUB in subcutaneous and intramuscular adipocytes.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Jenni K. Koskela, Anna Tahvanainen, Antti J. Tikkakoski, Pauliina Kangas, Marko Uitto, Jari Viik, Mika Kahonen, Jukka Mustonen, Ilkka Porsti
Summary: Resting heart rate (HR) is related to heart rate variability (HRV), with higher resting HR associated with higher sympathovagal balance (LF/HF ratio) and lower resting HR associated with lower sympathovagal balance. The association of HR with HRV during head-up tilt remains significant, indicating that resting HR can predict HRV levels during tilt-testing.
SCANDINAVIAN CARDIOVASCULAR JOURNAL
(2022)
Article
Oncology
Soon Young Kwon, Kyung Ju Chun, Hong Kwon Kil, Narae Jung, Hyun-Ah Shin, Jeon Yeob Jang, Hyo Geun Choi, Kyoung-Ho Oh, Min-Su Kim
Summary: The study found that beta 2-adrenergic receptor (AR) expression was positive in various head and neck cancer tissues, with higher levels in oral cavity cancer. Norepinephrine (NE) could stimulate the viability and proliferation of head and neck cancer cells in a dose-dependent manner, while propranolol could attenuate this stimulation. Overall, stress-related neurotransmitters may directly stimulate the viability and proliferation of head and neck cancers, which could be mitigated by beta-blockers.
Review
Cardiac & Cardiovascular Systems
Peyton B. Sandroni, Kelsey H. Fisher-Wellman, Brian C. Jensen
Summary: This article reviews recent studies demonstrating the differential regulation of cardiac contractility by alpha 1- and beta-ARs in cardiomyocytes, with evidence suggesting that alpha 1-ARs may mitigate the deleterious effects of chronic beta-AR activation.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
E. V. Marietta, A. M. Nadeau, A. K. Cartee, I. Singh, A. Rishi, R. S. Choung, T. -T. Wu, A. Rubio-Tapia, J. A. Murray
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2015)
Article
Gastroenterology & Hepatology
Rok Seon Choung, Ivo C. Ditah, Ashley M. Nadeau, Alberto Rubio-Tapia, Eric V. Marietta, Tricia L. Brantner, Michael J. Camilleri, S. Vincent Rajkumar, Ola Landgren, James E. Everhart, Joseph A. Murray
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2015)
Article
Public, Environmental & Occupational Health
Christi A. Patten, Christina M. Smith, Tabetha A. Brockman, Paul A. Decker, Christine A. Hughes, Ashley M. Nadeau, Pamela S. Sinicrope, Kenneth P. Offord, Edward Lichtenstein, Shu-Hong Zhu
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2011)
Article
Anesthesiology
Christopher J. Jankowski, Toby N. Weingarten, David P. Martin, Francis X. Whalen, John B. Gebhart, Lavonne M. Liedl, David R. Danielson, Ashley M. Nadeau, Darrell R. Schroeder, David O. Warner, Juraj Sprung
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
(2011)
Article
Gastroenterology & Hepatology
M. Camilleri, A. Nadeau, W. J. Tremaine, J. Lamsam, D. Burton, S. Odunsi, S. Sweetser, R. Singh
NEUROGASTROENTEROLOGY AND MOTILITY
(2009)
Article
Gastroenterology & Hepatology
A. Shin, M. Camilleri, A. Nadeau, S. Nullens, J. C. Rhee, I. D. Jeong, D. D. Burton
NEUROGASTROENTEROLOGY AND MOTILITY
(2013)
Article
Gastroenterology & Hepatology
G. J. Kolar, M. Camilleri, D. Burton, A. Nadeau, A. R. Zinsmeister
NEUROGASTROENTEROLOGY AND MOTILITY
(2014)
Article
Oncology
Lisa A. Howell, Pamela S. Sinicrope, Tabetha A. Brockman, Christi A. Patten, Paul A. Decker, Shawna L. Ehlers, Ashley Nadeau, Kari G. Rabe, Carmen Radecki Breitkopf, Gloria M. Petersen
HEREDITARY CANCER IN CLINICAL PRACTICE
(2013)
Meeting Abstract
Gastroenterology & Hepatology
Andrea Shin, Michael Camilleri, Ashley Nadeau, Sara Nullens, Jong Chul Rhee, In Du Jeong, Duane Burton
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2012)